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*  IκB kinase β inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells | Molecular...
The NF-κB/Rel family of transcription factors is comprised of homodimers and heterodimers of p65/RelA, c-Rel, RelB, NF-κB1/p50 ... Expression of constitutively active NF-κB RelA transcription factor in blasts of acute myeloid leukemia. Hum Pathol 2004;35:246 ... Additionally, we reported previously that BCR-ABL activates the transcription factor nuclear factor-κB (NF-κB) in a manner ... BCR-ABL activates the transcription factor nuclear factor-κB (NF-κB) at least partly in a manner dependent on Ras (6). ...
http://mct.aacrjournals.org/content/7/2/391.long
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The NF-κB3/Rel family of transcription factors is comprised of RelA, RelB, c-Rel, p50 (nfκb1), and p52 (nfκb2; Ref. 1). ... Chromosomal localization of genes encoding the transcription factors, c-rel, NF-κBp50, NF-κBp65, and lyt-10 by fluorescence in ... Weidner, N. Intratumor microvessel density as a prognostic factor in cancer. Am. J. Pathol., 147: 9 -19,1995 .. ... Increased levels of NF-κB subunits, including p50, p52, and RelA, were found in SUM149 cells in comparison with immortalized ...
http://mct.aacrjournals.org/content/2/7/617
*  A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein | Molecular Cancer Therapeutics
S3C). Moreover, the fact that BRD32048 did not bind to low isoelectric point surfaces (such as TBX21 and RELA) suggests that ... Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase ... of oncogene transcription factors in general and ETS factors in particular.. Small molecule microarray (SMM) screening has been ... A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein. Marius S. Pop, Nicolas Stransky, Colin W. ...
http://mct.aacrjournals.org/content/13/6/1492.long
*  YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells | Molecular...
The NF-κB/Rel family of transcription factors is composed of five mammalian homologues: Rel (also known as c-Rel), RelA (also ... The transcription factor is subsequently translocated from the cytoplasm to the nucleus, where it binds to cognate sequences in ... The NF-κB/p65 transcription factor ELISA kits purchased from Active Motif, Inc. (Carlsbad, CA) were used for the detection of ... Shukla S, Gupta S. Suppression of constitutive and tumor necrosis factor α-induced nuclear factor (NF)-κ B activation and ...
http://mct.aacrjournals.org/content/4/10/1628
*  Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-κB signaling | Molecular...
NF-κB refers to a family of transcription factors [p50, p65 (RelA), p52, RelB, c-Rel] that form homo- and heterodimers and ... Genes regulated by Notch include helix-loop-helix inhibitory transcription factors of the Hes (Hairy/Enhancer of Split) and the ... a transcription factor that is normally bound to DNA sequences in the presence of a corepressor complex containing silencing ... CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc Natl Acad Sci U S A 1999;96:23- ...
http://mct.aacrjournals.org/content/6/7/1983.full
*  Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases...
... through TNF induction of the NFκB2/RelB or NFκB1/RelB transcription factors, and subsequent binding of the NFκB complex to the ... TNF-neutralizing antibodies inhibited the activation of the RelA subunit of nuclear factor-κB (NFκB) and induced the apoptosis ... Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev 2002;13:135-41. ... The epidermal growth factor receptor is not required for tumor necrosis factor-α action in normal mammary epithelial cells. ...
http://mct.aacrjournals.org/content/8/9/2655
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To this end, we have recently shown that the transcription factor NF-κB activates a survival program that protects mammalian ... The anti-RelA-supershifted complex is not seen in these autoradiograms as it can often be too large to enter the gel (12). B, ... NF-κB, however, is a master transcription factor with multiple functions, and agents that inhibit NF-κB therefore have numerous ... 1/2-mediated phosphorylation of the transcription factor STAT1, which then translocates to the nucleus and transactivates ...
http://mct.aacrjournals.org/content/12/8/1568
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NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res 2003;Suppl:S75-85. ... Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. Mol Cell Biol 2010;30:2170-80. ... and stability of transcription factors but also to other cellular proteins by acetylation (3). For that reason, HATs are also ... Both proteins are fundamental coactivators of a large number of transcription factors by remodeling chromatin. Moreover, p300 ...
http://mct.aacrjournals.org/content/10/9/1644
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The role of IKK in constitutive activation of NF-κB transcription factor in prostate carcinoma cells. J Cell Sci 2002;115:141- ... MUC1-C interacts with both IKKβ and RelA and contributes to constitutive NF-κB activation (9, 10). Therefore, it is formally ... MUC1-C oncoprotein functions as a direct activator of the NF-κB p65 transcription factor. Cancer Res 2009;69:7013-21. ... MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. J Biol Chem 2004;279: ...
https://mct.aacrjournals.org/content/8/11/3056
*  Nuclear factor κB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos ...
The nuclear factor κB (NF-κB) family of transcription factors represents a diverse and shared signaling mechanism activated ... Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κ B. Nature 1995;376:167-70. ... Acquisition of stable inducible up-regulation of nuclear factor-κB by tumor necrosis factor exposure confers increased ... an oxidant-responsive bZIP transcription factor (40, 41). Whereas EP is an effective ROS scavenger in irradiated zebrafish ...
http://mct.aacrjournals.org/content/8/9/2625
*  SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-κB...
... of these nuclear transcription factors to the Sin3A complex and targets the repressor complex to the transcription factor ... A critical role for the RelA subunit of nuclear factor κB in regulation of multiple immune response genes and in Fas-induced ... IκB kinase α and p65/RelA contribute to optimal epidermal growth factor-induced c-fos gene expression independent of IκBα ... These are often targeted to specific DNA sequences by the binding of nuclear transcription factors. The Sin3 proteins (A and B ...
http://mct.aacrjournals.org/content/8/6/1625
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MUC1-C oncoprotein functions as a direct activator of the NF-kappaB p65 transcription factor. Cancer Res 2009;69:7013-21. ... NF-κB RelA (26, 27), and STAT1/3 (28, 29) signaling. In concert with these functions, an inhibitor of MUC1-C oligomerization ... Transforming growth factor {alpha} dependent cancer progression is modulated by MUC1. Cancer Res 2007;67:6591-8. ... Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology. J Clin ...
http://mct.aacrjournals.org/content/10/5/806