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*  AID 755109 - Antiviral activity against HCV JFH-1 infected in human Huh7.5.1 cells assessed as viral core protein expression at...
Antiviral activity against HCV JFH-1 infected in human Huh7.5.1 cells assessed as viral core protein expression at 0.8 to 8 uM ...
https://pubchem.ncbi.nlm.nih.gov/bioassay/755109
*  Investigation of the roles of viral proteinases in the vaccinia virus life cycle
These proteins are involved in the maturation of viral core proteins, p4a, p4b, and p25K, to form infectious virions. DNA ... state had significantly lower viral titers throughout the last 6 hours of the cycle. Viral core protein processing in the "on" ... Protein processing was difficult to effectively visualize, with the best processing occurring at a MOI of 0.2, using Fugene as ... The multiplicity of infection (MOI) was optimized, and a MOI of 0.5 was best, with a 99.25% reduction in viral plaque formation ...
https://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/x059c920x
*  Recombinant Hepatitis C Virus Core 1b protein (Beta-Galactosidase) (ab67745)
Ab67745 is an active protein fragment produced in Escherichia coli and has been… ... Buy our Recombinant Hepatitis C Virus Core 1b protein (Beta-Galactosidase). ... HCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in ... Recombinant Hepatitis C Virus Core 1b protein (Beta-Galactosidase). See all Hepatitis C Virus Core 1b proteins and peptides. ...
http://www.abcam.com/recombinant-hepatitis-c-virus-core-1b-protein-beta-galactosidase-ab67745.html
*  An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation
The HBV virion has four overlapping open reading frames (ORFs) that encode seven proteins: core protein, precore protein, viral ... Fortunately, three forms of the envelope protein HBsAg and the viral polymerase were encoded by the overlapping ORF where ... Journal of viral hepatitis. 2002;9:52-61 9. Gish RG, Chang TT, Lai CL, de Man R, Gadano A, Poordad F. et al. Loss of HBsAg ... targeting S4 region could affect not only the synthesis of those three envelope proteins but the viral polymerase and it is ...
http://www.ijbs.com/v12p1104.htm
*  Control of capsid disassembly is crucial for efficient HIV-1 cDNA activity
In conditions of capsid phosphorylation by virion-associated kinases, the catalytic subunit of cAMP-dependent proteins kinase ( ... Phosphorylation of other amino acidity residues in California offers been reported to contribute to viral duplication [24C27] ... The development of change transcription causes morphological and mechanised adjustments in the HIV-1 cores [14]. General, these ... the pathogen situations many bottlenecks constituted by a range of sponsor cell protein important for or inhibitory to HIV-1 ...
http://researchhunt.com/2017/11/16/control-of-capsid-disassembly-is-crucial-for-efficient-hiv-1-cdna-activity/
*  Publication - TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
... is required for the degradation of the immature core protein. The expression of the HCV core protein alters endoplasmic ... TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis. Aizawa, S; ... Oral administration of the SPP inhibitor to transgenic mice expressing HCV core protein (CoreTg) reduces the expression of core ... The immature core protein produced in SPP-knockout cells or by treatment with an SPP inhibitor is quickly degraded by the ...
https://www.ozgene.com/publication/papers?view=publication&task=show&id=324
*  Viruses | Free Full-Text | Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral...
Here, we provide electron microscopy-based data demonstrating the association of both nuclear capsids and NEC proteins at ... The latter has been studied intensely pointing to the formation of a viral core nuclear egress complex (NEC) that recruits a ... Specifically, immunogold labelling of the core NEC constituent pUL53 and NEC-associated viral kinase pUL97 suggested an ... Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. ...
http://mdpi.com/1999-4915/10/1/35
*  Split responses of the F5 transgenic T cells to peptid | Open-i
F5 spleen cells (2 × 105/well) were stimulated with given concentration of the viral peptides or control P1A peptides for 48 h ... F5 spleen cells (2 × 105/well) were stimulated with given concentration of the viral peptides or control P1A peptides for 48 h ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199130_JEM.971488f1a&req=4
*  Role of Adenovirus Core Proteins in Innate Signaling and Viral Genome Packaging - Patrick Hearing
The major Ad core protein, protein VII, protects the viral genome from recognition by the DDR immediately after infection. As ... Role of Adenovirus Core Proteins in Innate Signaling and Viral Genome Packaging Hearing, Patrick State University New York ... Core protein VII is tightly associated with the viral genome within the Ad virus particle, the capsid. It is not clear how ... Role of Adenovirus Core Proteins in Innate Signaling and Viral Genome Packaging. Hearing, Patrick / State University New York ...
http://grantome.com/grant/NIH/R21-AI102577-02
*  Cross-reactive cells are oligoclonal T memory cell expa | Open-i
RNA-Binding Proteins*. *Viral Core Proteins/genetics*/immunology. Minor. *Animals. *Cell Division ... Selective expansion of cross-reactive CD8(+) memory T cells by viral variants. ... Selective expansion of cross-reactive CD8(+) memory T cells by viral variants. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195685_JEM991162.f3b&req=4
*  Small Things Considered: The Immunological Synapse Goes Viral
... virus core; red = viral core protein at budding site). Bars = 500 nm (A) and 200 nm (B-E). Source. ... The Immunological Synapse Goes Viral. by Merry Youle. Structural proteins in the HTLV-I virion include Gag (a capsid protein) ... The addition of 33 nM nocodazole, which blocks microtubule polymerization, also prevents transfer of the viral proteins to the ... A) The viral synapse is characterized by a tight membrane-membrane contact with an inter-membrane spacing of about 20 nm. Viral ...
https://schaechter.asmblog.org/schaechter/2012/04/the-immunological-synapse-goes-viral.html
*  The Hepatitis B Virus (HBV) HBx Protein Activates AKT To Simultaneously Regulate HBV Replication and Hepatocyte Survival |...
HBV replication occurs within the viral capsid in the cytosol of hepatocytes; the capsid is composed of the viral core protein ... we also analyzed HBV core protein levels after HNF4α knockdown. LY294002 treatment increased the HBV core protein levels in ... 2E). HBV core protein levels were also reduced by mAKT1 and mAKT2 (Fig. 2F). We also analyzed HBV mRNA levels by Northern blot ... 3E, lanes 1 and 3); however, when HNF4α was knocked down, we did not see an increase in HBV core protein levels after LY294002 ...
https://jvi.asm.org/content/89/2/999
*  Assembly Pharmaceuticals and BioCrossroads Announce Investment to Advance Potentially Curative Therapy for Chronic Hepatitis B...
BioCrossroads Joins Twilight Ventures, Luson Bioventures and Other Investors- -Breakthrough Anti-viral Science Is Based on ... "Our HBV drug candidates modulate the viral core protein. By altering the core protein's functions across multiple stages in the ... which target the HBV core protein, a unique viral protein with no human analogue that is involved in multiple stages of the HBV ... CpAMs can alter the activities of the HBV core protein, a unique viral protein with no human analogue that is involved in ...
https://www.biocrossroads.com/assembly-pharmaceuticals-biocrossroads-announce-investment-advance-potentially-curative-therapy-chronic-hepatitis-b-virus/
*  Guo H[au] - PubMed - NCBI
NS38 is required for aquareovirus replication via interaction with viral core proteins and host eIF3A. ... Value of the detection of BRAF(V600E) gene mutation and protein expression in auxiliary cytological diagnosis of papillary ... Facile Preparation of Cu/Ag Core/Shell Electrospun Nanofibers as Highly Stable and Flexible Transparent Conductive Electrodes ... Physiological functions of Wilms' tumor 1-associating protein and its role in tumourigenesis. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Guo+H%5Bau%5D&dispmax=50
*  DNA viruses Flashcards by Isabel Leach | Brainscape
Cytoplasmic gene expression and replication, so viral core has to carry all necessary proteins. Viral RNAs are not spliced. ... 2) Viral DNA replication leads to lots of free viral genome ends which are proapoptotic. 3) Viral replication centres lead to ... All viral. Include DNA pol, TK, topoisomerase, Uracil DNA glycosylase, protein kinase. ... Expression of viion associated host shutoff protein which causes the degradation of cellular and viral RNA. ...
https://www.brainscape.com/flashcards/dna-viruses-3710762/packs/5494219
*  Locker JK[au] - PubMed - NCBI
A vaccinia virus lacking A10L: viral core proteins accumulate on structures derived from the endoplasmic reticulum. ... Characterization of vaccinia virus intracellular cores: implications for viral uncoating and core structure. ... Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral ... Another triple-spanning envelope protein among intracellularly budding RNA viruses: the torovirus E protein. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Locker+JK%5Bau%5D&dispmax=50
*  Set - Protein SET - Mus musculus (Mouse) - Set gene & protein
Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 ... Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF- ... Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti- ... Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 ...
http://www.uniprot.org/uniprot/Q9EQU5
*  Autophagy Required for Hepatitis B Virus Replication in Transgenic Mice | Journal of Virology
This core protein mRNA, which is also termed the pregenomic RNA (pgRNA), is packaged by the core protein to form the viral core ... which then directs the transcription of viral mRNAs. The mRNA of the viral core protein is larger than the genome length. ... which is also packaged in the core particle. The core particle subsequently interacts with the viral envelope proteins for the ... which then resulted in the accumulation of core protein in hepatocytes and compensated for the reduction of the core protein ...
https://jvi.asm.org/content/85/24/13453.long
*  Anti-SET antibody (ab92872) | Abcam
Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010) . ... Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF- ...
http://www.abcam.com/set-antibody-ab92872.html
*  Epidemiology of AIDS
The confirmatory test is Western Blot - detecting specific antibody to viral core protein (p24) and envelop glycoprotein (gp41 ... RETRO VIRAL GENES • gag (group-specific antigen): makes the cone shape viral capsid • pol (polymerase): codes for viral enzymes ... Virus protein U gene is required for efficient viral replication • Found only in HIV-1 • vpx • The virus protein X gene has an ... Outer matrix protein (p17) • Major capsid protein (p24) • Nuclear protein (p7) • RNA with reverse transcriptase ...
https://www.slideshare.net/AnushaDivvi/epidemiology-of-aids
*  Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97 |...
Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97. ... Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97 ... pointing to the formation of a viral core nuclear egress complex (NEC) that recruits a multimeric assembly of viral and ... herpesviral nuclear egress nuclear egress complex (NEC) viral protein kinase pUL97 immunogold-electron microscopy NEC-capsid ...
https://repository.medri.uniri.hr/en/islandora/object/medri%3A1974
*  Bio Informatics (IBIVU) - Vrije Universiteit Amsterdam
Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients. van der Ree, M. H., ... Seeing the Trees through the Forest: Sequence-based Homo- and Heteromeric Protein-protein Interaction sites prediction using ...
https://research.vu.nl/en/organisations/bio-informatics-ibivu-2
*  "T cells with regulatory activity in hepatitis C virus infection: what " by Angela Dolganiuc and Gyongyi Szabo
Animals; Hepacivirus; Hepatitis C; Humans; Immunity, Cellular; T-Lymphocytes, Regulatory; Viral Core Proteins ...
https://escholarship.umassmed.edu/oapubs/1927/
*  Integrative Bioinformatics<...
Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients. van der Ree, M. H., ... Seeing the Trees through the Forest: Sequence-based Homo- and Heteromeric Protein-protein Interaction sites prediction using ... The characteristics of molten globule states and folding pathways strongly depend on the sequence of a protein. Dijkstra, M. J ...
https://research.vu.nl/en/organisations/integrative-bioinformatics-2
*  'genes gag' Protocols and Video...
Genes, gag: DNA sequences that form the coding region for proteins associated with the viral core in retroviruses. gag is short ...
https://www.jove.com/keyword/genes+gag