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*  Isolated Recombinant Vaccinia Virus Complement Control Protein (Hrvcp) Polypeptide - Patent application
... recombinant vaccinia virus complement control protein [0215]hrVCP: humanized recombinant vaccinia virus complement control ... 0002]Vaccinia virus complement control protein (VCP) is known to be a strong inhibitor of the classical, lectin and alternative ... The humanised recombinant vaccinia virus complement control protein (hrVCP) of the invention has three amino acid changes as ... An isolated recombinant vaccinia virus complement control protein (hrVCP) polypeptide comprises a modified amino acid sequence ...
http://www.patentsencyclopedia.com/app/20080318858
*  Vaccinia virus intracellular mature virions contain only one lipid membrane. - Oxford Neuroscience
Moreover, crescents were found to form at sites remote from IC membranes-namely, within the center of virus factories and ... Serial-section analysis and angular tilt analysis of sections detected no continuity between virus lipid crescents or IV ... Consistent with this, we have demonstrated previously by confocal microscopy that uncoated virus cores within the cytoplasm ... 5-nm-thick lipid bilayer in virus crescents, IV, and IMV particles that is covered by a 8-nm-thick protein coat. In contrast, ...
https://www.neuroscience.ox.ac.uk/publications/14570
*  JCVI: Analysis of the Complete Genome of Smallpox Variola Major Virus Strain Bangladesh-1975
Variola virus has a group of proteins that are truncated compared with vaccinia virus counterparts and a smaller group of ... identity to major gene products encoded by vaccinia virus, the smallpox vaccine. ... We analyzed the 186,102 base pairs (bp) that constitute the entire DNA genome of a highly virulent variola virus isolated from ... Most of the virus proteins correspond to proteins in current databases, including 150 proteins that have , 90% ...
http://www.jcvi.org/cms/publications/listing/abstract/article/analysis-of-the-complete-genome-of-smallpox-variola-major-virus-strain-bangladesh-1975/
*  Vaccinia immune globulin (By injection)
Treats conditions caused by vaccinia virus, which can affect the skin, eyes, and mouth. ... Vaccinia Immune Globulin, Human (vax-IN-ee-a i-MUNE GLOB-ue-lin, HUE-man) ... Vaccinia Immune Globulin, Human (vax-IN-ee-a i-MUNE GLOB-ue-lin, HUE-man). Treats conditions caused by vaccinia virus, which ... Vaccinia immune globulin (By injection) Vaccinia immune globulin (By injection). Drug Information ...
https://www.baptistjax.com/health-library/drugnotes/vaccinia-immune-globulin-by-injection
*  Smallpox Vaccine: Contraindications, Administration, and Adverse Reactions - American Family Physician
Some of these reactions can be treated with vaccinia immune globulin or cidofovir. Proper patient screening and site care are ... The most serious side effects of smallpox vaccine include progressive vaccinia, postvaccinial central nervous system disease, ... Cidofovir has in vivo and in vitro activity against vaccinia virus.8 Cidofovir never has been used to treat vaccinia virus ... Smallpox vaccine contains live vaccinia virus, a milder cousin of the variola (smallpox) virus.5 It does not contain smallpox ...
https://www.aafp.org/afp/2003/0901/p889.html
*  Smallpox Vaccine | Reston Hospital Center
The smallpox vaccine contains a live virus, called the vaccinia virus. This is related to smallpox. The vaccine is given as ... A live virus is injected into the skin. It is possible to spread it to other areas of the body, or even to other people. The ... As the virus advances, a red rash appears on the tongue and in the mouth. The rash then spreads. Spots begin to break open. The ... You should get the vaccine if you have come in contact with the virus or if you are at risk. The vaccine is not given to the ...
https://restonhospital.com/hl/?/2010817038/Smallpox-Vaccine
*  CDC Releases Guidelines for Treating Adverse Reactions to Smallpox Vaccination - Practice Guidelines - American Family Physician
Smallpox vaccine is made from live vaccinia virus but does not contain variola virus, which causes smallpox. ... Smallpox vaccine is made from live vaccinia virus but does not contain variola virus, which causes smallpox. Different vaccinia ... Ocular vaccinia. Inadvertent periocular or ocular implantation with vaccinia virus, can range from mild to severe Keratitis: ... Ocular vaccinia. Inadvertent periocular or ocular implantation with vaccinia virus, can range from mild to severe Keratitis: ...
https://www.aafp.org/afp/2003/0415/p1827.html
*  ACAM2000â ¢: The new smallpox vaccine for United States Strategic | DDDT
The US government has therefore recently supported development of an improved live vaccinia virus smallpox vaccine. This ... a single plaque-purified vaccinia virus derivative of Dryvax®, aseptically propagated in cell culture. Preclinical and clinical ... Additionally, Dryvax® had a questionable safety profile since it consisted of a pool of vaccinia virus strains with varying ... Additionally, Dryvax® had a questionable safety profile since it consisted of a pool of vaccinia virus strains with varying ...
https://www.dovepress.com/articles.php?article_id=4449
*  Floridian: Calling the shots on smallpox
It contains a live virus, vaccinia. The virus is introduced through a two-pronged needle and multiple pricks through the skin ... The virus lived only in laboratories in the United States and the Soviet Union. Intelligence experts believe it has since been ... Intelligence reports said Saddam Hussein had the lethal virus and could unleash it on U.S. troops in the Iraqi desert. A ... The recipient's body responds by producing antibodies and T-cells to fight the virus. These defenders then stand ready, if ...
http://www.sptimes.com/2003/10/26/news_pf/Floridian/Calling_the_shots_on_.shtml
*  I was vaccinated against smallpox 40 years ago. Am I still protected? - Scientific American
The old Dryvax vaccine, made in the 1970s by Wyeth Laboratories, was made by purifying vaccinia virus obtained from pustules ... People who suffer from progressive vaccinia, generalized vaccinia or eczema vaccinatum are treated with vaccine immunoglobulin ... Both vaccines use the same strain of vaccinia virus, the so-called New York Board of Health strain, and they differ only in the ... a preparation of antibodies to the vaccinia virus obtained from the plasma of recently vaccinated donors.. There are two types ...
https://www.scientificamerican.com/article/i-was-vaccinated-against/
*  Smallpox vaccine extends life in cancer trial | Lifescript.com
JX-594 is derived from a strain of the virus vaccinia, once commonly used to vaccinate children against smallpox. ... "Viruses are inherently cancer selective and tumor cells are inherently susceptible to viral attack," said Dr. David Kirn, chief ... Scientists have been intrigued for decades with the idea of using viruses to alert the immune system to seek and destroy ... Other forays into using engineered viruses include biotech giant Amgen Inc's deal in January to pay up to $1 billion for BioVex ...
http://www.lifescript.com/health/centers/digestive/news/2011/11/07/smallpox_vaccine_extends_life_in_cancer_trial.aspx
*  Identification of SNPs associated with variola virus virulence | BioData Mining | Full Text
It is found in the extracellular enveloped virus form of VARV. In the vaccinia virus model, in which it is known as the A56 ... Parkinson JE, Smith GL: Vaccinia virus gene A36R encodes a M(r) 43-50 K protein on the surface of extracellular enveloped virus ... the vaccinia virus complement control protein, to the surface of infected host cells. With A56, K2 reduces the amount of virus ... Deletion of this gene impacts vaccinia virus virulence [12].. Other models identified by our MDR analysis performed inferiorly ...
https://biodatamining.biomedcentral.com/articles/10.1186/1756-0381-6-3
*  Smallpox | Hacienda Publishing
Given the ease of administration and the availability of the vaccinia virus as a vaccine against smallpox,(8) some have argued ... could theoretically engineer a recombinant virus exhibiting variola virus's virulence by starting with monkeypox virus. ... Vaccines, Viruses, and Chronic Illnesses (September/October 1999) *Futility of Care and the "Duty to Die" (November/December ... Why the smallpox virus stocks should not be destroyed. Science. 1993;262:1225-1226.. 16. Buller RM, Palumbo GJ. Poxvirus ...
http://haciendapub.com/medicalsentinel/smallpox
*  Researchers seek what links smallpox vaccine, heart ills
... vaccinia virus - a less dangerous relative of smallpox - might be exciting an immune response in the heart. ... heart tissue which might have been caused by the vaccinia virus in the smallpox vaccine. ... It could be a case of 'molecular mimicry,' he said, in which molecules of the virus mimic molecules of the heart, and both are ... He pointed out that small virus particles may routinely show up in the heart tissue of vaccinated individuals - the issue just ...
http://www.ph.ucla.edu/epi/bioter/researchersseek.html
*  dreddyclinic.com - Smallpox (variola)
... disfiguring and often deadly disease caused by the variola virus. ... were stopped contained live vaccinia virus - a virus similar to ... The researchers evaluated how immune system cells responded when participants were exposed to vaccinia, a virus related to the ... But the virus didn't disappear entirely. Stocks of smallpox virus, set aside for research purposes, are officially stored in ... What were the results of vaccinia exposure?. Exposure to vaccinia produced a robust response in people who had been vaccinated ...
http://www.dreddyclinic.com/findinformation/vv/variolavirus.php
*  Smallpox (variola, variola major, variola minor, variola vera, alastrim, the pox, variole, viruela, pocken, blattern
... smallpox virus infects only humans in nature, whereas cowpox, monkeypox and vaccinia viruses infect both humans and animals. ... vaccinia virus) is highly protective, even after exposure.. Smallpox was declared "eradicated" from nature in 1979, but remains ... active against vaccinia virus or other orthopoxviruses in vitro and in laboratory animals. Tecovirimat, given orphan drug ... herpes viruses; 2) Tzanck smear for features of varicella-zoster, herpes viruses ...
http://www.psychiatryadvisor.com/dermatology/smallpox-variola-variola-major-variola-minor-variola-vera-alastrim-the-pox-variole-viruela-pocken-blattern/article/591502/
*  FDA approves new smallpox vaccine - Drug Store News
ACAM2000 is made using a pox virus called vaccinia, which is related to but different from the virus that causes smallpox. ... Smallpox is caused by the variola virus, which spreads through close contact with infected individuals or contaminated objects ... The drug inoculates people who are at high risk of exposure to the virus. ...
https://www.drugstorenews.com/article/fda-approves-new-smallpox-vaccine/
*  Antiviral Research - Orthopoxvirus targets for the development of new antiviral agents | ViroBlogy
The prototype of the orthopoxvirus group is vaccinia virus and its replication cycle will be discussed in detail noting ... Useful illustration of what a good idea it is to understand the "Entrance, Entertainment and Exit" strategies fo a virus! ... for the treatment of these infections and might also reveal new approaches for antiviral drug development with other viruses. ...
https://rybicki.wordpress.com/2012/04/02/antiviral-research-orthopoxvirus-targets-for-the-development-of-new-antiviral-agents/
*  PPT - Recognition of Adverse Reactions following Smallpox Vaccination PowerPoint presentation | free to download - id: 119269...
The most famous example of this type of vaccine is vaccinia virus: Both cowpox ... , PowerPoint PPT presentation , free to view ... Vaccinia Specific Adverse Events. Palebral Autoinoculation 17. Generalized vaccinia 18. Generalized Vaccinia*Differential ... Anti-Viral Vaccines - Medicinal Chemistry Donlene Webb SMU Viruses A virus is a submicroscopic obligate parasitic particle that ... Buynak Synopsis Vaccines - Medicinal Chemistry Donlene Mallon SMU Viruses A virus is a submicroscopic obligate parasitic ...
http://www.powershow.com/view/119269-ODM3M/Recognition_of_Adverse_Reactions_following_Smallpox_Vaccination_powerpoint_ppt_presentation
*  Worldandnation: Bush launches smallpox vaccination program
... and progressive vaccinia, where the vaccination site does not heal and the virus spreads, eating away at flesh, bone and gut. ... People who live with others who have these conditions should not be vaccinated, because the live virus used in the vaccine can ... While all stocks of the virus beyond two official labs were supposed to be destroyed, experts fear that hostile nations or ... as President Bush said the threat of a bioterror attack with the virus is real though not imminent. Bush said Friday he will ...
http://www.sptimes.com/2002/12/14/Worldandnation/Bush_launches_smallpo.shtml
*  What does variola virus mean?
Meaning of variola virus. What does variola virus mean? Information and translations of variola virus in the most comprehensive ... Definition of variola virus in the Definitions.net dictionary. ... variola virus, smallpox virus(noun). the virus that causes ... What does variola virus mean?. Definitions for variola virus. Here are all the possible meanings and translations of the word ... Discuss these variola virus definitions with the community:. Word of the Day. Would you like us to send you a FREE new word ...
http://www.definitions.net/definition/variola%20virus
*  Smallpox - BioTech Weblog
Contact with the virus is very unlikely unless you have worked with the virus in a lab or you have been exposed through ... Taking antibodies against a disease similar to smallpox, which is the vaccinia immune globulin, may help shorten the duration ... Smallpox is caused by infection with the variola virus. The virus can be transmitted either directly from person to person, ... The virus can stay alive between 6 and 24 hours. People were once vaccinated against this disease. However, the disease has ...
http://www.biotech-weblog.com/smallpox/
*  HHS Buys Next Generation Smallpox Vaccine | EmaxHealth
"To protect ourselves from the remote but extremely grave threat of a deliberate release of smallpox virus, we need vaccines ... Denmark to manufacture and deliver 20 million doses of a next generation modified vaccinia Ankara smallpox vaccine. ...
https://www.emaxhealth.com/39/12908.html
*  Vaccinia Virus Expression
... Allergan kedziekm at class.class.org Wed Nov 9 14:46:28 EST 1994 *Previous message: Level 2 ... Our group is considering using a vaccinia virus for expression of cDNAs in tissue culture cells. 1. Is such a system ... Are there safety issue involved with using vaccinia virus (Level 2 biosafety?). Thanks, Karen Kedzie Allergan Pharmaceuticals, ...
http://www.bio.net/bionet/mm/methods/1994-November/020761.html
*  Vaccinia virus, A37 (IPR009641) | InterPro | EMBL-EBI
This family contains a number of poxviral proteins, which include Vaccinia virus, A37, the function of which is unknown. ... Vaccinia virus, A37 (IPR009641). Short name: Vaccinia_virus_A37 Overlapping homologous superfamilies None. ...
http://www.ebi.ac.uk/interpro/entry/IPR009641