Effects of psychotropic drugs on inflammation: consequence or mediator of therapeutic effects in psychiatric treatment? |...
Inflammatory markers have been associated with fluctuations in clinical status and with treatment response both in depression ... Bleeker MWP, Netea MG, Kullberg BJ et al (1997) The effects of dexamethasone and chlorpromazine on tumour necrosis factor-α, ... which could partly be attributed to the interaction in vivo with various biological systems or lifestyle factors that can ... Inflammatory markers seem to hold potential for developing more individualised treatment strategies in the future. In this ...
The scientific basis of rational prescribing. A guide to precision clinical pharmacology based on the WHO 6-step method |...
... cells in tumors [8]) or protein/gene expression in biological samples such as tumor biopsies, blood, cerebrospinal fluid, or ... The assumption is that these intermediate markers of efficacy will allow optimizing the drug effects and predict the impact on ... Ahn JC, Teng PC, Chen PJ, Posadas E, Tseng HR, Lu SC et al (2020) Detection of circulating tumor cells and their implications ... Precision clinical pharmacology expands this to an analysis of the underlying molecular biological and pathophysiological ...
Minimal information about T cell assays: the process of reaching the community of T cell immunologists in cancer and beyond |...
Mallett S, Timmer A, Sauerbrei W, Altman DG (2010) Reporting of prognostic studies of tumour markers: a review of published ... now set the stage for a new era of immunotherapy with greater availability of biological samples from large controlled clinical ... McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM (2005) Reporting recommendations for tumor marker prognostic ... and Reporting recommendations for tumor Marker prognostic studies (REMARK) [30]. Each of these projects is unique, and all are ...
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism |...
Role of Nrf2/HO-1 in tumor initiation and progression. Both Nrf2 and HO-1 may decrease tumor initiation through the ... Besides cardiovascular disorders, the presence of long (GT) n repeats has been suggested to be a prognostic marker for several ... Phase I is realized by many enzymes, like cytochrome P450 monooxygenases, which decrease biological activity of xenobiotics. ... However, in some tumors the opposite, inhibitory effect on progression of tumors have been reported ...
The Influence of Selected Insecticides on the Oxidative Response of Atta sexdens (Myrmicinae, Attini) Workers | Neotropical...
GSSG ratio as a marker for oxidative stress in paediatric tumour patients. Oncol Lett 4:1247-1253. https://doi.org/10.3892/ol. ... One of the most employed procedures to evaluate the antioxidant status of biological tissue is the total radical-trapping ... Masella R, Di Benedetto R, Varì R et al (2005) Novel mechanisms of natural antioxidant compounds in biological systems: ... Olivero-Verbel J, Tao L, Johnson-Restrepo B et al (2006) Perfluorooctanesulfonate and related fluorochemicals in biological ...
Science-based policy: targeted nutrition for all ages and the role of bioactives | European Journal of Nutrition
Ganji V, Al-Obahi A, Yusuf S, Dookhy Z, Shi Z (2020) Serum vitamin D is associated with improved lung function markers but not ... The five cardinal signs of inflammation: rubor (flusing), tumor (swelling), calor (fever), dolor (pain), and function lesa ( ... The biological activities of (poly)phenols, however, extend beyond their mere indirect antioxidant action and include ... Data on nutrient intake, corroborated with biochemical markers of nutritional status where available, and association with ...
Sprouty2-a Novel Therapeutic Target in the Nervous System? | Molecular Neurobiology
Hence, constitutively active Ras can circumvent the function of Spry2 as an inhibitor of ERK in tumor cells [6]. In addition to ... regulate the biological activity of Sprouties [39, 52]. The ubiquitin ligase casitas b-lineage lymphoma (c-Cbl) and seven in ... examples of neuronal morphologies of sympathetic superior cervical ganglion neurons stained for the tubulin marker Tuj-1. ... Edwin F, Singh R, Endersby R, Baker SJ, Patel TB (2006) The tumor suppressor PTEN is necessary for human Sprouty 2-mediated ...
Targeting Macrophages for Tumor Therapy | SpringerLink
... play an important role in tumor development and metastasis. The frequency and polarizati ... as one of the most abundant tumor-infiltrating cells, ... a marker of alternative immunologic macrophage activation. J ... Uribe-Querol E, Rosales C. Phagocytosis: our current understanding of a universal biological process. Front Immunol. 2020;11: ... Zheng Y, Han Y, Sun Q, Li Z. Harnessing anti-tumor and tumor-tropism functions of macrophages via nanotechnology for tumor ...
Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist | Reviews in Endocrine and Metabolic...
Biological activity of vitamin D analogues in the skin, with special reference to antipsoriatic mechanisms. Br J Dermatol. 1995 ... Existing and potentially novel functional markers of vitamin D status: a systematic review. Am J Clin Nutr. 2009;89(6):1997S- ... including tumour-necrosis factor-α (TNF-α), IL-6 and IL-17 [26]. The activity of these cells is modulated by specific T ... Ovesen L, Brot C, Jakobsen J. Food contents and biological activity of 25-hydroxyvitamin D: a vitamin D metabolite to be ...
NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte...
CD68, a marker of microglia phagocytic activity, peaks and invades the ischemic core at 7d after stroke onset (Perego et al. ... M1 and M2 microglia can be distinguished by looking at the cells biological function and their secreted chemokines and ... Clausen BH, Lambertsen KL, Babcock AA et al (2008) Interleukin-1beta and tumor necrosis factor-alpha are expressed by different ... Lisi L, Ciotti GMP, Braun D et al (2017) Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial ...
Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors | SpringerLink
Habermann, N., Schön, A., Lund, E. K., & Glei, M. (2010). Fish fatty acids alter markers of apoptosis in colorectal adenoma and ... Rozengurt, E. (2011). Protein kinase D signaling: multiple biological functions in health and disease. Physiology (Bethesda), ... Comba, A., Lin, YH., Eynard, A.R. et al. Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors. ... Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors. *Andrea Comba1, ...
Olive Leaf (Oleuropein) and Its Role in Cancer: Therapeutic Updates | SpringerLink
Visioli F, Poli A, Gall C (2002) Antioxidant and other biological activities of phenols from olives and olive oil. Med Res Rev ... Hamdi HK, Castellon R (2005) Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptor. Biochem ... plasma lipids and inflammatory markers: a randomised controlled trial. Eur J Nutr 56(4):1421-1432 ... López-Biedma A, Sánchez-Quesada C, Delgado-Rodríguez M, Gaforio JJ (2016) The biological activities of natural lignans from ...
Application of artificial intelligence in nuclear medicine and molecular imaging: a review of current status and future...
If a biomarker is claimed to be an early marker of disease, it is less relevant at which statistical significance level the ... It should tailor the treatment towards the genetic composition of the tumour(s) and take into account the extent of the disease ... The objective is to identify those imaging features that are associated or causally related with a given clinical or biological ... FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42:328-54. ...
Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review | SpringerLink
Biological therapies play an increasing role in cancer treatment, although the number of naked antibodies showing clinical ... Wang X, Ma D, Olson WC et al (2011) In vitro and in vivo responses of advanced prostate tumors to PSMA ADC, an auristatin- ... Biological therapies play an increasing role in cancer treatment, although the number of naked antibodies showing clinical ... Hoashi T, Sato S, Yamaguchi Y et al (2010) Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a ...
New perspectives of Lactobacillus plantarum as a probiotic: The gut-heart-brain axis | Journal of Microbiology
Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 7: suitability ... Childhood maltreatment and inflammatory markers: a systematic review. Acta Psychiatr. Scand. 129, 180-192. ... Toll-like receptor-4 promotes the development of colitisassociated colorectal tumors. Gastroenterology 133, 1869-1881. ...
Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation | Cancer and...
Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to radiation therapy and cancer ... and reoxygenation-dependent manner in irradiated tumors. Journal of Biological Chemistry, 284, 5332-5342. ... 2012). Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and ... Important mechanisms we discuss include (1) improved DNA repair in normal, but not tumor cells; (2) inhibition of tumor cell ...
Therapeutic importance of sulfated polysaccharides from seaweeds: updating the recent findings | 3 Biotech
... characterization and biological studies (Fig. 2). The biological features of the SP reported till now are antioxidant, ... The inhibition rates of sarcoma 180 tumor development were 48.62 and 48.16 % at the doses of 10 and 25 mg/kg, respectively. It ... evidenced by decreased lipid accumulation and down-regulation of adipocyte markers. Also, it inhibited the expression of ... In vivo treatment of the cancer transplanted in mice also showed partial inhibition of the tumors. Now that, cancer has assumed ...
Sequencing technologies and genome sequencing | Journal of Applied Genetics
Bhaijee F, Pepper DJ, Pitman KT, Bell D (2011) New developments in the molecular pathogenesis of head and neck tumors: a review ... Shah AA, Meese E, Blin N (2010) Profiling of regulatory microRNA transcriptomes in various biological processes. a review. J ... step in which the BACs were each positioned on the genomes chromosomes by looking for distinctive marker sequences, called ... 2010), as researchers re-sequence the tumor and normal genomes comparision from specific types of cancer (Pfeifer and Hainaut ...
Encapsulation of Aconitine in Self-Assembled Licorice Protein Nanoparticles Reduces the Toxicity In Vivo | Discover Nano
Samples: M marker; Lane1, crude extract of Radix glycyrrhizae; GP, licorice protein. Electrophoresis was performed at following ... Foroozandeh P, Aziz AA (2015) Merging worlds of nanomaterials and biological environment: factors governing protein corona ... When the tumor cells and nonphagocytic cells tend to absorb relatively small particles (50 to 200 nm), NPs with such diameter ... diversely alters the biological fate and pharmaceutical efficacy of particles [10]. The intracellular protein extracts of a ...
Impact of Endocrine Disorders on Autoimmune Diseases | SpringerLink
Wang X, Bao W, Liu J, Ouyang Y-Y, Wang D, Rong S, … Liu L-G. Inflammatory markers and risk of type 2 diabetes: a systematic ... Kaklamanos M, Thomas D, Pikazis D, Kaltsas G. Thyroid specific changes flowing treatment with biological therapies in patients ... Diabetes mellitus risk in rheumatoid arthritis: reduced incidence with anti-tumor necrosis factor α therapy. Arthritis Care Res ... and clinical significance of non-organ specific antibodies in patients with autoimmune thyroiditis as predictor markers for ...
Fibrosis as a Cause or a Consequence of White Adipose Tissue Inflammation in Obesity | SpringerLink
The extracellular matrix is essential for the architecture of the tissue and a myriad of associated biological functions. This ... have observed an acute collagen deposition associated with an increase of inflammatory markers and the concomitant accumulation ... Adipocyte-derived endotrophin promotes malignant tumor progression. J Clin Invest. 2012. doi:10.1172/JCI63930. ... These enzymes are crucial to maintain ECM structure but also for the release of active molecules with various biological ...
Expanding roles for leukotrienes in airway inflammation | SpringerLink
Sandrini A, Ferreira IM, Gutierrez C, et al.: Effect of montelukast on exhaled nitric oxide and nonvolatile markers of ... Spinozzi F, Russano AM, Piattoni S, et al.: Biological effects of montelukast, a cysteinyl-leukotriene receptor-antagonist, on ... Ichiyama T, Kajimoto M, Hasegawa M, et al.: Cysteinyl leukotrienes enhance tumour necrosis factor-alpha-induced matrix ...
ALMS1 and Alström syndrome: a recessive form of metabolic, neurosensory and cardiac deficits | Journal of Molecular Medicine
This review focuses on the quest to understand AS at the molecular and cell biological levels. In addition to results from ... It was defined on the basis of similarity to mammalian orthologues of C10orf90/FATS (fragile site-associated tumour suppressor ... Ball-like staining of the ciliary axoneme marker acetylated tubulin was apparent in Alms1-depleted mouse inner medullary ... Because the markers used are not core structural components of cilia, it is formally possible that their trafficking to cilia ...
Mechanisms of chronic alcohol exposure-induced aggressiveness in cellular model of HCC and recovery after alcohol withdrawal |...
Cancer stem cell (CSC) markers have often been described as markers for tumour aggressiveness and their expression often ... ARLD is defined by a broad spectrum of clinical and biological liver states whose HCC remains one of the most critical ... CAE promoted expression of CSC markers in Huh-7 cells, inhibited by withdrawal. Expression of CSC markers CD133 (A and B), CD44 ... CD133 is a CSC marker correlated with poor prognosis in HCC patients, while CD24, another CSC marker, is associated with number ...
Multiplex proteomics for prediction of major cardiovascular events in type 2 diabetes | Diabetologia
We aimed to identify markers of future risk of MACE and to assess the assays performance against an established risk model in ... Carlsson AC, Ostgren CJ, Nystrom FH et al (2016) Association of soluble tumor necrosis factor receptors 1 and 2 with ... and a number of studies have demonstrated how proteomics can discover new biological insights [16,17,18]. ... Ligthart S, Sedaghat S, Ikram MA, Hofman A, Franco OH, Dehghan A (2014) EN-RAGE: a novel inflammatory marker for incident ...
Cellular stress response mechanisms of Rhizoma coptidis: a systematic review | Chinese Medicine
They can down regulate the expression of adipocyte marker proteins, including C/EBP-α and PPAR-γ. The inhibition ability is as ... Once Akt is activated, downstream signals (i.e. GSK3β, mTOR, Nrf2) will be stimulated to demonstrate multiple biological ... Effect of berberine on proinflammatory cytokine production by ARPE-19 cells following stimulation with tumor necrosis factor- ... downstream signals of AMPK will be stimulated to demonstrate multiple biological effects, including anti-obesity, anti-diabetes ...
Proceedings of the 4th Annual PROMIS® Health Organization Conference: Global Advances in Methodology and Clinical Science |...
Amongst data reports, capture rate and completion rate were the primary markers for success. ... were biological parents. The average child age was 9 years (SD=5). The same pattern emerged across different health domains, ... real-world evidence study of patients initiating treatment with a Tumor Necrosis Factor inhibitor (TNFi; Simponi Aria or ... mental and social health outcomes to complement exposure and biological biomarkers. This framework was the foundation for ...
Cure in metastatic breast cancer | memo - Magazine of European Medical Oncology
Early detection of metastatic disease in asymptomatic breast cancer patients with whole-body imaging and defined tumour marker ... Biological characteristics including molecular breast cancer subtypes, specific mutations or microRNA profiles [73] might ... Liquid biopsies nowadays allow detection of circulating tumor deoxyribonucleic acid (ctDNA); [67, 68]), circulating tumor cells ... tumor eradication by excellent systemic anticancer therapy, (3) long-term immunologic tumor control induced by immunotherapy or ...
Analysis of the quinoa genome reveals conservation and divergence of the flowering pathways | Functional & Integrative Genomics
6a), TRANSLATIONALLY CONTROLLED TUMOUR PROTEIN (TCTP) and CENTRORADIALIS (ATC). The two genes classified as other are AGAMOUS- ... genes are useful markers for tracking paternity in tetraploid Chenopodium quinoa Willd. Genet Resour Crop Evol 62:913-925. ... molecular analysis and elucidation of the role of the gibberellin pathway in quinoa flowering as well as other biological ...
Prospective evaluation of the conversion rate in the receptor status between primary breast cancer and metastasis: results from...
... they are still uncertain as to whether it is due to a biological change in the tumor or due to a methodological inconsistency. ... In 36 (26 %) tumors, the immunohistochemical subtype between the primary tumor and the metastatic lesion had changed. The most ... In 16 (10 %) tumors, the immunohistochemical subtype changed between the primary tumor and the metastasis. The most frequent ... Table 2 Conversion rates of receptor status between primary tumor and metastasis at local and central laboratories. Full size ...