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*  A-867744 | Antibody-based exosite inhibitors of ADAMTS-5
Neratinib NPI-2358 Omecamtiv mecarbil Otamixaban PD173074 Pevonedistat PKI-402 Rabbit Polyclonal to DP-1 Rabbit Polyclonal to ... The initial two factors are because of the two-stage activation procedure for clopidogrel, involving several cytochrome P450 ... Signal Transducers and Activators of Transcription *Sirtuin *Syk Kinase *T-Type Calcium Channels ...
http://isvhld2012.org/tag/a-867744/
*  Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Osteoblasts - drug effects Osteoblasts - metabolism ... The observed 15d-PGJ2-mediated signalling events are independent of PGD2 receptors (DP1 and DP2) and PPARγ. In addition, the ... This pathway induced nuclear expression of Nrf2 and Egr1, and increased transcription of haem oxygenase-1 (HO-1) and the ...
https://forschung.medunigraz.at/fodok/suchen.publikationen_mug_autoren?sprache_in=de&menue_id_in=205&id_in=4030&publikation_id_in=149785
*  ncbi.life | The Human Reference Genome
... transcription factor Dp family member 3 (TFDP3) transcription factor Dp-1 (TFDP1) transcription factor Dp-1-like pseudogene ( ... E2F transcription factor 6 (E2F6) E2F transcription factor 6 pseudogene 4 (E2F6P4) E74 like ETS transcription factor 4 (ELF4) ... transcription elongation factor A like 1 (TCEAL1) transcription elongation factor A like 2 (TCEAL2) transcription elongation ... transcription elongation factor A like 4 (TCEAL4) transcription elongation factor A like 5 (TCEAL5) transcription elongation ...
https://ncbi.life/CX
*  Niacin ameliorates ulcerative colitis via prostaglandin D2‐mediated D prostanoid receptor 1 activation | EMBO Molecular Medicine
DP1F/F, DP1F/F/Tie2Cre, DP1F/F/LysMCre, DP1F/F/SM22Cre n = 6; DP1F/F/VillinCre, n = 7. (C, D) **P , 0.01 vs. DP1F/F. ... The reverse transcription reactions were performed by use of Reverse Transcription Reagent kits (Takara, Otsu, Shiga, Japan). ... tumor necrosis factor‐α (TNF‐α), MCP‐1] is markedly induced and expression of anti‐inflammatory genes (IL‐4, IL‐5, and IL‐10) ... DP1F/F; DP1F/F, DP1F/F/SM22Cre, n = 8; DP1F/F/Tie2Cre, DP1F/F/VillinCre, DP1F/F/LysMCre, n = 7. ...
http://embomolmed.embopress.org/content/9/5/571
*  Ubiquitin Isopeptidase | Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors
Transcription Factors *Transferases *Transforming Growth Factor Beta Receptors *Transporters *TRH Receptors *Triphosphoinositol ... As proven in Amount 2, Rabbit Polyclonal to DP-1. IRI triggered kidney dysfunction in charge Ig-treated mice, Huperzine A shown ...
http://researchreport-digital.com/category/ubiquitin-isopeptidase/
*  Seiji Nishino | Stanford Medicine Profiles
These rats exhibited FOS, a transcription factor, in 21% of their orexin neurons and in 1.0% of their melanin-concentrating ... Wake-promoting effects of ONO-4127, a prostaglandin DP1 receptor antagonist, in hypocretin deficient narcoleptic mice 21st ... and genetic factors other than HLA-DQ are also likely to be implicated. In addition, environmental factors are involved in ... EFFECTS OF INTRAVENOUS ADMINISTRATION OF PROSTAGLANDINS ON CANINE NARCOLEPSY 2ND INTERNATIONAL SYMP ON ENDOGENOUS SLEEP FACTORS ...
https://med.stanford.edu/profiles/seiji-nishino
*  WO2007081841A2 - Reaction buffer composition for nucleic acid replication with packed dna polymerases - Google Patents
DNA polymerase-related factors WO2001009347A2 (en) 1999-07-30. 2001-02-08. Stratagene. Archaeal replication accessory factors ... Pyrococcus furiosus DP1/DP2 2-subunit DNA polymerase). 'Archaeal' DNA polymerase refers to a thermostable DNA polymerases ... High temperature reverse transcription using mutant- type dna polymerase Legal Events. Date. Code. Title. Description. ... 0023] PCR enhancing factors may also be used to improve efficiency of amplification. As used herein, a 'PCR enhancing factor' ...
https://patents.google.com/patent/WO2007081841A2/en
*  Endothelin-Converting Enzyme
... Azacitidine small molecule kinase inhibitor, order Troglitazone, Rabbit Polyclonal to DP-1, Rabbit ... have already been used to handle fundamental biological concerns such as for example RNA localization and active transcription ... an extremely conserved transforming growth factor (TGF)-family member and potent negative regulator of skeletal muscle growth. ... there's a significant relationship in osteosarcoma between CXCR4 and manifestation of vascular endothelial development factor ( ...
http://www.ovarian-cancersymptoms.com/category/endothelin-converting-enzyme/
*  Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes | Molecular Systems...
Three of these complexes-the exosome complex, eukaryotic initiation factor 3 (eIF3) complex, and the 19S proteasome-were ... and DP1 GM106408, R01 DK110520, R35 GM122480 to E.M.M.), NSF and CPRIT (to E.M.M.), and the Welch foundation (F‐1515, to E.M.M ... Xenopus laevis cDNA was prepared by reverse transcription (SuperScriptIII First‐Strand Synthesis, Invitrogen), and KIAA1328, ... dx.doi.org/10.13039/100000002 F32 GM1124951R01 HL117164R21 GM119021R01 HD085901DP1 GM106408R01 DK110520R35 GM122480 ...
http://msb.embopress.org/content/13/6/932.share
*  Cooperative activation of tissue-specific genes by pRB and E2F...
Cooperative activation of tissue-specific genes by pRB and E2F1.: The retinoblastoma tumor suppressor protein pRB is conventionally regarded as an inhibitor of
https://www.mysciencework.com/publication/show/cooperative-activation-tissue-specific-genes-prb-e2f1-ff5f521e
*  p53 and Retinoblastoma protein (pRb): A complex network of interactions - Semantic Scholar
p53 and the Retinoblastoma protein (pRb) are two oncosuppressive proteins whose loss of function is linked to the development of many cancers. Both of them play a central role in the regulation of both cell cycle and apoptosis. Different observations have led to a paradigm in which p53 and pRb can regulate each other, pRb playing an important role in the outcome-growth arrest versus apoptosis-of p53 activation.
https://www.semanticscholar.org/paper/p53-and-Retinoblastoma-protein-pRb-A-complex-netwo-Godefroy-Lemaire/1b11c0e04f8ee310683efa277b29c4c21cc27f3a
*  Liquid biopsy could lead to precision therapies for retinoblastoma tumors
Researchers have found a non-invasive way to biopsy retinoblastoma tumors, which could enable precision therapies for children with the rare cancer.
https://www.statnews.com/2017/10/12/retinoblastoma-liquid-biopsy/
*  miR-145 inhibits cell proliferation through E2F3 depend | Open-i
miR-145 inhibits cell proliferation through E2F3 dependent cell cycle regulation(A) qRT-PCR were performed to determine the expression level of E2F3 after tra
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4480708_oncotarget-06-7675-g006&req=4
*  DP-022W Data Protection Implementation for Windows using NetBackup 5.0 Test Answer | Plaza de la Exam
Latest Exam Dumps Veritas DP-022W Demo, Latest Exam Dumps DP-022W Pdf With Accurate Answers Data Protection Implementation for Windows using NetBackup 5.0 Test Answer | Plaza de la Exam
http://www.plazadelatecnologia.com/ccna.php?exam=DP-022W.html
*  Frontiers | Ectopic Expression of the Wild Grape WRKY Transcription Factor VqWRKY52 in Arabidopsis thaliana Enhances Resistance...
WRKY transcription factors are known to play important roles in plant responses to biotic stresses. We previously showed that the expression of the WRKY gene, VqWRKY52, from Chinese wild Vitis quinquangularis was strongly induced 24 h post inoculation with powdery mildew. In this study, we analyzed the expression levels of VqWRKY52 following treatment with the defense related hormones salicylic acid (SA) and methyl jasmonate (MeJA), revealing that VqWRKY52 was strongly induced by SA but not JA. We characterized the VqWRKY52 gene, which encodes a WRKY III gene family member, and found that ectopic expression in Arabidopsis thaliana enhanced resistance to powdery mildew and Pseudomonas syringae pv. tomato DC3000, but increased susceptibility to Botrytis cinerea, compared with wild type plants. The transgenic A. thaliana lines displayed strong cell death induced by the biotrophic powdery mildew pathogen, the hemibiotrophic Pseudomonas syringe pathogen and the necrotrophic ...
https://www.frontiersin.org/articles/10.3389/fpls.2017.00097/full
*  PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to...
Background: Congenital central hypoventilation syndrome (CCHS) is characterized by compromised chemo-reflexes that results in hypoventilation during sleep. Recently, a heterozygous PHOX2B gene mutation was identified in CCHS. This report was made to increase physicians' awareness of this rare disease.. Methods: A Chinese family of CCHS with presentations from newborn to adulthood and genetic analysis confirming the PHOX2B mutation was analyzed. After identifying central hypoventilation in an adult male (index case), clinical evaluation was performed on the complete family, which consisted of the parents, five siblings, and five offsprings. In addition, pulmonary function test, overnight polysomnography, arterial blood gas, and hypercapnia ventilatory response, and genetic screening for PHOX2B gene mutations were performed on living family members. ...
https://clinicaltrials.gov/ct2/show/NCT00652964?cond=CENTRAL+HYPOVENTILATION+SYNDROME%2C+CONGENITAL&rank=3
*  Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B Gene - Full Text View - ClinicalTrials.gov
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of respiratory control characterized by ventilatory impairment that results in arterial hypoxemia. This condition worse during sleep and occurs in patients with normal mechanical properties of the lung. It is diagnosed in the absence of primary neuromuscular disease, identifiable brainstem lesions, and other sleep disturbances or substance use.. Amiel et al. (2003) identified a mutation in the Phox2B gene associated with CCHS, characterized by 5 to 9 alanine expansions within a 20-residue polyalanine region in exon 3 of the Phox2B gene. Several reports confirmed the findings of Amiel et al., supporting the view that this gene is a master switch for the development of the autonomic nervous system network linked to respiratory control. Transgenic animals carrying the human Phox2B mutation develop a similar phenotype and lack glutamatergic neurons located in the parafacial region in the brainstem, which are involved in breathing ...
https://clinicaltrials.gov/ct2/show/NCT01225679?cond=%22Congenital+central+hypoventilation+syndrome%22&rank=1
*  Oestrogen nuclear receptor coactivator 1 | definition of oestrogen nuclear receptor coactivator 1 by Medical dictionary
Looking for online definition of oestrogen nuclear receptor coactivator 1 in the Medical Dictionary? oestrogen nuclear receptor coactivator 1 explanation free. What is oestrogen nuclear receptor coactivator 1? Meaning of oestrogen nuclear receptor coactivator 1 medical term. What does oestrogen nuclear receptor coactivator 1 mean?
http://medical-dictionary.thefreedictionary.com/oestrogen+nuclear+receptor+coactivator+1
*  Ventilatory responses to passive leg motion in children with congenital central hypoventilation syndrome.
During exercise, children with congenital central hypoventilation syndrome (CCHS) demonstrate coupling of VE to exercise load, despite the absence of a VE response to changes in FICO2. To assess the effect of movement on VE, we studied six CCHS patie
http://www.biomedsearch.com/nih/Ventilatory-responses-to-passive-leg/8564130.html
*  PLOS ONE: NF-Y Recruits Both Transcription Activator and Repressor to Modulate Tissue- and Developmental Stage-Specific...
The human embryonic, fetal and adult β-like globin genes provide a paradigm for tissue- and developmental stage-specific gene regulation. The fetal γ-globin gene is expressed in fetal erythroid cells but is repressed in adult erythroid cells. The molecular mechanism underlying this transcriptional switch during erythroid development is not completely understood. Here, we used a combination of in vitro and in vivo assays to dissect the molecular assemblies of the active and the repressed proximal γ-globin promoter complexes in K562 human erythroleukemia cell line and primary human fetal and adult erythroid cells. We found that the proximal γ-globin promoter complex is assembled by a developmentally regulated, general transcription activator NF-Y bound strongly at the tandem CCAAT motifs near the TATA box. NF-Y recruits to neighboring DNA motifs the developmentally regulated, erythroid transcription activator GATA-2 and general repressor BCL11A, which in turn ...
http://journals.plos.org/plosone/article/related?id=10.1371/journal.pone.0047175
*  开放获取论文一站式发现平台
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that are widely involved in various physiological functions. They are widely expressed through the reproductive system. Their roles in the metabolism and function of sex steroids and thus the etiology of reproductive disorders receive great concern. Various kinds of exogenous chemicals, especially environmental pollutants, exert their adverse impact on the reproductive system through disturbing the PPAR signaling pathway. Chemicals could bind to PPARs and modulate the transcription of downstream genes containing PPRE (peroxisome proliferator response element). This will lead to altered expression of genes related to metabolism of sex steroids and thus the abnormal physiological function of sex steroids. In this review, various kinds of environmental ligands are summarized and discussed. Their interactions with three types of PPARs are classified by various data from transcript profiles, PPRE reporter ...
http://gooa.las.ac.cn/external/index?type=-1&pid=1425560
*  Activation of the carbohydrate response element binding protein (ChRESP) in response to anoxia in the turtle Trachemys scripta...
Background: ChREBP (carbohydrate response element binding protein) is a glucose-responsive transcription factor that is known to be an important regulator of glycolytic and lipogenic genes in response to glucose. We hypothesized that activation of ChREBP could be relevant to anoxia survival by the anoxia-tolerant turtle, Trachemys scripta elegans. Methods: Expression of ChREBP in response to 5 and 20 h of anoxia was examined using RT-PCR and Western immunoblotting. In addition, subcellular localization and DNA-binding activity of ChREBP protein were assessed and transcript levels of liver pyruvate kinase (LPK), a downstream gene under ChREBP control were quantified using RT-PCR. Results: ChREBP was anoxia-responsive in kidney and liver, with transcript levels increasing by 1.2-1.8 fold in response to anoxia and protein levels increasing by 1.8-1.9 fold. Enhanced nuclear presence under anoxia was also observed in both tissues by 22-2.8 fold. A 4.2 fold increase in DNA binding ...
http://publications.lib.chalmers.se/publication/203994-activation-of-the-carbohydrate-response-element-binding-protein-chresp-in-response-to-anoxia-in-the
*  Biomolecules | Free Full-Text | Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter...
Chronic alcohol consumption induces multi-organ damage, including alcoholic liver disease (ALD), pancreatitis and hypertension. Ethanol and ethanol metabolic products play a significant role in the manifestation of its toxicity. Ethanol metabolizes to acetaldehyde and produces reduced nicotinamide adenine dinucleotide (NADH) by cytosolic alcohol dehydrogenase. Ethanol metabolism mediated by cytochrome-P450 2E1 causes oxidative stress due to increased production of reactive oxygen species (ROS). Acetaldehyde, increased redox cellular state and ROS activate transcription factors, which in turn activate genes for lipid biosynthesis and offer protection of hepatocytes from alcohol toxicity. Sterol regulatory element binding proteins (SREBPs) and peroxisome proliferator activated-receptors (PPARs) are two key lipogenic transcription factors implicated in the development of fatty liver in alcoholic and non-alcoholic steatohepatitis. SREBP-1 is ...
http://www.mdpi.com/2218-273X/6/3/29/htm
*  Liver X receptor beta - Wikipedia
Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). The liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins. Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element. Liver X ...
https://en.wikipedia.org/wiki/Liver_X_receptor_beta
*  HKU Scholars Hub: Dual transcriptional control of claudin-11 via an overlapping GATA/NF-Y motif: Positive regulation through...
The expression of claudin-11, a key integral tight junction protein, is tightly regulated to ensure that the integrity of the seminiferous epithelium could be maintained during the translocation of spermatocytes at the blood-testis barrier at stages VIII-IX. In this study, we elucidate how the overlapping GATA/NF-Y motif within the core promoter of claudin-11 gene is modulated by differential binding of various transcription factors, resulting in dual transcriptional control. Using electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assay, we confirmed that GATA, nuclear factor YA (NF-YA), and cAMP response element-binding protein (CREB) form a complex in vivo and bind to the GATA/NF-Y region to promote claudin-11 gene transcription. Such gene activations were significantly reduced in the presence of siRNA specific to these transcription factors. GATA and ...
http://hub.hku.hk/handle/10722/84938