In addition, xenograft tumor experiments showed that circIFT80 accelerated the tumorigenesis of CRC in vivo. In conclusion, our ... In this present study, we found that circIFT80 was abnormally overexpression in colorectal cancer tissues and tumor cells. ... is the third most common form of malignant tumor and is characterized by high rates of proliferation and metastases. Circular ... Furthermore, the clear heterogeneity of CRC tumors indicates a clear need for new biological markers and therapeutic targets ...

However, the poor sensitivity and specificity of those markers and many other molecules are serious limitations for their ... combined markers) provide probably more useful information as shown in some reports. Routine use of tumor markers is an ... Because biomarkers are a useful way to understand the biological diversity of melanoma, new biomarkers should be defined and ... With this technique, the identification of tumor-specific or tumor-associated genes leads to specific detection of tumor cells. ...

Evaluation of protein-protein interaction networks and biological processes revealed that CYP2J2 was principally involved in ... which may be related to the change of tumor immune microenvironment. Moreover, all these new understandings of CYP2J2 may ... Simultaneously, CYP2J2 network-related functions were evaluated using the GeneMANIA interactive tool while the biological ... and Tumor Immune Estimation Resource (TIMER) databases. The prognostic value of CYP2J2 for KIRC was analyzed using GEPIA, ...

... shown that ALDH1 is one of the markers of CSC that can be used as a prognosis indicator because it can be a biological marker ... About 20% of all breast cancers are triple-negative breast cancers (TNBCs). BCSC is a subset of tumor cells that has stem cell- ... like characteristics, such as a high capacity for self-renewal and tumor initiation, which implies that BCSC may cause ... Regarding tumor size, a significant result was found in T4 tumor size compared to T1-T2 tumor size (. ). The group with T4 size ...

Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF ,i,in vivo,/i, on tumor nerve invasion ... Further, exosomes were extracted from PC cells and identified by examining the levels of specific markers for exosomes. Then RT ... was applied to test miR-21-5p level in tumor derived exosomal (TDE-miR-21-5p). RIP assay was performed to validate NGF and miR- ... Although this more specific biological behavior is seen in biliary tract tumors, PC, parotid gland tumors, prostate cancer, and ...

We further proved that miR-381-3p-targeted ANTXR1 was able to counteract the suppression of miR-381-3p on biological functions ... In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. Additionally, we also ... L. G. Gutwein, S. Z. al-Quran, S. Fernando, B. S. Fletcher, E. M. Copeland, and S. R. Grobmyer, "Tumor endothelial marker 8 ... Yellow and blue represent tumor and normal tissue, respectively. (b) Level of miR-381-3p in glioma. , , and . ...

These beneficial biological properties have been extensively studied in humans and animal models, both ,i,in vitro,/i, and ,i, ... a very active enzyme involved in tumor progression. In addition, at 11 μM, it induces phenotypic nonproliferative markers, like ... This ability to interact with biological molecules provides resveratrol with multiple biological activities that are evident ... These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo. ...

... the usage of Pt NCs-based antitumour drugs as a new class chemotherapeutics for malignant tumour therapy, and the utilization ... of Pt NCs such as the bioimaging of various cells as a preferred fluorophore in contrast to traditional fluorescent markers (e. ... The analogue of Au and Ag NCs and platinum nanoclusters (Pt NCs), especially their biological applications, is relatively and ... and attempt in diverse biological applications that need to be urgently tackled in future. ...

Thus, it can change the formation and progression of tumors by acting on human immunity. ... Those marker genes utilized the analysis of the tumor-infiltrating immune cells involving B cells, T cells, monocytes, TAMs, M2 ... To understand the biological properties of DOK5 completely, we carried out GO and KEGG analyses. On the basis of the outcomes ... b) Human DOK5 expression levels in different tumor types from TCGA database were determined by TIMER (. , , and ). ...

The system has been used in various tissues and organs (in vitro or in vivo), including tumor tissues, kidney, cardiac, ... E. Wagner, "Programmed drug delivery: nanosystems for tumor targeting," Expert Opinion on Biological Therapy, vol. 7, no. 5, pp ... Similar PFC nanoparticles targeted to markers of angiogenesis had been successfully used to detect neovasculature around tumors ... G. ter Haar, "Biological effects of ultrasound in clinical applications," in Ultrasound: Its Chemical, Physical, and Biological ...

The K-M survival analysis indicated that ,i,SCARA5,/i, expression quantity was not related to prognosis, but tumor volume and T ... Experiments in the literature on liver cancer (LC) were repeated to verify the functions of these genes in different tumors. We ... The effects of these target genes on ESCC malignant biological behavior were performed ,i,in vivo,/i, and ,i,in vitro,/i,. The ... Proliferation and migration are important markers of malignancy, and SCARA5 can alter these properties [5, 19]. Our data ...

... and these might be potential biological markers and processes for treatment and etiology mechanism in ccRCC. ... if we control these signatures and the biological progress in the early stage of the tumor, there might be positive effects on ... and these genes and pathways might be potential biological markers and processes for treatment and etiology mechanism in ccRCC. ... expression of CCNA2 was found to be elevated in a variety of tumors such as breast, cervical, liver, and kidney tumors [32]. It ...

By evaluating the tumor microenvironment, we observed that the immune and metabolic microenvironments of the two groups were ... Several bioinformatic approaches were used to analyze the biological functions of DEPRGs and to identify prognostic DERPGs. A ... The expression of immunological checkpoints is a crucial marker utilized in tumor immunotherapy. As a result, we investigated ... G. Yu, L. G. Wang, Y. Han, and Q. Y. He, "clusterProfiler: an R package for comparing biological themes among gene clusters," ...

Moreover, the expression level of hsa_circ_001242 was negatively correlated with tumor size and T stage (,span class=inline_ ... As presented in Table 1, hsa_circ_001242 expression levels were negatively related to tumor size (. ) and T stage (. ) but were ... Disease Markers. Journal overview. For authorsFor reviewersFor editorsTable of Contents. Special Issues. ... To further understand the biological role of circRNAs in OSCC, both in vitro and in vivo assays should be performed in the ...

... and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. Clinicopathological parameter correlation and ... The fraction of Ki67 positive cells is often correlated with the clinical course of the tumors. Currently, this marker of ... Table S5. Enrichment analysis of miRNA-34a targets on numerous biological process. Table S6. Enrichment analysis of miRNA-34a ... tumor size (. , ), LN invasion (. , ), and capsular infiltration (. , ). TGFB1 protein showed moderate correlation with ...

M. A. Khan, H.-c. Chen, D. Zhang, and J. Fu, "Twist: a molecular target in cancer therapeutics," Tumor Biology, vol. 34, no. 5 ... b) The protein level EMT-related marker in si NC and siSNHG3 groups. (c) and (d) Effect of lncRNA SNHG3 knockdown on cell ... Our current goal is to investigate the biological function of miR-326 in GC and explore its potential mechanism. ... b) The protein level expression of expression EMT-related marker in miR-326 mimic or mimic NC groups. (c) and (d) Effect of miR ...

Both mice model with xenograft prostate tumor model and canine model were used. The best PSP was selected to construct a ... J. E. Oesterling, "Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the ... Androgen regulation of two closely related abundant mRNAs," The Journal of Biological Chemistry, vol. 258, no. 17, pp. 10731- ... The tumors were harvested in 72 hr and processed to whole-mount tumor X-gal staining. Shown is X-gal staining of tumors ...

Furthermore, new approaches involving GAGs/PGs as potential prognostic/diagnostic markers or as therapeutic agents for cancer- ... Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution ... are markedly altered during tumor pathogenesis and progression. GAGs and PGs perform multiple functions in specific stages of ... consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor ...

In conclusion, CD44v6 and ALDH1A1 are candidate stem cell markers for NPC, and the increased formation of DNA lesions by ... inflammation may result in the mutation of stem cells, leading to tumor development in NPC. ... we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, and ALDH1A1) ... Sino Biological, Beijing, China) were then added at a final concentration of 200 ng/mL and incubated for 25 min at 4°C in the ...

UBM is useful to investigate the growth and differentiation of tumors as well as to detect early molecular expression of cancer ... Target contrast ultrasound combines ultrasound with novel molecular targeted contrast agent to assess biological processes at ... it can be used to quantify blood flow and to image microcirculation as well as the response of tumor blood supply to cancer ... Since the microbubbles remain within the vasculature, because of their size in the micron range, specific marker molecules have ...

Recently, bioinformatics research revealed that m6A-related genes including METTL3 and YTHDF1 were biological markers and ... a, b) The heatmaps for the expression levels of m6A RNA methylation regulators in HCC tumor and normal tissues in TCGA (a) and ... Disease Markers. Journal overview. For authorsFor reviewersFor editorsTable of Contents. Special Issues. ... c, d) The quantitative analyses for the expression levels of m6A RNA methylation regulators in HCC tumor and normal tissues in ...

Together, this data sheds new light about NFE2L family factors in pigment tumors and suggests that these factors are worth for ... the dysregulated NRF1 might be a mere surrogate marker for more robust biological processes behind the pigment cell malignancy ... they can be exploited as tumor-progressing factors in the malignant phase, as suggested earlier in other tumor types [51]. ... L. Wang, C. Zhang, L. Qin et al., "The prognostic value of NRF2 in solid tumor patients: a meta-analysis," Oncotarget, vol. 9, ...

Sleep restriction can elevate inflammatory markers, including interleukin-6 (IL-6), tumor necrosis factor (TNF), and C-reactive ... Current studies believe that psychological, social, cultural, and biological factors will affect the pain perception of ... combination on oxidative stress markers in healthy subjects," Irish Journal of Medical Science, vol. 180, no. 3, pp. 703-707, ...

Consideration of tumor heterogeneity is therefore important in the critical analysis of gene associations in cancer. ... Based on the heterogeneity within a specific tumor type, a combination of genomic alterations defines the cancer subtype, ... Initiation and propagation of tumors reflect underlying genomic alterations such as mutations, polymorphisms, and copy number ... A. R. Venkitaraman, "Functions of BRCA1 and BRCA2 in the biological response to DNA damage," Journal of Cell Science, vol. 114 ...

Rh4 significantly upregulated autophagy and ferroptosis marker expression in CRC cells and xenograft tumor tissues in the ... The CRC xenograft model showed that Rh4 inhibited xenograft tumor growth with few side effects (,span class=inline_break,,svg ... Differential expression analysis of two groups (three biological replicates per group) was performed using the DESeq2 R package ... j), (k) Relative expression levels of ferroptosis-related proteins in HT29 and HCT116 cell xenograft tumor tissues. , : ...

RSV also inhibited expression of interleukin- (IL-) 1,i,β,/i,, IL-6, tumor necrosis factor-,i,α,/i,, and IL-18 ,i ... inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF-,i,κ,/i,B, hence alleviating infarction area ... RSV inhibited the expression of senescence markers (p53, p16, and p19), ... Thus, RSV might be a potential drug for treatment or auxiliary therapy for IHD as a result of its multiple biological functions ...

... tumour mutational burden (TMB), microsatellite instability (MSI), and immunological features based on public databases and find ... Studies have shown that a high expression of neuropilins (NRPs) promotes tumourigenesis and tumour malignancy. ,i,Method,/i,. A ... Our findings reveal that NRPs may be a potential prognostic marker associated with immune infiltration, tumour mutations, and ... These genes are involved various biological processes such as neuroangiogenesis, cell migration, and immune regulation [36, 37 ...

... the biological processes related to the purity of lung cancer tumors remains unclear. ,i,Methods,/i,. We measured tumor purity ... These nontumor cells dilute the tumor purity in lung cancer tissues. Tumor purity plays an essential role in the immune ... i,Purpose,/i,. Lung cancer tissue includes tumor tissue, stromal cells, immune cells, and epithelial cells. ... M.-Y. Huang, H.-M. Wang, T.-S. Tok et al., "EVI2B, ATP2A2, S100B, TM4SF3, and OLFM4 as potential prognostic markers for ...

... and LAYN expression was found significantly correlated with tumor immune cell infiltration in LIHC tissues. In general, our ... We further explored the LAYN crosstalk with diverse tumor-infiltrating immune cell markers, including markers of B cells, CD4+ ... To further investigate the biological functions of LAYN in LIHC, we next explored the coexpressed genes of LAYN in the LIHC ... As shown in Figure 7(a), LAYN expression is significantly correlated with tumor purity (. , ) and the infiltration of six types ...

In addition, as a marker of IDD, the involvement of the above-mentioned axis in the pathological development of IDD remains to ... After multimodel screening and verification, key gene marker was found, namely, ATF2. The lncRNA/miRNA/mRNA axis closely ... and the key gene markers were verified by GSE34095 and GSE126883. Finally, the infiltration of immune cells in the data were ... Therefore, the search for early biological markers of IDD can not only better maintain the biological function of the patients ...