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*  A Role for Tumor Suppressor Protein p53 in the Fidelity of DNA Synthesis and Resistance Towards Nucleoside Analogs |...
Title: A Role for Tumor Suppressor Protein p53 in the Fidelity of DNA Synthesis and Resistance Towards Nucleoside Analogs. VOLUME: 2 ISSUE: 3. Author(s):Mary Bakhanashvili and Galia Rahav. Affiliation:Infectious Diseases Unit,Chaim Sheba Medical Center, Tel Hashomer 52621, Israel.. Keywords:p53, 3'→ 5'exonuclease activity, genomic stability, nucleoside analogs. Abstract: The tumor suppressor protein p53 plays an important role in maintaining genomic integrity. p53 possesses an intrinsic 3→ 5 exonuclease activity. The presence of exonuclease activity has been implicated in the prevention of mutator phenotype and in acquired resistance to chemotherapeutic agents. p53 may act as proofreading exonuclease for DNA polymerases during DNA replication. The recombinant wild-type p53 can proofread for various exonuclease-deficient cellular and viral DNA polymerases. The preferential excision of mismatched nucleotides from DNA by 3→5 exonuclease ...
http://www.eurekaselect.com/56415
*  Plus it
MDM2 is an E3 ubiquitin ligase that binds and ubiquitinates the tumor suppressor protein p53, leading to its proteasomal degradation. Nutlin-3a (Nutlin) is a preclinical drug that binds MDM2 and prevents the interaction between MDM2 and p53, leading to p53 stabilization and activation of p53 signaling events. Previous studies have reported that Nutlin promotes growth arrest and/or apoptosis in cancer cells that express wild-type p53. In the current study, Nutlin treatment caused a cytoskeletal rearrangement in p53 wild-type human cancer cells from multiple etiologies. Specifically, Nutlin decreased actin stress fibers and reduced the size and number of focal adhesions in treated cells. This process was dependent on p53 expression but was independent of p21 expression and growth arrest. Consistent with this, Nutlin-treated cells failed to form filamentous actin-based motility structures (lamellipodia) and displayed significantly decreased directional persistence in response ...
http://mct.aacrjournals.org/content/early/2010/04/02/1535-7163.MCT-09-1220
*  Anti-Human p53 Antibody | Human p53 Antibody | p53 Antibody
Tumor protein p53, encoded in humans by the TP53 gene, was originally identified based on its interaction with the large T antigen of simian virus 40 (SV40). p53 is expressed at low levels in most cell types but is upregulated in many transformed (cancer) cell lines. In response to cellular stress, p53 regulates over 100 target genes that control cell cycle arrest, apoptosis, senescence, DNA repair, and metabolic changes. p53 protein has multiple domains that include DNA-binding, transactivation, and oligomerization activities. Mutations in the TP53 gene cause loss of tumor suppression activity and are found in more than 50% of human tumors. Multiple isoforms of p53 are known, with distinct DNA-binding and transcriptional activation properties. p53 is also known as cellular tumor antigen p53, p53 tumor suppressor, transformation-related protein 53, BCC7, LFS1, TRP53, and antigen NY-CO-13.. ...
http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Cancer_and_Inflammation/p53?sitex=10020:22372:US&PEBCL1=emJ41nU3QJoAgitO9S6N5SguI2&PEBCL1_pses=ZGDED148394D90EF4C33B8669482C7E1DA7943D5CC187D961A271A0D7E8BFC1E86D0EE22CA2084EF39A5A83EB50D02D50865002F0222472B31
*  Tumor Suppressor Proteins - Proteins, Tumor Suppressor Summary Report | CureHunter
Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
http://www.curehunter.com/public/keywordSummaryD025521-Tumor-Suppressor-Proteins-Proteins--Tumor-Suppressor.do
*  anti-SV40 T-antigen antibody [PAb419] | GeneTex
SV40 T-antigen antibody [PAb419] for ICC/IF, IP. Anti-SV40 T-antigen mAb (GTX16848) is tested in Simian virus 40 samples. 100% Ab-Assurance.
http://www.genetex.com/SV40-T-antigen-antibody-PAb419-GTX16848.html
*  Grad Student Jin Hyup Lee receives a 2011 GEAB Impact Award - Biochemistry and Biophysics - UNC School of Medicine
Treating Cancer by Tinkering with the Clock E. Cancer is the leading cause of death in North Carolina, and death rates from cancer have been escalating since the early 1980s. One of the most significant advances in cancer prevention and treatment in recent years has been recognition of the importance of apoptosis, or programmed cell death, which provides new opportunities for the discovery of cancer therapeutic targets and agents. The protein tumor suppressor p53 plays a critical role in apoptosis induced by anticancer drugs; however, at least 50 percent of human cancers lack functional p53. Lee discovered that disrupting the circadian clock-the major regulatory system that ensures proper adaptation to the constantly changing environment-functionally activates the p73 tumor suppressor protein, which induces cell death in p53-deficient cancer cells. His study indicates that this mechanism provides another way to overcome the resistance to ...
http://www.med.unc.edu/biochem/news/2011/jin-lee-is-recipient-of-a-2011-geab-impact-award
*  Tumor protein p53-inducible protein 11
PIG11 protein may play an important role by interaction with other biological molecules in the regulation of apoptosis and provided us a novel angel of view to explore the possible function of PIG11 in vivo ...
https://pharos.nih.gov/idg/targets/O14683
*  Plus it
The retinoblastoma and p53 pathways represent the major tumor suppressor pathways in mammals and are crucial for the control of cell proliferation and the response to cellular insults (19-21). Rb is frequently mutated or expressed at low levels in several tumors such as retinoblastoma, osteosarcoma, as well as small lung, prostate, bladder, and breast carcinomas (22-26). Thus, miRNAs controlling Rb protein levels are of high clinical interest. Here, we show that miR-335 efficiently controls Rb1 (pRb/p105) protein levels by directly targeting a conserved region in the 3′UTR of Rb1 in placental mammals. Our data show that miR-335-mediated reduction of Rb1 protein results in the activation of the p53 pathway in human and mouse cells, impairing cell proliferation and neoplastic transformation in vitro. In line with this, impairing the p53 pathway is sufficient to drive hyperproliferation and increased transformation in the context of ectopically increased ...
http://cancerres.aacrjournals.org/content/70/17/6925
*  Evaluation of Coupled Nuclear and Cytoplasmic p53 Dynamics: Medicine & Healthcare Book Chapter | IGI Global
Evaluation of Coupled Nuclear and Cytoplasmic p53 Dynamics: 10.4018/978-1-4666-3604-0.ch061: The tumor suppressor protein p53 predominantly serves as a sequence specific transcription factor that may be activated upon exposure to diverse stimuli. One
https://www.igi-global.com/chapter/evaluation-coupled-nuclear-cytoplasmic-p53/76114
*  ATCC Cell Lines by TP53 Gene Mutation Page 1
TP53 encodes a major tumor suppressor transcription factor, p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies.
https://www.atcc.org/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=N:4294927352
*  ATCC Cell Lines by TP53 Gene Mutation Page 2
TP53 encodes a major tumor suppressor transcription factor, p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies.
https://www.atcc.org/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=N:4294928640&slp=1
*  ATCC Cell Lines by TP53 Gene Mutation Page 1
TP53 encodes a major tumor suppressor transcription factor, p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies.
https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=N:4294967245
*  ATCC Cell Lines by TP53 Gene Mutation Page 1
TP53 encodes a major tumor suppressor transcription factor, p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies.
https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=Ro:10,Up:Page_Product_Listing,N:4294925102
*  ATCC Cell Lines by TP53 Gene Mutation Page 4
TP53 encodes a major tumor suppressor transcription factor, p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies.
https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=Up:Page_Product_Listing,N:4294925149&slp=1
*  ATCC Cell Lines by TP53 Gene Mutation Page 1
TP53 encodes a major tumor suppressor transcription factor, p53, which plays a significant role in regulating cellular responses to DNA damage and other genomic anomalies.
https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Disease__Model/Cancer/Tumor_Cell_Panels/Cell_lines_by_genetic_mutation/TP53.aspx?dsNav=Up:Page_Product_Listing,N:4294927644
*  Tumor-suppressor Protein Gives Up Its Secrets
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
https://www.technologynetworks.com/cell-science/news/tumorsuppressor-protein-gives-up-its-secrets-212514
*  anti-p53 antibody [DO-7] (ready-to-use) | GeneTex
p53 antibody [DO-7] (ready-to-use) (tumor protein p53) for IHC-Fr, IHC-P. Anti-p53 mAb (GTX20911) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/p53-antibody-DO-7-ready-to-use-GTX20911.html
*  Cold viruses point the way to new cancer therapies - Salk Institute for Biological Studies
Two years ago, O'Shea discovered that E4-ORF3 clears the way for adenovirus to proliferate by deactivating genes that help the cell defend itself against the virus. "It literally creates zip files of p53 target genes by compressing them until they can no longer be read," she explains. E4-ORF3 self-assembles inside cells into a disordered, web-like structure that captures and inactivates different tumor suppressor protein complexes. Horng Ou, a postdoctoral researcher in O'Shea's laboratory, says E4-ORF3 is unusual. "It doesn't resemble any known proteins that assemble polymers or that function in cellular tumor suppressor pathways," he says. "Most cellular polymers and filaments form uniform, rigid chains. But E4-ORF3 is the virus's Swiss army knife-it assembles into something that is highly versatile. It has the ability to build itself into all sorts of different shapes and sizes that can capture and deactivate the many ...
http://www.salk.edu/news-release/cold-viruses-point-the-way-to-new-cancer-therapies/
*  anti-p73 antibody [N1C1] | GeneTex
p73 antibody [N1C1] (tumor protein p73) for ICC/IF, IHC-P, WB. Anti-p73 pAb (GTX109045) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/p73-antibody-N1C1-GTX109045.html