Circadian rhythm and its role in malignancy | Journal of Circadian Rhythms | Full Text
... which in turn activates tumour suppressor protein p53 and subsequently causes cell cycle arrest or apoptosis . It has been ... PER2 protein has also been proposed to function as a tumor suppressor. Per2 mutant mice develop γ radiation-induced lymphomas ... Fu L, Lee CC: The circadian clock: pacemaker and tumour suppressor. Nat Rev Cancer 2003, 3:350-361.PubMedGoogle Scholar. ... Xiang S, Coffelt SB, Mao L, Yuan L, Cheng Q, Hill SM: Period-2: a tumor suppressor gene in breast cancer. Journal of Circadian ...https://jcircadianrhythms.biomedcentral.com/articles/10.1186/1740-3391-8-3
Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53 | Springer for Research & Development
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations ... on the tetrameric structure of tumor suppressor protein p53, which plays ... and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53 ... Quantitative Analysis for p53 Tetramerization Domain Mutants Reveals a Low Threshold for Tumor Suppressor Inactivation ...https://rd.springer.com/book/10.1007/978-4-431-54135-6
481044: p53 Tumor Suppressor Gene Protein,... | LabCorp
Accumulation of p53 tumor suppressor gene protein: An independent marker of prognosis in breast cancers. J Natl Cancer Inst. ... p53 Tumor Suppressor Gene Protein, Immunohistochemical, Paraffin Block. TEST: 481044 Test number copied ... Alterations of the p53 tumor suppressor gene have been shown to serve as an independent prognostic marker in a wide variety of ... Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J ...https://www.labcorp.com/test-menu/32621/p53-tumor-suppressor-gene-protein-immunohistochemical-paraffin-block
Autoantibodies Against The Tumor Suppressor Protein P53 - Autoimmune Diseases
Autoantibodies Against The Tumor Suppressor Protein P53. Last Updated on Thu, 16 Apr 2015 , Autoimmune Diseases ... Mutations of this tumor suppressor gene are the most frequently reported gene alteration in human cancers [26, 27]. In 1982, it ... p53 antibody response (in%). 10 Ways To Fight Off Cancer. Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For ... As the 'guardian of the genome', p53 is the main regulator preventing carcinogenic and teratogenic lesions [24, 25]. Therefore ...https://www.clicktocurecancer.info/autoimmune-diseases/autoantibodies-against-the-tumor-suppressor-protein-p53.html
DNA and p53 Tumor Suppressor Protein - Stock Image - G200/0097 - Science Photo Library
Protein p53 is an important checkpoint in the cell cycle, ensuring the integrity of DNA replication. ... Shown here are the DNA-binding regions of the p53 tumor suppressor protein, bound to DNA. ... Shown here are the DNA-binding regions of the p53 tumor suppressor protein, bound to DNA. Protein p53 is an important ...https://www.sciencephoto.com/media/210735/view
Involvement of the p53 tumor-suppressor protein in the development of antinociceptive tolerance to morphine
... Tan-No, Koichi ... The present study was designed to determine whether the p53 tumor-suppressor protein is involved in the development of ... Moreover, p53 expression in the spinal cord had increased significantly 14h after the last morphine administration. These ... Morphine, Antinociceptive tolerance, p53, Caspase, Nitric oxide, Intrathecal injection National Category Pharmaceutical ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:302486
The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity - White Rose Research Online
p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete ... The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity ... 5 more authors) (2006) The structure of p53 tumour suppressor protein reveals the basis for its funcitonal plasticity. EMBO ... which enables the protein to bind variably spaced DNA target sequences, essential for p53 transactivation and tumour suppressor ...http://eprints.whiterose.ac.uk/6065/
p53 Tumor Suppressor Protein Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone BP53-12 ] WB, IHC-P, IF, FC -...
p53 Tumor Suppressor Protein Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone BP53-12 ] validated in WB, IHC- ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide p53 Tumor Suppressor Protein Antibody - Without BSA and Azide. ... Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53. ... p53 Tumor Suppressor Protein Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or ...http://www.abgent.com/products/AH10775-p53-Tumor-Suppressor-Protein-Antibody-Without-BSA-and-Azide
Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. - PubMed - NCBI
It has been implicated in transcriptional regulation by modulating protein-protein interactions with p53 tumor suppressor ... Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.. Liao JC1, Lam R, Brazda V, Duan S, ... Interferon-Inducible Protein 16: Insight into the Interaction with Tumor Suppressor p53 ... Interferon-Inducible Protein 16: Insight into the Interaction with Tumor Suppressor p53 ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&=&term=21397192%5Buid%5D
Vitamin C | GreenMedInfo | Substance | Natural Medicine | Alternative
Tumor Suppressor Protein p53 Upregulation Research. [x] Remove Focus on Tumor Suppressor Protein p53 Upregulation. Filter by ... Pharmacological Actions : Apoptotic, Bcl-2 protein down-regulation, Cell cycle arrest, Tumor Suppressor Protein p53 ... Pharmacological Actions : Apoptotic, Tumor Suppressor Protein p53 Upregulation. Additional Keywords : Natural Substance/Drug ... Pharmacological Actions : Antioxidants, Apoptotic, Tumor Suppressor Protein p53 Upregulation. Additional Keywords : ...http://www.greenmedinfo.com/substance/vitamin-c?ed=14135
Apoptosis - Springer
Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival Rosi Bissinger, Elisabeth Lang, Irene ...https://link.springer.com/journal/10495
Segregation of genomes in polyploid tumour cells following mitotic catastrophe. - PubMed - NCBI
Tumor Suppressor Protein p53/genetics. *Tumor Suppressor Protein p53/physiology. Substance. *Tumor Suppressor Protein p53 ... Following irradiation p53-function-deficient tumour cells undergo mitotic catastrophe and form endopolyploid cells. A small ... Here we studied this process in five tumour cell lines. After mitotic failure, tumour cells enter the endocycle and form mono- ... Segregation of genomes in polyploid tumour cells following mitotic catastrophe.. Erenpreisa J1, Kalejs M, Ianzini F, Kosmacek ...https://www.ncbi.nlm.nih.gov/pubmed/16314119?dopt=Abstract
Cancers | Free Full-Text | Emerging Biomarkers in Glioblastoma | HTML
... tumor suppressor protein p53, phosphatase and tensin homolog (PTEN), p16INK4a gene, cytochrome c oxidase (CcO), phospholipid ... Molecular signatures associated with tumor aggressiveness as well as with disease progression and their relation to differences ... and 7 transmembrane domain-containing protein 1 on chromosome 1 (ELTD1), vascular endothelial growth factor (VEGF), ... the most common primary brain tumor, has few available therapies providing significant improvement in survival. ...http://www.mdpi.com/2072-6694/5/3/1103/htm
Molecular tweezers - Wikipedia
... aggregation-prone mutants of the tumor-suppressor protein p53; and semen proteins whose aggregation enhances HIV infection. ... Examples include the proteins involved in Alzheimer's disease - amyloid β-protein (Aβ) and tau; α-synuclein, which is thought ... Amyloid β-protein Assembly: The Effect of Molecular Tweezer CLR01 and CLR03. J. Phys. Chem. B, 2015; 119: 4831-4841. S ... T Schrader, G Bitan, and F-G Klärner, Molecular Tweezers for Lysine and Arginine - Powerful Inhibitors of Pathologic Protein ...https://en.wikipedia.org/wiki/Molecular_tweezers
Sorafenib With Irinotecan in Metastatic Colorectal Cancer (mCRC) and K-RAS Mutation
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is ... Tumor suppressor genes located in the 18q21-qter region of human chromosome 18. The absence of these genes is associated with ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...https://www.bioportfolio.com/resources/trial/72123/Sorafenib-With-Irinotecan-in-Metastatic-Colorectal-Cancer-mCRC-and-K-RAS-Mutation.html
A Study of OSI-906 and Irinotecan in Patients With Advanced Cancer With Expanded Cohorts of Patients With KRAS Mutant...
Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ... Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is ... Tumor suppressor genes located in the 18q21-qter region of human chromosome 18. The absence of these genes is associated with ... A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. ...https://www.bioportfolio.com/resources/trial/70653/A-Study-of-OSI-906-and-Irinotecan-in-Patients-With-Advanced-Cancer.html
Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects
Protooncogene proteins c-bcl-2; Tumor suppressor protein p53. ... Tumor suppressor genes and cell proliferation regulatory ... In general, physicians and dentists know little about what causes oral tumor development and progression. ... Keywords : Carcinoma; squamous cell; Cheilitis; Cyclin-dependent kinase inhibitor proteins; Cyclin D1; ... proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. ...http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0365-05962012000100013&lng=en&nrm=iso&tlng=en
The transduction of His-TAT-p53 fusion protein into the human osteogenic sarcoma cell line (Saos-2) and its influence on cell...
It encodes a nuclear phosphoprotein p53 involved in the regulation of cell cycle arrest and apoptosis to maintain the genomic ... As mutations of p53 gene are found in most human cancers, p5 ... The p53 gene is a tumor suppressor gene. ... Recombinant Fusion Proteins / isolation & purification, metabolism*. Transduction, Genetic*. Tumor Suppressor Protein p53 / ... 0/Gene Products, tat; 0/Recombinant Fusion Proteins; 0/Tumor Suppressor Protein p53 ...http://www.biomedsearch.com/nih/transduction-His-TAT-p53-fusion/17206471.html
Honokiol | GreenMedInfo | Substance | Natural Medicine | Alternative
Tumor Suppressor Protein p53 Upregulation. 1. 1. Vascular smooth muscle cell (VSMC) inhibitor. 1. 1. ... Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer.Jun 04, 2017. ... Honokiol can repress human glioma growth by inducing apoptosis and cell cycle arrest in tumor cells.May 14, 2016. ... Honokiol is a promising candidate to suppress the development and even progression of lung tumors driven by EGFR deregulation. ...http://www.greenmedinfo.com/substance/honokiol
Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt...
0/TP53 protein, human; 0/Tumor Suppressor Protein p53; 0/Wnt Proteins; 136601-57-5/Cyclin D1; 147604-94-2/Cyclin-Dependent ... Resveratrol activates tumor suppressor protein p53 and elevates activated forkhead transcription factor 1 levels A critical ... Resveratrol treatment induced apoptosis by activating tumor suppressor p53 protein, whereas IGF-1R siRNA treatment did not ... The tumor suppressor p53, suppresses IGF-1R gene expression and phosphorylation. P53 attenuates IGF-1R transcription through ...http://www.biomedsearch.com/nih/Resveratrol-suppresses-IGF-1-induced/20504360.html
The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated...
Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity.. *Ayesha Elias, Jing Wu, Taosheng Chen ... Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion. *Karishma Bakshi, B. Ranjitha ...https://www.semanticscholar.org/paper/The-major-human-pregnane-X-receptor-%28PXR%29-splice-Lin-Yasuda/1ffbeb47ce086dbf6b403121e547aad609ca3652
Virus and Other Infection-associated Cancers > Yale Cancer Center | Yale School of...
Tumor Suppressor; Head and Neck Neoplasms; Human papillomavirus 11; Oncogenes; Otolaryngology; Tumor Suppressor Protein p53 ... DNA Virus Infections; Membrane Lipids; Neoplasms; Papillomaviridae; Peptides; Polyomaviridae; Proteins; Tumor Virus Infections ...http://yalecancercenter.org/research/people/virology.aspx
Tumor Suppressor; Head and Neck Neoplasms; Human papillomavirus 11; Oncogenes; Otolaryngology; Tumor Suppressor Protein p53 ... DNA Virus Infections; Membrane Lipids; Neoplasms; Papillomaviridae; Peptides; Polyomaviridae; Proteins; Tumor Virus Infections ...http://www.yalecancercenter.org/research/programs/virology/people/
TEP1 - Wikipedia
"Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene. 18 (48): 6785-94. doi: ... The telomerase-associated proteins are conserved from ciliates to humans. It is also a minor vault protein. GRCh38: Ensembl ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene. This gene product is a component of the ...https://en.wikipedia.org/wiki/TEP1
Gastrin-regulated expression of p53 in transformed enterochromaffin-like cells in the African rodent mastomys. | CureHunter
Gastrin-regulated expression of p53 in transformed enterochromaffin-like cells in the African rodent mastomys. - E A Luque, L H ... Tumor Suppressor Protein p53 (biosynthesis, chemistry, genetics) Join CureHunter, for free Research Interface BASIC access!. ... The tumor suppressor p53 functions at the G1/S-phase checkpoint of the cell cycle to direct cells that have accumulated somatic ... p53 was mutated at the C-terminus in ECLoma induced by hypergastrinemia. Therefore, p53 is altered from overproduction to ...http://www.curehunter.com/public/pubmed9872508.do