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*  Vascular endothelial growth factor B - Wikipedia
Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member. In contrast to VEGF-A, VEGF-B plays a less pronounced role in the vascular system: Whereas VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions, VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B plays also an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis. VEGF-B exerts its ...
https://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor_B
*  Vascular Endothelial Growth Factor B | CTD
A vascular endothelial growth factor expressed in a variety of tissues. It binds with high specificity to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 and NEUROPILIN-1 ...
http://ctdbase.org/detail.go?type=chem&acc=D042561
*  Correlation between concentration of vitreous angiogenic cytokines (VEGF-B and PIGF) with central retinal thickness and macular...
Purpose : Placental growth factor (PlGF) and vascular endothelial growth factor B (VEGF-B) are members of the vascular endothelial growth factor family, binding to VEGF-R1. PIGF inhibition suppresses pathological angiogenesis in inflammatory disorders and diabetic retinas. PIGF levels are overexpressed in the vitreous of diabetic retinopathy (DR) patients and levels may increase with the severity of the disease. VEGF-B is a vascular survival factor, safeguarding the balance between blood vessel growth and degeneration. Under degenerative conditions VEGF-B is a survival factor to protect cells from apoptosis; during certain pathologies can act as antiangiogenic factor to prevent overgrowth of blood vessels. Angiogenic VEGF-B activity during ...
http://iovs.arvojournals.org/article.aspx?articleid=2558154
*  Medical Sciences | Free Full-Text | VEGF-B Levels in the Vitreous of Diabetic and Non-Diabetic Patients with Ocular Diseases...
Vascular endothelial growth factor B (VEGF-B) is one of the enigmatic members of the VEGF family. The knowledge gap about VEGF-B expression and how its levels are altered in diabetic eyes were the focus of this investigation that was addressed by comparing and correlating vitreous VEGF-B between diabetic and non-diabetic patients. VEGF-B levels were measured by enzyme-linked immunosorbent assay in vitreous samples (n = 33) from diabetic (n = 25) and non-diabetic (n = 8) patients. Results were compared between groups. Optical coherence tomography from diabetic patients was evaluated for central retinal thickness (CRT) and macular volume (MV). Mean vitreous VEGF-B concentration was higher in diabetic (18.82 ± 1.44 pg/mL ) vs. non-diabetic patients (17.90 ± 0.32 pg/mL) (p = 0.006), and in proliferative diabetic retinopathy (PDR) (19.03 ± 1.52 pg/mL) vs. non-PDR (NPDR) patients (18.18 ±0.96 pg/mL) (p = 0.025). In diabetic retinopathy (DR) ...
http://www.mdpi.com/2076-3271/5/3/17
*  OriGene - VEGFB (NM 003377) Human ORF cDNA Clone
VEGFB - VEGFB (Myc-DDK-tagged)-Human vascular endothelial growth factor B (VEGFB) available for purchase from OriGene - Your Gene Company.
http://www.origene.com/Human_ORF/RC202426.aspx
*  Intramyocardial VEGF-B167 Gene Delivery Delays the Progression Towards Congestive Failure in Dogs With Pacing-Induced Dilated...
Vascular endothelial growth factor (VEGF)-B, 1 of the 5 members of the VEGF family,1 is relatively understudied compared to VEGF-A, yet is emerging as a major cytoprotective factor.2,3 Expressed in tissues with elevated metabolism, including myocardium,4 the VEGF-B gene encodes for 2 isoforms, VEGF-B167 and VEGF-B186, which selectively bind the receptors VEGFR-1 and neuropilin-1.4,5 Based on data from knockout and transgenic animals, this growth factor is minimally angiogenic and its absence is compatible with birth and growth, although it seems important for physiological cardiac development.6-8 Li et al have recently elucidated mechanisms responsible for VEGF-B-induced cytoprotection: VEGF-B167, via VEGFR-1, downregulates genes of the apoptosis/cell death-related pathways, in vitro, and can rescue neurons from apoptosis in mouse models of retinal and brain damage.2 The ...
http://circres.ahajournals.org/content/106/12/1893
*  Vegfb polyclonal antibody - (PAB13528) - Products - Abnova
Rat polyclonal antibody raised against recombinant Vegfb. Recombinant protein corresponding to mouse Vegfb. (PAB13528) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=PAB13528
*  VEGFB elisa kit product blog
Blog on VEGFB elisa kit product: The Bovine VEGFB n/a (Catalog #MBS055549) is an ELISA Kit and is intended for research purposes only. The...
http://assay.mybiosource.com/vegfb-elisa-kit_55549
*  VEGFB (Human) Recombinant Protein (P01) - (H00007423-P01) - Products - Abnova
Human VEGFB full-length ORF ( AAH08818.1, 1 a.a. - 207 a.a.) recombinant protein with GST-tag at N-terminal. (H00007423-P01) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00007423-P01
*  Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC3534223/?lang=en-ca
*  British Library EThOS: Genomic and post-genomic studies in endometrial cancer
Genomic abnormalities lead to aberrant cell growth and signalling, contributing to the development of malignancy. Growth and metastasis also require the development of tumour vasculature. The VEGFs and angiopoietins are growth factor families central to this process. This thesis examines their expression in endometrial cancer. Genomic and post-genomic studies are used to broaden the investigation of angiogenesis and include related pathways. Using in situ hybridisation VEGF-A mRNA was detected in epithelial cancer cells but not pre-malignant and benign endometrium while VEGF-B was localised to both epithelial and stromal cells and was most abundant in benign endometrium. These findings suggest that VEGF-B may modulate the actions of VEGF-A by occupying receptors. Larger, gene microarray studies confirmed the differential expression of angiogenic factors and also identified a distinct set of coherently regulated genes in ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604158
*  Cotransfection of Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Via Recombinant Adeno-Associated...
In the present pre-clinical study, we used a long-acting vector (AAV) as a means to ensure long-term efficacy of transduction. Moreover, we sought to overcome the weakness of VEGF-A with respect to inducing vessel maturation and collateral growth by combining it with PDGF-B, a factor well-known for its role in mural cell recruitment. In a peripheral artery occlusion model, we found that the VEGF-A/PDGF-B combination did not alter the capillary density induced by VEGF-A alone (Figs. 1A and 1B). However, pericyte coverage of capillaries as well as growth of the conductance vessels (collaterals) increased significantly after PDGF-B cotransduction (Figs. 1C, 1D, 2A, and 2B), enabling a gain in limb perfusion. Combined VEGF-A/PDGF-B gene therapy was also found capable of improving the function of hibernating myocardium in a large-animal model (pigs) of chronic ischemia, in contrast to VEGF-A alone, even though the latter was given at a 5-fold higher dose (1 × ...
http://www.onlinejacc.org/content/56/5/414
*  A New Angiogenesis Weapon | Science
Tumors need blood, and they secrete angiogenic molecules such as vascular endothelial growth factor (VEGF) to encourage new blood vessels to form. Although an antibody directed against VEGF (αVEGF) can prolong life when given in conjunction with chemotherapy to individuals with certain cancers, inhibiting VEGF signaling can elicit adverse side effects and switch on alternative angiogenic mechanisms in tumor cells. Noting that placental growth factor (PlGF, a VEGF family member) is not required for normal development of the vasculature but has been implicated in pathological angiogenesis, Fischer et al. investigated the effect on tumors of an antibody directed against PlGF (αPlGF). In a mouse model, αPIGF by itself inhibited the growth or metastasis of melanoma and of colon and pancreatic carcinomas, and enhanced inhibition of tumor growth by the chemotherapeutic agents ...
http://science.sciencemag.org/content/318/5853/1041.3.full
*  Browsing Student Research, Projects and Publications by Subject "Placenta Growth Factor (PIGF)"
Placenta growth factor (PlGF) is known to induce angiogenesis and protect placental trophoblast from apoptosis. We have shown that PlGF mRNA expression is increased in hypoxic human myocardium and in rat neonatal ...
http://escholarshare.drake.edu/handle/2092/230/browse?value=Placenta+Growth+Factor+
*  High-Resolution Ultrasound Perfusion Imaging of Therapeutic Angiogenesis | JACC: Cardiovascular Imaging
Imaging of growing vasculature and quantitative measurement of perfusion are very important in the assessment of clinical efficacy of angiogenic therapies. Strong vascular growth during therapeutic angiogenesis by overexpression of VEGF family members involving abundant capillary enlargement leading to capillary arterialization (6) and increased vascular permeability interferes with many current vascular imaging and perfusion measurement techniques. We found in this study that real-time CPS ultrasound imaging is a feasible and accurate perfusion measurement method after GT for therapeutic vascular growth in peripheral muscles of small and large experimental animals.. None of the current noninvasive perfusion measurement techniques, such as DCE-MRI, CT, SPECT, PET, laser Doppler, optical imaging methods, and previous ultrasound techniques, can provide simultaneous capillary level imaging at a high frame-rate, ...
http://imaging.onlinejacc.org/content/1/1/83
*  Is the Fetal Heart a Hematopoietic Organ? | Circulation Research
To the Editor:. The article by Tomanek et al1 presents well the in vivo data on the requirement of VEGF family members for tubulogenesis and coronary artery formation. The authors observed that VEGF-Trap (a chimera of R1 and R2), apart from precluding formation of coronary arteries, causes a massive accumulation of erythrocytes in the subepicardium and in the interventricular septum. The important finding of this study was that erythrocytes that are components of blood islands derive from epicardial-derived precursors. The authors assume that proepicardial cells include a hemangioblast population. From this observation a conclusion can be drawn that either the proepicardium or the fetal heart exhibits a hematopoietic activity.. Considering the topic of blood island derivation in the embryonic heart I would like to comment that although the derivation of the endothelial cell component in these structures has been proven, the origin of erythrocytes is ambiguous and has not yet been resolved. ...
http://circres.ahajournals.org/content/98/10/e72
*  Plus it
The presence of tumor-associated macrophages (TAM) has been linked to increased tumor grade and poor clinical outcome in glioblastoma multiforme (GBM), suggesting that depletion or inhibition of these cells may suppress tumor growth. Colony-stimulating factor 1 receptor (CSF1R) is required for macrophage differentiation and survival, prompting Pyonteck and colleagues to investigate the therapeutic potential of CSF1R blockade in preclinical models of GBM. Treatment with BLZ945, a brain-penetrant, selective CSF1R inhibitor, specifically reduced macrophage proliferation and survival in vitro without affecting glioma cell viability. Furthermore, in a transgenic mouse model of proneural GBM driven by expression of the platelet-derived growth factor B (PDGFB) oncogene, CSF1R blockade reduced the malignant progression of GBMs and induced tumor regression in mice bearing established high-grade gliomas, resulting in prolonged survival. In addition, ...
http://cancerdiscovery.aacrjournals.org/content/3/11/1217.1
*  IJMS | Free Full-Text | Role of Btg2 in the Progression of a PDGF-Induced Oligodendroglioma Model | HTML
Tumor progression is a key aspect in oncology. Not even the overexpression of a powerful oncogenic stimulus such as platelet derived growth factor-B (PDGF-B) is sufficient per se to confer full malignancy to cells. In previous studies we showed that neural progenitors overexpressing PDGF-B need to undergo progression to acquire the capability to give rise to secondary tumor following transplant. By comparing the expression profile of PDGF-expressing cells before and after progression, we found that progressed tumors consistently downregulate the expression of the antiproliferative gene Btg2. We therefore tested whether the downregulation of Btg2 is sufficient and necessary for glioma progression with loss and gain of function experiments. Our results show that downregulation of Btg2 is not sufficient but is necessary for tumor progression since the re-introduction of Btg2 in fully progressed tumors dramatically impairs their gliomagenic potential. These results suggest an ...
http://www.mdpi.com/1422-0067/13/11/14667/htm
*  Difference between revisions of "User:Jungwhan Kim" - OpenWetWare
Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, '''Jung-whan Kim''', Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. '''Int. J. Cancer,94:500-507 (2001 ...
https://openwetware.org/wiki/?title=User:Jungwhan_Kim&diff=677427&oldid=315217
*  Difference between revisions of "User:Jungwhan Kim" - OpenWetWare
Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, '''Jung-whan Kim''', Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. '''Int. J. Cancer,94:500-507 (2001 ...
https://openwetware.org/wiki/?title=User:Jungwhan_Kim&diff=677427&oldid=317499
*  Difference between revisions of "User:Jungwhan Kim" - OpenWetWare
Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, Jung-whan Kim, Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. Int. J. Cancer,94:500-507 (2001) ...
https://openwetware.org/wiki/?title=User:Jungwhan_Kim&diff=prev&oldid=600659
*  Difference between revisions of "User:Jungwhan Kim" - OpenWetWare
Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, Jung-whan Kim, Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. Int. J. Cancer,94:500-507 (2001) ...
https://openwetware.org/wiki/?title=User:Jungwhan_Kim&diff=prev&oldid=611742
*  Difference between revisions of "User:Jungwhan Kim" - OpenWetWare
Seung-Hoon Lee, Yong-Suk Cho, Chan-sub Shim, Jung-joo Choi, Sun-Hee Oh, Jung-whan Kim, Wei Zhang and Jeho Lee. Aberrant Expression of Smad4 Results in Resistance against the Growth Inhibitory Effect of Transforming Growth Factor-b (TGF-b) in the SiHa Human Cervical Carcinoma Cell Lines. Int. J. Cancer,94:500-507 (2001) ...
https://openwetware.org/wiki/?title=User:Jungwhan_Kim&diff=prev&oldid=611755
*  VEGF-C 与VEGF-D 比值变化与肿瘤淋巴道转移的研究进展 · 临床与病理杂志
肿瘤侵袭周边原有淋巴管以及诱导组织内新生淋巴管的形成,是肿瘤淋巴道转移的必要条件。VEGF-C和VEGF-D是特异性淋巴管生长调节因子,与淋巴管的增生和分化密切相关。二者的比值升高可能是肿瘤淋巴道转移的早期事件和潜在评估指标。本文介绍VEGF-C和VEGF-D的结构、功能、比值变化以及二者与肿瘤淋巴道转移关系的研究进展。
http://lcbl.amegroups.com/articles/356
*  Specimen-Specific Vertebral Fracture Modeling: A Feasibility Study using the Extended Finite Element Method
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
http://pubmedcentralcanada.ca/pmcc/articles/PMC4852468/