Defining antigen targets to dissect vaccinia virus and monkeypox virus-specific T cell responses in humans. Grifoni A, Zhang Y ... The monkeypox virus (MPXV) outbreak confirmed in May 2022 in non-endemic countries is raising concern about the pandemic ... Little is known regarding MPXV immunity in the context of MPXV infection or vaccination with vaccinia-based vaccines (VACV). As ... with vaccinia, T cells are likely to provide an important contribution to overall immunity to MPXV. Here, we leveraged the ...