Therapeutic opportunities for targeting microRNAs in cancer | Molecular and Cellular Therapies | Full Text
... miR-10b expression is upregulated by the EMT-promoting transcription factor, Twist, which results in miR-10b-mediated ... not its transcription. Accordingly, receptor-regulated Smad transcription factors for TGF-β (Smads 2 and 3) and BMP-4 (Smads 1 ... Piriyapongsa J, Jordan IK, Conley AB, Ronan T, Smalheiser NR: Transcription factor binding sites are highly enriched within ... It should be noted that the ability of transcription factors to drive miRNA processing is not unique to TGF-β/BMP-regulated ...
MicroRNA-186 induces sensitivity of ovarian cancer cells to paclitaxel and cisplatin by targeting ABCB1 | Journal of Ovarian...
Sandalwood Album Oil as a Botanical Therapeutic in Dermatology.
MicroRNA-296-5p inhibits cell metastasis and invasion in nasopharyngeal carcinoma by reversing transforming growth factor-β...
... it positively regulates the expression of a panel of transcription factors, including Twist, Snail, Slug, and Zeb1 [35,36,37,38 ... we performed real-time PCR and western blot assays to determine the expression of EMT-related markers and transcription factors ... EMT plays a central role in the complex process of tumor metastasis [34]. TGF-β is a key regulatory factor of EMT: ... Transforming growth factor-beta promotes liver tumorigenesis in mice via up-regulation of snail. Gastroenterology. 2017;153(5): ...
The relationship between platinum drug resistance and epithelial-mesenchymal transition FULIR
JCM | Free Full-Text | New Insights into the Crossroads between EMT and Stemness in the Context of Cancer
EMT-inducing transcription factors, such as Twist, Snail and Slug, up-regulate ATP-binding cassette (ABC) transporter genes [68 ... EMT; MET; stem; Transforming Growth Factor-β (TGF-β); Snail; Zeb; Twist; Prrx; CD44; CD133 ... The β-catenin/T-cell Factor 4 (TCF4) complex binds directly to the Zeb1 promoter and activates its transcription [46]. The ... Puisieux, A.; Brabletz, T.; Caramel, J. Oncogenic roles of EMT-inducing transcription factors. Nat. Cell Biol. 2014, 16, 488- ...
Autophagy and cancer metastasis: a Trojan horse | JIM
15 16 Activation of PI3K/Akt/mTOR pathway induces EMT in several cancer models via activation of EMT transcription factors.17 ... and TWIST).20 On the other hand, NF-κB has a dual role in autophagy (inhibition and induction) by different mechanisms14 which ... wild-type p53 inhibits EMT and metastasis via inhibition of transcription factors that are involved in the regulation of EMT.27 ... 14 20 It has been shown that it induces EMT and increases metastasis via activating EMT-related transcription factors (SNAIL, ...
Regulation of EMT Process in Cancer Progression | Encyclopedia MDPI
All of these pathways eventually converge at the level of transcription factors such as ZEB, SNAIL, and TWIST to regulate the ... Some TFs, including SNAIL1, SNAIL2, ZEB1, ZEB2, E47 (also known as transcription factor-3, TCF-3), kruppel-like factor 8 (KLF8 ... EMT-inducing transcription factors (EMT-TFs) are the core of the transcriptional control network of EMT, and multiple signaling ... Among these TFs, some are very common in most studies about EMT, particularly the nuclear factors of the SNAIL, ZEB, and TWIST ...
Analysis of Several Pathways for Efficient Killing of Prostate Cancer Stem Cells: A Central Role of NF-κB RELA
... the transcription factors SNAI1 (SNAIL) and SNAI2 (SLUG) and cancer markers such as CD44 and prominin-1 (CD133). All ... CSCs were characterized by the expression of the stem cell markers TWIST, the epithelial cell adhesion molecule (EPCAM), ... nuclear factor "kappa-light-chain-enhancer" of acti-vated B-cells; tumor necrosis factor; interferon gamma; immune checkpoint ... which can be efficiently killed by tumor necrosis factor (TNF). Thus, culturing of PCSCs and analysis of respective NF-κB ...
Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses cancer motility by interfering with epithelial-to...
control group) of SKOV3 cells, and inhibited transforming growth factor-β1 (TGF-β1)-induced E-cadherin loss (4 μg/mL, P = ... The individual extracellular inducers provoke the expression of EMT-associated transcription factors [24], such as Twist, Snail ... Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors ... Many growth and differentiation factors, including growth factors [35, 36], Wnt [37] and Notch proteins [38], can induce EMT. ...
Análisis genómico funcional de la resistencia a las terapias anti-EGFR asociada al fenotipo mesenquimal en el cáncer pulmonar.
Genetic instability in the tumor microenvironment: a new look at an old neighbor | Molecular Cancer | Full Text
Furthermore, an unfortunate association of factors such as tumor genetic complexity, overestimation of biomarker and drug ... Twist and Zinc Finger E-Box Binding Homeobox (Zeb) 1/2. These transcription factors are also associated with matrix ... The ETS-domain transcription factor family. Nat Rev Mol Cell Biol. 2001;2:827-37. ... Expression and function of Ets transcription factors in mammalian development: a regulatory network. Oncogene. 2000;19:6432-42. ...
Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression<...
Notch signaling and transcription factors STAT3 (signal transducer and activator of transcription 3) and Twist regulate tumor ... Notch signaling and transcription factors STAT3 (signal transducer and activator of transcription 3) and Twist regulate tumor ... Notch signaling and transcription factors STAT3 (signal transducer and activator of transcription 3) and Twist regulate tumor ... Notch signaling and transcription factors STAT3 (signal transducer and activator of transcription 3) and Twist regulate tumor ...
October | 2014 | Screening Libraries
In particular, regulatory proteins, such as the transcription factors Sox9, Runx2, Osterix, Twist and Mef2c have distinct ... chemo kines and development factors also as other soluble factors this kind of as lysophosphatidic acid. OC tumorigen esis is ... The results showed that all of the fusion proteins exhibited a transcription suppres sion result on RBP J mediated ... Elevated water temperatures selleck are typically utilized, normally without having explicit manage of factors like nutrition, ...
Metastatic Neoplasms to the Oral Cavity: Background, Pathophysiology, Epidemiology
4] EMT programs are orchestrated by a set of pleiotropically acting transcription factors, including Slug, Snail, Twist, ZEB1, ... Hypoxia leads to the up-regulation of hypoxia-induced transcription factors (HIF)-a and HIF-2a, which are the master regulators ... vascular endothelial growth factor and thrombospondin, respectively), inflammatory, and coagulation factors. [8, 9] ... Race has not been studied as a factor in the metastatic process in the oral region; however, changes can occur in different ...
Metastatic Neoplasms to the Oral Cavity: Background, Pathophysiology, Epidemiology
4] EMT programs are orchestrated by a set of pleiotropically acting transcription factors, including Slug, Snail, Twist, ZEB1, ... Hypoxia leads to the up-regulation of hypoxia-induced transcription factors (HIF)-a and HIF-2a, which are the master regulators ... vascular endothelial growth factor and thrombospondin, respectively), inflammatory, and coagulation factors. [8, 9] ... Race has not been studied as a factor in the metastatic process in the oral region; however, changes can occur in different ...
PlantTFDB - Plant Transcription Factor Database @ CBI, PKU
... a portal for the functional and evolutionary study of plant transcription factors ... Immunophilin-like FKBP42/TWISTED DWARF1 Interacts with the Receptor Kinase BRI1 to Regulate Brassinosteroid Signaling in ... Arabidopsis NAC transcription factor JUB1 regulates GA/BR metabolism and signalling.. Nat Plants, 2016. 2: p. 16013. [PMID: ... The brassinosteroid-regulated transcription factors BZR1/BES1 function as a coordinator in multisignal-regulated plant growth. ...
ONDER CDH1 SIGNALING VIA CTNNB1
TFT: Transcription Factor Targets TFT:GTRD: GTRD TFT:TFT_LEGACY: TFT_Legacy C4: Computational CGN: Cancer Gene Neighborhoods CM ... Twist, is necessary for E-cadherin loss-induced metastasis. These findings indicate that E-cadherin loss in tumors contributes ... In addition, gene expression analysis shows that E-cadherin loss results in the induction of multiple transcription factors, at ...
Rac and Rho GTPases in cancer cell motility control | Cell Communication and Signaling | Full Text
... transcription, and proliferation. A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has ... Twist, ZEB-1-2, etc. The large number of transcription factors which can be engaged to elicit the same phenotype, i. e. the ... Jun is a component of the activator protein 1 (AP-1) transcription factor complex and regulates transcription of many genes, ... enhancing expression of transcription factors correlated with mesenchymal or inflammatory programs as Snail-1, Twist, hypoxia ...
A cowpea severe mosaic virus-based vector bolsters virus-induced gene silencing and foreign protein expression in soybean |...
Finally, FZ-mediated expression of the Arabidopsis transcription factor MYB75 caused N. benthamiana to bear brown leaves and ... became bent and twisted in FZ-AtMYB75-infected plants. This phenotype has not been reported in Arabidopsis, thus may suggest ... The coding sequence of the MYB75 transcription factor of Arabidopsis was cloned into FZ. MYB75, also known as PAP1 (for ... The total RNA, containing both CPSMV RNAs, was used to generate viral cDNAs through reverse transcription (RT), with a poly-dT- ...
Epithelial-Mesenchymal Transition Contributes to Pulmonary Fibrosis via Aberrant Epithelial/Fibroblastic Cross-Talk
Twist and others6. Pleotropic signalling factors such as transforming growth factor β (TGFβ), fibroblast growth factor (FGF), ... The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol. 2000; 2 ... A number of EMT transcription factors (EMT-TFs) have been demonstrated to induce EMT programs in a variety of tissues in the ... The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. ...
Twist Bioscience
... which are bound by transcription factor (TF) and co-factor proteins.. Until recently, knowledge of the intricate nature of ... Find out how Twist oligo pools can support transcriptional regulation studies - providing new insights into functional genomics ... Decoding transcriptional regulation using massively parallel reporter assays and Twist Oligo Pools. The latest advances in ...
mycobacterium avium complex - Hiv Pharmacogenomics
Mouse TWIST(Twist Transcription Factor) ELISA Kit. *Human FAAH(Fatty Acid Amide Hydrolase) ELISA Kit ... Cattle FGF2(Fibroblast Growth Factor 2, Basic) ELISA Kit. *Human RKHD1(Ring Finger And KH Domain Containing Protein 1) ELISA ... Rat STAT2(Signal Transducer And Activator Of Transcription 2) ELISA Kit. *Pig NT-ProBNP(N-Terminal Pro-Brain Natriuretic ... Human VEGF206(Vascular Endothelial Growth Factor 206) ELISA Kit. *Human DNAJC13(DnaJ/HSP40 Homolog Subfamily C, Member 13) ...
hormone monster - Lotus Bio-Technology
Human TWIST(Twist Transcription Factor) ELISA Kit. *Human TYMS(Thymidylate Synthetase) ELISA Kit ... Human TERF2(Telomeric Repeat Binding Factor 2) ELISA Kit. *Human TERF2IP(Telomeric Repeat Binding Factor 2 Interacting Protein ... Human TNFSF12(Tumor Necrosis Factor Ligand Superfamily, Member 12) ELISA Kit. *Human TNFSF14(Tumor Necrosis Factor Ligand ... Mouse TNFRSF17(Tumor Necrosis Factor Receptor Superfamily, Member 17) ELISA Kit. *Mouse TNFRSF4(Tumor Necrosis Factor Receptor ...
Human GRIN2C(Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2C) ELISA Kit - Elisa kits Gentaur
Human TWIST(Twist Transcription Factor) ELISA Kit. *Human UBA52(Ubiquitin A 52 Residue Ribosomal Protein Fusion Product 1) ... Human TERF2(Telomeric Repeat Binding Factor 2) ELISA Kit. *Human TERF2IP(Telomeric Repeat Binding Factor 2 Interacting Protein ... Human TNFSF12(Tumor Necrosis Factor Ligand Superfamily, Member 12) ELISA Kit. *Human TNFSF14(Tumor Necrosis Factor Ligand ... Mouse TNFRSF17(Tumor Necrosis Factor Receptor Superfamily, Member 17) ELISA Kit. *Mouse TNFRSF4(Tumor Necrosis Factor Receptor ...
Human PRDX6(Peroxiredoxin 6) ELISA Kit - Lotuskring Poeldijk
Human TWIST(Twist Transcription Factor) ELISA Kit. *Human TYMS(Thymidylate Synthetase) ELISA Kit ... Human TERF2(Telomeric Repeat Binding Factor 2) ELISA Kit. *Human TERF2IP(Telomeric Repeat Binding Factor 2 Interacting Protein ... Human TNFSF12(Tumor Necrosis Factor Ligand Superfamily, Member 12) ELISA Kit. *Human TNFSF14(Tumor Necrosis Factor Ligand ... Mouse TNFRSF17(Tumor Necrosis Factor Receptor Superfamily, Member 17) ELISA Kit. *Mouse TNFRSF4(Tumor Necrosis Factor Receptor ...
Human Ang1-7(Angiotensin 1-7) ELISA Kit - Clinical Trial Logistics
Mouse TWIST(Twist Transcription Factor) ELISA Kit. *Human FAAH(Fatty Acid Amide Hydrolase) ELISA Kit ... Cattle FGF2(Fibroblast Growth Factor 2, Basic) ELISA Kit. *Human RKHD1(Ring Finger And KH Domain Containing Protein 1) ELISA ... Rat STAT2(Signal Transducer And Activator Of Transcription 2) ELISA Kit. *Pig NT-ProBNP(N-Terminal Pro-Brain Natriuretic ... Human VEGF206(Vascular Endothelial Growth Factor 206) ELISA Kit. *Human DNAJC13(DnaJ/HSP40 Homolog Subfamily C, Member 13) ...
Gels
Human TWIST(Twist Transcription Factor) ELISA Kit. *Human TYMS(Thymidylate Synthetase) ELISA Kit ... Human TERF2(Telomeric Repeat Binding Factor 2) ELISA Kit. *Human TERF2IP(Telomeric Repeat Binding Factor 2 Interacting Protein ... Human TNFSF12(Tumor Necrosis Factor Ligand Superfamily, Member 12) ELISA Kit. *Human TNFSF14(Tumor Necrosis Factor Ligand ... Mouse TNFRSF17(Tumor Necrosis Factor Receptor Superfamily, Member 17) ELISA Kit. *Mouse TNFRSF4(Tumor Necrosis Factor Receptor ...
Horse FN(Fibronectin) ELISA Kit - Hiv Pharmacogenomics
Mouse TWIST(Twist Transcription Factor) ELISA Kit. *Human FAAH(Fatty Acid Amide Hydrolase) ELISA Kit ... Cattle FGF2(Fibroblast Growth Factor 2, Basic) ELISA Kit. *Human RKHD1(Ring Finger And KH Domain Containing Protein 1) ELISA ... Rat STAT2(Signal Transducer And Activator Of Transcription 2) ELISA Kit. *Pig NT-ProBNP(N-Terminal Pro-Brain Natriuretic ... Human VEGF206(Vascular Endothelial Growth Factor 206) ELISA Kit. *Human DNAJC13(DnaJ/HSP40 Homolog Subfamily C, Member 13) ...
Kaitlyn - Elisa kits Gentaur
Human TWIST(Twist Transcription Factor) ELISA Kit. *Human UBA52(Ubiquitin A 52 Residue Ribosomal Protein Fusion Product 1) ... Human TERF2(Telomeric Repeat Binding Factor 2) ELISA Kit. *Human TERF2IP(Telomeric Repeat Binding Factor 2 Interacting Protein ... Human TNFSF12(Tumor Necrosis Factor Ligand Superfamily, Member 12) ELISA Kit. *Human TNFSF14(Tumor Necrosis Factor Ligand ... Mouse TNFRSF17(Tumor Necrosis Factor Receptor Superfamily, Member 17) ELISA Kit. *Mouse TNFRSF4(Tumor Necrosis Factor Receptor ...