The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability - ScienceOpen
Here, we show that Rev7 binds to the transcription factor TFII-I in human cells. TFII-I is required for TLS and DNA damage ... The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability. Authors: Farjana J. Fattah 1 , 2 , ... we have discovered the transcription factor TFII-I as a new Pol ζ-binding protein in human cells. We show that TFII-I is indeed ... The TLS function of TFII-I appears to be independent of its role in transcription, but requires homodimerization and binding to ...https://www.scienceopen.com/document?vid=20c49889-6893-4d47-96fa-4314165223c5
The adenovirus E4-ORF3 protein stimulates SUMOylation of general transcription factor TFII-I to direct proteasomal degradation ...
Among the proteins most abundantly modified in an E4-ORF3-dependent manner was the general transcription factor II-I (TFII-I). ... The adenovirus E4-ORF3 protein stimulates SUMOylation of general transcription factor TFII-I to direct proteasomal degradation ... 2016) The adenovirus E4-ORF3 protein stimulates SUMOylation of general transcription factor TFII-I to direct proteasomal ... mechanism of TFII-I regulation by Ad and highlight how a viral protein can modulate a critical cellular transcription factor ...http://wrap.warwick.ac.uk/76688/
XRCC5 VNTR, XRCC6 -61C|G, and XRCC7 6721G|T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case...
TFII-I = transcription factor II-I; STAT4 = signal transducer and activator of transcription 4; c-Ets-1 = c-E-twenty-six-1; E2F ... E2F transcription factor 1; GR-beta = glucocorticoid receptor-beta; GCF = GC factor; NF-kappaB = nuclear factor-kappaB; RelA = ... Figure 4: Potential binding sites for transcription factors of 1R, 2R, and 3R tandem repeat elements of the XRCC5 VNTR: XBP-1 ... K. S. El-Darwish, M. Parvinen, and J. Toppari, "Differential expression of members of the E2F family of transcription factors ...https://www.hindawi.com/journals/ije/2017/4795076/
"Characterization of a novel interaction between transcription factor T" by Catarina Sacristan, Stefan A. Schattgen et al.
... previously shown to bind and phosphorylate the transcription factor TFII-I. TFII-I plays major roles in transcription and ... We show that Itk physically interacts with TFII-I and potentiates TFII-I-driven c-fos transcription. We demonstrate that TFII-I ... previously shown to bind and phosphorylate the transcription factor TFII-I. TFII-I plays major roles in transcription and ... We show that Itk physically interacts with TFII-I and potentiates TFII-I-driven c-fos transcription. We demonstrate that TFII-I ...https://escholarship.umassmed.edu/gsbs_sp/1629/
5′-UTR extension at non-tDNA/non-ETC Pol III associat | Open-i
... we used RNA sequencing to compare transcriptomes of wild type versus Pol III transcription factor TFIIIC depleted mutants. The ... we used RNA sequencing to compare transcriptomes of wild type versus Pol III transcription factor TFIIIC depleted mutants. The ... Bottom Line: Previous coding sequence microarray studies using Pol III factor mutants to determine global effects of Pol III ... Bottom Line: Previous coding sequence microarray studies using Pol III factor mutants to determine global effects of Pol III ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4228148_12915_2014_89_Fig6_HTML&req=4
Histone deacetylase 2 - Wikipedia
"Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". J. Biol. Chem. 278 (3): 1841-7. ... Sp1 transcription factor, Sp3 transcription factor, TOP2B, and YY1. Histone deacetylase GRCh38: Ensembl release 89: ... Yao YL, Yang WM, Seto E. "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell. Biol. 21 (17): ... "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". ...https://en.wikipedia.org/wiki/Histone_deacetylase_2
HDAC3 - Wikipedia
"Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". J. Biol. Chem. 278 (3): 1841-7. ... Yao YL, Yang WM, Seto E (September 2001). "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell ... "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood. 98 (7): 2116-23. doi:10.1182/blood ... suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression". J. Immunol. 173 (6 ...https://en.wikipedia.org/wiki/HDAC3
This Week in Science | Science
... including the transcription factor TFII-I. Caraveo et al. (p. 122; see the Perspective by Park and Dolmetsch) found that TFII-I ... The interaction of TFII-I with PLC-γ appears to depend on TFII-I's phosphorylation, which may keep PLC-γ from interacting with ... in the brain-derived neurotrophic factor (BDNF) gene may be related to mood and anxiety disorders common in human populations. ...http://science.sciencemag.org/content/314/5796/twis
Dr. Patrick Desgranges, Internal Medicine, Seattle, WA
Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. ...https://www.healthtap.com/experts/11209949-dr-patrick-desgranges
Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity | proLékaře.cz
The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability * An Operon of Three Transcriptional ... Článek The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability ... The POU Factor Ventral Veins Lacking/Drifter Directs the Timing of Metamorphosis through Ecdysteroid and Juvenile Hormone ... Článek The POU Factor Ventral Veins Lacking/Drifter Directs the Timing of Metamorphosis through Ecdysteroid and Juvenile ...https://www.prolekare.cz/casopisy/plos-genetics/2014-6/loss-of-ucp2-attenuates-mitochondrial-dysfunction-without-altering-ros-production-and-uncoupling-activity-55182
Frontiers | The Genetics of Reading Disabilities: From Phenotypes to Candidate Genes | Psychology
The transcription factors TFII-I, poly (ADP-ribose) polymerase 1 (PARP1), and splicing factor proline/glutamine-rich (SFPQ) ... and to be recognition sites for transcription factors TFII-I and Sp1: TFII-1 toboth alleles of rs3743205 and Sp1 to rs16787 (− ... Recent studies in a human neuroblastoma cell line found that estrogen receptor beta and the transcription factor TFII-I are ... Transcription factor: a gene product that regulates the function of another gene. ...https://www.frontiersin.org/articles/10.3389/fpsyg.2012.00601/full
Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.
Transcription Elongation, Genetic. Transcription Factors, TFIII. Research team. Paediatric Solid Tumour Biology and ...https://repository.icr.ac.uk/handle/internal/1323
Craniofacial Development Protein 1 (CFDP1) ELISA Kits
... the chromatin immunoprecipitation analysis showed that TFII-I transcription factors are recruited to these sites in vivo in ... Cfdp1 contains consensus TFII-I binding sites in the proximal promoters; ... provide a basis for our understanding of the specific regulation of the cp27 gene in the NF-Y-mediated gene transcription ...https://www.antibodies-online.com/abstract/Craniofacial+Development+Protein+1+
Stargardt Phenotype Associated With Two ELOVL4 Promoter Variants and ELOVL4 Downregulation: New Possible Perspective to...
Role for transcription factor TFII-I in the suppression of SSeCKS/Gravin/Akap12 transcription by Src. Int J Cancer. 2011; 128: ... Co-operative interactions between NFAT (nuclear factor of activated t cells) c1 and the zinc finger transcription factors Sp1/ ... An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. Cell Rep. 2013 ... Despite this, it is not possible to exclude that the whole transcription factors set in glioblastoma cells could be quite ...https://iovs.arvojournals.org/article.aspx?articleid=2672672
RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the...
Wen YD, Cress WD, Roy AL, Seto E. Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I ... Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor. FEBS J. 2007;274( ... As a transcriptional factor, GTF2I-RARA fusion selectively binds to RNF8 and upregulates the expression of RNF8. RNF8 interacts ... 3b). The number of genes proximal to the GTF2I-RARA binding sites [within 5 kb upstream from the transcription start site (TSS ...https://rd.springer.com/article/10.1186%2Fs12935-019-0803-4
Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16,...
Ginsberg A, King BO, Roeder RG (1984) Xenopus 5 S gene transcription factor, TF III A: characterization of a cDNA clone and ... Miller J, McLachlan AD, Klug A (1985) Repetitive zinc binding domains in the protein transcription factor III A from Xenopus ... Structural homology of the product of the Drosophila Krüppel gene with Xenopus transcription factor III A. Nature 319:336-339 ...https://link.springer.com/article/10.1007%2FBF00420943
Anti-Müllerian hormone in disorders of sex determination and differentiation
... by transcription factor TFII-I (11). Cloning of 3.6kb of the 5'-flanking sequences of the human AMH gene allowed to identify a ... Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the ... Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian ... a cAMP-PKA mediated signalling pathway involving transcription factors AP2 and NFB, which bind to specific response elements in ...http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302005000100005&lng=en&nrm=iso&tlng=en
Instituto de Biotecnologia UNAM
Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells ... CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes ... toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor- ...http://www.ibt.unam.mx/server/PRG.base?tipo:doc,dir:PRG.curriculum,par:yvonne
Math argot « Why Evolution Is True
Here, we demonstrate a direct interaction of OCA-B with transcription factor TFII-I, which binds to DICE elements in Igh ... Come on! Enhancers and silencers do exactly what they say to promoters which initiate or promote transcription. Transcription ... First, OCA-B relieves HDAC3-mediated Igh promoter repression by competing with HDAC3 for binding to promoter-bound TFII-I. ... that are important for Igh transcription. These and other results reveal an important function for OCA-B in Igh 3′ enhancer ...https://whyevolutionistrue.wordpress.com/2011/05/19/math-argot/
TFII-I Regulates Vβ Promoter Activity through an Initiator Element | Molecular and Cellular Biology
Here we show by transient-transfection assays that the Inr binding transcription factor TFII-I is required for efficient ... Positions of GST-TFII-I (p146) and native TFII-I (p120) are indicated. (C) EMSA with Vβ Inr to demonstrate that the GST-TFII-I ... 2C). GST-TFII-I (146 kDa) was used as the wild-type TFII-I for all transfection experiments. Cotransfection of TFII-I with the ... which were expected to contain all of the factors necessary for Inr function, TFII-I is required for transcription of the Vβ ...https://mcb.asm.org/content/18/8/4444
1b55 - Proteopedia, life in 3D
Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol Cell Biol. ... BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor ... BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating ...http://proteopedia.org/wiki/index.php/1b55
Jaya Rajaiya | Harvard Catalyst Profiles | Harvard Catalyst
Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol Cell Biol. ... The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. Cell Immunol. 2004 Mar; 228(1):42- ... Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with ... Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright. Mol ...https://connects.catalyst.harvard.edu/Profiles/display/Person/15137
Protocols and Video Articles Authored by Solomon H. Snyder
TFII-I is a transcription factor and a target of phosphorylation by Bruton's tyrosine kinase. In humans, deletions spanning the ... Serum response factor (SRF) is a major transcription factor for a wide range of immediate early genes. We report that IPMK, in ... Jan, 2012 , Pubmed ID: 22244329 Nuclear factor κB (NF-κB) is an antiapoptotic transcription factor. We show that the ... associated transcription elicited by brain-derived neurotrophic factor (BDNF) and nerve-growth factor (NGF). Roles for histone ...https://www.jove.com/author/Solomon+H._Snyder
Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation | JEM
... transcription factor II-I (TFII-I [BAP-135]), protein kinase C (PKC) isoforms, Wiskott-Aldrich syndrome protein (WASP), Ewing's ... We examined the ability of BTK to regulate the nuclear factor (NF)-κB/Rel family of transcription factors, as the activation of ... nuclear factor and activator of transcription (NF-AT), and signal tranducers and activators of transcription (STATs), ... Reduced DNA Binding and Nuclear Translocation of NF-κB/Rel Transcription Factors in IgM- but not CD40-stimulated XID B Cells.. ...http://jem.rupress.org/content/191/10/1735
Recombinant Human GTF2IRD2 protein (ab164511) | Abcam
... that share homology with the TFII-I family of transcription factors. The C-terminal half of GTF2IRD2A contains a CHARLIE8 ... general transcription factor II i repeat domain 2 alpha. *general transcription factor II I repeat domain-containing protein 2A ... It is inferred to be a transcription factor based on the presence of GTF2I-like repeats (containing helix-loop-helix motifs), ...http://www.abcam.com/recombinant-human-gtf2ird2-protein-ab164511.html