Warburgs Lens: A Mathematical oncology pre-print discussion forum: Recasting the cancer stem cell hypothesis: unification...  Warburg's Lens: A Mathematical oncology pre-print discussion forum: Recasting the cancer stem cell hypothesis: unification...
On one side, the cancer stem cell hypothesis posits that a small subset of cells within a tumor are responsible for ... We present experimental results from clonogenic assays that demonstrate the importance of defining this novel formulation, and ... Alternatively, the stochastic model states that all cells in a tumor can have stem-like properties, and have an equally small ... Recasting the cancer stem cell hypothesis: unification using a continuum model of microenvironmental forces. Jacob G. Scott, ...
more infohttp://mathematicaloncology.blogspot.fr/2017/07/recasting-cancer-stem-cell-hypothesis.html
JoVE Table of Contents: Issue 67, September 2012  JoVE Table of Contents: Issue 67, September 2012
Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting. Chitra Venugopal1, Nicole M. McFarlane1, Sara ... Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea. Ahmed E. Hegab1, Vi Luan Ha1, Yasser S. Attiga1, ... Micropipette Aspiration of Substrate-attached Cells to Estimate Cell Stiffness. Myung-Jin Oh1, Frank Kuhr1, Fitzroy Byfield2, ... Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations. Dominik Schnerch1, Marie Follo1, Julia ...
more infohttps://www.jove.com/archive/67/september-2012
Fibroblast growth factor 2 Protocols and Video Articles  Fibroblast growth factor 2 Protocols and Video Articles
Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting. ... Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations, Improved Generation of Induced ... RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells, Zika Virus Infection of Cultured ... Human Fetal Brain Neural Stem Cells for Immunocytochemical Analysis, ...
more infohttps://www.jove.com/search?q=fibroblast%20growth%20factor%202
POU1F1 | Cancer Genetics Web  POU1F1 | Cancer Genetics Web
Tumor Stem Cell Assay. *Transcription. *Adolescents. *Young Adult. *Apoptosis. *Helix-Loop-Helix Motifs ... To target these tumors specifically, we chose to inactivate a gene coding for a crucial factor in cell proliferation and ... PRKAR1A and the evolution of pituitary tumors.. Mol Cell Endocrinol. 2010; 326(1-2):3-7 [PubMed] Free Access to Full Article ... The pattern of tumors is likely related to the signaling pathways employed in specific pituitary cell types. ...
more infohttp://www.cancerindex.org/geneweb/POU1F1.htm
IGF2 | Cancer Genetics Web  IGF2 | Cancer Genetics Web
Tumor Stem Cell Assay. *Translocation. *Vascular Endothelial Growth Factor Receptor-2. *Testicular Cancer ... TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.. J Clin Invest. ... IGF2 knockdown inhibited cell proliferation in both cell lines induced G1 cell cycle blockade and decreased adhesion to several ... Wilms tumor, a common childhood tumor of the kidney, is thought to arise from undifferentiated renal mesenchyme. Variable tumor ...
more infohttp://www.cancerindex.org/geneweb/IGF2.htm
Amniotic Mesenchymal Stem Cells Can Enhance Angiogenic Capacity via MMPs In Vitro and In Vivo.  Amniotic Mesenchymal Stem Cells Can Enhance Angiogenic Capacity via MMPs In Vitro and In Vivo.
... was to evaluate the angiogenic capacity and proteolytic mechanism of coculture using human amniotic mesenchymal stem cells ( ... Tumor Stem Cell Assay. A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their ... Mesenchymal Stem Cell Engineering.. Mesenchymal stem cells (MSC) are multipotent stem cells that display the capacity to ... Stem Cells Track and monitor developments in stem cell research and commercial development. Follow the tabs above to read the ...
more infohttps://www.bioportfolio.com/resources/pmarticle/1352572/Amniotic-Mesenchymal-Stem-Cells-Can-Enhance-Angiogenic-Capacity-via-MMPs-In-Vitro.html
Influence of DNMT inhibitors on radiation-induced γH2A | Open-i  Influence of DNMT inhibitors on radiation-induced γH2A | Open-i
A549 and U373MG cells growing in chamber slides were exposed to DNMT inhibitors for 18 hours, irr ... after which cell survival was evaluated via clonogenic assays. Cell cycle and apoptosis were analyzed via flow cytometry. ... Cell Line, Tumor/drug effects/radiation effects. *Cytidine/analogs & derivatives/pharmacology. *DNA Breaks, Double-Stranded/ ... after which cell survival was evaluated via clonogenic assays. Cell cycle and apoptosis were analyzed via flow cytometry. ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3375186_1748-717X-7-39-7&req=4
Casazza AM[au] - PubMed - NCBI  Casazza AM[au] - PubMed - NCBI
Evaluation of new anthracycline analogs with the human tumor stem cell assay. ... Fluorescence assays and pharmacokinetic studies of 4-deoxydoxorubicin and doxorubicin in organs of mice bearing solid tumors. ... Fluorescence assay of tissue distribution of 4-demethoxydaunorubicin and 4-demethoxydoxorubicin in mice bearing solid tumors. ... Biologic characterization and chemotherapeutic response of MS-2 tumor: a non-regressing mouse sarcoma derived from MSV-M- ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Casazza+AM%5Bau%5D&dispmax=50
The Human Tumor Cloning Assay: An In Vitro Assay for Antitumor Activity in Solid Tumors | SpringerLink  The Human Tumor Cloning Assay: An In Vitro Assay for Antitumor Activity in Solid Tumors | SpringerLink
Human Tumor Soft Agar Human Tumor Cell Drug Sensitivity Tumor Stem Cell These keywords were added by machine and not by the ... Park CH, Bergsagel DE, McCulloch EA: Mouse myeloma tumor stem cells: a primary cell culture assay. J Natl Cancer Inst 46: 411- ... Trent JM: Cytogenetic analysis of human tumor cells cloned in agar. In: Cloning of human tumor stem cells, Salmon SE (ed). New ... Initial experience with the human tumor stem cell assay system: potentials and problems. In: Human tumor cloning, Salmon SE (ed ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4613-3903-8_4
The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non-small cell lung carcinoma cells to DNA double...  The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non-small cell lung carcinoma cells to DNA double...
Tumor Stem Cell Assay National Category Medical and Health Sciences Identifiers. URN: urn:nbn:se:uu:diva-15056DOI: 10.1158/1535 ... Cell Death/drug effects, Cell Line; Tumor, DNA Breaks; Double-Stranded/*drug effects, DNA Repair/*drug effects, Drug Synergism ... The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non-small cell lung carcinoma cells to DNA double- ... repair pathway in mammalian cells. By using a clonogenic survival assay, we show here that concomitant administration of ...
more infohttp://uu.diva-portal.org/smash/record.jsf?pid=diva2:42827
Spalax fibroblasts suppress colony formation of human b | Open-i  Spalax fibroblasts suppress colony formation of human b | Open-i
A) MDA-MB-231 cells (5 × 103 cells) cells were sus ... suppress colony formation of human breast cancer cells MDA-MB- ... While all mice and rats developed the expected tumors following treatment with both carcinogens, among Spalax no tumors were ... A) MDA-MB-231 cells (5 × 103 cells) cells were suspended in 0.35% agar and added as the cancer cell top layer to base layer ... A) MDA-MB-231 cells (5 × 103 cells) cells were suspended in 0.35% agar and added as the cancer cell top layer to base layer ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3750378_1741-7007-11-91-10&req=4
Antitumoral treatments - Patent # 7576188 - PatentGenius  Antitumoral treatments - Patent # 7576188 - PatentGenius
"Antitumor Activity of Didemnin B in the Human Tumor Stem Cell Assay". Cancer Chemotherapy and Pharmacology, 1983. 11:1-4. cited ... Cell viability is measured by XTT assay in an automated plate reader. We found aplidine to be cytotoxic to all cell lines with ... The cells used were: fresh cells obtained from six chronic lymphocytic leukemia patients primary cell from a patient with preB- ... Drug combination studies were carried out on established cell lines rather than primary cells. We studied three cell lines viz ...
more infohttp://www.patentgenius.com/patent/7576188.html
Pearson - Science News  Pearson - Science News
Antitumor activity of bovine cartilage extract (Catrix-S) in the human tumor stem cell assay. Journal of Biological Response ... Forty-two tumors may not be many, Ostrander acknowledges. However, he points out, sick fish usually dont show up on hooks or ... A tumor lures blood vessels to form on its expanding periphery, providing the pipelines to nourish it. Without this extra blood ... Phase I/II trial of the safety and efficacy of Æ-941 (Neovastat®) in the treatment if non-small-cell lung cancer. Clinical Lung ...
more infohttp://www.phschool.com/science/science_news/articles/fishy_therapy.html
Therapy of malignant brain tumors: comparison of the in vitro activities of vidarabin-monophosphate, BCNU and 5-fluorouracil  -...  Therapy of malignant brain tumors: comparison of the in vitro activities of vidarabin-monophosphate, BCNU and 5-fluorouracil -...
A tumor stem cell assay was performed under similar conditions. The cytotoxic effect of each drug on individual cell lines was ... A micro assay was employed to screen for drug toxicity in individual tumor cell lines; cells were exposed to the drugs at ... Mean sensitivity indices for ARA-A5P, BCNU and 5-FU in brain tumor cell lines (in brackets: primary CNS-tumors) were 0.64 ( ... ARA-A5P had a suppressive effect on formation of brain tumor stem cell colonies. There was no cross-resistance of ARA-A5P to ...
more infohttps://epub.uni-regensburg.de/29394/
In Vitro Assays for Directing Therapy of Genitourinary Cancers | Springer for Research & Development  In Vitro Assays for Directing Therapy of Genitourinary Cancers | Springer for Research & Development
Agrez MV, Kovach JS, Lieber MM: Cell aggregates in the soft agar human tumour stem-cell assay. Br J Cancer 46:880-887, 1982. ... Selby P, Buick RN, Tannock I: A critical appraisal of the human tumor stem cell assay. N Engl J Med 308:129-134, 1983.PubMed ... Clonogenic assay for Wilms tumor: improved technique for obtaining single cell suspensions and evidence for tumor cell ... Renal Cell Carcinoma Soft Agar Single Cell Suspension Transitional Cell Carcinoma Clonogenic Assay These keywords were added by ...
more infohttps://rd.springer.com/chapter/10.1007/978-1-4613-2843-8_4
https://www.cancer.gov/about-cancer/treatment/cam/hp/cartilage-pdq  https://www.cancer.gov/about-cancer/treatment/cam/hp/cartilage-pdq
Durie BG, Soehnlen B, Prudden JF: Antitumor activity of bovine cartilage extract (Catrix-S) in the human tumor stem cell assay ... Durie BG, Soehnlen B, Prudden JF: Antitumor activity of bovine cartilage extract (Catrix-S) in the human tumor stem cell assay ... Durie BG, Soehnlen B, Prudden JF: Antitumor activity of bovine cartilage extract (Catrix-S) in the human tumor stem cell assay ... total T cell counts, total B cell counts, percentage of T cells, percentage of B cells, and ratio of helper T cells to ...
more infohttps://www.cancer.gov/about-cancer/treatment/cam/hp/cartilage-pdq
NHIC Medicare Reconsideration  NHIC Medicare Reconsideration
... "human tumor stem cell" assay and the second was the "fluorescent cytoprint assay." The first was based on measuring tumor cell ... on human tumor stem cell sensitivity assays which states:. "Human tumor drug sensitivity assays are considered experimental, ... "The clinical application of the assay, based on testing in tumor microorgans rather than in clones derived from single cells, ... This study was NOT a comparison of a "comparison group" and an "assay-directed treatment group!" The DISC assay was NOT used to ...
more infohttp://weisenthal.org/nhic_medicare_reconsideration.htm
Medicines | Free Full-Text | Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications  Medicines | Free Full-Text | Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications
Three stages of development of human prostate tumors have been identified: intraepithelial neoplasia, adenocarcinoma androgen- ... cancer stem cells; tumor xenotrasplantation assay; gene sequencing; gene expression profiling prostate cancer; cancer stem ... Three stages of development of human prostate tumors have been identified: intraepithelial neoplasia, adenocarcinoma androgen- ...
more infohttps://www.mdpi.com/2305-6320/6/3/82
PTC Therapeutics | BMI1 - PTC596  PTC Therapeutics | BMI1 - PTC596
... an orally active small molecule that targets tumor stem cell products and provides tumor control. ... Specifically, PTC596 preferentially depleted cancer stem cells in assays with tumor cell lines from fibrosarcoma, prostate and ... the resulting tumors treated with PTC596 had lower levels of cancer stem cells than either untreated tumors or tumors treated ... indicating a reduction in cancer stem cells. Consistent with this reduction in BMI1 levels, after transplanting tumor cells ...
more infohttps://ptcbio.com/en/pipeline/bmi1-ptc596/