Loading...
*  Mif1: A Missing Link between the Unfolded Protein Response Pathway and ER-Associated Protein Degradation? | BenthamScience
Current Protein & Peptide Science. Title: Mif1: A Missing Link between the Unfolded Protein Response Pathway and ER-Associated ... Mif1: A Missing Link between the Unfolded Protein Response Pathway and ER-Associated Protein Degradation?. Author(s): Theo van ... Expression of proteins involved in polypeptide folding is strongly enhanced by a process called the Unfolded Protein Response ( ... Expression of proteins involved in polypeptide folding is strongly enhanced by a process called the Unfolded Protein Response ( ...
http://www.eurekaselect.com/81690/article
*  A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non...
... the unfolded protein response and growth factor stimulation. In mammalian cells, the accumulation of unfolded proteins bound to ... unfolded protein response. Introduction. The biogenesis of nascent proteins translocated into the calcium‐rich, oxidizing ... This response, termed the unfolded protein response (UPR), includes the coordinate transcriptional up‐regulation of ER ... Welihinda AA and Kaufman RJ (1996) The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans ...
http://emboj.embopress.org/content/16/23/7207
*  Oxidized Low-Density Lipoproteins Trigger Endoplasmic Reticulum Stress in Vascular Cells | Circulation Research
... leading to the unfolded protein response (UPR). UPR triggers adaptive responses to ER dysfunction,11,19 and switches to ... The mammalian unfolded protein response. Annu Rev Biochem. 2005; 74: 739-789. ... Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J Mol ... Disturbing endoplasmic reticulum (ER) function results in ER stress and unfolded protein response, which tends to restore ER ...
http://circres.ahajournals.org/content/104/3/328
*  Transcriptional Regulation of Metabolic Genes by the Basic Leucine Zipper Transcription Factor Hac1ip and Nutrient Stimuli -...
growth are two major differentiation outcomes in response to nitrogen starvation. A central component of unfolded protein ... We also tested for induction of pseudohyphal growth in diploids from SK1 genetic background in response to nitrogen starvation ... response pathway, the bZIP transcription factor Hac1ip, negatively regulates meiosis and pseudohyphal growth. The present study ...
http://etheses.dur.ac.uk/3415/
*  Unfolded protein response - Wikipedia
The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It is a ... Endoplasmic reticulum stress response (ER stress) Mitochondrial unfolded protein response PERK inhibitors "Peter Walter's short ... Brefeldin A is a very common inducer of the unfolded protein response or endoplasmic reticulum stress response (ER stress). ... The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum ...
https://en.wikipedia.org/wiki/Unfolded_protein_response
*  Mitochondrial unfolded protein response - Wikipedia
Unfolded protein response Pellegrino MW, Nargund AM, Haynes CM (2013). "Signaling the mitochondrial unfolded protein response ... The mitochondrial unfolded protein response (UPRmt) is a cellular stress response related to the mitochondria. The UPRmt ... Papa L, Germain D (2014). "SirT3 regulates the mitochondrial unfolded protein response". Molecular and Cellular Biology. 34 (4 ... results from unfolded or misfolded proteins in mitochondria beyond the capacity of chaperone proteins to handle them. The UPRmt ...
https://en.wikipedia.org/wiki/Mitochondrial_unfolded_protein_response
*  unfolded protein response tagged stories - MIT Technology Review
The mission of MIT Technology Review is to bring about better-informed and more conscious decisions about technology through authoritative, influential, and trustworthy journalism.
https://www.technologyreview.com/g/unfolded-protein-response/
*  Unfolded Protein Response - QIAGEN
Unfolded Protein Response RT2 Profiler PCR Array The Human Unfolded Protein Response RT² Profiler PCR Array profiles the ... Unfolded Protein Response RT2 Profiler PCR Array The Mouse Unfolded Protein Response RT² Profiler PCR Array profiles the ... Unfolded Protein Response RT2 Profiler PCR Array The Rat Unfolded Protein Response RT² Profiler PCR Array profiles the ... The unfolded protein response (UPR) recognizes and reacts to misfolded protein accumulation in the endoplasmic reticulum (ER). ...
https://www.qiagen.com/us/shop/genes-and-pathways/complete-biology-list/unfolded-protein-response/
*  Uncovering a Mitochondrial Unfolded Protein Response | Science Signaling
... or misfolded proteins have been characterized and are called the heat shock response and the ER unfolded protein response (UPR ... Uncovering a Mitochondrial Unfolded Protein Response Message Subject. (Your Name) has forwarded a page to you from Science ... C. M. Haynes, K. Petrova, C. Benedetti, Y. Yang, D. Ron, ClpP mediates activation of a mitochondrial unfolded protein response ... Protease inhibitors also prevented the stimulation of ubl-5 expression in response to mitochondrial unfolded protein stress, ...
https://stke.sciencemag.org/content/2007/408/tw374
*  Unfolded Protein Response (UPR): Novus Biologicals
Antibodies for Unfolded Protein Response (UPR) is an eight page flyer for research on UPR signaling, a mechanism in eukaryotic ... cells for coping with an accumulation of unfolded proteins in the ER lumen (endoplasmic reticulum/ER stress). This flyer ...
https://www.novusbio.com/support/unfolded-protein-response-flyer
*  Heterotrimeric G protein signaling in the Arabidopsis unfolded protein response | PNAS
Heterotrimeric G protein signaling in the Arabidopsis unfolded protein response Message Subject (Your Name) has sent you a ... Heterotrimeric G protein signaling in the Arabidopsis unfolded protein response. Shiyu Wang, Savitha Narendra, and Nina ... triggering a complex protective response termed the unfolded protein response (UPR) (1). In yeast and mammalian cells, the ... protein disulfide isomerase;. PERK,. PKR-like ER kinase;. PLC,. phospholipase C;. Tm,. tunicamycin;. UPR,. unfolded protein ...
https://www.pnas.org/content/104/10/3817
*  The unfolded protein response in virus infections. | Frontiers Research Topic
... is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of ... reactivation from latency and to evade the immune response. When this delicate balance of virus-host UPR interaction is broken ... host UPR may pave the way to the design of a new class of anti-viral that targets this particular pathway to skew the response ... Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in ...
https://www.frontiersin.org/research-topics/2059/the-unfolded-protein-response-in-virus-infections
*  Antibody Duet Unfolded Protein Response from Cell Signaling Technology
Antibody Duet Unfolded Protein Response. Also showing Antibody Duet Response to Unfolded Protein. PhosphoPlus® PERK (Thr980) ... Monoclonal Antibody Immunoprecipitation Unfolded Protein Response * Polyclonal Antibody Flow Cytometry Unfolded Protein ... Background: Protein kinase-like endoplasmic reticulum kinase (PERK) is an eIF2α kinase and transmembrane protein resident in ... Background: Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in ...
https://www.cellsignal.com/1/3/antibody-duet-unfolded-protein-response
*  Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure
... biological response modifiers and the family of cell adhesion-promoting molecules. ... Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure. Patrick Geraghty,1,2 Nathalie ... "Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure," Mediators of Inflammation, ...
https://www.hindawi.com/journals/mi/2016/9461289/cta/
*  The unfolded protein response regulator ATF6 promotes mesodermal differentiation | Science Signaling
The unfolded protein response regulator ATF6 promotes mesodermal differentiation. By Heike Kroeger, Neil Grimsey, Ryan Paxman, ... The unfolded protein response regulator ATF6 promotes mesodermal differentiation. By Heike Kroeger, Neil Grimsey, Ryan Paxman, ... The unfolded protein response regulator ATF6 promotes mesodermal differentiation Message Subject. (Your Name) has forwarded a ... The unfolded protein response (UPR) preserves ER homeostasis in the adult organism; however, inactivating mutations in the UPR- ...
http://stke.sciencemag.org/content/11/517/eaan5785
*  The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation | Science
Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science 333, 1891 (2011); ... Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response. Virus Res. 124, 44 (2007 ... Unfolded Protein Sensing and Alternative Modes of UPR Activation. To sense unfolded proteins in the ER lumen, UPR signaling ... In response to protein misfolding (step 2), the luminal domain rearranges, allowing unfolded protein binding (proposed peptide- ...
https://science.sciencemag.org/content/334/6059/1081?ijkey=a6f8df516d3b16d973827045f14541a4ae7ad383&keytype2=tf_ipsecsha
*  The unfolded protein response signals through high-order assembly of Ire1. - PubMed - NCBI
The unfolded protein response signals through high-order assembly of Ire1.. Korennykh AV1, Egea PF, Korostelev AA, Finer-Moore ... This non-conventional mRNA splicing event initiates the unfolded protein response, a transcriptional program that relieves the ... Aberrant folding of proteins in the endoplasmic reticulum activates the bifunctional transmembrane kinase/endoribonuclease Ire1 ...
https://www.ncbi.nlm.nih.gov/pubmed/19079236
*  The Paradox of the Unfolded Protein Response in Cancer
... Vandewyncicel, Yves-Paul ... Cancer, endoplasmic reticulum, stress, unfolded protein response, molecular chaperones, activating transcription factor 6, PERK ... which are detected by transmembrane sensors that then initiate the unfolded protein response (UPR) to restore ER proteostasis. ... Conditions that interfere with ER functioning can lead to the accumulation of unfolded proteins, ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:683617
*  Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells | Blood Journal
Marcu MG, Doyle M, Bertolotti A, Ron D, Hendershot L, Neckers L. Heat shock protein 90 modulates the unfolded protein response ... Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc Natl Acad Sci U S A. 1999; ... Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J Biol Chem. 2002;277: 49047- ... Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Esther A. Obeng, Louise M. Carlson ...
http://www.bloodjournal.org/content/107/12/4907?ijkey=d45449bf0458567cbe74a62343a895cb3e1b9907&keytype2=tf_ipsecsha&sso-checked=true
*  Frontiers | Modulation of the unfolded protein response by the human hepatitis B virus | Microbiology
... designated as the unfolded proteins response (UPR), which essentially increase their folding capacity, arrest protein ... designated as the unfolded proteins response (UPR), which essentially increase their folding capacity, arrest protein ... During productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be ... During productive viral infection the host cell is confronted with synthesis of a vast amount of viral proteins which must be ...
https://www.frontiersin.org/articles/10.3389/fmicb.2014.00433/full
*  Disparity among neural injury models and the unfolded protein response
When unfolded proteins are not properly refolded or degraded, stress response genes are upregulated. These stress response ... When the unfolded proteins accumulate a chaperone protein, binding immunoglobulin protein (BiP), dissociates from the ER ... The ER stress response shuts down protein folding, but if left unchecked these unfolded proteins can have long-term detrimental ... upregulation of stress response genes, and (3) degradation of unfolded proteins [12]. However, when the response is prolonged, ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC4896636/
*  Regulation of the mammalian mitochondrial unfolded protein response - Kölner UniversitätsPublikationsServer
Seiferling, Dominic (2015) Regulation of the mammalian mitochondrial unfolded protein response. PhD thesis, Universität zu Köln ... The molecular mechanisms of the mammalian mitochondrial unfolded protein response (UPRmt) are largely unknown. In this study, ... Intriguingly, it was also found that the matrix protease LONP1 not only responds to mitochondrial unfolded protein stress, but ... regular cell culture conditions in various cell types and not amenable to further induction by mutant mitochondrial proteins or ...
http://kups.ub.uni-koeln.de/6679/
*  Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. - PubMed - NCBI
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.. Iwakoshi NN1, Lee ... is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced ... The transcription factor X-box binding protein 1 (XBP-1) ... DNA-Binding Proteins/genetics. *DNA-Binding Proteins/immunology ...
https://www.ncbi.nlm.nih.gov/pubmed/12612580?dopt=Abstract
*  Targeting the Unfolded Protein Response (UPR) Transcription Factor XBP-1 to Treat Parkinson's Disease | Parkinson's Disease
BH3-only proteins control the sustained signaling of the Unfolded Protein Response sensor IRE1α. Signaling in cell death ... BH3-only proteins control the sustained signaling of the Unfolded Protein Response sensor IRE1α. FASEB Research Conferences ... Targeting the Unfolded Protein Response (UPR) Transcription Factor XBP-1 to Treat Parkinson's Disease. Target Validation, 2010 ... 2011). The Unfolded Protein Response: Integrating stress signals through the stress sensor IRE1a. Physiological Reviews. In ...
https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=679