Association of EGFR mutations and HMGB1 genetic polymorphisms in lung adenocarcinoma patients
... untranslated region (3 UTR)) and rs1045411 (2262C/T; 3 UTR) selected according to Chinese HapMap data. Minor allelic ... We genotyped four HMGB1 SNPs including rs1412125 (-1615T/C; promoter region), rs2249825 (3814C/G; intron 1), rs1360485 (T/C; 3 ... Distributions of HMGB1 genetic polymorphisms in the promoter region (rs1412125, -1615T/C), intron 1 (rs2249825, 3814C/G), and ...
WDR4 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study
... untranslated regions, 5 near regions, 3 near regions and exons of the WDR4 gene. Moreover, the selected SNPs had a minor ... 45] discovered that the rs465663 polymorphism in the WDR4 gene, located in the intronic region, was related to ... in the G-rich regions of miRNAs, m7G appeared to form an unstable structure of G-quadruplexes, facilitating the process of pre- ... elucidation of SNPs for cancer predisposition is that most nucleotide substitutions occur in noncoding regulatory regions, ...
Regulatory sequence analysis of semaphorin 4D 5' non-coding region
The 5 untranslated region of Sema4D was cloned into the pGL3 luciferase reporter vector, while pRL-CMV acted as an internal ... Mutation on Sema4D 5 non-coding region led to DNA secondary structure change. The Sema4D 5non-coding region of ten cancer ... Mutation of HRE1, HRE2, HRE3 resulted in a decrease ranging from 10- 40% (A). B, Sema4D 5 untranslated region containing ... within the untranslated region of target genes (11). In hypoxic tissues, hypoxia inducible factor HIF-1α is accumulated and ...