Tags: Bcl-3, drug screening, IkBa, IkBz, Ikka, Ikkb, lentivirus, NEMO, NF-kB, p100, p50/RelA, p52/RelB, signaling pathways, ... NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) refers to a protein complex functional in signaling ... of various genes and thereby activates their transcription. In a negative feedback loop, NF-kB activation also leads to the ... Tags: cell fate, cell polarity, cell proliferation, conditioned medium, growth factors, lentivirus, signaling pathways, Wnt ...http://blog.allelebiotech.com/tag/signaling-pathways/
Transcription Factor RelA - Semantic Scholar
Transcription Factor RelA. Known as: p65, Transcription Factor, v-Rel Reticuloendotheliosis Viral Oncogene Homolog A, NF-kappa ... Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 ... MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor. ... Single binding sites for transcription factors NF-IL6 and NF-kappa B are present in the promoter of the interleukin (IL) 6 gene ...https://www.semanticscholar.org/topic/Transcription-Factor-RelA/27894
Transcription factor p65 (Q04206) | InterPro | EMBL-EBI
GO:0006355 regulation of transcription, DNA-templated GO:0051092 positive regulation of NF-kappaB transcription factor activity ...http://www.ebi.ac.uk/interpro/protein/Q04206
ELKS | Cancer Genetics Web
Transcription Factor RelA. *Single Nucleotide Polymorphism. *Oxidative Stress. *Neoplasm Recurrence, Local. *Cancer Gene ... We have previously observed that basal activity of the powerfully oncogenic transcription factor NF-κB in cultured breast ... The gene is approximately 500 kb long, with 19 exons and 18 introns; the transcription initiation site within exon 1 is ... to downregulation of ATM-dependent NF-κB signaling in MDA-MB-231 cells as RNAi-mediated knockdown of the NF-κB subunit RelA or ...http://www.cancerindex.org/geneweb/ELKS.htm
CASP7 | Cancer Genetics Web
The transcription factor NF-κB is overexpressed in human MB and is a critical factor for MB tumor growth. NF-κB is known to ... UNLABELLED: Transcription factors of the far-upstream element-binding protein (FBP) family represent cellular pathway hubs, and ... Transcription Factor RelA. *cdc25 Phosphatases. *Vitamin E. *Unfolded Protein Response. *p53 Protein ... Here we reveal that DDIAS is a target gene of nuclear factor of activated T cells 2 (NFATc1) and is associated with cisplatin ...http://www.cancerindex.org/geneweb/CASP7.htm
MCI-p individuals presented intermediate deficits of ep | Open-i
Transcription Factor RelA/metabolism*. Minor. *Aged. *Aged, 80 and over. *Alzheimer Disease/pathology ... Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic ... Interaction of transactive response DNA binding protein 43 with nuclear factor κB in mild cognitive impairment with episodic ... was reported to contribute to pathogenesis in amyotrophic lateral sclerosis through its interaction with p65 nuclear factor κB ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4230634_2051-5960-2-37-4&req=4
NF-κB signaling in human myotubes from Non-Ob and obes | Open-i
Transcription Factor RelA/metabolism. *Tumor Necrosis Factor-alpha/metabolism. Related in: MedlinePlus ... Bottom Line: This correlated to a significant increase in tumor necrosis factor-α concentration in cell culture media.This work ... Bottom Line: This correlated to a significant increase in tumor necrosis factor-α concentration in cell culture media.This work ... This correlated to a significant increase in tumor necrosis factor-α concentration in cell culture media. In addition, insulin- ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3198079_2810fig2&req=4
Frontiers | Post-translational Modification-Based Regulation of HIV Replication | Microbiology
To exploit cellular proteins for replication and to overcome host factors with antiviral activity, HIV has evolved a set of ... To exploit cellular proteins for replication and to overcome host factors with antiviral activity, HIV has evolved a set of ... Along with histone acetylation was the recruitment of EP300/CREBBP, KAT2B and KAT2A as well as the transcription factor RELA by ... transcription intermediary factor 1-beta (TRIM28, also known as TIF1B), transcription factor BTF3 (BTF3B), thyroid hormone ...https://www.frontiersin.org/articles/10.3389/fmicb.2018.02131/full
Frontiers | The Role of microRNAs in Helicobacter pylori Pathogenesis and Gastric Carcinogenesis | Cellular and Infection...
H. pylori expresses a spectrum of virulence factors that dysregulate host intracellular signaling pathways that lower the ... H. pylori expresses a spectrum of virulence factors that dysregulate host intracellular signaling pathways that lower the ... In addition to bacterial determinants, numerous host and environmental factors increase the risk of gastric carcinogenesis. ... In addition to bacterial determinants, numerous host and environmental factors increase the risk of gastric carcinogenesis. ...https://www.frontiersin.org/articles/10.3389/fcimb.2011.00021/full
Welcome to LibAge, the ageing reference resource
Entries tagged Transcription Factor RelA (11). Sort:. Number of citations. Author. Title. Year. PubMed ID. ... 1996) "Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in ... 1995) "Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B." Nature 376(6536):167-170 ( ... 1998) "Rb interacts with histone deacetylase to repress transcription." Cell 92(4):463-473 (PubMed) ...http://libage.ageing-map.org/entries/tags/1756/
Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells | Blood Journal
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin ... B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle ... with particular emphasis on the transcription factor, nuclear factor-κB (NF-κB). Previous experiments have shown that ... The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance. Biochim Biophys Acta. 2000;1470:M55- ...http://www.bloodjournal.org/content/98/8/2301?ijkey=1e79d509edff2b3c11f53b51d72314a866c7761f&keytype2=tf_ipsecsha&sso-checked=true
The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin ... Series introduction: the transcription factor NfκB and human disease. J Clin Invest 2001; 107: 3-6. ... We also observed that adrenomedullin treatment of pancreatic cancer cells activated the transcription factor NFκB. NFκB is a ... Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of ...http://cancerres.aacrjournals.org/content/67/6/2666
IκB kinase β inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells | Molecular...
The NF-κB/Rel family of transcription factors is comprised of homodimers and heterodimers of p65/RelA, c-Rel, RelB, NF-κB1/p50 ... Expression of constitutively active NF-κB RelA transcription factor in blasts of acute myeloid leukemia. Hum Pathol 2004;35:246 ... Additionally, we reported previously that BCR-ABL activates the transcription factor nuclear factor-κB (NF-κB) in a manner ... BCR-ABL activates the transcription factor nuclear factor-κB (NF-κB) at least partly in a manner dependent on Ras (6). ...http://mct.aacrjournals.org/content/7/2/391.long
Nuclear Factor-κB Modulation in Patients Undergoing Induction Chemotherapy for Acute Myelogenous Leukemia | Clinical Cancer...
Expression of constitutively active nuclear-κB RelA transcription factor in blasts of acute myeloid leukemia. Hum Pathol 2004; ... One potential AML and LSC target is the transcription factor nuclear factor-κB (NF-κB) family. NF-κB transcription factors ... The nuclear transcription factor κB/bcl-2 pathway correlates with pathologic complete response to doxorubicin-based neoadjuvant ... Nuclear factor-κB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-κB- ...http://clincancerres.aacrjournals.org/content/14/22/7564
The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin ... where it is thought to participate in the regulation of gene transcription through the phosphorylation of transcription factors ... Glycogen synthase kinase-3β participates in nuclear factor-κB-mediated gene transcription and cell survival in pancreatic ... There are numerous factors that contribute to progression of this disease, including constitutively active nuclear factor-κB ( ...http://clincancerres.aacrjournals.org/content/12/17/5074
The AMEDEO Literature Guide
The NF-kappaB transcription factor RelA is required for the tolerogenic function of Foxp3(+) regulatory T cells.. J Autoimmun. ... The genetic basis of systemic lupus erythematosus: What are the risk factors and what have we learned.. J Autoimmun. 2016 Aug ... Expression level of risk genes of MHC class II is a susceptibility factor for autoimmunity: New insights.. J Autoimmun. 2018 ... Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with ...https://amedeo.com/medicine/aut/jauto.htm
IL-17 Boosts Proinflammatory Outcome of Antiviral Response in Human Cells | The Journal of Immunology
... and chemical inhibitors demonstrate a critical role of the transcription factors RelA and IFN regulatory factor 3 (IRF3) and I ... Poly(I:C)/IL-17 synergistic induction of gene expression relies on the transcription factors RelA and IRF3. A-C, HSFs were ... which at the transcriptional level involves IKKs and transcription factors IRF3 and RelA. It would therefore be interesting to ... is mediated by IKKs and also depends on the IRF3 and RelA transcription factors. ...http://www.jimmunol.org/content/187/10/5357
OPUS at UTS: Dimethylfumarate inhibits NF-κB function at multiple levels to limit airway smooth muscle cell cytokine secretion ...
Transcription Factor RelA. en_US. dc.subject.mesh. Tumor Necrosis Factor-alpha. en_US. ... DMF decreases the expression of proinflammatory mediators by inhibiting the transcription factor NF-κB and might therefore be ... DMF decreases the expression of proinflammatory mediators by inhibiting the transcription factor NF-κB and might therefore be ... In this study, we determined the effect of DMF on platelet-derived growth factor (PDGF)-BB- and TNFα-induced asthma-relevant ...https://opus.lib.uts.edu.au/handle/10453/29765
"Acute alcohol exposure exerts anti-inflammatory effects by inhibiting " by Pranoti Mandrekar, Valentina Jeliazkova et al.
Transcription Factor RelA ...https://escholarship.umassmed.edu/oapubs/1291/
Galectin-1 promotes tumor progression via NF-κB signaling pathway in epithelial ovarian cancer
Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. Clin ... NF-κB is an important multifunctional transcription factor, with a wide range of biological activities. Studies have shown high ... Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nat Rev Cancer. 2002;2:289-300 ... Expression and regulation of tumor necrosis factor alpha in normal and malignant ovarian epithelium. Molecular cancer ...http://www.jcancer.org/v08p3733.htm
Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the...
Nuclear factor-κB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. Clin Cancer ... Series introduction: the transcription factor NF-κB and human disease. J Clin Invest. 2001;107(1):3-6 ... which function as transcription factors and consist of special DNA binding peptides that participate in cellular physiological ... Wang et al. reported that the tumor necrosis factor α (TNF-α) is a regulator of tumor cell apoptosis in a hERG1 expression ...http://jcancer.org/v07p0746.htm
Or Gozani | Stanford Medicine Profiles
This enzyme had previously been shown to methylate the transcription factor RelA, but it was not known whether SETD6 had other ... In addition to histones, several other nuclear factors such as the tumor suppressor and transcription factor p53 undergo lysine ... Here we report that, in contrast to the PHD fingers of the bromodomain PHD finger transcription factor (BPTF) and inhibitor of ... SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-κB). The ankyrin repeats of G9a- ...https://med.stanford.edu/profiles/or-gozani
Ash A. Alizadeh, MD/PhD | Stanford Medicine Profiles
This enzyme had previously been shown to methylate the transcription factor RelA, but it was not known whether SETD6 had other ... transcription factors. This enhancement was nearly abolished by blocking the nuclear translocation of NFATc by using the ... as evidenced by the potent phenotypes that result from disruption of transcription factor genes in mice. It is now possible to ... Combining these three factors segregates patients in three well-defined risk groups. These data suggest that ALC can be used in ...https://med.stanford.edu/profiles/arash-alizadeh
Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig
Transcription factor assay to determine relative amounts of activated RELA. Nuclear (light bars; day effect, P = 0.005) and ... Transcription factor ELISA demonstrated an overall increase in RELA during the peri-implantation period in both cyclic and ... Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig. Jason ... subunit RELA in nuclear and cytoplasmic protein extractions was determined using the TransAM NFKB RELA transcription factor ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2876169/
Origins of γδ T Cell Effector Subsets: A Riddle Wrapped in an Enigma | The Journal of Immunology
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production ... The link between transcription factor expression and effector fate was then re-established upon maturation into CD24lo cytokine ... TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR ... A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity 38: 681-693. ...http://www.jimmunol.org/content/193/9/4289