NPS-1034 | CAS 1221713-92-3 | AbMole BioScience | NPS-1034 Price
Canlitinib is a tyrosine kinase inhibitor, extracted from patent WO2018072614 (IV-2). ...
JAK Inhibitors | Kinase Inhibitors on JAK Signaling Pathways | AbMole BioScience
AG490 (Tyrphostin AG490) is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ... Ritlecitinib tosylate is a first-in-class, orally active, dual covalent inhibitor of tyrosine kinases in the JAK3 and TEC ... GLPG3667 is a selective tyrosine kinase 2 (TYK2) inhibitor for studies related to systemic lupus erythematosus and psoriasis.. ... ESK-001 is a highly selective and potentially first-in-class heterotrimeric tyrosine kinase 2 (TYK2) inhibitor for studies ...
SB431542 (SB-431542) | CAS 301836-41-9 | AbMole BioScience | SB431542 Price
Conteltinib (CT-707) is a potent second-generation mesenchymal lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) with ...
Autophagy Signaling Pathway | AbMole BioScience
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Autophagy plays a wide variety of physiological and pathophysiological roles. Different selective forms of autophagy have been identified and characterized, leading to the specific degradation of organelles or pathogens. These selective pathways include the autophagic degradation of mitochondria (mitophagy), peroxisomes (pexophagy), endoplasmic reticulum (reticulophagy or ER-phagy), ribosomes (ribophagy), protein aggregates (aggrephagy), lipid droplets (lipophagy), spermatozoon-inherited organelles following fertilization (allophagy), secretory granules within pancreatic cells (zymophagy), or intracellular pathogens (xenophagy).
Monensin sodium salt (Monensin A sodium salt) | CAS 22373-78-0 | AbMole BioScience | Monensin sodium salt Price
Monensin Sodium Salt is an antibiotic secreted by Streptomyces Cinnamonensis. Monensin Sodium Salt is an ionic carrier that mediates Na+/H+ exchange. Monensin sodium salt causes the enlargement of cellular multivesicular bodies (MVBs) and regulates secretion of exosomes. Buy Antibiotic inhibitor Monensin sodium salt (Monensin A sodium salt) from AbMole BioScience.
Cilazapril Monohydrate (Ro 31-2848 monohydrate) | CAS 92077-78-6 | AbMole BioScience | Cilazapril Monohydrate Price
Cilazapril Monohydrate is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure. Buy ACE inhibitor Cilazapril Monohydrate (Ro 31-2848 monohydrate) from AbMole BioScience.
p97 Inhibitors | Kinase Inhibitors on p97 Signaling Pathways | AbMole BioScience
CB-5083 is a first-in-class, potent and selective, orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM ...
S1P Receptor Inhibitors | Kinase Inhibitors on S1P Receptor Signaling Pathways | AbMole BioScience
Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for the research of relapsing multiple sclerosis (MS ...
Apoptosis - Search Results | AbMole BioScience
2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa ...
JQ1 (JQ1) | CAS 1268524-70-4 | AbMole BioScience | (+)-JQ1 Price
(+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway. Buy Epigenetic Reader Domain inhibitor (+)-JQ1 (JQ1) from AbMole BioScience.
BIO-32546 | CAS 1548743-66-3 | AbMole BioScience | BIO-32546 Price
Compound BIO-32546 is a potent (IC50=1 nM), selective, orally administered, non-zinc-binding reversible inhibitor of autophagy (ATX). Buy PDE inhibitor BIO-32546 from AbMole BioScience.
Malacidin A | CAS 2254483-95-7 | AbMole BioScience | Malacidin A Price
Malacidin A is a calcium-dependent antibiotic that is highly active against many drug-resistant pathogens, especially Gram-positive bacteria. Buy Antibiotic inhibitor Malacidin A from AbMole BioScience.
AbMole Kinase Inhibitor Library | AbMole BioScience | AbMole Kinase Inhibitor Library Price
A unique collection of 408 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS). Buy AbMole Kinase Inhibitor Library from AbMole BioScience.
YH14618 (SB-01; P2K) | AbMole BioScience | YH14618 Price
YH14618 is a synthetic peptide that is also a TGF-β1 modulator and can be used in studies related to disc degenerative diseases. Buy TGF-beta/Smad inhibitor YH14618 (SB-01; P2K) from AbMole BioScience.
IR808 (MHI-148; IR 808) | CAS 172971-76-5 | AbMole BioScience | IR808 Price
IR808 (MHI-148) is a near-infrared heptamethine cyanine dye with tumor-targeting properties for cancer detection, diagnosis and research. IR808, which acts as an optical imaging agent, targeting moiety and also trigger on-demand drug release on application of NIR 808 nm laser. Buy Fluorescent Dye inhibitor IR808 (MHI-148; IR 808) from AbMole BioScience.
Ice Box Inhibitors | Kinase Inhibitors on Ice Box Signaling Pathways | AbMole BioScience
AbMole Temperature Sensitive Ice Box uses Thermochromic Materials to indcate the temperature change, it is suitable for short-term transportation and storage of temperature sensitive samples (such as enzymes, antibodies, PCR samples, etc ...
Labware Signaling Pathway | AbMole BioScience
Products are for research use only. Not for human use. We do not sell to patients ...
Nicotinamide Riboside Chloride (SRT647; NIAGEN) | CAS 23111-00-4 | AbMole BioScience | Nicotinamide Riboside Chloride Price
Nicotinamide Riboside Chloride is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+. Buy Sirtuin inhibitor Nicotinamide Riboside Chloride (SRT647; NIAGEN) from AbMole BioScience.
Menadiol (Dihydrovitamin K3) | CAS 481-85-6 | AbMole BioScience | Menadiol Price
Menadiol (Dihydrovitamin K3), a menaquinol analogue, is an electron donor for reversed oxidative phosphorylation in submitochondrial particles. Buy Vitamin inhibitor Menadiol (Dihydrovitamin K3) from AbMole BioScience.
VER-50589 - Search Results | AbMole BioScience
VER-50589 is a Hsp90 inhibitor, with an IC50 of 21 nM and a Kd of 4.5 nM ...
Metronidazole Benzoate (Benzoyl metronidazole) | CAS 13182-89-3 | AbMole BioScience | Metronidazole Benzoate Price
Metronidazole Benzoate is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Buy Anti-infection inhibitor Metronidazole Benzoate (Benzoyl metronidazole) from AbMole BioScience.
Bioactive Compounds Signaling Pathway | AbMole BioScience
Products are for research use only. Not for human use. We do not sell to patients ...
Dapagliflozin (BMS-512148) | CAS 461432-26-8 | AbMole BioScience | Dapagliflozin Price
Dapagliflozin (BMS-512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). Buy SGLT inhibitor Dapagliflozin (BMS-512148) from AbMole BioScience.
Raf Inhibitors | Kinase Inhibitors on Raf Signaling Pathways | AbMole BioScience
Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy ...
Well Plate Inhibitors | Kinase Inhibitors on Well Plate Signaling Pathways | AbMole BioScience
Products are for research use only. Not for human use. We do not sell to patients ...
Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) | CAS 2437-29-8 | AbMole BioScience |...
Malachite green is a synthetic dyestuff and antimicrobial with potential carcinogenicity. Buy IκB/IKK inhibitor Malachite green (Aniline green, Basic green 4, Diamond green B, Victoria green B) from AbMole BioScience.
Recombinant Proteins Inhibitors | Kinase Inhibitors on Recombinant Proteins Signaling Pathways | AbMole BioScience
Recombinant GM-CSF Protein is a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. GM-CSF is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory stimuli. ED50 < 0.05 ng/ml, measured in a cell proliferation assay using mouse FDC-P1 cells, corresponding to a specific activity of > 2.0 × 107 units/mg ...
Carbonic Anhydrase Inhibitors | Kinase Inhibitors on Carbonic Anhydrase Signaling Pathways | AbMole BioScience
hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and >50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo ...
3-Methylxanthine (3-MX) | CAS 1076-22-8 | AbMole BioScience | 3-Methylxanthine Price
3-Methylxanthine (3-MX), a 3-alkylxanthine, is an inhibitor of cyclic guanosine monophosphate (GMP) phosphodiesterase (PDE) with IC50 of 920 μM on guinea-pig isolated trachealis muscle. Buy PDE inhibitor 3-Methylxanthine (3-MX) from AbMole BioScience.
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