Left ventricular ejection fraction (LVEF) of ≥50% assessed by echocardiography or cardiac multi-gated acquisition (MUGA) scan ... Adequate hematologic, liver and renal function. * Females of childbearing potential (FCBP) must:. *not be pregnant ...
... or left ventricular ejection fraction (LVEF) , 50% ... severe lung function impairment. *Prior exposure to a BTK or ... Subjects who have indications for treatment (threatened end-organ function, bulky disease ,5cm, symptoms, steady progression, ... Disease significantly affecting gastrointestinal function such as dysphagia, chronic diarrhea, intestinal obstruction, or ...