A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARα to target promoters | The EMBO Journal
S77 is phosphorylated by the CAK subcomplex of the general transcription factor TFIIH either in vitro (Figure 2B) or in vivo ( ... in association with TFIIH and RNA PolII. Whether and how other chromatin remodelling and/or transcription factors are also ... 1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7. Cell 90: 97-107. ... As RARα binds TFIIH after RA addition (see Figure 3D), we also examined the recruitment of TFIIH in ChIP experiments performed ...http://emboj.embopress.org/content/28/1/34
In vivo live imaging of RNA polymerase II transcription factories in primary cells. - Radcliffe Department of Medicine
... or with splicing factor SC35. In conclusion, transcription factories exist in living cells, and initiation and elongation of ... as part of TFIIH marks initiation, whereas phosphorylation of Ser2 by CDK9 marks elongation. These processes are thought to ... We show that transcription factories exist in living cells as distinct foci by live-imaging fluorescently labeled CDK9, a ... take place in localized transcription foci in the nucleus, known as 'transcription factories,' but it has been argued that the ...https://www.rdm.ox.ac.uk/publications/701855
Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7....
Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. ... we have dissected the role of the basal transcription/DNA repair factor TFIIH. Having succeeded in reconstituting a ... stimulates transcription and allows the CAK complex to be anchored to TFIIH. In addition, we also show that cdk7 may ... Designing mutated recombinant subunits, we show that the XPB helicase is absolutely required for transcription to open the ...https://www.ncbi.nlm.nih.gov/pubmed/10024882?dopt=Abstract
Function of Conserved Topological Regions within the Saccharomyces cerevisiae Basal Transcription Factor TFIIH | Molecular and...
TFIIH and TFIIE are the last basal factors to join the transcription preinitiation complex (PIC) (4). In transcription, TFIIH ... TFIIH is a 10-subunit RNA polymerase II basal transcription factor with a dual role in DNA repair. TFIIH contains three ... TFIIH is the most complex RNA Pol II basal transcription factor and plays essential roles in transcription and NER. Previous ... Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH. J Biol Chem 278:43897- ...https://mcb.asm.org/content/36/19/2464
It takes ten to tango: the structure of transcription factor TFIIH. - [email protected] Hutch
It takes ten to tango the structure of transcription factor TFIIH.pdf - Published Version Available under License Creative ... Koch, Lori (2015) It takes ten to tango: the structure of transcription factor TFIIH. Science Spotlight, 5 (10). ... Architecture of the human and yeast general transcription and DNA repair factor TFIIH. Molecular Cell. 59:794-806.. ...http://authors.fhcrc.org/1116/
Gentaur Molecular :GenWay \ TFIIH basal transcription factor complex p62 subunit - Basic transcription factor 62 kDa subunit;...
Basic transcription factor 62 kDa subunit; BTF2-p62; General transcription factor IIH polypeptide 1 Polyclonal \ 15-288-22005B ... TFIIH basal transcription factor complex p62 subunit). [GTF2H3] General transcription factor IIH subunit 3 (Basic transcription ... TFIIH basal transcription factor complex p34 subunit). [GTF2H4] General transcription factor IIH subunit 4 (Basic transcription ... Product name : TFIIH basal transcription factor complex p62 subunit - Basic transcription factor 62 kDa subunit; BTF2-p62; ...http://www.antibody-antibodies.com/product1879914-search-TFIIH_basal_transcription_factor_complex_p62_subunit___Basic_transcription_factor_62_kDa_subunit
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy :...
The transcription factor TFIIH is involved in both basal transcription and DNA repair. Mutations in the XPD helicase component ... Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy ... Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy. Human ... of TFIIH can result in the diverse clinical features associated with xeroderma pigmentosum (XP) and trichothiodystrophy (TTD). ...http://sro.sussex.ac.uk/1072/
GENTAUR antibody-antibodies.com The Marketplace for Antibodies : Revised subunit structure of yeast transcription factor IIH ...
Revised subunit structure of yeast transcription factor IIH (TFIIH) and reconciliation with human TFIIH. ... TFIIH basal transcription factor complex TTD-A subunit. H5485. TFIIH basal transcription factor complex helicase XPD subunit ( ... TFIIH basal transcription EIAAB42042. Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH ... TFIIH basal transcription facto. EIAAB42050. Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor ...http://www.antibody-antibodies.com/pubmed-PubMed:14500720-PubMedArticl.html
Assembly, subunit composition, and footprint of human DNA repair excision nuclease | PNAS
... transcription factor IIH (TFIIH), XPC⋅HHR23B, XPG, and XPF⋅ERCC1 repair factors (3-5). By using substrates with single lesions ... Abbreviations: XP, xeroderma pigmentosum; RPA, replication protein A; TFIIH, transcription factor IIH; HHR23B, human homolog B ... The (6-4) substrate was incubated for 2 h with the five repair factors (RFI-V: XPA, RPA, TFIIH, XPC, XPG) at the concentration ... A stable complex of high specificity can be detected only when XPA/RPA, transcription factor IIH, XPC⋅HHR23B, and XPG and ATP ...http://www.pnas.org/content/95/12/6669?ijkey=731b92e400c316b8685174941116146b2ef3a5a4&keytype2=tf_ipsecsha
ERCC2 - General transcription and DNA repair factor IIH helicase subunit XPD - Cricetulus griseus (Chinese hamster) - ERCC2...
In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been ... in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the ... TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and ... XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor ...https://www.uniprot.org/uniprot/Q60452
TFB4 - General transcription and DNA repair factor IIH subunit TFB4 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been ... in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the ... TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and ... of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. ...https://www.uniprot.org/uniprot/Q12004&format=html
Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV...
TFIIH: transcription factor II H; RPA1: replication protein A; ERCC1: excision repair cross-complementation group 1; PCNA: ... The transcription of the different NER factors is under tight balance due to the effects of both transcription factors and ... S. Kannan and A. K. Jaiswal, "Low and high dose UVB regulation of transcription factor NF-E2-related factor 2," Cancer Research ... S. Braun, C. Hanselmann, M. G. Gassmann et al., "Nrf2 transcription factor, a novel target of keratinocyte growth factor action ...https://www.hindawi.com/journals/omcl/2019/4654206/
Cyclic Dependent Kinase (CDK): Role in Cancer Pathogenesis and as Drug Target in Cancer Therapeutics | OMICS International
TFIIH: Transcription Factor IIH; DSIF: DRB-Sensitive-Inducing Factor; NELF: Negative Elongation Factor; JNK: c-Jun N-terminal ... General Transcription Factors; P-TEFb: Positive Transcription Elongation Factor b; TAK: Tat Activating Kinase; snRNA: Small ... CDK9 is a key elongation factor for RNA transcription and functions by phosphorylating the CTD of RNAPII [25,31,71]. ... Transcription regulators. CDKs are key cell cycle regulators and some also have regulatory functions in mRNA transcription at ...https://www.omicsonline.org/open-access/cyclic-dependent-kinase-cdk-role-in-cancer-pathogenesis-and-as-drugtarget-in-cancer-therapeutics-1948-5956-1000408.php?aid=75466
HNRNPU Gene - GeneCards | HNRPU Protein | HNRPU Antibody
TFIIH-class transcription factor binding. IDA. 10490622. GO:0003677. DNA binding. TAS,IDA. 9204873. ... Binding Sites for Transcription Factors within promoters. ENSR00000022956. 1360. 4001. MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF548 ... Transcription Factor Binding Sites within enhancer. Gene Targets for Enhancer. GH01H244860. 1.7. Ensembl ENCODE dbSUPER 93.2. + ... Transcription Factor Targets and HOMER Transcription for HNRNPU Gene ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=HNRNPU&keywords=hsa-mir-597-3p
RAD3 | SGD
5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH ... ATP-dependent 5'-3' DNA helicase involved in transcription by polymerase II and positive regulation of mitotic recombination; ... transcription factor TFIIH core complex (IDA) * transcription factor TFIIH holo complex (IDA) ... subunit of core TFIIH complex. View computational annotations ... and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of ...https://www.yeastgenome.org/locus/RAD3
Transcription factor II H - Wikipedia
Transcription factor II Human (Transcription Factor II H; TFIIH) is an important protein complex, having roles in transcription ... TFIIH first came to light in 1989 when general transcription factor-δ or basic transcription factor 2 was characterized as an ... indispensable transcription factor in vitro. This factor was also isolated from yeast and finally named as TFIIH in 1992. TFIIH ... Le May N, Dubaele S, Proietti De Santis L, Billecocq A, Bouloy M, Egly JM (February 2004). "TFIIH transcription factor, a ...https://en.wikipedia.org/wiki/Transcription_factor_II_H
Structure Cluster - 4ERN: Crystal structure of the C-terminal domain of human XPB/ERCC-3 excision repair protein at 1...
Description: TFIIH basal transcription factor complex helicase XPB subunit protein , Length: 289 ...http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=4ERN
Progeroid syndromes - Wikipedia
XPD and p8/TTDA of the general transcription factor IIH (TFIIH) complex, which is involved in transcription and DNA damage ... Hashimoto, S; Egly, JM (2009). "Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH". ... Andressoo, J.O.; Hoeijmakers, J.H.J. (2005). "Transcription-coupled repair and premature ageing". Mutation Research/Fundamental ... Andressoo, JO; Hoeijmakers, JH (2005). "Transcription-coupled repair and premature ageing". Mutation research. 577 (1-2): 179- ...https://en.wikipedia.org/wiki/Accelerated_aging_disease
GTF2H5 Gene - GeneCards | TF2H5 Protein | TF2H5 Antibody
General Transcription Factor IIH Subunit 5, including: function, proteins, disorders, pathways, orthologs, and expression. ... This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This ... Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and ... Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and ...https://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=404672
Anti-Cdk7 antibody [MO1] (ab115181) | Abcam
CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the ... Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant ...http://www.abcam.com/cdk7-antibody-mo1-ab115181.html