Tunicamycin - Wikipedia
Tunicamycin blocks N-linked glycosylation (N-glycans) and treatment of cultured human cells with tunicamycin causes cell cycle ... Tunicamycin is produced by several bacteria, including Streptomyces clavuligerus and Streptomyces lysosuperificus. Tunicamycin ... TunC then attaches the fatty acid to the free amine, producing tunicamycin. Glycosylation - tunicamycin blocks all N- ... Book section of Essentials in Glycobiology (1999) Tunicamycin: Inhibition of DOL-PP-GlcNAc Assembly Tunicamycin data sheet ...https://en.wikipedia.org/wiki/Tunicamycin
Tunicamycin Induces Paraptosis Potentiated by Inhibition of BRAFV600E in FRO Anaplastic Thyroid Carcinoma Cells.
The aim of the present study was to elucidate whether tunicamycin (TM) induces paraptosis as a cell death subroutine in ... BACKGROUND/AIM: The aim of the present study was to elucidate whether tunicamycin (TM) induces paraptosis as a cell death ...http://www.biomedsearch.com/nih/Tunicamycin-Induces-Paraptosis-Potentiated-by/25202067.html
Effect of co-pretreatment with tunicamycin and celecoxi | Open-i
Effect of co-pretreatment with tunicamycin and celecoxib on cell viability induced by doxorubicin in HepG2 cells.HepG2 cells ... However, co-pretreatment with tunicamycin and Pae decreased the expression of COX-2 and levels of activation of Akt as well as ... pone-0062627-g005: Effect of co-pretreatment with tunicamycin and celecoxib on cell viability induced by doxorubicin in HepG2 ... pone-0062627-g005: Effect of co-pretreatment with tunicamycin and celecoxib on cell viability induced by doxorubicin in HepG2 ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3643935_pone.0062627.g005&req=4
4-Phenylbutyrate Inhibits Tunicamycin-Induced Acute Kidney Injury via CHOP/GADD153 Repression
Tunicamycin (TM) is a nucleoside antibiotic known to induce ER stress and is a commonly used inducer of AKI. 4-phenylbutyrate ( ... In addition, tunicamycin (TM), a known inducer of ER stress, has previously been used as a model of antibiotic-induced AKI  ... Tunicamycin (TM) is a nucleoside antibiotic known to induce ER stress and is a commonly used inducer of AKI. 4-phenylbutyrate ( ... Figure 3. 4-PBA significantly inhibits tunicamycin (TM)-induced CHOP expression.. HK-2 cells were treated with DMSO (VEH), TM ( ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084663
Induction of cleft lip in cultured rat embryos by localized administration of tunicamycin | Development
The purpose of this study was to ascertain whether localized administration of tunicamycin (TM) an inhibitor of protein ... Induction of cleft lip in cultured rat embryos by localized administration of tunicamycin ... Induction of cleft lip in cultured rat embryos by localized administration of tunicamycin ... Induction of cleft lip in cultured rat embryos by localized administration of tunicamycin ...http://dev.biologists.org/content/64/1/1
The effect of tunicamycin on the glycosylation of lactating-rabbit mammary glycoproteins | Biochemical Journal
The effect of tunicamycin on the glycosylation of lactating-rabbit mammary glycoproteins. Brian K. Speake, David A. White ... 5. Tunicamycin inhibited the incorporation of radioactivity from N-acetyl-d-[1-14C]glucosamine into the glycopolypeptides with ... 1. Tunicamycin inhibited the incorporation of d-[2-3H]mannose into dolichol-linked oligosaccharide and glycoprotein of ... It appears that tunicamycin inhibits the incorporation of mannose and N-acetylglucosamine into a number of mammary ...http://www.biochemj.org/content/180/3/481
Molecules | Free Full-Text | Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells | HTML
This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells. ... F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the ... compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant ... Tunicamycin is a well-known as an inhibitor of protein glycosylation and a ER stress inducer. As shown in Figure 2, verrucarin ...http://www.mdpi.com/1420-3049/20/5/8988/htm
IJMS | Free Full-Text | Tunicamycin Depresses P-Glycoprotein Glycosylation Without an Effect on Its Membrane Localization and...
Tunicamycin inhibited P-gp N-glycosylation in both of the P-gp-positive cells. However, tunicamycin treatment did not alter ... The effects of tunicamycin on glycosylation, drug efflux activity and cellular localization of P-gp in R and T cells were ... Treatment with tunicamycin caused less concentration-dependent cellular damage to R and T cells compared with S cells. ... tunicamycin induces inhibition of N-glycosylation of this protein, without altering its function as plasma membrane drug efflux ...http://www.mdpi.com/1422-0067/12/11/7772/notes
Corynetoxins causative agents of annual ryegrass toxicity; their identification as tunicamycin group antibiotics - Journal of...
... are identified as new members of the tunicamycin group of antibiotics. ... Corynetoxins causative agents of annual ryegrass toxicity; their identification as tunicamycin group antibiotics J. A. Edgar, J ... Corynetoxins causative agents of annual ryegrass toxicity; their identification as tunicamycin group antibiotics ... are identified as new members of the tunicamycin group of antibiotics. ...https://pubs.rsc.org/en/Content/ArticleLanding/1982/C3/C39820000222
Effects of Tunicamycin on B16 Metastatic Melanoma Cell Surface Glycoproteins and Blood-borne Arrest and Survival Properties |...
Tunicamycin-treated B16-F1 and B16-F10 cells adhered at lower rates to endothelial cells such that after 24 to 36 hr of drug ( ... Effects of Tunicamycin on B16 Metastatic Melanoma Cell Surface Glycoproteins and Blood-borne Arrest and Survival Properties. ... Tunicamycin induced morphological changes in B16-F1 and B16-F10 cells such as cellular rounding. Cell growth was also inhibited ... Incubation of B16-F1 or B16-F10 cells with 0.5 µg (or above) tunicamycin per ml for 12 to 36 hr inhibited significantly lung ...http://cancerres.aacrjournals.org/content/41/9_Part_1/3411
Tunicamycin Sensitizes Human Melanoma Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Up...
Tunicamycin sensitizes melanoma cells to TRAIL-induced apoptosis. To study if up-regulation of TRAIL-R2 by tunicamycin results ... Tunicamycin increases transcription of TRAIL-R2 and its total protein levels. To understand the mechanism by which tunicamycin ... Tunicamycin up-regulates TRAIL-R2 and enhances TRAIL-induced apoptosis in fresh melanoma isolates. We studied if tunicamycin ... Mel-RM and MM200 cells were treated with tunicamycin alone (3 μmol/L) for 16 h, TRAIL (200 ng/mL) alone for 3 h, or tunicamycin ...http://cancerres.aacrjournals.org/content/67/12/5880
The lack of effect of tunicamycin and 2-deoxy-D-glucose on corneal stromal herpes in rabbits. | IOVS | ARVO Journals
V K Raju, E D Varnell, H E Kaufman; The lack of effect of tunicamycin and 2-deoxy-D-glucose on corneal stromal herpes in ... However, when topical therapy with tunicamycin and/or 2-deoxy-D-glucose was begun in rabbit eyes, the day after intrastromal ... Also, various studies have shown that tunicamycin and 2-deoxy-D-glucose inhibit the production of complete HSV-specific ... The lack of effect of tunicamycin and 2-deoxy-D-glucose on corneal stromal herpes in rabbits. ...https://iovs.arvojournals.org/article.aspx?articleid=2176832
Tunicamycin increases desensitization of junctional and extrajunctional acetylcholine receptors expressed in Xenopus oocytes by...
The effect of tunicamycin on the AChR desensitization appeared to be reversible, and coapplication of tunicamycin with ... In addition, tunicamycin increased the amplitude of membrane current elicited by application of lower doses of ACh and ... Tunicamycin also increased the membrane current decay elicited by ACh in oocytes expressing incomplete AChRs, missing the beta ... The two types of AChR expressed in non-tunicamycin-treated oocytes could be distinguished by their different rates of ...http://molpharm.aspetjournals.org/content/42/1/152
Tunicamycin Facts Sheet
... (main). This mini website about Tunicamycin was prepared by a student of BioInformatics, the Open ... Effect of tunicamycin on hepatocytes in vitro.. 8. Tunicamycin and Brefeldin A induce in plant cells a programmed cell death ... the 10 selected Tunicamycin abstracts. 1. Effect of 2-fluoropalmitate, cerulenin and tunicamycin on the palmitoylation and ... Tunicamycin is an antibiotic that blocks the reaction of UDP-GlcNAc and Dol-P in the first step of glycoprotein synthesis, thus ...http://tunicamycin.noneto.com
Tunicamycin Induced Unfolded Protein Response (UPR) In Cultured Bovine Trabecular Meshwork (TM) Cells | IOVS | ARVO Journals
In BTM cells, TRP-1, TRP-3, and TRP-4 were expressed but only TRP-3 expression was enhanced in response to Tunicamycin. Peak ... ER stress was induced by exposure to tunicamycin, a nucleoside antibiotic that inhibits N-glycosylation in ER. Expression of ... Tunicamycin Induced Unfolded Protein Response (UPR) In Cultured Bovine Trabecular Meshwork (TM) Cells ... Tunicamycin Induced Unfolded Protein Response (UPR) In Cultured Bovine Trabecular Meshwork (TM) Cells ...http://iovs.arvojournals.org/article.aspx?articleid=2421330
TmrB protein, responsible for tunicamycin resistance of Bacill...
... responsible for tunicamycin resistance of Bacillus subtilis, is a novel ATP-binding membrane protein.: tmrB is the gene ... TmrB protein, responsible for tunicamycin resistance of Bacillus subtilis, is a novel ATP-binding membrane protein.. Authors * ... These C-terminal or N-terminal mutant genes were unable to confer tunicamycin resistance on B. subtilis in a multicopy state. ... tmrB is the gene responsible for tunicamycin resistance in Bacillus subtilis. It is predicted that an increase in tmrB gene ...https://www.mysciencework.com/publication/show/tmrb-protein-responsible-tunicamycin-resistance-bacillus-subtilis-novel-atp-binding-membrane-protein-ec642980
ChemIDplus - 11089-65-9 - ZHSGGJXRNHWHRS-VIDYELAYSA-N - Tunicamycin - Similar structures search, synonyms, formulas, resource...
Tunicamycin - Similar structures search, synonyms, formulas, resource links, and other chemical information. ... Substance Name: Tunicamycin. RN: 11089-65-9. UNII: 55W4525Q2E. InChIKey: ZHSGGJXRNHWHRS-VIDYELAYSA-N. Note. *. An N- ... Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms. ...https://chem.nlm.nih.gov/chemidplus/rn/11089-65-9
Combination of tunicamycin with anticancer drugs synergistically enhances their toxicity in multidrug-resistant human ovarian...
Tunicamycin stock solutions were prepared by dissolving the contents of a 10-mg vial in 25 mM NaOH and then diluting to 0.8 mg/ ... Effect of tunicamycin (5 ?g/ml) on the incorporation of [3H]mannose by UWOV2 ovarian carcinoma cells in culture and the ... Effects of tunicamycin on the retention of vincristine in drug-resistant UWOV2 human ovarian carcinoma cells at different time ... Effects of tunicamycin (TM) on protein synthesis (A) and glycoprotein synthesis (B) in UWOV2 ovarian carcinoma cells in culture ...https://cancerci.biomedcentral.com/articles/10.1186/1475-2867-7-5
Frontiers | The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel |...
Stock of tunicamycin was prepared in Me2SO at 5 mg/ml. The vehicle was added to the control (i.e., untreated) cells. For each ... Tunicamycin Treatment. To study potential effects of N-glycosylation on TRPA1 channel functioning, transiently transfected ... Wild-type current responses are indicated with white circles, wild type treated with tunicamycin (5 μg/ml, 24 h) with orange ... When the transiently transfected HEK293T cells were grown for 24 h in the presence of 5 μg/ml tunicamycin, a drug that prevents ...https://www.frontiersin.org/articles/10.3389/fnmol.2017.00016/full
Carbenicillin | CAS 4800-94-6 | Gene Selection Antibiotic | AG Sci.
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Gentamycin Sulfate, USP Grade | CAS 1405-41-0 | Antibiotic | AG Scientific, Inc.
Gentamycin is a broad spectrum cell culture antibiotic. AG Scientific is a leading supplier of biochemicals for life sciences research.https://www.agscientific.com/gentamycin-sulfate.html
Heterotrimeric G protein signaling in the Arabidopsis unfolded protein response | PNAS
tunicamycin;. UPR,. unfolded protein response;. XBP1,. X-box binding protein 1.. *© 2007 by The National Academy of Sciences of ... Activation of the UPR in cultured plant cells by the antibiotic tunicamycin (Tm), an inhibitor of N-linked protein ... mutant plants are markedly more resistant to growth inhibition by the protein glycosylation inhibitor tunicamycin (Tm) than ...https://www.pnas.org/content/104/10/3817
Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a...
Tm, tunicamycin. (c) Northern blot analysis of total yeast RNA from heat-shocked cells. Yeast cultures grown at 23°C in liquid ... Upon tunicamycin treatment, in comparison to wild-type cells (Fig. 3b, lanes 1 and 2), transcriptional induction of KAR2 was ... The UPR was monitored on 5-bromo-4-chloro-3-indolyl β-d-galactoside (X-Gal) plates either with or without tunicamycin, a drug ... Wild-type cells turned blue on X-Gal plates containing tunicamycin within 24 hr, indicating an intact UPR pathway (Fig. 3a). In ...https://www.pnas.org/content/94/9/4289?ijkey=01b7964522349b9e233cc034dac879ea0e8075c3&keytype2=tf_ipsecsha
Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin *Hai-Yan ... Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycin-treated PC12 cells in vitro * ...HUANG, Cong ... Rights & permissionsfor article Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent ... Rights & permissionsfor article Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycin-treated PC12 ...https://www.nature.com/search?author=%22Yan%20Gao%22&error=cookies_not_supported&code=1fc807c8-ff1a-4290-b143-f4a6ca2f16b3
MraY-antibiotic complex reveals details of tunicamycin mode of action Details Published:. Nature Chemical Biology (2017) ...https://www.astrazeneca.com/our-science/publications.html