TGF-Beta1 derived peptides mimicking the activity of transforming growth factor-Beta1 - Patent EP-0877031-A1 - PubChemTGF-Beta1 derived peptides mimicking the activity of transforming growth factor-Beta1 - Patent EP-0877031-A1 - PubChem
EP-0877031-A1 chemical patent summary.
https://pubchem.ncbi.nlm.nih.gov/patent/EP-0877031-A1
The results of vitreous surgery for chronic macular holesThe results of vitreous surgery for chronic macular holes
... bovine transforming growth factor beta-2, recombinant transforming growth factor beta-2, or autologous platelet extract). Of 51 ...
https://pubmed.ncbi.nlm.nih.gov/9428011/?dopt=Abstract
TGFbeta2 in corneal morphogenesis during mouse embryonic developmentTGFbeta2 in corneal morphogenesis during mouse embryonic development
Transforming Growth Factor beta / genetics * Transforming Growth Factor beta / physiology* Substances * Cadherins ...
https://pubmed.ncbi.nlm.nih.gov/11784073/
TGFbeta pathobiology in the eyeTGFbeta pathobiology in the eye
... a multifunctional growth factor, is one of the most important ligands involved in the regulation of cell behavior in ocular ... although various other growth factors are also in … ... Transforming growth factor beta (TGFbeta), a multifunctional ... although various other growth factors are also involved. Increased activity of this ligand may induce unfavorable inflammatory ... growth factor, is one of the most important ligands involved in the regulation of cell behavior in ocular tissues in ...
https://pubmed.ncbi.nlm.nih.gov/16341020/
Phorbol ester-induced activation of a membrane-bound candidate pro-transforming growth factor-alpha processing enzymePhorbol ester-induced activation of a membrane-bound candidate pro-transforming growth factor-alpha processing enzyme
Transforming growth factor-alpha (TGF-alpha) is synthesized and transported to the cell surface as a membrane-anchored ... Transforming growth factor-alpha (TGF-alpha) is synthesized and transported to the cell surface as a membrane-anchored ... Phorbol ester-induced activation of a membrane-bound candidate pro-transforming growth factor-alpha processing enzyme J Biol ...
https://pubmed.ncbi.nlm.nih.gov/8051125/
Scar wars: implications of fetal wound healing for the pediatric burn patientScar wars: implications of fetal wound healing for the pediatric burn patient
Platelet-Derived Growth Factor * Transforming Growth Factor beta * Fibroblast Growth Factor 2 ...
https://pubmed.ncbi.nlm.nih.gov/9238112/?dopt=Abstract
Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapyCholine kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy
Transforming Growth Factor beta / antagonists & inhibitors * Transforming Growth Factor beta / metabolism Substances * Enzyme ... In addition, this novel oncogene has been recently defined as a prognostic factor in human cancer, and as a promising target ...
https://pubmed.ncbi.nlm.nih.gov/18296102/?dopt=Abstract
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
... and miR-205 were markedly downregulated in cells that had undergone EMT in response to transforming growth factor (TGF)-beta or ... factors previously implicated in EMT and tumour metastasis. Inhibition of the microRNAs was sufficient to induce EMT in a ...
https://pubmed.ncbi.nlm.nih.gov/18376396/?dopt=Abstract
Specificity and versatility in tgf-beta signaling through SmadsSpecificity and versatility in tgf-beta signaling through Smads
The TGF-beta family comprises many structurally related differentiation factors that act through a heteromeric receptor complex ... Receptors, Transforming Growth Factor beta * Smad Proteins * Transforming Growth Factor beta * Bone Morphogenetic Protein ... The TGF-beta family comprises many structurally related differentiation factors that act through a heteromeric receptor complex ... where they cooperate with sequence-specific transcription factors to regulate gene expression. The vertebrate genome encodes ...
https://pubmed.ncbi.nlm.nih.gov/16212511/
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptorMetalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor
Ligands that activate the epidermal growth factor receptor (EGFR) are synthesized as membrane-anchored precursors that appear ... These cells express both transforming growth factor alpha and amphiregulin and require autocrine signaling through the EGFR for ... Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor Proc Natl ... that metalloprotease inhibitors reduced cell proliferation in direct proportion to their effect on transforming growth factor ...
https://pubmed.ncbi.nlm.nih.gov/10339571/
Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronismLack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism
0.76 + or - 0.04; P , 0.001), transforming growth factor-beta (0.99 + or - 0.06 vs. 0.84 + or - 0.04; P , 0.05), collagen type ...
https://pubmed.ncbi.nlm.nih.gov/19749160/?dopt=Abstract
Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formationTransforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation
Fibroblast growth factors, in concert with other growth factors, are key regulators of lens fiber cell differentiation. While ... The vertebrate lens has a distinct polarity and structure that are regulated by growth factors resident in the ocular media. ... Recent studies implicate other factors [such as fibroblast growth factor (FGFs), hepatocyte growth factor, integrins], present ... Fibroblast growth factors, in concert with other growth factors, are key regulators of lens fiber cell differentiation. While ...
https://pubmed.ncbi.nlm.nih.gov/15942192/
Mesenchyme-specific deletion of Tgf-β1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasiaMesenchyme-specific deletion of Tgf-β1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia
Proper lung development depends on the precise temporal and spatial expression of several morphogenic factors, including Fgf10 ... Transforming Growth Factor beta1* / genetics * Transforming Growth Factor beta1* / metabolism Substances * Tgfb1 protein, mouse ... Proper lung development depends on the precise temporal and spatial expression of several morphogenic factors, including Fgf10 ...
https://pubmed.ncbi.nlm.nih.gov/31028279/
A screen for secreted factors of the suprachiasmatic nucleusA screen for secreted factors of the suprachiasmatic nucleus
... drives daily locomotor activity rhythms presumably by secreting diffusible factors whose target sites are accessible from the ... Using this approach combined with further experiments, we identified transforming growth factor-alpha (TGF-alpha) as a likely ... A screen for secreted factors of the suprachiasmatic nucleus Methods Enzymol. 2005;393:645-63. doi: 10.1016/S0076-6879(05)93034 ... To find SCN-secreted factors not previously documented, a hamster SCN cDNA library was screened in a yeast signal sequence trap ...
https://pubmed.ncbi.nlm.nih.gov/15817317/?dopt=Abstract
CD38 expression and functional activities are up-regulated by IFN-gamma on human monocytes and monocytic cell linesCD38 expression and functional activities are up-regulated by IFN-gamma on human monocytes and monocytic cell lines
Transforming Growth Factor beta / pharmacology * Tumor Necrosis Factor-alpha / pharmacology * U937 Cells / drug effects ...
https://pubmed.ncbi.nlm.nih.gov/11310847/
CFTR dysfunction increases endoglin and TGF-β signaling in airway epitheliaCFTR dysfunction increases endoglin and TGF-β signaling in airway epithelia
... regulates signaling by transforming growth factor-β (TGF-β), a genetic modifier of cystic fibrosis (CF) lung disease severity. ... Endoglin (ENG) regulates signaling by transforming growth factor-β (TGF-β), a genetic modifier of cystic fibrosis (CF) lung ...
https://pubmed.ncbi.nlm.nih.gov/30806029/
Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulationTransforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation
Transforming growth factor (TGF)-beta represents a prototype of multifunctional cytokine. Its broad activities include, among ... Transforming growth factor-beta (TGF-beta) plays a critical role in the regulation of extracellular matrix gene expression. Its ... Transforming growth factor (TGF)-beta represents a prototype of multifunctional cytokine. Its broad activities include, among ... TGF-beta receptor kinase substrates that translocate into the cell nucleus to act as transcription factors, has increased our ...
https://pubmed.ncbi.nlm.nih.gov/11841535/
Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathyCytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
... with decreased levels of transforming growth factor beta1 and inadequately raised interleukin-10 in relation to the elevated ... Patients with CHF had increased plasma concentrations of tumor necrosis factor (TNF)alpha, interleukin-6, soluble TNF receptors ... and in the present study several of these interacting factors were examined simultaneously in 38 CHF patients with various ...
https://pubmed.ncbi.nlm.nih.gov/10072227/?dopt=Abstract
Regulation of human Gc (vitamin D--binding) protein levels: hormonal and cytokine control of gene expression in vitroRegulation of human Gc (vitamin D--binding) protein levels: hormonal and cytokine control of gene expression in vitro
Interleukin-6 (IL-6) and dexamethasone were shown to increase Gc mRNA approximately twofold while transforming growth factor ... Transforming Growth Factor beta / pharmacology* * Tumor Necrosis Factor-alpha / pharmacology* * Vitamin D-Binding Protein / ...
https://pubmed.ncbi.nlm.nih.gov/7539397/?dopt=Abstract
Expression of profibrotic mediators in small airways versus parenchyma after cigarette smoke exposureExpression of profibrotic mediators in small airways versus parenchyma after cigarette smoke exposure
Transforming Growth Factor beta1 / genetics * Transforming Growth Factor beta1 / metabolism Substances * Smoke ... Gene expression of 13 fibrogenic growth/signaling factors (particularly TGF-beta-related genes), matrix proteins, or enzymes ...
https://pubmed.ncbi.nlm.nih.gov/18723441/?dopt=Abstract
The TGF-beta-pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzaeThe TGF-beta-pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae
... the influence of acute and persistent infection on tissue remodelling and repair factors such as transforming growth factor ( ... CXC chemokine ligand (CXCL)-8, tumor necrosis factor (TNF)-alpha and TGF-beta expression were evaluated in lung tissue and cell ...
https://pubmed.ncbi.nlm.nih.gov/20513241/?dopt=Abstract
Corneal dystrophies in JapanCorneal dystrophies in Japan
Transforming Growth Factor beta / genetics* Substances * Extracellular Matrix Proteins * Neoplasm Proteins * Transforming ...
https://pubmed.ncbi.nlm.nih.gov/11501939/
p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblastsp38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts
Transforming Growth Factor beta / pharmacology* * Up-Regulation * p38 Mitogen-Activated Protein Kinases / antagonists & ...
https://pubmed.ncbi.nlm.nih.gov/16565385/
Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiationThy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation
Transforming Growth Factor beta1 Grants and funding * P01 HL119165/HL/NHLBI NIH HHS/United States ...
https://pubmed.ncbi.nlm.nih.gov/29273797/
CircRNA 33702 Promotes Renal Fibrosis by Targeting the miR-29b-3p/WNT1-Inducible Signaling Pathway Protein 1 PathwayCircRNA 33702 Promotes Renal Fibrosis by Targeting the miR-29b-3p/WNT1-Inducible Signaling Pathway Protein 1 Pathway
Transforming Growth Factor beta1 / metabolism Substances * RNA, Circular * MicroRNAs * Transforming Growth Factor beta1 ...
https://pubmed.ncbi.nlm.nih.gov/36153002/?utm_source=Other&utm_medium=rss&utm_content=16uwQpOeqFYN8R4TKOtwPy2utpqy9ex2oldalD2yF_fQHv2caq&ff=20230128211544&v=2.17.9.post6+86293ac
Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3
Transforming Growth Factor beta * Ovalbumin Grants and funding * HL-60995/HL/NHLBI NIH HHS/United States ...
https://pubmed.ncbi.nlm.nih.gov/15232609/?dopt=Abstract
Caveolin-1 deficiency may predispose African Americans to systemic sclerosis-related interstitial lung diseaseCaveolin-1 deficiency may predispose African Americans to systemic sclerosis-related interstitial lung disease
The monocytes of African Americans may lack caveolin-1 due to high levels of transforming growth factor β in th … ... The monocytes of African Americans may lack caveolin-1 due to high levels of transforming growth factor β in their blood. ... Methods: Assays of monocyte migration toward stromal cell-derived factor 1 (SDF-1) were performed using monocytes from ... little is known about factors underlying this significant health disparity. The aim of this study was to examine the role that ...
https://pubmed.ncbi.nlm.nih.gov/24578173/?dopt=Abstract
The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exerciseThe serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise
Namely Platelet Derived Growth Factor (PDGF), Transforming Growth Factor-bet … ... Activated by inflammatory process cells may serve as the source of wide spectrum of inflammatory mediators and growth factors. ... Namely Platelet Derived Growth Factor (PDGF), Transforming Growth Factor-beta (TGF-beta) and Vascular Endothelial Growth Factor ... The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise J Physiol Pharmacol ...
https://pubmed.ncbi.nlm.nih.gov/16845225/
Growth factors and collagen distribution in vernal keratoconjunctivitisGrowth factors and collagen distribution in vernal keratoconjunctivitis
Expression of growth factors in the conjunctiva by resident cells (mast cells, epithelial cells, endothelial cells) and ... transforming growth factor (TGF)-ss1; basic fibroblast growth factor (bFGF); and platelet-derived growth factor (PDGF). The ... Growth factors and collagen distribution in vernal keratoconjunctivitis Invest Ophthalmol Vis Sci. 2000 Dec;41(13):4175-81. ... Expression of growth factors in the conjunctiva by resident cells (mast cells, epithelial cells, endothelial cells) and ...
https://pubmed.ncbi.nlm.nih.gov/11095612/
GCNT2 glucosaminyl (N-acetyl) transferase 2 (I blood group) [Homo sapiens (human)] - Gene - NCBIGCNT2 glucosaminyl (N-acetyl) transferase 2 (I blood group) [Homo sapiens (human)] - Gene - NCBI
involved_in transforming growth factor beta receptor signaling pathway IBA Inferred from Biological aspect of Ancestor. more ... involved_in transforming growth factor beta receptor signaling pathway IMP Inferred from Mutant Phenotype. more info ...
https://www.ncbi.nlm.nih.gov/gene/2651