Pertactin - Wikipedia
Emsley, P.; Charles, I. G.; Fairweather, N. F.; Isaacs, N. W. (1996). "Structure of Bordetella pertussis virulence factor P.69 ... Emsley P, Charles IG, Fairweather NF, Isaacs NW (May 1996). "Structure of Bordetella pertussis virulence factor P.69 pertactin ... In molecular biology, pertactin (PRN) is a highly immunogenic virulence factor of Bordetella pertussis, the bacterium that ... v t e (Articles with short description, Short description is different from Wikidata, Bacteriology, Virulence factors, Whooping ...
Adenylate cyclase toxin - Wikipedia
Adenylate cyclase toxin is a virulence factor produced by some members of the genus Bordetella. Together with the pertussis ... Carbonetti, Nicholas H (March 2010). "Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella ... toxin it is the most important virulence factor of the causative agent of whooping cough, Bordetella pertussis. Bordetella ... Vaccination against Bordetella pertussis is used in infancy to prevent whooping cough. The recent switch from whole-cell ...
RTX toxin - Wikipedia
Adenylate cyclase toxin (ACT or CyaA), is a primary virulence factor in Bordetella pertussis. CyaA is a multifunctional RTX ... are the primary virulence factors in enterohaemorrhagic E. coli but EHEC produces several other virulence factors capable of ... RtxA is a virulence factor involved in cholera which facilitates colonization of V. cholerae the small intestine. RtxA causes ... The prototypical RTX toxin, α-haemolysin (HlyA; TC# 1.C.11.1.3), is a common virulence factor in uropathogenic E. coli (UPEC), ...
AB5 toxin - Wikipedia
Carbonetti, N. H. (2010). "Pertussis toxin and adenylate cyclase toxin: Key virulence factors of Bordetella pertussis and cell ... The bacterium Bordetella pertussis was first identified as the cause of whooping cough and isolated by Jules Bordet and Octave ... Guiso N. 2009.Bordetella pertussis and pertussis vaccines. Clin. Infect. Dis. 49:1565-1569 "1.C.72 The Pertussis Toxin (PTX) ... Pertussis toxin is secreted by the gram-negative bacterium, Bordetella pertussis. Whooping cough is very contagious and cases ...
Pertussis toxin - Wikipedia
Carbonetti NH (2010). "Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell ... PT, a decisive virulence determinant of B. pertussis, is able to cross the blood-brain barrier by increasing its permeability. ... Bordetella parapertussis shows the most similarity to B. pertussis and was therefore used for research determining the role of ... One difference between the different species of Bordetella is that B. pertussis produces PT and the other species do not. ...
Filamentous haemagglutinin adhesin - Wikipedia
v t e (Bacterial proteins, Whooping cough, Virulence factors, All stub articles, Protein stubs). ... One notable bacterium that produces filamentous haemagglutinin adhesin is Bordetella pertussis, which uses this protein as a ... virulence factor. Adhesin (disambiguation) Locht, C; Bertin, P; Menozzi, FD; Renauld, G. (1993). "The filamentous ... The filamentous haemagglutinin adhesin (FHA) is a large, filamentous protein that serves as a dominant attachment factor for ...
Teresa Lagergård - Wikipedia
Her main field of research include investigation of bacterial virulence factors, mechanisms of infection, infections immunology ... Bordetella pertussis 1. She was a full professor of biomedicine at Mucosal Immunology and Vaccine Center in Gothenburg. ...
Vaccine resistance - Wikipedia
"Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal ... Witter, R. L. (1997). "Increased Virulence of Mareks Disease Virus Field Isolates". Avian Diseases. 41 (1): 149-163. doi: ... Hegerle, Nicolas; Guiso, Nicole (2014-09-01). "Bordetella pertussis and pertactin-deficient clinical isolates: lessons for ... Soubeyrand, Benoit; Plotkin, Stanley A. (June 2002). "Antitoxin vaccines and pathogen virulence". Nature. 417 (6889): 609-610. ...
Haemagglutination activity domain - Wikipedia
... is a surface-exposed and secreted protein that acts as a major virulence attachment factor, functioning as both a primary ... In Bordetella pertussis, the infectious agent in childhood whooping cough, filamentous haemagglutinin (FHA) ... Inatsuka CS, Julio SM, Cotter PA (December 2005). "Bordetella filamentous hemagglutinin plays a critical role in ... "Filamentous hemagglutinin of Bordetella pertussis. A bacterial adhesin formed as a 50-nm monomeric rigid rod based on a 19- ...
List of MeSH codes (D23) - Wikipedia
... virulence factors, bordetella MeSH D23.946.896.980.040 - adenylate cyclase toxin MeSH D23.946.896.980.690 - pertussis toxin The ... factor viiia MeSH D23.119.375.310 - factor ixa MeSH D23.119.400.315 - factor xa MeSH D23.119.425.320 - factor xia MeSH D23.119. ... virulence factors, bordetella MeSH D23.946.123.946.040 - adenylate cyclase toxin MeSH D23.946.123.946.690 - pertussis toxin ... fibroblast growth factor 1 MeSH D23.348.383.120 - fibroblast growth factor 2 MeSH D23.348.383.130 - fibroblast growth factor 3 ...
LuxR-type DNA-binding HTH domain - Wikipedia
Bordetella pertussis bvgA (virulence factor) Bacillus subtilis comA (involved in expression of late-expressing competence genes ... virulence factor for soft rot disease; activates plant tissue macerating enzyme genes) Pseudomonas aeruginosa lasR (activates ... "Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA". Nature. 417 (6892): 971-4. doi: ...
Bordetella - Wikipedia
Differences in virulence factors relate to the loss of regulatory or control functions. Bordetella sp. is typically found to ... The virulence factors identified in the Bordetella are common to all three species. These include adhesins, such as filamentous ... In these conditions, some, but not all of the virulence factors associated with the Bvg+ phase are expressed, suggesting this ... Cotter P, Miller J (1997). "A mutation in the Bordetella bronchiseptica bvgS gene results in reduced virulence and increased ...
Bordetella pertussis - Wikipedia
Its virulence factors include pertussis toxin, adenylate cyclase toxin, filamentous hæmagglutinin, pertactin, fimbria, and ... 2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella ... Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the ... Nieves DJ, Heininger U (2016). "Bordetella pertussis". Bordetella pertussis. pp. 311-339. doi:10.1128/microbiolspec.EI10-0008- ...
Bordetella avium - Wikipedia
... as well as genes responsible for regulating the expression of virulence factors, such as bvgA (Bordetella virulence gene), have ... Bordetella avium is a gram negative, nonfermentative, strictly aerobic, motile bacterium from the genus Bordetella which has ... virulence attributes, and antibiogram of Bordetella avium isolated from turkeys in Egypt". Tropical Animal Health and ... avium is through fimbrial attachment to the respiratory epithelium and release of a variety of virulence factors, leading to ...
Bordetella bronchiseptica - Wikipedia
B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis, but ... Bordetella bronchiseptica is a small, gram-negative, rod-shaped bacterium of the genus Bordetella. It can cause infectious ... Genetic sequences of the Bordetella bronchiseptica complex (Sanger Institute) Type strain of Bordetella bronchiseptica at ... Hewlett, EL (1995). "Bordetella species." In: Principles and Practice of Infectious Diseases (Mandel, GL, Bennett, JE, Dolin, R ...
Aerobactin - Wikipedia
It is a virulence factor enabling E. coli to sequester iron in iron-poor environments such as the urinary tract. Aerobactin is ... Rhizobactin from Sinorhizobium Alcaligin from Bordetella J. B. Neilands (1995). "Siderophores: Structure and Function of ... Johnson JR, Moseley SL, Roberts PL, Stamm WE (February 1988). "Aerobactin and other virulence factor genes among strains of ...
Rhamnolipid - Wikipedia
A variety of virulence factors were analysed in Pseudomonas aeruginosa strains isolated from pneumonia patients. Rhamnolipids ... Rhamnolipids have been suggested as antimicrobials able to remove Bordetella bronchiseptica biofilms. The mode of killing has ... In summary, rhamnolipids have been shown unequivocally to be a potent virulence factor in the human host, however, they are ... Zulianello L, Canard C, Köhler T, Caille D, Lacroix JS, Meda P (June 2006). "Rhamnolipids are virulence factors that promote ...
Exotoxin - Wikipedia
They are often referred to as virulence factors, since they allow the organisms to move deeper into the hosts tissues. ... DPT vaccine protects against pertussis, tetanus and diphtheria infections, caused by the exotoxin-producing Bordetella ... DAuria G, Jiménez N, Peris-Bondia F, Pelaz C, Latorre A, Moya A (January 2008). "Virulence factor rtx in Legionella ... Other toxins act at elongation factor-2. In the case of the diphtheria toxin, EF2 is ADP-ribosylated and becomes unable to ...
Secretion - Wikipedia
T4SS also secrete virulence factor proteins directly into host cells as well as taking up DNA from the medium during natural ... Bordetella pertussis, the causative agent of whooping cough, secretes the pertussis toxin partly through the type IV system. ... Vesicles from a number of bacterial species have been found to contain virulence factors, some have immunomodulatory effects, ... Lawley TD, Klimke WA, Gubbins MJ, Frost LS (July 2003). "F factor conjugation is a true type IV secretion system". FEMS ...
Bacterial secretion system - Wikipedia
The system is involved variably in one type of gliding motility, in the proper targeting of certain virulence factors to the ... Bordetella pertussis, the causative bacterium of whooping cough, secretes its pertussis toxin partly through T4SS. Legionella ... Specifically, they are the cellular devices used by pathogenic bacteria to secrete their virulence factors (mainly of proteins ... In SecA pathway, a chaperone trigger factor (TF) first bind to the exposed N-terminal signal sequence of the peptide chain. As ...
Alpha-D-phosphohexomutase superfamily - Wikipedia
"Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of ... "Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence". Infection and ... "Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development". Infection and Immunity. 73 ... Liu XD, Duan J, Guo LH (August 2009). "Role of phosphoglucosamine mutase on virulence properties of Streptococcus mutans". Oral ...
Bacterial adhesin - Wikipedia
Identified Virulence Factors of UPEC : Adherence, State Key Laboratory for Moleclular Virology and Genetic Engineering, Beijing ... Moreover, the Bordetella pertussis adhesins FHA and pertactin are components of three of the four acellular pertussis vaccines ... The majority of bacterial pathogens exploit specific adhesion to host cells as their main virulence factor. "A large number of ... This prevalence marks them as key microbial virulence factors in addition to a bacteriums ability to produce toxins and resist ...
Microbial toxin - Wikipedia
These secreted virulence factors assist the bacterium in surviving immune response mechanisms. Examples of toxins produced by ... Bordetella pertussis targets cilia of the upper respiratory tract which are damaged by the Pertussis toxin, an ADP- ... Anthrax toxin is composed of three domains: protective antigen (PA), edema factor (EF), and lethal factor (LF). EF is an ... represent a class of pathogens with more severe virulence factors in addition to the ability to produce Stxs. EHEC infections ...
Whooping cough - Wikipedia
... have already been infected for several weeks to determine whether antibody against pertussis toxin or another virulence factor ... Pertussis is caused by the bacterium Bordetella pertussis. It is spread easily through the coughs and sneezes of an infected ... Single factors are much less useful. In adults with a cough of less than 8 weeks, vomiting after coughing or a "whoop" is ... Pertussis is caused by the bacterium Bordetella pertussis. It is an airborne disease (through droplets) that spreads easily ...
Siderophore - Wikipedia
This study focused on the construction, modeling, and dynamic simulation of PVD biosynthesis, a virulence factor, through a ... They may invade the gastro-intestinal tract (Escherichia, Shigella and Salmonella), the lung (Pseudomonas, Bordetella, ... Harrison F, Browning LE, Vos M, Buckling A (July 2006). "Cooperation and virulence in acute Pseudomonas aeruginosa infections ... campestris, is required for optimum virulence and growth inside cabbage". Molecular Plant Pathology. 18 (7): 949-962. doi: ...
Pilus - Wikipedia
... virulence factors and impunity factors on the cell surface of a number of species of Gram negative and some Gram positive ... Fimbriae are one of the primary mechanisms of virulence for E. coli, Bordetella pertussis, Staphylococcus and Streptococcus ... Pili are responsible for virulence in the pathogenic strains of many bacteria, including E. coli, Vibrio cholerae, and many ... The development of attachment pili may then result in the development of further virulence traits. ...
Bacillus anthracis - Wikipedia
... and other virulence factors. The enterotoxins and virulence factors are encoded on the chromosome, while the emetic toxin is ... Like Bordetella pertussis, it forms a calmodulin-dependent adenylate cyclase exotoxin known as anthrax edema factor, along with ... lethal factor, LF), and cya (edema factor, EF). These factors are contained within a 44.8-kb pathogenicity island (PAI). The ... While B. cereus and B. thuringiensis depend on the plcR gene for expression of their virulence factors, B. anthracis relies on ...
Filamentation - Wikipedia
Filamentation can also be induced by signalling factors produced by other bacteria. In addition, Agrobacterium spp. filament in ... In addition, filamentation is induced by nutrient-rich conditions in the intracellular pathogen Bordetella atropi. This occurs ... and is associated with other aspects of bacterial virulence such as biofilm formation. The number and length of filaments ... April 2008). "Interspecies signalling via the Stenotrophomonas maltophilia diffusible signal factor influences biofilm ...
Vaccine - Wikipedia
assorted factors such as ethnicity, age, or genetic predisposition. If a vaccinated individual does develop the disease ... Bordetella, canine parainfluenza virus, and Lyme disease, among others. Cases of veterinary vaccines used in humans have been ... of identified bacterial proteins that are involved in complement inhibition would neutralize the key bacterial virulence ... Factors that affect the trends of vaccine development include progress in translatory medicine, demographics, regulatory ...
Linezolid - Wikipedia
Linezolid Failure and Strain Characterization of Virulence Factors". Journal of Clinical Microbiology. 45 (2): 631-5. doi: ... In vitro, it is active against Pasteurella multocida, Fusobacterium, Moraxella catarrhalis, Legionella, Bordetella, and ... Vardakas KZ, Horianopoulou M, Falagas ME (June 2008). "Factors associated with treatment failure in patients with diabetic foot ...