One of the most promising candidates is the Whole-Cell Pneumococcal Vaccine (WCV). The new generation of whole-cell vaccines is ... These vaccines have been extensively studied, are currently in human trial phase 1/2, and seem to be the best treatment choice ... there is still a need for new vaccines with unlimited serotype coverage, long-lasting protection, and lower cost to be ... Although Pneumococcal Conjugate Vaccines (PCVs) are available and have significantly reduced the rate of invasive pneumococcal ...

Vaccines 2010, 9, 645-664. [Google Scholar]. *Gomara, M.J.; Ercilla, G.; Alsina, M.A.; Haro, I. Assessment of synthetic ... Vaccine 2000, 18, 362-370. [Google Scholar]. *Gomes, P.; Giralt, E.; Andreu, D. Direct single-step surface plasmon resonance ... The panel of MS and BD sera was also tested against the synthetic peptide CSF114(Glc) following the previously validated ELISA ... A synthetic glycopeptide of human myelin oligodendrocyte glycoprotein to detect antibody responses in multiple sclerosis and ...

The live attenuated vaccine BPZE1 was developed to mimic immunogenicity of natural infection without causing disease, and in ... C and maintained its vaccine potency, as evaluated in a murine protection assay. This manufacturing process thus enables ... Current pertussis vaccines protect against disease, but not against colonization by and transmission of Bordetella pertussis, ... The BPZE1 vaccine strain [8] Working Cell Bank (WCB) was grown in fully synthetic Thijs medium [15] under agitation. After ...

HPV vaccines are highly immunogenic. The efficacy and effectiveness of vaccines has been remarkably high among young women who ... Moreover, the direct effect of the nonavalent vaccine with the cross-protection of bivalent and quadrivalent vaccines results ... In anal infections and anal intraepithelial neoplasia, the vaccines demonstrate high efficacy. While HPV vaccines are very ... Two-dose HPV vaccine schedules showed no difference in seroconversion from three-dose schedules. However, the use of a single- ...

Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro synthetic ... Recent updates are briefly described in the status of mRNA vaccines against SARS-CoV-2, influenza virus, and other viral ... The unprecedently speedy development of mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was ... Unique features of mRNA vaccine platforms and future perspectives are discussed. ...

Several vaccine candidates are in the pipeline. The likely earliest Phase 1 vaccine trial is a synthetic DNA-based candidate. A ... An incidence-minimizing vaccination strategy is highly sensitive to vaccine efficacy, and vaccines with lower efficacy should ... Consideration of age-specific contact rates and vaccine efficacy is critical to optimize vaccine allocation. New ... and various levels of vaccine efficacy. A transmission-blocking vaccine should be prioritized in adults aged 20-49 years and ...

Improvement of the synthetic tri-peptide vaccine (S3Pvac) against porcine Taenia solium cysticercosis in search of a more ... Subsequently, the DC vaccine is injected into groups of mice injected with melanoma cells. The vaccine DCs that reach the lymph ... Vaccine 2007, 25, 1368-1378. [Google Scholar] [CrossRef] [PubMed]. *Piñon-Zárate, G.; Herrera-Enríquez, M.; Hernández-Téllez, B ... Emens, L.A. Cancer vaccines: On the threshold of success. Expert Opin. Emerg. Drugs 2008, 13, 295-308. [Google Scholar] [ ...

The mechanism by which vaccine adjuvants enhance immune responses has historically been considered to be the creation of an ... Aachoui, Y.; Schulte, M.L.; Fitch, R.W.; Ghosh, S.K. Synthetic adjuvants for vaccine formulations: Evaluation of new phytol ... Hilleman, M.R. Vaccines in historic evolution and perspective: A narrative of vaccine discoveries. Vaccine 2000, 18, 1436-1447 ... adjuvants for mucosal vaccines [8], genetic adjuvants for DNA vaccines [9], or adjuvants for vaccines against select diseases ...

... including new platform technologies such as viral-vectored vaccines. We discuss the different vectored vaccines that have been ... Unfortunately, influenza vaccine composition needs to be updated annually due to antigenic shift and drift in the viral ... We also discuss future perspectives and limitations in the field that will need to be addressed before new vaccines can ... A Synthetic Influenza Virus Vaccine Induces a Cellular Immune Response That Correlates with Reduction in Symptomatology and ...

In this study, a modified, HexaPro S protein subunit vaccine, delivered using a needle-free high-density microarray patch (HD- ... Mice given two doses of the vaccine candidate generated potent antibody responses capable of neutralizing the parental SARS-CoV ... has been the prime target for current vaccine research since antibodies directed against the S protein were found to neutralize ... protein have given rise to potential immune evasion of the response generated by the current generation of SARS-CoV-2 vaccines ...

Vaccines based on tumor antigens (Ag) have emerged as an innovative strategy with the potential to address these areas. Here, ... we review the fundamental aspects relevant for the development of cancer vaccines and the critical role of dendritic cells (DCs ... peptide vaccinations and the use of larger constructs such as synthetic therapeutic peptide conjugate vaccines [150] to induce ... Chung, E.H. Vaccine allergies. Clin. Exp. Vaccine Res. 2014, 3, 50-57. [Google Scholar] [CrossRef][Green Version] ...

Vaccines, an international, peer-reviewed Open Access journal. ... Various chemicals such as natural or synthetic polymers, ... Currently approved mRNA vaccines for COVID-19 were successfully produced with liposome-based NPs. NPs can become the active- ... Vaccines is an international peer-reviewed open access monthly journal published by MDPI. ... Special Issue "Role of Nanoparticles in Vaccines and Pharmaceuticals". * Special Issue Editors ...

... but antigenic differences between vaccine and mumps outbreak strains could also contribute to reduced vaccine effectiveness. ... obtained from Jeryl-Lynn mumps vaccine strains were compared with genomes from 462 circulating MuV strains. In 31 epitope ... epitope candidates the corresponding sequences in wild-type strains had reduced predicted HLA-I-binding compared to the vaccine ... Waning of vaccine-induced immunity plays a role, ... and mass spectrum as the corresponding synthetic MuV peptides ...

Tiling multiplex PCR allows for the amplification of numerous viral amplicons but can introduce synthetic artifacts with ... Sequencing will also serve an important function as antiviral and vaccine trials roll out, identifying antiviral resistance ... determinants and vaccine escape mutants, and is essential for detecting viral recombination. For reliable determination of ...

The activation of human blood leukocytes has been shown to increase in response to selenium-enriched foods [92]. Vaccine ... oral administration of synthetic selenium nanoparticles induced a robust Th1 cytokine pattern after a hepatitis B surface ... Oral administration of synthetic selenium nanoparticles induced robust Th1 cytokine pattern after HBs antigen vaccination in ... Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults. Clin. Nutr. ...

An Intramuscular DNA Vaccine for SARS-CoV-2 Decreases Viral Lung Load but Not Lung Pathology in Syrian Hamsters ... A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo- ...

Buskas, T.; Thompson, P.; Boons, G.J. Immunotherapy for cancer: Synthetic carbohydrate-based vaccines. Chem. Commun. 2009, 5335 ... Vaccines 2020, 8, 128. [Google Scholar] [CrossRef]. *Vermaelen, K. Vaccine Strategies to Improve Anti-cancer Cellular Immune ... Martins, K.A.; Bavari, S.; Salazar, A.M. Vaccine adjuvant uses of poly-IC and derivatives. Expert Rev. Vaccines 2015, 14, 447- ... glycopolymer-stabilized gold nanoparticles as potential synthetic cancer vaccines. J. Am. Chem. Soc. 2013, 135, 9362-9365. [ ...

Vaccine having recombinant replication-defective adenoviral vector in combination with human wild-type p53 showed improvement. ... the synthetic protein becomes trapped within the secondary structure via a chemical staple. These peptides directly target the ... such as a BCL-XL-based vaccine for prostate cancer and the inhibitor of BCL-XL, i.e., an antibody-drug conjugate, namely, ABBV- ... and synthetic glucocorticoids are given for the treatment of hematological malignancies [20,21]. Apoptosis has extensive ...

... , an international, peer-reviewed Open Access journal. ... synthetic neoglycoconjugate vaccines; organic synthesis; ... https://www.mdpi.com/journal/vaccines/sectioneditors/Cancer_vaccines. clear Back to TopTop ... Special Issue in Vaccines: The 10th Anniversary of Vaccines-Cancer Vaccines and Immunotherapy. ... Special Issue in Vaccines: Tumor Immunotherapy. Special Issue in Vaccines: Tumor Immunotherapy: Version II. Special Issue in ...

Special Issue in Vaccines: Vaccine Delivery. Special Issue in Cancers: Cancer Vaccines: Research and Applications. Special ... Interests: cannabinoids; endocannabinoids; endocannabinoid-like bioactive lipids; synthetic chemistry; plant extraction; ... Special Issue in Vaccines: Vaccines for Infectious and Chronic Diseases. Special Issue in Biologics: Anti-SARS-CoV-2/COVID-19 ... Special Issue in Vaccines: Vaccines for Infectious and Chronic Diseases 2.0. Special Issue in Biomedicines: Bioactive Compounds ...

Van Oosterwijk, J.G.; Wikel, S.K. Resistance to ticks and the path to anti-tick and transmission blocking vaccines. Vaccines ... Agwunobi, D.O.; Yu, Z.; Liu, J. A retrospective review on ixodid tick resistance against synthetic acaricides: Implications and ... Anti-tick vaccines are one approach that have proven efficacy for reducing infestations of cattle, and their development ... Lew-Tabor, A.E.; Rodriguez Valle, M. A review of reverse vaccinology approaches for the development of vaccines against ticks ...

In the present meta-analysis, we aimed to evaluate the serologic response to the COVID-19 vaccine in SOT recipients. A search ... Based on the results obtained using immunoinformatic predictions, synthetic B-cell peptides corresponding to the epitopes of ... In the present meta-analysis, we aimed to evaluate the serologic response to the COVID-19 vaccine in SOT recipients. A search ... Compared to controls, response rates were lower after a single and two doses of vaccine (OR 0.0049 [95% CI 0.0021-0.012] and ...

... chemotherapy and genome-targeted therapy entailing synthetic lethality of tumor cells exhibiting aberrant DNA damage response, ... AURKA inhibition induces synthetic lethality in CRPC variants exhibiting the combined loss of RB1 and TP53 [98]. EZH2, AURKA ... Two FDA-approved immunotherapy options for mCRPC are the vaccine Sipuleucel-T (Provenge®, Dendreon, Seattle, WA, USA) and the ... Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. Nat. Commun. 2017, 8, 374. [ ...

Special Issue in Vaccines: Vaccine on the Effective Management of Insect Vector Born Disease: An Implication for the Management ... the search for potent biocontrol agents has decreased since synthetic chemical sprays are comparatively low-priced and ...

Efforts to create vaccines against these viral diseases have been successful in some cases such as yellow fever, but other ... A complex of mGRFT bound to a synthetic nonamannoside (Man9) that contains the nine mannose residues present in full-length ... Liang, T.J. Current progress in development of hepatitis C virus vaccines. Nat. Med. 2013, 19, 869-878. [Google Scholar] [ ... Vaccine development against enveloped viruses has mostly focused on targeting the envelope glycoproteins primarily because they ...

One of the main limitations found with the production of synthetic theanine is that the synthetic product can be a racemic ... Co-administration of l-THE (280 mg) and cysteine (700 mg) before vaccination enhanced immune responses to influenza vaccine in ... synthetic and biosynthetic) vary in their yield and commercial viability; most are labour intensive and time consuming and have ... enhanced the primary antibody response to the influenza vaccine in elderly participants [74,75]. ...

In an experimental study of the physical properties of synthetic suture materials used in dentistry, the following results were ... I.I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia ... In a pilot clinical study of synthetic suture materials as a favorable microbiological environment for pathogenic and ... Research Institute of Vaccines and Serums named after I.I. Mechnikov, Moscow). The test tube was frozen for transportation to ...

This synthetic DNA exhibited 5′ and 3′ ends, which were similar to the target and amplified by the same primers and those used ... Vaccine Immunol. CVI 2008, 15, 293-296. [Google Scholar] [CrossRef][Green Version] ... Moreover, this kit allowed for us to assess the inhibitory potential of a sample, thanks to a synthetic DNA included in each ... for L. pneumophila. When compared to L. pneumophila PCR amplicon, synthetic DNA presented a modified sequence detected while ...

Targeted delivery of vaccine antigens to mouse pDCs via coupling to an anti-SIGLECH antibody also promotes the induction of ... In summary, in response to viral stimulations in vitro, or in vivo upon stimulation with synthetic TLR ligands, targeted ... Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8,, 9 to stimulate polyvalent immunity. J. ... is part of the explanation that has been proposed for the high efficacy of the attenuated yellow fever virus vaccine [166]. In ...

ENO1 is also recognized by T cells in PDA patients, so we developed a DNA vaccine that targets ENO1. This efficiently induces ... current drug design and opportunities for improved therapies through exploitable synthetic lethality pathways, and an ... Although promising, the ENO1 DNA vaccine does not completely eradicate the tumor, which, after an initial growth inhibition, ... It has been demonstrated in preclinical studies and early phase clinical trials that cancer vaccines were effective in ...