RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription (Journal...
RNA polymerase II-TFIIB structure and mechanism of transcription initiation journal, October 2009 * Kostrewa, Dirk; Zeller, ... Transcription Factor B Contacts Promoter DNA Near the Transcription Start Site of the Archaeal Transcription Initiation Complex ... 59 BASIC BIOLOGICAL SCIENCES; transcription initiation; initial transcription; promoter escape; sigma factor; initiation factor ... Displacement of the transcription factor B reader domain during transcription initiation journal, August 2018 * Dexl, Stefan; ...
Transcription factor II E - Wikipedia
TFIIH TFIIB TFIID Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636-637. ISBN 0-13- ... Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II ... Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes. TFIIE is thought to be involved in DNA melting at the ... Transcription+Factor+TFIIE at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ...
![TCF4 transcription factor 4 [Homo sapiens (human)] - Gene - NCBI](data:image/png;base64,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)
TCF4 transcription factor 4 [Homo sapiens (human)] - Gene - NCBI
enables TFIIB-class transcription factor binding ISS Inferred from Sequence or Structural Similarity. more info ... transcription factor 4. Names. SL3-3 enhancer factor 2. class B basic helix-loop-helix protein 19. immunoglobulin transcription ... This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an ... Transcription factor 4 expression and correlation with tumor progression in gallbladder cancer. Title: Transcription factor 4 ...
REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies
Zinc finger, TFIIB-type. ENSCPOP00000008664. Pfam. PF11521. IPR021600. 354. 431. 3.50e-31. Transcription factor TFIIE alpha ... Transcription factor TFE/TFIIEalpha HTH domain. ENSCPOP00000008664. SMART. SM00531. IPR002853. 28. 175. 1.20e-77. Transcription ... Copyright © 2017 REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies ... regulation of transcription, DNA-templated. ENSCPOP00000008664. GO:0006367. biological_process. transcription initiation from ...
REGULATOR: a database of metazoan transcription factors and maternal factors for developmental studies
JCI - Testicular differentiation factor SF-1 is required for human spleen development
... and interaction with transcription factor TFIIB and c-Jun. Mol Endocrinol. 1999;13(9):1588-1598.. View this article via: PubMed ... The transcription factor steroidogenic factor 1 (SF-1; also known as NR5A1) is a crucial mediator of both steroidogenic and ... Steroidogenic factor 1 (SF-1; also known as NR5A1) is a transcription factor involved in steroidogenesis, reproduction, and ... The R103Q mutation decreased SF-1 transactivation of TLX1, a transcription factor that has been shown to be essential for ...
2017 Nobel Prize in Chemistry
The cryo-electron microscopy structures of yeast initiation complexes containing the transcription factors TBP, TFIIA, TFIIB, ... Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex *Holger Stark ... Near-atomic resolution visualization of human transcription promoter opening Cryo-electron microscopy structural models of the ... providing new mechanistic insights into the processes of promoter melting and transcription-bubble formation, as well as an ...
IFN-β Down-Regulates the Expression of DNA Repair Gene MGMT and Sensitizes Resistant Glioma Cells to Temozolomide | Cancer...
The irrelevant antibody specific to TFIIB, which is a transcription factor of GAPDH, did not coprecipitate with MGMT promoter ( ... Transcription factor NFAT1 isoform C (NFAT1) U43342.1 2.289 SFPQ Splicing factor proline/glutamine-rich (polypyrimidine tract ... Transcription factor NFAT1 isoform C (NFAT1) U43342.1 2.289 SFPQ Splicing factor proline/glutamine-rich (polypyrimidine tract ... Lane 2, result of PCR using immunoprecipitated samples with control antibody against TFIIB, the known transcriptional factor of ...
JCM | Free Full-Text | VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV...
... the T allele has been related to a less efficient interaction between VDR protein and transcription factor IIB (TFIIB) [29], ... and to promote the secretion of growth factors and cytokines through the modulation of nuclear transcription factors [7]. The ... VitD effects are mediated by its nuclear receptor, vitamin D receptor (VDR), which acts as a transcription factor that promotes ... We should not rule out the influence of other factors, such as the exposure to sunlight, since vitamin D levels depend on the ...
Introductory Chapter: Gene Expression Controlling System and Its Application to Medical Sciences | IntechOpen
2. Transcription factors (TFs) in mammalian cells. Transcription factors are divided into two groups. First, the general TFs ( ... GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors ... The site-specific transcription factors. Transcription mediator interplays with the transcription activator proteins and the ... 2.2.7. β-Structure (β-scaffold, β-sheet, and β-barrel) containing transcription factors. This group includes DBP, NF-1, HMGA, ...
SMART: ZnF C2C2 domain annotation
... binding motifs which are conserved in archaea and homologous to those of the general transcription factors TFIIB and TFIIS. ... is modulated by general and specific transcription factors. The general transcription factors operate through common promoters ... Basal transcription factors. This information is based on mapping of SMART genomic protein database to KEGG orthologous groups ... They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), ...
Publications | Janelia Research Campus
Singer LabLavis LabTjian LabTranscription Imaging. 09/15/16 , Rapid dynamics of general transcription factor TFIIB binding ... 03/15/17 , Quantifying transcription factor binding dynamics at the single-molecule level in live cells. Presman DM, Ball DA, ... Here, we describe a detailed approach to perform single-molecule tracking (SMT) of transcription factors in living cells to ... Using the glucocorticoid receptor as a model transcription factor, we compared alternate tags (GFP, mEOS, HaloTag, SNAP-tag, ...
DDX5 Regulates DNA Replication and Is Required for Cell Proliferation in a Subset of Breast Cancer Cells | Cancer Discovery |...
DDX5 is required for the general transcription factor TFIIB and RNA polymerase II to localize to the promoters of genes ... Simian virus 40 large T antigen interacts with human TFIIB-related factor and small nuclear RNA-activating protein complex for ... We analyzed promoters of genes downregulated as a result of DDX5 knockdown for common transcription factor-binding motifs and ... S7). Thus, we tested whether DDX5 interacted with the transcription factor E2F1 and indeed found an interaction between these 2 ...
Research | Taatjes Lab | University of Colorado Boulder
Transcription Factors and PIC function Mediator is a common target of DNA-binding transcription factors (TFs) and also ... The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II ( ... The Taatjes lab investigates the molecular mechanisms by which the human transcription machinery functions and is regulated. ... Structure and function of the RNA polymerase II transcription machinery. ...
Saccharomyces cerevisiae displays a stable transcription start site landscape in multiple conditions | bioRxiv
... genes in eukaryotic cells is governed by the RNA polymerase II in concert with the general transcription initiation factors ( ... GTFs), namely TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH (reviewed in (1)). These proteins assemble at the core promoter of a ... Regulation of gene transcription is one of the fundamental processes that determine cellular fate. Transcription of protein ... At the core promoter, the regulatory region containing the transcription start site (TSS), all inputs regulating transcription ...
Affinity-based enrichment strategies to assay methyl-CpG binding activity and DNA methylation in early Xenopus embryos | BMC...
... which can recruit co-repressor complexes to silence transcription on targeted loci. The binding to methylated DNA may be ... TFIIB is one of the general transcription factors involved in RNA Polymerase II pre-initiation complex formation [51]. Our ... Smith AD, Sumazin P, Das D, Zhang MQ: Mining ChIP-chip data for transcription factor and cofactor binding sites. Bioinformatics ... Roeder RG: The role of general initiation factors in transcription by RNA polymerase II. Trends Biochem Sci. 1996, 21 (9): 327- ...
Kinetic trapping of DNA by transcription factor IIIB<...
TFIIIB-DNA complexes in yeast comprise the TATA-binding protein (TBP), the TFIIB-related factor TFIIIB70, and TFIIIB90. The ... "Kinetic trapping of DNA by transcription factor IIIB",. abstract = "High levels of RNA polymerase III gene transcription are ... Kinetic trapping of DNA by transcription factor IIIB. / Cloutier, Timothy E.; Librizzi, Monett D.; Mollah, A. K.M.M. et al. In ... Cloutier, TE, Librizzi, MD, Mollah, AKMM, Brenowitz, M & Willis, IM 2001, Kinetic trapping of DNA by transcription factor IIIB ...
Penicillium roqueforti DTO070G2 (CBS 147317)
Michael Rauchman - Research output
- Research Profiles at Washington University School of Medicine
Transcription Factor TFIID 100% * Crystallins 85% * Eye 81% * Genes 53% * Transcription Factor TFIIB 52% ... Murine Sall1 represses transcription by recruiting a histone deacetylase complex. Kiefer, S. M. L., McDill, B. W., Yang, J. & ... Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. Major Depressive ... Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive ...
Gene: PF3D7 0110800 - Summary - Plasmodium falciparum - Ensembl Genomes 57
"sequence id","alias","species","description",...
"Transcription factor TFIIB, cyclin-like domain; Zinc finger, TFIIB-type [Interproscan].","protein_coding" "Dusal.0480s00010.1 ... "Transcription factor TFIIB, cyclin-like domain; Brf1, TBP-binding domain [Interproscan].","protein_coding" "OT_13G01780.1","No ... "Whirly transcription factor [Interproscan].","protein_coding" "PTI_01G08530.1","No alias","Phaeodactylum tricornutum"," ... "G2-like myb-transcription factor with a n-terminal response regulator receiver domain","protein_coding" "XM_002508747.1"," ...
Publications
footprintDB - a database of transcription factors with annotated cis elements (DNA motifs and sites) and binding interfaces
Human TFIIB-related factor 2 (Brf2) and TBP bound to U6#2. ... T-BOX TRANSCRIPTION FACTOR TBX3. TnnnCACctAGgTGnnnA. Homo ... T-BOX TRANSCRIPTION FACTOR TBX3. gTGnnnA. Homo sapiens. Human TBX3, a transcription factor responsible for ulnar-mammary ... Transcription factor-DNA complex. 5d39_D. Signal transducer and activator of transcription 6. TtcC. Homo sapiens. Transcription ... Transcription factor-DNA complex. 5d39_AC. Signal transducer and activator of transcription 6. TTCCnGGAA. Homo sapiens. ...
Transcription: Synthesis of RNA | Basicmedical Key
Synthesis of RNA Synthesis of RNA from a DNA template is called transcription. Genes are transcribed by enzymes called RNA ... TFIIA and TFIIB interact with TBP. RNA polymerase II binds to the complex of transcription factors and to DNA and is aligned at ... 13.7). This binding process involves at least six basal transcription factors (labeled as TFIIs, transcription factors for RNA ... that interact with transcription factors through an activation domain on the transcription factor (which is bound to DNA). The ...
Recombinant Proteins | CU Experts | CU Boulder
Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB. Journal Article ... Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II. Journal Article ... The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA ... transcription elongation factor Book * Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase ...
Eukaryotic Transcription
... This article describes Eukaryotic Transcription with proper explanation and ... ... The transcription factors for Pol II are named TFIIA, TFIIB, TFIID and so on, while those for Pol I and Pol III are named TIF- ... transcription factors. These transcription factors assemble into a complex on the promoter, forming a transcription pre- ... for Transcription Factor for RNA polymerase II) .. The first event in initiation is the binding of the transcription factor IID ...
Xia & He Publishing
Chlamydia psittaci in ocular adnexa MALT lymphoma: a possible role in lymphomagenesis and a different geographical distribution...
MALT-lymphomas often recognize specific environmental factors responsible of lymphoma development and progression. In ... Characterization of bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB. ... Interestingly, environmental factors are specifically related to sites of acquired MALT development and furthermore the ... Abrams JT, Balin BJ, Vonderheid EC: Association between Sazary T-cell-activating factor, Chlamydia pneumonia, and cutaneus T ...