Patent US20030052839 - Stabilized viral envelope proteins and uses thereof - Google Patents
... a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral ... a viral envelope protein comprising a viral surface protein and a corresponding viral transmembrane protein wherein the viral ... acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. ... acid sequence that enhance the stability of the complex formed between the viral surface protein and transmembrane protein. ...http://www.google.com/patents/US20030052839
virus (MV) a member from the paramyxovirus family members remains a - Role of adrenergic receptors in human coronary vasomotion
13 18 32 46 accompanied by membrane fusion orchestrated from TMPA IC50 the fusion (F) envelope proteins (26). Viral-gene ... MV infection is set up by pH-independent fusion from the viral envelope with the prospective cell plasma membrane (19). The ... proteins (6 25 The only real focus on for RdRp is really a ribonucleoprotein complicated of viral RNA encapsidated from the MV ... 12 53 and fusion proteins including structures of the latter in both the prefusion (52) and intermediate to postfusion (10 51 ...http://researchreportone.com/?p=1551
David Weliky, MSU, Dept. of Chemistry 'Structure/Function of Membrane-Associated Viral Fusion Proteins and Structure of...
of Chemistry 'Structure/Function of Membrane-Associated Viral Fusion Proteins and Structure of Recombinant Proteins in ... of Chemistry 'Structure/Function of Membrane-Associated Viral Fusion Proteins and Structure of Recombinant Proteins in ... of Chemistry 'Structure/Function of Membrane-Associated Viral Fusion Proteins and Structure of Recombinant Proteins in ...https://lsa.umich.edu/biophysics/news-events/all-events/archived-events/2012/09/david-weliky--msu--dept--of-chemistry--structure-function-of-mem.html
What is definition of viral fusion proteins?
... found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake ... What is definition of viral fusion proteins?. 3 years ago by Pozzter Q&A 0 replies, read ~167926 times ... Proteins, usually glycoproteins, found in the. viral envelopes of a variety of viruses. They. promote cell membrane fusion and ...https://pozzter.com/post/what-is-definition-of-viral-fusion-proteins-izbm20O
Viral Fusion Protein Inhibitors | Profiles RNS
"Viral Fusion Protein Inhibitors" by people in this website by year, and whether "Viral Fusion Protein Inhibitors" was a major ... "Viral Fusion Protein Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH ( ... Drugs that are designed to block the action of VIRAL FUSION PROTEINS and prevent VIRUSES from entering the cell. ... Below are the most recent publications written about "Viral Fusion Protein Inhibitors" by people in Profiles. ...https://profiles.ctsicn.org/display/49668
Transient Transfection-based Fusion Assay for Viral Proteins
To understand the fusion mechanism in more detail, we use an infection free system whereby fusion can be induced by a minimal ... Here, we describe an optimized protocol of a transient transfection based fusion assay to quantify cell-cell fusion induced by ... Membrane fusion is vital for entry of enveloped viruses into host cells as well as for direct viral cell-to-cell spread. ... Transient Transfection-based Fusion Assay for Viral Proteins Edited by. Yannick Debing ...https://bio-protocol.org/e2162
Viral Fusion Inhibitors - Protein Interactions
Viral Fusion Inhibitors. Wed, 30 May 2012 , Protein Interactions Until recently, only two proteins essential for the viral life ... thus inhibiting membrane fusion and viral entry. Interestingly, the first peptides inhibiting viral fusion were designed in the ... In an effort to design more potent inhibitors of viral fusion, Dwyer et al. (2007) applied modifications to an HR2 peptide ... absence of high-resolution structural data on the fusion protein, and structural implications of the fusion process were merely ...https://www.pharmacologicalsciences.us/protein-interactions/viral-fusion-inhibitors.html
LearnCoil / LearnCoil-VMF - Computational Evidence for Coiled-coil-like Motifs in Histidine Kinase Linker Domains /Viral...
LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins.. Singh M, Berger B, ... Viral Membrane-Fusion Proteins. Protein Sequence Analysis ... Viral Membrane-Fusion Protein 98 views. Sorry, the comment form ... LearnCoil-VMF program uses an iterative learning algorithm to detect coiled-coil-like regions in viral membrane-fusion proteins ... Motif Network Next Generation Sequencing Phylogenetic Tree Population Predict Prediction Protein Protein Sequence Protein ...http://www.mybiosoftware.com/learncoil-learncoil-vmf-computational-evidence-coiled-coil-like-motifs-histidine-kinase-linker-domains-viral-membrane-fusion-proteins.html
Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm | Retrovirology | Full Text
Recent structural studies revealed a stunning diversity of viral fusion proteins in their native state. In spite of this ... The converging hairpin motif, along with biochemical and functional data, implies that disparate viral proteins promote ... the post-fusion structures of these proteins share a common trimeric hairpin motif in which the amino- and carboxy-terminal ... permitting the cytosolic release of the viral cores. Understanding the molecular details of this process is essential for ...https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-5-111
A Randomized, Double-blind, Placebo-controlled Trial, Followed by Single-arm Treatment of PRO 140 in Combination w/ Optimized...
HIV Fusion Inhibitors. Viral Fusion Protein Inhibitors. Molecular Mechanisms of Pharmacological Action. Anti-HIV Agents. Anti- ... Proportion of participants with ≥ 0.5 log10 reduction in HIV-1 RNA viral load from baseline at the end of the 1-week double- ... Proportion of participants with ≥ 0.5 log10 reduction in HIV-1 RNA viral load from baseline at the end of the 1-week double- ... Proportion of participants with ≥ 1 log10 reduction in HIV-1 RNA viral load from baseline at the end of the 1-week double-blind ...https://clinicaltrials.gov/ct2/show/NCT02483078?term=pro140&rank=1
Optimizing Treatment for Treatment-Experienced, HIV-Infected People - Full Text View - ClinicalTrials.gov
HIV Fusion Inhibitors. Viral Fusion Protein Inhibitors. To Top. *For Patients and Families ... Change in Plasma HIV-1 Viral Load From Baseline to Week 1 [ Time Frame: From baseline to Week 1 evaluation ]. Method of Kaplan ... If any previous HIV-1 viral co-receptor tropism result is available, then most recent specimen date and the tropism result of ... Number of Participants With Plasma HIV-1 Viral Load , 50 Copies/ml [ Time Frame: At Weeks 24, 48, 96 ]. Number of participants ...https://clinicaltrials.gov/show/NCT00537394?order=360
An Interaction Study to Assess Drug Levels in Healthy Adult Subjects - Full Text View - ClinicalTrials.gov
HIV Fusion Inhibitors. Viral Fusion Protein Inhibitors. CCR5 Receptor Antagonists. To Top ...https://www.clinicaltrials.gov/ct2/show/NCT00764465
Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses | PNAS
2004) Class I, class II viral fusion protein structures reveal similar principles in membrane fusion. Mol Membr Biol 21:361-371 ... 1995) Structural characterization of viral fusion proteins. Curr Biol 5:265-274.. ... The GP2 subunit is a transmembrane protein that mediates fusion of the viral and cellular membranes after internalization of ... 2006) Virus membrane-fusion proteins: More than one way to make a hairpin. Nat Rev Microbiol 4:67-76.. ...https://www.pnas.org/content/105/7/2664?ijkey=bf4cc233727c2057a5358f6879445a148a72c8f2&keytype2=tf_ipsecsha
Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient...
Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-defic.... ... Expression of an IRF-3 fusion protein and mouse estrogen receptor, inhibits hepatitis C viral replication in RIG-I-deficient ... Here, we established a stable Huh7.5-IRF3ER cell line expressing a fusion protein of IRF-3 and mouse estrogen receptor (ER) to ... Homodimerization of the IRF-3ER fusion protein was detected by Western blotting after treatment with the estrogen receptor ...http://ufdc.ufl.edu/AA00007507/00001
RCSB PDB - Protein Feature View - Hemagglutinin - Q6DQ33 (Q6DQ33 9INFA)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the ... This protein in other organisms (by gene name): Q6DQ33 - Influenza A virus (A/Viet Nam/1203/2004(H5N1)) 13 * Q1WDM0 - Influenza ... Protein disorder predictions are based on JRONN (Troshin, P. and Barton, G. J. unpublished), a Java implementation of RONN * ...http://www.rcsb.org/pdb/protein/Q6DQ33
HA - Hemagglutinin precursor - Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) - HA gene & protein
Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the ... Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several ... trimers are required to form a competent fusion pore. ... Class I viral fusion protein. Responsible for penetration of ... fusion of virus membrane with host plasma membrane Source: Reactome. *intracellular transport of viral protein in host cell ...https://www.uniprot.org/uniprot/P03452
HA - Hemagglutinin - Influenza A virus (A/Chicken/Hong Kong/FY20/99(H9N2)) - HA gene & protein
Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the ... Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several ... trimers are required to form a competent fusion pore. ... Class I viral fusion protein. Responsible for penetration of ... Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the ...https://www.uniprot.org/uniprot/Q9DRM9
Membrane Structure & Function
... including membrane proteins. As such, its mission is to provide an intellectual home base for its members as the Biophysical ... Viral Fusion Proteins: Progress in Structure and Function. 1997. The Physiological Role of Cellular Lipid Transfer Proteins ... membrane proteins and lipid-protein interactions generally relevant to biological membranes and their assembly.. ... Biological Membrane Fusion: Mechanisms and Intermediates. 2005. Relevance of Lipid Bilayer Structure and Dynamics for ...http://www.biophysics.org/subgroups/membrane-structure-function
SCOPe 2.07: Structural Classification of Proteins - extended
... and ASTRAL compendium for protein structure and sequence analysis ... viral protein. Keywords: Viral Fusion Protein, VIRAL PROTEIN. ... Compound: Envelope protein E. Species: Dengue virus 1 [TaxId:11059]. Gene: Envelope protein. Database cross-references and ... Compound: Envelope protein E. Species: Dengue virus 1 [TaxId:11059]. Gene: Envelope protein. Database cross-references and ... SCOPe: Structural Classification of Proteins - extended. Release 2.07 (updated 2018-10-18, stable release March 2018) Copyright ...http://scop.berkeley.edu/pdb/code=4gsx
life of pi (Example) - MindMeister
Viral Fusion Proteins and SNAREs May Use Similar Strategies. 10.4.2. + Transport from the ER through the Golgi Apparatus. 10.4. ... Chapter 3 Proteins. 6.3.1. + The Shape and Structure of Proteins. 6.3.2. + Protein Function. 6.3.3. + References. 7. Part II ... Chapter 6 How Cells Read the Genome: From DNA to Protein. 7.3.1. + From DNA to RNA. 7.3.2. + From RNA to Protein. 7.3.3. + The ... Chapter 8 Manipulating Proteins, DNA, and RNA. 8.1.1. + Isolating Cells and Growing Them in Culture. 8.1.2. + Fractionation of ...https://www.mindmeister.com/51222573/alberts-molecular-cell-biology-major-headings
Frontiers | Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies |...
Class I viral fusion proteins require cleavage of their single-chain precursors to a meta stable pre-fusion state. The pre- ... Keywords: HIV-1, immunogenicity, viral fusion proteins, vaccines, recombinant protein expression, adjuvants, immunologic ... 1. White JM, Delos SE, Brecher M, Schornberg K. Structures and mechanisms of viral membrane fusion proteins: multiple ... Viral membrane fusion. Virology (2015) 479-80:498-507. doi:10.1016/j.virol.2015.03.043 ...https://www.frontiersin.org/articles/10.3389/fimmu.2018.01116/full
Murray State's Digital Commons - Posters-at-the-Capitol: The Effects of Hendra Virus Fusion Protein Charged Residues on Viral...
One focus of the Dutch lab is to study the specific proteins in these viruses that promote fusion between the viral membranes ... I am continuing my research to study the effects of this on the viral fusion process by transfecting the mutated plasmid DNA ... My specific project involves altering the plasmid DNA residue to see if this has an effect on viral fusion. Using a ... In most viruses, these fusion (F) proteins have a positively charged plasmid DNA residue that interacts with the negatively ...https://digitalcommons.murraystate.edu/postersatthecapitol/2009/UK/8/
SCOP 1.67: Structural Classification of Proteins - extended
... and ASTRAL compendium for protein structure and sequence analysis ... Fold h.3: Stalk segment of viral fusion proteins  *Fold ... Protein DnaK  from a.8.4.1: Heat shock protein 70kD (HSP70), C-terminal subdomain *Protein Ku70 subunit  from e. ... Protein DnaK  from b.130.1.1: Heat shock protein 70kD (HSP70), peptide-binding domain *Protein DnaK  from e.20.1 ... Protein S-lac lectin, L-14-II  from b.29.1.3: Galectin (animal S-lectin) *Protein DinB homolog (DBH)  from e.8.1 ...https://scop.berkeley.edu/statistics/ver=1.67
Hong Lab Research - Hong Lab MIT
An important class of membrane proteins that induce membrane curvature is viral fusion proteins, which merge the virus envelope ... Solid-state NMR studies of virus-cell fusion. (A) Virus-cell fusion model. The fusion protein undergoes a series of ... 1C), and investigate the structures of protein-cholesterol complex (Fig. 1D) and protein-protein complexes. This wealth of ... we investigate the conformations and oligomeric structures of the hydrophobic FP and TMD of viral fusion proteins in ...http://meihonglab.com/honglabresearch/
Coronaviruses and their Diseases | SpringerLink
Detection of Mouse Hepatitis Virus Nonstructural Proteins Using Antisera Directed Against Bacterial Viral Fusion Proteins ... Biosynthesis and Function of the Coronavirus Spike Protein H. Vennema, P. J. M. Rottier, L. Heijnen, G. J. Godeke, M. C. ... MHV Leader RNA Secondary Structure Affects Binding to the Nucleocapsid Protein Lisa M. Welter, Stephen A. Stohlman, Robert J. ... Revised Nomenclature for Coronavirus Structural Proteins, mRNAs and Genes D. Cavanagh, D. Brian, L. Enjuanes, K. Holmes, M. Lai ...https://link.springer.com/book/10.1007/978-1-4684-5823-7