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*  Or Gozani | Stanford Medicine Profiles
This enzyme had previously been shown to methylate the transcription factor RelA, but it was not known whether SETD6 had other ... In addition to histones, several other nuclear factors such as the tumor suppressor and transcription factor p53 undergo lysine ... Here we report that, in contrast to the PHD fingers of the bromodomain PHD finger transcription factor (BPTF) and inhibitor of ... SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa B (NF-κB). The ankyrin repeats of G9a- ...
https://med.stanford.edu/profiles/or-gozani
*  Ash A. Alizadeh, MD/PhD | Stanford Medicine Profiles
This enzyme had previously been shown to methylate the transcription factor RelA, but it was not known whether SETD6 had other ... transcription factors. This enhancement was nearly abolished by blocking the nuclear translocation of NFATc by using the ... as evidenced by the potent phenotypes that result from disruption of transcription factor genes in mice. It is now possible to ... Combining these three factors segregates patients in three well-defined risk groups. These data suggest that ALC can be used in ...
https://med.stanford.edu/profiles/arash-alizadeh
*  Paul Utz | Stanford Medicine Profiles
This enzyme had previously been shown to methylate the transcription factor RelA, but it was not known whether SETD6 had other ... Polymorphisms in the transcription factor IFN regulatory factor 5 (IRF5) are strongly associated in human genetic studies with ... Utz co-discovered the transcription factor Nuclear Factor of Activated T Cells (NFAT) with J.P. Shaw in Dr. Gerald Crabtree's ... The presence of nuclear factor kappa B (NF kappa B), a B-lymphocyte-associated transcription factor, was demonstrated in ...
https://med.stanford.edu/profiles/paul-utz
*  Howard Y. Chang, MD PhD | Stanford Medicine Profiles
... cells mediated by the transcription factors Ascl1, Brn2, and Myt1l. Ascl1 acts as an "on-target" pioneer factor by immediately ... The majority of genes bound by NF-κB subunit RelA recruit Sirt6, and dynamic Sirt6 relocalization is largely driven in a RelA- ... The transcription factor ZNF217 is a candidate oncogene in the amplicon on chromosome 20q13 that occurs in 20% to 30% of ... The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression CANCER ...
https://med.stanford.edu/profiles/howard-chang
*  Rona Giffard | Stanford Medicine Profiles
Activation of the NF-κB transcription factor and its associated gene expression in microglia is a key component in the response ... Unexpectedly we find that Hsp72 overexpression reduces the initial amount of the RelA/p65 NF-κB subunit in cells, contributing ... We then sought evidence of heat shock transcription factor-1 (HSF-1) activation. An increase in apparent molecular weight of ... We study the effects of Hsp72 overexpression on activation of the transcription factor NF-κB in microglia combining ...
https://med.stanford.edu/profiles/rona-giffard
*  Sharon R. Long | Stanford Medicine Profiles
An ERF transcription factor in Medicago truncatula that is essential for nod factor signal transduction PLANT CELL Middleton, P ... and another reduces transcription of all genes tested in comparison to that in the relA parent strain. Our findings indicate ... σ factors and other transcription factors, and regulatory RNAs. ... Here, we identify an ERF transcription factor, ERF Required for ... Using Nod factor-induced calcium spiking as a tool to identify mutants blocked early in the response to Nod factor, we show ...
https://med.stanford.edu/profiles/sharon-long
*  AC Matin | Stanford Medicine Profiles
GROWTH-FACTOR REQUIREMENT OF THIOBACILLUS-NOVELLUS ARCHIVES OF MICROBIOLOGY Matin, A., KAHAN, F. J., LEEFELDT, R. H. 1980; 124 ... Taken together, these data suggest that the H-NS protein inhibits transcription in E. coli of the lux systems of all or most ... and RelA. For most of the above, tolerance does not appear if induction occurs and NaCl, sucrose, SDS or DOC are present. For ... THE PUTATIVE SIGMA-FACTOR KATF IS REGULATED POSTTRANSCRIPTIONALLY DURING CARBON STARVATION JOURNAL OF BACTERIOLOGY McCann, M. P ...
https://med.stanford.edu/profiles/ac-matin