DAndreas focus is the molecular pathogenesis of the human chromosomal instability syndromes: Fanconi anemia (FA), ataxia- ... Departmental research is focused on the treatment of tumors and on increasing the understanding of treatments at the molecular ... The unifying research aim of the department is the understanding of genomic instability in human cancer in order to tailor ... He has developed a range of methodologies for evaluation of tumor-specific genetic changes, such as mutation and methylation. ...
In particular, an increase in chromosomal instability turned up in metastatic forms of lung or prostate adenocarcinomas and in ... "Our work shows that genomic alterations identified in tumor samples can inform our understanding of a tumors potential to ... They also pointed to ties between enhanced chromosomal instability and metastatic burden, particularly in certain cancer types. ... In contrast to prior studies that centered on either primary or metastatic tumors as a group, the team set out to characterize ...
... chromosomal instability (CIN) and epigenetic instability (CIMP) are the three major causes of genetic instability resulting CRC ... Ratovitski, E. A. (2016). Tumor Protein (TP)-p53 Members as Regulators of Autophagy in Tumor Cells upon Marine Drug Exposure. ... Hypoxia is a hallmark of solid tumors and has been linked to the angiogenesis and related factors such as HIF-1 and VEGF in ... The formation of new blood vessels in hypoxic areas of solid tumor cells, such as colon cancer, will lead to better nutrition ...
Genome doubling and ongoing dynamic chromosomal instability were associated with intratumor heterogeneity and resulted in ... However, tumor response to BRAF/MEK inhibition, though rapid, is often short-lived as tumors develop resistance to this ... During the process of tumor dissemination, Ca2+ participates in the. invasion of healthy tissues by tumor cells with in ... the growth, invasion and tumor metastasis. Inhibition of T-type. calcium channels by mibefradil [17] or NecroX-5 [18] can ...
... it is unclear whether ecDNA is a later manifestation of genomic instability, or whether it can be an early event in the ... Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov. 4 ... b, Proportion of Cambridge EAC tumour samples with ecDNA separated by tumour stage I versus stage II or higher. ... Genomic signatures of past and present chromosomal instability in the evolution of Barretts esophagus to esophageal ...
Chromosomal instability and aneuploidy are not only symptoms of cancer cells, they can directly cause or enhance cancer ... formation, as they create dosage imbalances between oncogenes and tumour suppressors, and contribute to the development of ... how a deregulation of these mechanisms contribute to genetic instability in cancer cells, and how this erroneous process can ...
The chromosomal instability and the micro-satellite instability. The purpose of this paper is therefore to develop a new ... BACKGROUND AND PURPOSE: Studies by molecular biologists and geneticists have shown that tumors of human colon cancer are ... involving 2 different pathways-the chromosomal instability pathway and the micro-satellite instability pathway; the observation ...
Colorectal Cancer With High Tumor Mutation Burden: Pembrolizumab. Tumors with numerous chromosomal alterations express tumor- ... might therefore respond to pembrolizumab-as do those that are microsatellite instability-high. This was the rationale for the ... Patients with high tumor mutational load treated with pembrolizumab had a response rate of 11% and a disease control rate of 28 ... 3. Meiri E, Garrett-Mayer E, Halabi S, et al: Pembrolizumab in patients with colorectal cancer with high tumor mutational ...
Chromosomal Analysis Using G Banding and SKY.. G band and SKY analyses of the WISH-PC14 xenograft revealed a clone of tumor ... STK15 overexpression was significantly associated with chromosomal instability in breast cancers and was therefore suggested as ... The MU database includes gene expression profiles from 14 localized prostate tumors, 20 metastatic tumors, and 14 BPH samples ... 5 The tumor derived from a channel transurethral resection of the prostate of a late recurrent primary tumor, Gleason score 9 ( ...
... a recent study in mice showed that loss of Bard1 results in early embryonic lethality and chromosomal instability, indicating a ... The BARD1-CstF-50 interaction links mRNA 3′ end formation to DNA damage and tumor suppression. Cell2001;104:743-53. ... results in early embryonic lethality and chromosomal instability. Mol Cell Biol2003;23:5056-63. ... McCarthy EE, Celebi JT, Baer R, Ludwig T. Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, ...
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in ... Tumor-associated macrophage. TME. Tumor microenvironment. TNFR. Tumor necrosis factor receptor. αCSF-1R. Anti-colony ... Tumor-associated macrophage. TME. Tumor microenvironment. TNFR. Tumor necrosis factor receptor. αCSF-1R. Anti-colony ... The half of the spleen through which the tumor cells were injected was then removed to avoid leaving residual tumor cells ...
In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex ... E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to ...
A common characteristic of cancer cells is chromosomal instability (CIN), but whether mxc mutants exhibit this feature is ... Mutations in mxc Tumor-Suppressor Gene Induce Chromosome Instability in Drosophila Male Meiosis ... Moreover, we observed that the so-called lagging chromosomes retained between chromosomal masses separated toward spindle poles ... and severe mxc mutations generate tumors in larval hematopoietic tissues. ...
Chromosomal instability was prevalent in nonhypermutated cases, with similar patterns of chromosomal gains and losses. Although ... Achaete-scute homolog 1 levels were associated with the degree of STND tumor differentiation (high-grade tumors show increased ... Specificity was demonstrated by evaluation of 194 other tumor and corresponding normal tissues. Circulating tumor cells in the ... Among human primary tumors, 2/2 SCLC, 5/5 pulmonary carcinoids, and 10/41 non-SCLC (only 4 of which had NE features) were ...
... a term that describes the gain and loss of large chromosomal fragments. The chromosomal instability seen in the brain ... The study also found the metastases may alter macrophages and T cells in the tumor microenvironment, thereby promoting cancer ... Chromosomal instability is one of several ways that melanoma brain metastases may evade attack by the immune system. ... Melms and his collaborators know of several experimental drugs designed to reduce chromosomal instability that are scheduled to ...
Although chromosomal instability is a major driver of tumour evolution, its role in metastasis has not been established. Here ... Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how ... Genetic suppression of chromosomal instability markedly delays metastasis even in highly aneuploid tumour models, whereas ... we show that chromosomal instability promotes metastasis by sustaining a tumour cell-autonomous response to cytosolic DNA. ...
MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer. J Pathol 241(1): ... Tumor-specific low molecular weight forms of cyclin E induce genomic instability and resistance to p21, p27, and antiestrogens ... CCAT2, a novel non-coding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. ... Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in ...
DNA repair defects probably related to chromosomal instability and repetitive chromosomal defects in MDS. ... Elevated levels of tumor necrosis factor-alpha and cytotoxic T-cells can lead to ineffective hematopoiesis in some cases, ... MDS associated with chromosomal lesion del(5q) with losses that span 5q31-q33 and occur in isolation often exhibit macrocytic ... Deletions of chromosomes 7q an 5q most common chromosomal abnormalities.. Approximately 50% of patients harbor a deletion of ...
Telomer structure and chromosomal instability. - apoptosis and necrosis, as well as other forms of cell death. - Angiogenesis. ... Imaging techniques in tumor research (multiphoton microscopy, MRT, PET/CT, OCT). - Tumor-Stroma Interactions. - Basics of tumor ... Tumor Viruses. - Oncogenes, tumor suppressor genes and tumor modulators. - Signal transduction and growth factors. - ... Adult stem cells and "tumor stem cells", tumor metabolism. - Embryonic development of the mouse, embryonic stem cells, knock- ...
How does chromosomal instability drive tumor progression? Background and application. Background and implication. Chromosomal ... However, how chromosomal loss or gain drives tumor progression to metastasis remains unknown. It is technically difficult to ... Cancer genome sequencing has revealed dynamic chromosomal content changes during clonal evolution of the tumor cell population ... Recently, advanced genome-editing techniques have been used to delete large chromosomal region, even whole chromosomal arm [33 ...
Chromosomal instability (CIN) and microsatellite instability (MSI) constitute the predominant tumorigenic pathways in CRC ( ... Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol. 2002;20:1043- ... Reflex immunohistochemistry and microsatellite instability testing of colorectal tumors for Lynch syndrome among US cancer ... Recently, reviewing the BRAF V600E mutation in 4562 tumors from 35 studies and MLH1 promoter methylation in 2975 tumors from 43 ...
Tumor mutational burden and microsatellite instability can also be determined. *Hybridization-based capture sequencing allows ... Whole genome sequencing is used mainly for the detection of major chromosomal rearrangements, deletions, and hypomethylation. ... Low percentage of circulating tumor DNA relative to total cfDNA: The percentage of tumor-derived DNA in circulation may be as ... However, for solid tumors or more organ-specific diseases, cfDNA or RNA is typically much more informative. ...
... genomic instability, and related molecular, cytogenetic, and chromosomal effects during induction and progression to malignancy ... Tumor Biology and Microenvironment Branch. This branch supports research in tumor biology, focusing on the interaction of the ... Tumor Metastasis Branch. This branch plans, develops, and directs the Divisions research program in tumor metastasis, focusing ... and the tumor microenvironment, in order to facilitate the development of the field. ...
keywords = "Wnt-1, genomic instability, mammary tumors, mouse, p53, tumor model",. author = "Donehower, {Lawrence A.} and ... Mammary tumors lacking p53 display less fibrotic histopathology and increased genomic instability with aneuploidy, ... Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes and ... Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. In: Genes ...
... a biotech company based in New York City that is focused on developing novel cancer therapies targeting chromosomal instability ... Her research has focused on immune cell development and tumor immunology, and she has authored multiple peer-reviewed ... focused on developing first-in-class cancer immunotherapies to modulate endoplasmic reticulum stress responses in the tumor ...
The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity Many cancers possess an ... Genomic imbalances pinpoint potential oncogenes and tumor suppressors in Wilms tumors Wilms tumor (WT) has a not completely ... Chromosomal instability associated with adverse outcome: a case report of patient with Nijmegen breakage syndrome and rapidly ... Aneuploidy is often caused by Chromosomal Instability (CIN), a process of continuous chromosome mis-segregation. CIN is... ...
chromosomal instability. Immunodeficiency with centromeric instability and facial anomalies. (ICF types 1, 2, 3, 4). DNMT3B. AR ... In addition to chronic EBV infection, EBV-associated tumors such as smooth muscle tumors in the liver and nodular sclerosing ... and chromosomal instability Nijmegen breakage syndrome. NBS1. AR. Bacterial respiratory tract infections. Mycobacterial ... chromosomal instability. Bloom syndrome. BLM. AR. Respiratory and gastrointestinal infections with common microorganisms. No ...
... co-activators cooperated in the regulation of a gene signature that indicated the presence of chromosomal instability (CIN). A ... The pCCA TMA included 155 tumor tissues (grading: G1 = 8, G2 = 114, G3 = 33, G4 = 0), while the dCCA TMA consisted of 126 tumor ... Tóth, M., Wehling, L., Thiess, L. et al. Co-expression of YAP and TAZ associates with chromosomal instability in human ... Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma. *Marcell Tóth1, ...
... with consequent chromosomal instability manifested by increased micronuclei formation and numerical chromosomal aberrations. ... Aberrant hypermethylation of tumor suppressor genes is known to play an important role in the development of many tumors, and ... Here, we report that Dbc1 knockout mice are tumor prone, suggesting that DBC1 functions as a tumor suppressor in vivo. Our data ... However, the suggested functions of SIRT1 as a potential tumor promoter and of DBC1 as a potential tumor suppressor have been ...
Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome. ... An intermediate level of genetic instability of the tumor is more favorable to an increase in tumor aggressiveness than a low ... Genetic instability (GI) is a fundamental property of almost all cancers. In this work, we present a new statistical method for ... In addition, we observe that patients with a low level of genetic instability do not seem to benefit from chemotherapy and find ...