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*  IJMS | Free Full-Text | Effects of (−)-Gallocatechin-3-Gallate on Tetrodotoxin-Resistant Voltage-Gated Sodium Channels in Rat...
Voltage-gated sodium channels (Nav) mediate neuronal action potentials. Tetrodotoxin inhibits all Nav isoforms, but Nav1.8 and ... Furthermore, the inhibition was accompanied by a depolarizing shift of the activation voltage and a hyperpolarizing shift of ... steady-state inactivation voltage. The percentage block of GCG (1 μM) on tetrodotoxin-resistant Na+ current was 45.1% ± 1.1% in ... Voltage-gated sodium channels (Nav) mediate neuronal action potentials. Tetrodotoxin inhibits all Nav isoforms, but Nav1.8 and ...
http://mdpi.com/1422-0067/14/5/9779/xml
*  14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5 | Circulation Research
Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Trends Cardiovasc Med. 2005; 15: 35-40. ... 14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5. Marie Allouis, Françoise Le Bouffant, Ronald Wilders ... 14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5 ... 14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5 ...
http://circres.ahajournals.org/content/98/12/1538
*  Voltage-Gated Sodium Channel Nav1.7 Maintains the Membrane Potential and Regulates the Activation and Chemokine-Induced...
Voltage-Gated Sodium Channel Nav1.7 Maintains the Membrane Potential and Regulates the Activation and Chemokine-Induced ... Voltage-Gated Sodium Channel Nav1.7 Maintains the Membrane Potential and Regulates the Activation and Chemokine-Induced ... Voltage-Gated Sodium Channel Nav1.7 Maintains the Membrane Potential and Regulates the Activation and Chemokine-Induced ... Voltage-Gated Sodium Channel Nav1.7 Maintains the Membrane Potential and Regulates the Activation and Chemokine-Induced ...
http://www.jimmunol.org/content/early/2011/06/29/jimmunol.1003345
*  British Library EThOS: Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells :...
Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells : control of metastatic cell ... The specific aims were threefold, as follows: 1) To test the effects of several types of voltage-gated sodium channel (VGSC) ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539266
*  Provocation of an Autoimmune Response to Cardiac Voltage-Gated Sodium Channel NaV1.5 Induces Cardiac Conduction Defects in Rats...
cardiac voltage-gated sodium channel α-subunit. SCN5A. cardiac voltage-gated sodium channel α-subunit gene. TIMP. tissue ... cardiac voltage-gated sodium-channel current. Ito. cardiac transient outward potassium current. LV. left ventricular. MMP. ... on the density of voltage-gated sodium current (INa), transient outward potassium current (Ito) and voltage-gated L-type ... In cardiomyocytes, voltage-gated sodium channels are crucial for the initiation and conduction of action potentials. The alpha ...
http://www.onlinejacc.org/content/62/4/340
*  Short Hairpin RNA-mediated Selective Knockdown of NaV1.8 Tetrodotoxin-resistant Voltage-gated Sodium Channel in Dorsal Root...
VOLTAGE-GATED sodium channels (VGSCs) play a critical role in determining excitability by supporting the upstroke of the action ... Akopian AN, Sivilotti L, Wood JN: A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature ... Short Hairpin RNA-mediated Selective Knockdown of NaV1.8 Tetrodotoxin-resistant Voltage-gated Sodium Channel in Dorsal Root ... Short Hairpin RNA-mediated Selective Knockdown of NaV1.8 Tetrodotoxin-resistant Voltage-gated Sodium Channel in Dorsal Root ...
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923738
*  SCN1A sodium voltage-gated channel alpha subunit 1 - Gene - GTR - NCBI
Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene ... encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. ... Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and ... SCN1A sodium voltage-gated channel alpha subunit 1. Also known as: FEB3; FHM3; NAC1; SCN1; SMEI; EIEE6; FEB3A; HBSCI; GEFSP2; ...
https://www.ncbi.nlm.nih.gov/gtr/genes/6323/
*  Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel
... Beltrán-Álvarez, Pedro ... Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel. Repositori DSpace/ ... Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the ... Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the ...
http://dugi-doc.udg.edu/handle/10256/10361
*  "The Relationship Between Voltage-Gated Sodium Channel Inactivation Fir" by J. F. Atherton, A. J. Gillies et al.
The Relationship Between Voltage-Gated Sodium Channel Inactivation Firing Frequency in the Subthalamic Nucleus Projection ... The Relationship Between Voltage-Gated Sodium Channel Inactivation Firing Frequency in the Subthalamic Nucleus Projection ...
https://corescholar.libraries.wright.edu/ncbp/637/
*  Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory...
Background: Gain-of-function mutations of the nociceptive voltage-gated sodium channel Nav1.7 lead to inherited pain syndromes ... Resurgent currents are thought to depend on the presence of the sodium channel beta 4-subunit. Using RT-qPCR experiments, we ... Results: In large A-fiber related DRGs ATX-II (5 nM) enhances persistent and resurgent sodium currents, but failed to do so in ... Conclusion: ATX-II enhances persistent and resurgent sodium currents in large diameter DRGs, whereas small DRGs depend on the ...
https://epub.ub.uni-muenchen.de/23453/index.html
*  Indian Patents. 234877:BIARYL SUBSTITUTED 6-MEMBERED HETEROCYCLES AS SODIUM CHANNEL BLOCKERS
Voltage-gated sodium channels represent a multigene family. Nine sodium channel subtypes have been cloned and functionally ... All voltage-gated sodium channels are characterized by a high degree of selectivity for sodium over other ions and by their ... voltage-dependent gating. [Catterall, W. A. Structure and function of voltage-gated sodium and calcium channels. Current ... Voltage-gated sodium channels as therapeutic targets. Drug. Discovery Today 5, 506-520 (2000)]. Several regions in the sodium ...
http://www.allindianpatents.com/patents/234877-biaryl-substituted-6-membered-heterocycles-as-sodium-channel-blockers
*  Research programme: Dravet syndrome therapeutics - Xenon - AdisInsight
Xenon is developing small molecule inhibitors of the voltage-gated sodium channel Nav1.6 for the treatment of Dravet syndrome. ... Mechanism of Action Nav1.6 voltage-gated sodium channel inhibitors * Orphan Drug Status Orphan designation is assigned by a ...
http://adisinsight.springer.com/drugs/800041848?error=cookies_not_supported&code=02025b85-c7c1-4c21-a642-a54401cca7db
*  2nsq - Proteopedia, life in 3D
Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ Res. 2004 Aug 6;95(3):284-91 ... Henke G, Maier G, Wallisch S, Boehmer C, Lang F. Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4 ... The ubiquitin E3 protein ligase Nedd4-2 is a physiological regulator of the epithelial sodium channel ENaC, which is essential ... Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, ...
http://proteopedia.org/wiki/index.php/2nsq
*  Voltage-Gated Sodium Channels
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https://www.noteflight.com/scores/view/86502e9f2f0261a1da1ef92f2c0b8a9cefd2988a
*  Voltage gated sodium channel, alpha-11 subunit (IPR028821) | InterPro | EMBL-EBI
Voltage gated sodium channel, alpha subunit (IPR001696) *Voltage gated sodium channel, alpha-11 subunit (IPR028821) ... Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels ... Voltage gated sodium channel, alpha-11 subunit (IPR028821). Short name: Na_channel_a11su ... From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.. Neuron 26 13-25 2000 ...
http://www.ebi.ac.uk/interpro/entry/IPR028821
*  A One-Domain Voltage-Gated Sodium Channel in Bacteria | Science
Voltage-gated sodium channels are a feature of excitable mammalian cells such as neurons, but have never been found in bacteria ... In his Perspective, Catterall discusses the discovery of the first bacterial voltage-gated sodium channel ( Ren et al.) and ... compares the structure and function of this channel with its mammalian counterpart. ... A One-Domain Voltage-Gated Sodium Channel in Bacteria Message Subject. (Your Name) has forwarded a page to you from Science ...
http://science.sciencemag.org/content/294/5550/2306
*  Voltage-Gated Sodium Channels - Semantic Scholar
... with a core alpha subunit that defines the sodium channel subtype and several beta subunits that modulate sodium channel ... A family of membrane proteins that selectively conduct SODIUM ions due to changes in the TRANSMEMBRANE POTENTIAL DIFFERENCE. ... Voltage-Gated Sodium Channels. Known as: Voltage-Gated Sodium Channels [Chemical/Ingredient], Sodium Channels, Voltage-Gated, ... Voltage Gated Sodium Channels (More). A family of membrane proteins that selectively conduct SODIUM ions due to changes in the ...
https://www.semanticscholar.org/topic/Voltage-Gated-Sodium-Channels/665681
*  Frontiers | Propranolol Blocks Cardiac and Neuronal Voltage-Gated Sodium Channels | Pharmacology
Propranolol blocks cardiac and neuronal voltage-gated sodium channels. Dao W. Wang1,2, Akshitkumar M. Mistry1, Kristopher M. ... Voltage-gated sodium channels are established pharmacological targets for local anesthetics and many other drugs with shared ... We found that the ability of propranolol to block voltage-gated sodium channels is not stereospecific, nor a class effect of β- ... 2010) Propranolol blocks cardiac and neuronal voltage-gated sodium channels. Front. Pharmacol. 1:144. doi: 10.3389/fphar. ...
https://www.frontiersin.org/articles/10.3389/fphar.2010.00144/full
*  Voltage Gated Sodium Channels | Springer for Research & Development
Ion channel biophysicists have at their disposal a rich and ever-growi ... A number of techniques to study ion channels have been developed since the electrical basis of excitability was first ... The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels ... culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with ...
https://rd.springer.com/book/10.1007/978-3-642-41588-3
*  Voltage-Gated Sodium Channels in Neurological Disorders | BenthamScience
Voltage-Gated Sodium Channels in Neurological Disorders. Author(s): Mohamed Chahine, Aurelien Chatelier, Olga Babich, Johannes ... Abstract: Voltage-gated sodium channels play an essential biophysical role in many excitable cells such as neurons. They ... Voltage-gated sodium channels play an essential biophysical role in many excitable cells such as neurons. They transmit ... This review describes the biochemical, biophysical and pharmacological properties of neuronal voltage-gated sodium channels ( ...
http://www.eurekaselect.com/92595/article
*  Marine Drugs | Free Full-Text | Shellfish Toxins Targeting Voltage-Gated Sodium Channels | Notes
Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in excitable ...
http://www.mdpi.com/1660-3397/11/12/4698/notes
*  Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin | Science
Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin ... Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin ... Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin ... Voltage-Gated Sodium Channel in Grasshopper Mice Defends Against Bark Scorpion Toxin ...
http://science.sciencemag.org/content/342/6157/441.full
*  Scn8a MGI Mouse Gene Detail - MGI:103169 - sodium channel, voltage-gated, type VIII, alpha
SCN8A, sodium voltage-gated channel alpha subunit 8. Orthology source: HomoloGene, HGNC ... IPR008054 Voltage gated sodium channel, alpha-8 subunit. IPR001696 Voltage gated sodium channel, alpha subunit ... IPR024583 Voltage-gated Na+ ion channel, cytoplasmic domain. ... PR:000002103 sodium channel protein type 8 subunit alpha. (term ... J:265777 Katz E, et al., Role of sodium channel subtype in action potential generation by neocortical pyramidal neurons. Proc ...
http://www.informatics.jax.org/marker/MGI:103169
*  The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels | SpringerLink
Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins that co-purify with pore-forming α ... Brackenbury WJ (2012) Voltage-gated sodium channels and metastatic disease. Channels 6(5):352-361PubMedCentralPubMedGoogle ... Johnson D, Bennett ES (2006) Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating. J Biol Chem ... that sodium channel β subunits not only regulate sodium channel function and localization but also modulate voltage-gated ...
https://link.springer.com/chapter/10.1007/978-3-642-41588-3_4
*  Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels | Molecular Pharmacology
Voltage-gated sodium (Na+) channels are targets for local anesthetic (LA) drugs that bind in the inner pore of the channel with ... Catterall WA, Goldin AL, and Waxman SG (2003) Compendium of voltage-gated ion channels: sodium channels. Physiol Rev 76: 887- ... Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels. Gregory M. Lipkind and Harry A. Fozzard ... Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels. Gregory M. Lipkind and Harry A. Fozzard ...
http://molpharm.aspetjournals.org/content/68/6/1611