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*  Cancers | Free Full-Text | BRCA1 and Oxidative Stress | HTML
BRCA1 augments transcription by the NF-κB transcription factor by binding to the Rel domain of the p65/RelA subunit. J. Biol. ... Table 1. Transcription factors that bind to BRCA1.. Transcription factor. Region in BRCA1 (aa). Assays. References. ... BRCA1 also modulates transcriptional activity of diverse transcription factors including the activating transcription factor 1 ... induces GADD45α transcription through interaction with transcription factors such as the octamer-binding transcription factor-1 ...
http://www.mdpi.com/2072-6694/6/2/771/htm
*  e2f1 Protein, E2F transcription factor 1 - Creative BioMart
The E2F transcription factors are essential for regulation of the cell cycle. Physiological E2F is a heterodimer composed of an ... E2F1; E2F transcription factor 1; RBBP3; transcription factor E2F1; RBP3; PBR3; RBAP-1; RBBP-3; PRB-binding protein E2F-1; ... PPP3CB; CDKN2A; NTRK1; NGF; CASP6; CSF2RB; PPP3CA; RELA; IKBKB; PIK3CD. Assembly of the pre-replicative complex ... The E2F transcription factors are essential for regulation of the cell cycle. Physiological E2F is a heterodimer composed of an ...
https://www.creativebiomart.net/symbolsearch_E2F1.htm
*  Immunity drives TET1 regulation in cancer through NF-κB | Science Advances
NF-κB, composed of five members, p65 (RelA), RelB, c-Rel, NF-κB1, and NF-κB2, was first identified as a transcription factor ... and the NF-κB family transcription factor RELA (p65). Additional examples are shown in fig. S3A. ... This major immunoregulatory transcription factor is known to be activated in many cancer types (36). It is mostly viewed as ... The NF-κB family of transcription factors and its regulation. Cold Spring Harb. Perspect. Biol. 1, a000034 (2009).. ...
https://advances.sciencemag.org/content/4/6/eaap7309
*  Gene Report for G00001621 - Genes2Cognition Neuroscience Research Programme
The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription.. Ishaq M, Ma L, ... In this study, we identified RelA (p65), a subunit of nuclear factor-kappaB (NF-kappaB), as a cellular co-factor of DEAD-box ... Currently, the HLA risk factors and the 10 established non-HLA risk factors explain approximately 40% of the heritability of ... A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev.. Fang J, Kubota S, Yang B, Zhou N, Zhang H, ...
http://www.genes2cognition.org/db/Gene/G00001621
*  RCSB PDB - Protein Feature View - Forkhead box protein P3 - Q9BZS1 (FOXP3 HUMAN)
Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and ... IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532 ... Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4. UniProt ... Interacts with RELA and NFATC2. Interacts with RUNX2, RUNX3 and IKZF4. UniProt ...
http://www.rcsb.org/pdb/protein/Q9BZS1
*  Anti-RELA NF-kB p65 | NSJ Bioreagents | Biomol.de
... is a protein that in humans is encoded by the RELA gene. It is mapped to 11q13.1. RELA is an essential transcription factor ... Transcription factor p65, also known as NFKB3 or NF-kB p65, ... RELA is an essential transcription factor complex involved in ... Transcription factor p65, also known as NFKB3 or NF-kB p65, is a protein that in humans is encoded by the RELA gene. It is ... Protein function: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a ...
https://www.biomol.com/de/produkte/antikoerper/primaerantikoerper/allgemein/anti-rela-nf-kb-p65-nsj-r31513
*  Mechanosensing by the nucleus: From pathways to scaling relationships | JCB
Rupture has been seen to regulate localization of transcription factors (e.g., RELA and OCT1) as well as constructs of GFP- ... and decreased transcription by the transcription factor serum response factor (SRF), which is a master regulator of numerous ... and SRF transcription. (C and c) Mechanosensitive transcription factors such as YAP and TAZ translocate into the nucleus under ... Heterochromatin at the nuclear periphery (Paddy et al., 1990; Solovei et al., 2013) and a wide range of transcription factors ( ...
http://jcb.rupress.org/content/early/2017/01/01/jcb.201610042
*  Direct observation of a transient ternary complex during IκBα-mediated dissociation of NF-κB from DNA | PNAS
The NF-κB family of transcription factors consists of different homodimers or heterodimers of RelA (p65), p50, p52, c-Rel, and ... The nuclear factor kappa B (NF-κB) family of transcription factors regulates hundreds of genes in response to stress. Stress ... 1993) Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system. Curr Opin Cell Biol 5(3):477-487. ... 1998) Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature 391(6665):410-413. ...
http://www.pnas.org/content/111/1/225
*  Failure to Activate Transcription Factor NF-κB in Corneal Stromal Cells (Keratocytes) | IOVS | ARVO Journals
sc-109), RelA/p65 (cat. no. sc-114), and c-Rel (cat. no. sc-272), or the unrelated transcription factor AP-2α (cat. no. sc-184 ... Here we report our findings with regard to the role of transcription factor nuclear factor(NF)-κB in stromal cell competence to ... Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. New Engl J Med. ... IL-1 activates transcription of the gene for IL-1α via a pathway requiring ROS and transcription factor NF-κB, while activation ...
https://iovs.arvojournals.org/article.aspx?articleid=2123275
*  Licht:Publications - OpenWetWare
BRCA1 augments transcription by the NF- B transcription factor by binding to the Rel domain of the p65/RelA subunit. J Biol ... 3. Tenen DG, Hromas R, Licht JD, Zhang D-E. Transcription factors, normal myeloid development and Leukemia. Blood 90: 489-519, ... K. Ravid, J.D. Licht- Transcription factors: Normal and malignant development of blood cells. John Wiley and Sons, 2001 ... Cloning and characterization of a novel mouse AP-2 transcription factor AP2δ, with unique DNA binding and transactivation ...
https://openwetware.org/wiki/Licht:Publications
*  DISEASES - FOXP3
Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and ... Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity); Forkhead boxes ... IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the ... as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, ...
https://diseases.jensenlab.org/Entity?documents=10&type1=9606&id2=DOID:1936&id1=ENSP00000365380
*  Active Motif » Recombinant transcription factors for use in transcriptional regulation assays
Active Motif offers a large number of recombinant transcription factor proteins that can be used in a variety of assays to ... Recombinant NFκB3 (RELA / p65) protein Baculovirus 20 µg 81086 $395 Buy Now ... Transcription Factors. recombinant transcription factors for your transcription assays. Transcription factors are DNA-binding ... Transcription factors can operate alone or form homodimers and heterodimers. Some transcription factors, such as NFκB and STAT ...
https://www.activemotif.com/catalog/749/recombinant-transcription-factors
*  rela, v-rel avian reticuloendotheliosis viral oncogene homolog A - Creative Biogene
Transcription factor p65 is a protein that in humans is encoded by the RELA gene. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is ... Nuclear factor NF-kappa-B p65 subunit; MGC131774; transcription factor p65; OTTHUMP00000233473; OTHUMP00000233474; ... nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)); NFKB3, nuclear factor of kappa light polypeptide ... The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NF-κB. The NF-κB complex is inhibited by IκB (NFKBIA, MIM ...
https://www.creative-biogene.com/symbolsearch_rela.html
*  Transcription factor site dependencies in human, mouse and rat genomes | BMC Bioinformatics | Full Text
Scanning promoter sequences with dependent groups of transcription factor binding sites improve the quality of transcription ... about transcription factor binding sites dependencies can be used for prediction of groups of dependent transcription factors ... Our approach for quantifying tendencies of transcription factor binding sites to co-occur is based on a binding site scoring ... Our results, as well as a scanning tool for predicting groups of dependent transcription factors binding sites are available on ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-10-339
*  Latent Semantic Indexing of PubMed abstracts for identification of transcription factor candidates from microarray derived gene...
Identification of transcription factors (TFs) responsible for modulation of differentially expressed genes is a key step in ... Yu JH, Zhu BM, Wickre M, et al.: The transcription factors signal transducer and activator of transcription 5A (STAT5A) and ... Nuclear Factor IC Links Platelet-Derived Growth Factor and Transforming Growth Factor β1 Signaling to Skin Wound Healing ... Identification of transcription factors (TFs) responsible for modulation of differentially expressed genes is a key step in ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-12-S10-S19
*  A/PROF Timothy Thomas - The University of Melbourne
The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct ... One important aspect of this is to define the role of co-activators of transcription in stem and progenitors cells during ... Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3. Nature Medicine. 9. ... but preserved RNA polymerase II transcription. Human Molecular Genetics. 27. 2018 ...
https://findanexpert.unimelb.edu.au/display/person59755
*  Stage-Specific Repression by the EKLF Transcriptional Activator | Molecular and Cellular Biology
A number of transcription factors have been shown to be deacetylation substrates, including MyoD (36), RelA (11), YY1 (66), and ... Erythroid Krüppel-like factor (EKLF) is an erythroid cell-specific transcription factor that plays a critical role in β-globin ... Regulation of transcription factor YY1 by acetylation and deacetylation. Mol. Cell. Biol. 21:5979-5991. ... The function of individual zinc fingers in sequence-specific DNA recognition by transcription factor IIIA. J. Mol. Biol. 233: ...
https://mcb.asm.org/content/24/23/10416?ijkey=795c55d79e01770fb3517b5b1eb024107cf8174b&keytype2=tf_ipsecsha
*  Mutagenetix > Phenotypic Mutation ...
NF-κB proteins are dimeric transcription factors consisting of RelA (p65), RelB, NF-κB1 (p105, processed to p50), NF-κB2 (p100 ... a Novel Tumor Necrosis Factor Receptor-Associated Factor Protein that Mediates Signaling from an Amino-Terminal Domain of the ... Regulation of the NF-kappaB-Inducing Kinase by Tumor Necrosis Factor Receptor-Associated Factor 3-Induced Degradation. J. Biol ... CD40 Signaling through a Newly Identified Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) Binding Site. J. Biol. ...
http://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=569&rn=551&rl=584&so=al&ac=1&r0=500&nr=100
*  CST - NF-κB Pathway Sampler Kit
The NF-κB family of transcription factors is comprised of five proteins in mammals, p65/RelA, c-Rel, RelB, NF-κB1 (p105/p50) ... The transcriptional nuclear factor κB (NF-κB)/Rel transcription factors are present in the cytosol in an inactive state, ... Phosphorylation of p65/RelA at Ser276 by PKA C and MSK1 enhances transcriptional activity. p65 phosphorylation at Ser536 ... The p50 and p52 products form dimeric complexes with Rel proteins, which are then able to bind DNA and regulate transcription. ...
https://www.cellsignal.com/products/primary-antibodies/nf-kb-pathway-sampler-kit/9936
*  Events | CCTST
NFkB transcription factors operate across genetic risk loci: RELA in SLE, MS, and IBD ...
https://cctst.uc.edu/calendar-node-field-event-date/day/2017-09-22
*  Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. -...
... and had no effects on alpha tubulin gene transcription. Thus, TNF alpha decreases collagen gene transcription, collagen mRNA ... The effects of recombinant human tumor necrosis factor alpha (TNF alpha) on collagen production and gene expression in cultured ... AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression. *Yunqian Peng, Ji-Min Kim, +4 ... Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.. @ ...
https://www.semanticscholar.org/paper/Tumor-necrosis-factor-alpha-inhibits-collagen-gene-Sol%C3%ADs-Herruzo-Brenner/fa94af61b208f66e246c810563369ded87df201e
*  Anti-c-Rel antibodies, mouse - Primary antibodies - Antibodies - MACS Flow Cytometry - Products - Miltenyi Biotec
... which also includes the proteins RelA (p65), RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). NF-κB transcription factors can ... While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic ... Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells is crucial for T cell ... a 65 kDa member of the NF-κB family of eukaryotic transcription factors, ...
https://www.miltenyibiotec.com/BE-en/products/macs-flow-cytometry/antibodies/primary-antibodies/anti-c-rel-antibodies-mouse-rea397-1-11.html
*  Recombinant mouse MSK2 / RSK-B protein (ab125610) | Abcam
Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription ... factor CREB. Essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of ... histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF) and result in the transcriptional ...
https://www.abcam.com/recombinant-mouse-msk2-rsk-b-protein-ab125610.html
*  Issues Archive - Pancreatic Cell News
NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, C-Rel, and RelB ... The authors discuss recent knowledge highlighting the role of Rel transcription factors (TFs) RelA, RelB, and c-Rel in ... Ranked by impact factor of the journal). DIABETES & PANCREATITIS. Patient-Derived Pancreas-on-a-Chip to Model Cystic Fibrosis- ... Their analysis of chromatin accessibility dynamics led them to uncover a requirement for FOXA2, known as a pioneer factor, in ...
http://www.pancreaticcellnews.com/issue/