Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target...
The voltage-gated Na+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a ... Pertin M, Ji RR, Berta T, Powell AJ, Karchewski L, Tate SN, et al. Upregulation of the voltage-gated sodium channel beta2 ... Huang CJ, Harootunian A, Maher MP, Quan C, Raj CD, McCormack K, et al. Characterization of voltage-gated sodium-channel ... Expression and role of voltage-gated sodium channels in human dorsal root ganglion neurons with special focus on Nav1.7, ...
Evaluation of the computational efficacy in GPU-accelerated simulations of spiking neurons | Computing
The model has terms derived from a sodium current, a potassium current, and a leak current. m, n, and h are gating variables ... alpha (V)\) and \(\beta (V)\) are voltage-dependent rates:. $$\begin{aligned} \alpha _m(V)= & {} -\, 0.1\times (v+40)/(\exp (-( ... and leak channels, and \(E_{\mathrm {Na}}, E_{\mathrm {Na}}\), and \(E_L\) are respectively the reversal potentials of \(\hbox ... Morris C, Lecar H (1981) Voltage oscillations in the barnacle giant muscle fiber. Biophys J 35:193-213 ...
Differential association of GABAB receptors with their effector ion channels in Purkinje cells | Brain Structure and Function
... the G protein-gated inwardly rectifying K+ (GIRK/Kir3) channel and the voltage-dependent Ca2+ channel, biochemical and ... Then, 100 µL of sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) sample buffer (0.125 M Tris-HCl pH 6.8, 4 ... If GABAB receptors do not couple to GIRK channels in dendritic shafts, N- or P/Q-type voltage-dependent Ca2+ channels might ( ... suppress neurotransmitter release by depressing Ca2+ influx via P/Q-type and N-type voltage-gated Ca2+ (CaV) channels (Huston ...
An Unusual Family of Glycosylated Peptides Isolated from Dendroaspis angusticeps Venom and Characterized by Combination of...
... such as voltage-gated and ligand-gated ionic channels, highly involved in controlling the mobility of their prey [4, 6-8], but ... Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) experiments reveal, however, a mass of approximately 67.4 ... Terlau, H., Olivera, B.M.: Conus venoms: A Rich Source of Novel Ion Channel-Targeted Peptides. Physiol. Rev. 84(1), 41-68 (2004 ... Other experiment are, however, being made on other kind of GPCRs and also on ion channels. ...