"Characterization of a novel interaction between transcription factor T" by Catarina Sacristan, Stefan A. Schattgen et al.
... previously shown to bind and phosphorylate the transcription factor TFII-I. TFII-I plays major roles in transcription and ... We show that Itk physically interacts with TFII-I and potentiates TFII-I-driven c-fos transcription. We demonstrate that TFII-I ... Structural analysis of TFII-I-Itk interactions revealed that the first 90 residues of TFII-I are dispensable for Itk binding. ... to uncover the existence of Itk-TFII-I signaling in T lymphocytes. We report for the first time that TFII-I is tyrosine ...https://escholarship.umassmed.edu/gsbs_sp/1629/
The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability - ScienceOpen
Here, we show that Rev7 binds to the transcription factor TFII-I in human cells. TFII-I is required for TLS and DNA damage ... we have discovered the transcription factor TFII-I as a new Pol ζ-binding protein in human cells. We show that TFII-I is indeed ... The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability. ... The TLS function of TFII-I appears to be independent of its role in transcription, but requires homodimerization and binding to ...https://www.scienceopen.com/document?vid=20c49889-6893-4d47-96fa-4314165223c5
Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2...
NKX2.1, OLIG2 and COUP-TFII expression occupied distinct (although overlapping) neurogenic domains which extended into the ... Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 ... We examined expression of three interneuron precursor transcription factors, alongside other markers, using ... in both cases COUP-TFII was co-expressed with PAX6 in proliferative zones and TBR1 or calretinin in post-mitotic cortical ...https://eprint.ncl.ac.uk/pub_details2.aspx?pub_id=230328
Human Developmental Biology Resource (HDBR) » The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in...
The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ...http://hdbr.org/news/articles/74/the-transcription-factors-coup-tfi-and-coup-tfii-have-distinct-roles-in-arealisation-and-gabaergic-interneuron-specification-in-the-early-human-fetal-telencephalon
RNA Structure And Synthesis Flashcards by Prachi Patel | Brainscape
TFII- transcription factors for Pol II TBP- TATA binding protein. TAF- TATA associated factors Protein-protein interactions are ... Transcription bubble always 12 bases As the enzyme moves to the region in front, creates + super coils and the region behind it ... Has no sigma factor to locate promoter region but interacts with specific proteins which bind core promoter regulatory elements ... Enhancer- regulates efficiency of transcription Constitutive- will be specific to the tissue its in Basal- where it starts TATA ...https://www.brainscape.com/flashcards/rna-structure-and-synthesis-5331674/packs/7951019
XRCC5 VNTR, XRCC6 -61C|G, and XRCC7 6721G|T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case...
TFII-I = transcription factor II-I; STAT4 = signal transducer and activator of transcription 4; c-Ets-1 = c-E-twenty-six-1; E2F ... E2F transcription factor 1; GR-beta = glucocorticoid receptor-beta; GCF = GC factor; NF-kappaB = nuclear factor-kappaB; RelA = ... Figure 4: Potential binding sites for transcription factors of 1R, 2R, and 3R tandem repeat elements of the XRCC5 VNTR: XBP-1 ... K. S. El-Darwish, M. Parvinen, and J. Toppari, "Differential expression of members of the E2F family of transcription factors ...https://www.hindawi.com/journals/ije/2017/4795076/
Lymph Node Metastasis Is Associated with Allelic Loss on Chromosome 13q12-13 in Esophageal Squamous Cell Carcinoma1 | Cancer...
... reverse transcription-PCR; pRB, retinoblastoma protein; TFII H, transcription factor II H. ... Lymph node metastasis was shown to be one of the most important prognostic factors in ESC (1 , 35) . Shibagaki et al. (11) have ... A large deletion disrupts the exon 3 transcription activation domain of the BRCA2 gene in a breast/ovarian cancer family. ... Amplification of epidermal growth factor receptor gene but no evidence of ras mutation in primary human esophageal cancers. ...http://cancerres.aacrjournals.org/content/59/15/3724.full
Nuclear receptors as target of new drug therapy
Chicken ovalbumin upstream promoter-transcription factor II ( COUP-TFII ; NR2F2 ) ,/li,,/ul,,/ul,,ul,,ul,,li,6: V-erbA-related ... Conclusion: ,ul,,li,Functioning as transcription factors and controlling cellular process at the level of gene expression. ,/li ... Gene transcription cartoon showing interactions of ligand/PPAR/RXR heterodimer with cofactors and basal transcription machinery ... Germ Cell Nuclear Factor-like ,/li,,/ul,,ul,,li,Group A: GCNF ,/li,,/ul,,ul,,ul,,li,1: Germ cell nuclear factor ( GCNF ; NR6A1 ...https://www.slideshare.net/HabiburRahman5/nuclear-receptors-as-target-of-new-drug-therapy
COUP-TFI controls Notch regulation of hair cell and support cell differentiation | Development
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature 435,98 -104. ... Wang, L. H., Tsai, S. Y., Cook, R. G., Beattie, W. G., Tsai, M. J. and O'Malley, B. W. (1989). COUP transcription factor is a ... Cooney, A. J., Tsai, S. Y., O'Malley, B. W. and Tsai, M. J. (1992). Chicken ovalbumin upstream promoter transcription factor ( ... C) Expression of COUP-TFI and COUP-TFII transcripts in cochleae treated with DAPT. COUP-TFI and COUP-TFII expression was not ...http://dev.biologists.org/content/133/18/3683.full
finals - gene expression Flashcards by Estee C | Brainscape
T/F) general transcription factors (TFII) perform function similar to that of σ factor in bacteria ... are TFII subunits that bind TATA box; a universal transcription factor since also required for Pol l and Pol lll-mediated ... T/F) The CAP site is a silencer element since it binds a transcription factor cAMP-CAP. complex and enhances transcription ... whichi of the ff does not apply to eukaryotic transcription?. a. has σ factors to direct enzyme to promoters. b. require a ...https://www.brainscape.com/flashcards/finals-gene-expression-4548148/packs/6223664
COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1 | Journal of Cell...
Transcription factor NR2F2 (also known as chicken ovalbumin upstream promoter transcription factor II, COUP-TFII) plays a key ... 2005). Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature 435, 98-104. doi: ... 2011). Transcription factor COUP-TFII is indispensable for venous and lymphatic development in zebrafish and Xenopus laevis. ... One of these is the transcription factor COUP-TFII, which we will refer to as 'NR2F2'. It belongs to a family of nuclear orphan ...http://jcs.biologists.org/content/126/5/1164
The Role of Wnt Signaling in Physiological and Pathological Angiogenesis | Circulation Research
... the transcription factor COUP-TFII is required for venous identity. This factor acts by inhibiting Notch signaling and other ... In the nucleus, β-catenin interacts with T-cell factor (TCF)/Lef transcription factors and activates cell transcription.22,29,- ... Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature. 2005;435:98-104. ... In the nucleus, β-catenin binds TCF/Lef transcription factors, inducing Wnt target gene transcription. In the retina ...http://circres.ahajournals.org/content/107/8/943
Dr. Patrick Desgranges, Internal Medicine, Seattle, WA
Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. ...https://www.healthtap.com/experts/11209949-dr-patrick-desgranges
This Week in Science | Science
... including the transcription factor TFII-I. Caraveo et al. (p. 122; see the Perspective by Park and Dolmetsch) found that TFII-I ... The interaction of TFII-I with PLC-γ appears to depend on TFII-I's phosphorylation, which may keep PLC-γ from interacting with ... in the brain-derived neurotrophic factor (BDNF) gene may be related to mood and anxiety disorders common in human populations. ...http://science.sciencemag.org/content/314/5796/twis
Frontiers | Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal...
Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse ... It will greatly improve our understanding of transcription factors, like RORα and TRα1, which are already well known to be ... suggesting that several of the small ligand molecules that bind these transcription factors are required locally. We have ... Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and low-affinity nerve growth factor receptor ...https://www.frontiersin.org/articles/10.3389/fnana.2012.00011/full
Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity | proLékaře.cz
The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability ... Článek The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability ... The POU Factor Ventral Veins Lacking/Drifter Directs the Timing of Metamorphosis through Ecdysteroid and Juvenile Hormone ... Článek The POU Factor Ventral Veins Lacking/Drifter Directs the Timing of Metamorphosis through Ecdysteroid and Juvenile ...https://www.prolekare.cz/casopisy/plos-genetics/2014-6/loss-of-ucp2-attenuates-mitochondrial-dysfunction-without-altering-ros-production-and-uncoupling-activity-55182
JCI - Axial tubule junctions control rapid calcium signaling in atria
This is consistent with an earlier study showing that the transcription factor COUP-TFII suppresses PLN transcription in atria ... Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013;25(4):417-426.. View this article via: PubMed ... As has been established before, the control of RyR2 sensitivity to cytosolic [Ca2+]i appears to depend on multiple factors and ... Among the risk factors associated with atrial dysfunction, hypertension is present in 60% to 80% of European patients (2). ...https://www.jci.org/articles/view/88241
This Week in Science | Science
Working in mice, Zhao et al. discovered that this process instead was actively promoted by the transcription factor COUP-TFII ( ... is associated with increased transforming growth factor-β (TGFβ) signaling, which can promote metastasis. Working in mice, Chen ... see the Perspective by Swain). Without the action of this factor, embryos retained male reproductive tracts, independently of ...http://science.sciencemag.org/content/357/6352/twis
Griffin P. Rodgers - Wikipedia
... the stem cell factor (SCF) induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII, which can ... "CF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII". Blood. 114 (1): 187-194. doi: ... The 2015 study concludes that "we were unable to provide evidence for COUP-TFII expression under any in vivo or in vitro ...https://en.wikipedia.org/wiki/Griffin_P._Rodgers
Staff Profile - Institute of Neuroscience - Newcastle University
The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in ... Distinct cortical and sub-cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 ... and COUP-TFII in early fetal human telencephalon. Brain Structure and Function 2017, 222(5), 2309-2328. ...https://www.ncl.ac.uk/ion/staff/profile/gavinclowry.html
Histone deacetylase 2 - Wikipedia
"Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". J. Biol. Chem. 278 (3): 1841-7. ... Sp1 transcription factor, Sp3 transcription factor, TOP2B, and YY1. Histone deacetylase GRCh38: Ensembl release 89: ... Yao YL, Yang WM, Seto E. "Regulation of transcription factor YY1 by acetylation and deacetylation". Mol. Cell. Biol. 21 (17): ... "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". ...https://en.wikipedia.org/wiki/Histone_deacetylase_2
Frontiers | The Genetics of Reading Disabilities: From Phenotypes to Candidate Genes | Psychology
... and to be recognition sites for transcription factors TFII-I and Sp1: TFII-1 toboth alleles of rs3743205 and Sp1 to rs16787 (− ... The transcription factors TFII-I, poly (ADP-ribose) polymerase 1 (PARP1), and splicing factor proline/glutamine-rich (SFPQ) ... Recent studies in a human neuroblastoma cell line found that estrogen receptor beta and the transcription factor TFII-I are ... Transcription factor: a gene product that regulates the function of another gene. ...https://www.frontiersin.org/articles/10.3389/fpsyg.2012.00601/full
"Distinct classes of yeast promoters revealed by differential TAF recru" by Xiao-Yong Li, Sukesh R. Bhaumik et al.
After inactivation of several general transcription factors, including TBP, TAFs are still recruited by activators to TAFdep ... and multiple TBP-associated factors (TAFs). Here, the association of TFIID components with promoters that either are dependent ... The transcription factor TFIID contains the TATA box binding protein (TBP) ... Transcription Factors; Transcription Factors, TFII ... The transcription factor TFIID contains the TATA box binding ...https://escholarship.umassmed.edu/oapubs/1640/
Craniofacial Development Protein 1 (CFDP1) ELISA Kits
... the chromatin immunoprecipitation analysis showed that TFII-I transcription factors are recruited to these sites in vivo in ... Cfdp1 contains consensus TFII-I binding sites in the proximal promoters; ... provide a basis for our understanding of the specific regulation of the cp27 gene in the NF-Y-mediated gene transcription ...https://www.antibodies-online.com/abstract/Craniofacial+Development+Protein+1+
Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus...
Expression level of Coup-TFII and Ucp3 mRNA in tissues of P. sungorus. Coup-TFII mRNA is expressed in all examined tissue types ... Several studies have demonstrated interaction of these factors with chicken ovalbumin upstream promoter transcription factor II ... Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus ... Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus ...https://www.ncbi.nlm.nih.gov/pubmed/17204145?dopt=Abstract