Reversal of Physiological Stress-Induced Resistance to Topoisomerase II Inhibitors Using an Inducible Phosphorylation Site- ... Reversal of Physiological Stress-Induced Resistance to Topoisomerase II Inhibitors Using an Inducible Phosphorylation Site- ... Reversal of Physiological Stress-Induced Resistance to Topoisomerase II Inhibitors Using an Inducible Phosphorylation Site- ... Reversal of Physiological Stress-Induced Resistance to Topoisomerase II Inhibitors Using an Inducible Phosphorylation Site- ...

... which are broken into two broad subtypes: type I topoisomerases (TopI) and type II topoisomerases (TopII). Topoisomerase plays ... Topoisomerase inhibitors influence these essential cellular processes. Some topoisomerase inhibitors prevent topoisomerases ... Andoh, Toshiwo; Ishida, Ryoji (1998-10-01). "Catalytic inhibitors of DNA topoisomerase II". Biochimica et Biophysica Acta (BBA ... Ganapathi, Ram N.; Ganapathi, Mahrukh K. (2013-08-01). "Mechanisms regulating resistance to inhibitors of topoisomerase II". ...

Two predominant and clinically significant types of therapy-related myeloid neoplasms (t-MN) have been defined, those arising ... Topoisomerase II inhibitors. Cases of therapy-related myeloid neoplasms (t-MNs) arising after use of topoisomerase II ... Acute myeloid leukemia from a patient who presented 10 months after therapy with topoisomerase II inhibitor. View Media Gallery ... Acute myeloid leukemia from a patient who presented 10 months after therapy with topoisomerase II inhibitor. View Media Gallery ...

Topoisomerase I/II inhibitor 3 (compound 7) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase ... We do not sell to patients.Topoisomerase I/II inhibitor 3Biological Activity： ... I/II inhibitor 3 can inhibit cell proliferation, invasion and migration, and induce apoptosis by inhibiting PI3K/Akt/mTOR ... Topoisomerase I/II inhibitor 3 (compound 7) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase ...

A new series of triazolophthalazine derivatives was designed and synthesized as topoisomerase II (Topo II) inhibitors and DNA ... Discovery of novel triazolophthalazine derivatives as DNA intercalators and topoisomerase II inhibitors. Sakr, Helmy,Ayyad, ... Additionally, compound IXb showed Topo II poisoning effects at 2.5 μM and Topo II catalytic inhibitory effects at 5 and 10 μM. ... Finally, molecular docking studies were carried out against the DNA-Topo II complex and DNA, to investigate the binding ...

Topoisomerase II Inhibitors. *Topoisomerase I Inhibitors. *Thyroid Cancer. *Tumor Suppressor Proteins. *Chromosome 20 ... Topoisomerase IIα expression correlated with cavernous sinus invasion.. CONCLUSIONS: The topoisomerase IIα expression ... that OTIs can be used to direct the sites of etoposide-induced DNA cleavage mediated by topoisomerase IIα and topoisomerase IIβ ... bacterial topoisomerase inhibitors and regulatory proteins may inspire the discovery of novel human topoisomerase inhibitors. ...

"The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines". Oncology ... The DNA Topoisomerase II Inhibitor Hypothesis: A Report from the Childrens Oncology Group". Cancer Epidemiology, Biomarkers & ... "Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II". Cancer Research. 49 (18): ... "Bioflavonoids as Poisons of Human Topoisomerase IIα and IIβ". Biochemistry. 46 (20): 6097-108. doi:10.1021/bi7000664. PMC ...

Similar events related to treatment with DNA topoisomerase II inhibitors? Leukemia 1997;11:1571-1574. ... 2.. Sharon WW, John RG: Malignant Fibrohistiocytic Tumors: Soft Tissue Tumors. St. Louis, Mosby, 2001, pp 535-570. ...

Epipodophyllotoxin, topoisomerase II inhibitor. Plant alkaloid. NSC Number. 141540. Primary Site. Gastric cancer ...

Lee, J.H.; Wendorff, T.J.; Berger, J.M. Resveratrol: A novel type of topoisomerase II inhibitor. J. Biol. Chem. 2017, 292, ... The ASFV type II topoisomerase (P1192R) [36,37] is likewise absent from the ASFV proteome, but has been detected at ... Garcia-Beato, R.; Freije, J.M.P.; López-Otín, C.; Blasco, R.; Viñuela, E.; Salas, M.L. A gene homologous to topoisomerase II in ... Coelho, J.; Leitão, A. The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control. ...

The drug inhibits topoisomerase II and produces free radicals, which may cause destruction of DNA; these 2 events can, in turn ... Selective Inhibitor of Nuclear Export. Class Summary. A selective inhibitor of nuclear export (SINE) acts on tumor suppressor ... It inhibits topoisomerase II and produces free radicals, which may cause destruction of DNA; these 2 events, in turn, can ... CXCR4 Inhibitors. Class Summary. These drugs inhibit the C-X-C motif chemokine receptor 4 (CXCR4) and block binding of its ...

Topoisomerase inhibitors are further segmented into Topoisomerase I inhibitors and Topoisomerase II inhibitors. ... topoisomerase inhibitors, mitotic inhibitors, and others. Alkylating agents are further segmented into mustard gas derivatives ...

Homology modeling of trypanosoma cruzi topoisomerase ii and docking of putative inhibitors ... In vivo mutagenicity test in two samples of artemisinine.. Invitro pharmacological evaluations of s-adenosyl l-methionine on ... Tackling the Internet and Patient Safety - Part II (Enforcement). Update on WHO activities and International Medical Products ... Development of culture-specific pictograms for type ii diabetes patient counseling. Development of the medication error ...

Antineoplastics, Topoisomerase Inhibitors. Class Summary. Topoisomerase inhibitors inhibit cell growth and proliferation. ... It acts throughout the entire cell cycle and by direct intercalating into DNA triggers DNA breakage by topoisomerase II, ... Antineoplastics, VEGF Inhibitor. Class Summary. Vascular endothelial growth factor inhibitors reduce tumor vascularity and ... which is composed of a cleavable linker and topoisomerase inhibitor (DXd). The drug binds to HER2 on tumors and undergoes ...

... is a potent topoisomerase I poison and topoisomerase II catalytic inhibitor. Ann N Y Acad Sci ... As a dual topoisomerase inhibitor, BN80927 should be compared with other recently reported dual inhibitors of topoisomerase (32 ... Etievant C, Kruczynski A, Barret JM, et al F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of ... Dual topoisomerase I/II inhibitors in cancer therapy. Curr Top Med Chem ...

Absence of NSMCE2 affects survival upon topoisomerase II inhibitor etoposide-induced DNA double-strand breaks double-strand ... Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in ... non-SMC element 2, MMS21 homolog. non-structural maintenance of chromosomes element 2 homolog. zinc finger, MIZ-type containing ... Transcript Variant: This variant (2) lacks an alternate exon in the 5 UTR compared to variant 1. Variants 1-3 encode the same ...

DG01529 Topoisomerase inhibitor. DG01527 Topoisomerase II inhibitor. DG00702 Pirarubicin. D08386 Pirarubicin hydrochloride. ... DNA topoisomerase. TOP2. D08386 Pirarubicin hydrochloride ,JP,. Drug groups [BR:br08330]. Antineoplastic. DG01682 Anthracycline ... 2 O2x O 31.4300 -21.4200. 3 C1x C 32.6200 -20.7200. 4 C1x C 32.6900 -19.3200. 5 C1x C 31.3600 -18.6200. 6 C1x C 30.1700 - ... DG01529 Topoisomerase inhibitor. DG01527 Topoisomerase II inhibitor. DG00702 Pirarubicin. BRITE hierarchy. Other DBs. CAS: ...

Topoisomerase II beta/TOP2B antibody [EPR5377]. Validated in WB, IHC, ICC/IF, Flow Cyt (Intra) and tested in Mouse, Rat, Human ... Flörkemeier I et al. High Antitumor Activity of the Dual Topoisomerase Inhibitor P8-D6 in Breast Cancer. Cancers (Basel) 14:N/A ... Anti-Topoisomerase II alpha + Topoisomerase II beta/TOP2B antibody [EPR5377]. See all Topoisomerase II alpha+Topoisomerase II ... Topoisomerase II beta/TOP2B antibody [EPR5377] (ab200993) *Alexa Fluor® 488 Anti-Topoisomerase II alpha + Topoisomerase II beta ...

A Mini Review of Novel Topoisomerase II Inhibitors as Future Anticancer Agents. Publication Type: Academic Journal ... Abstract: Several reviews of inhibitors of topoisomerase II have been published, covering research before 2018. Therefore, this ... Separation of SNP profiles from DNA mixtures with two contributors via massively parallel sequencing technology. Publication ... Academic Journals (1,278) Magazines (2) Books (1) Conference Materials (1) Subject. nucleic acids (212) genetics (184) ...

Adenovirus-mediated E2F-1 gene transfer sensitizes melanoma cells to apoptosis induced by topoisomerase II inhibitors. Cancer ... particularly topoisomerase II poisons in vitro and in vivo. These results suggested a new chemosensitization strategy for ... Uni-variate two-sided analysis of matched t-test for dependent samples was used, the dose-response curve was obtained using ... B: Two days after adding 50 μg/ml of GCV, cells became round and smaller, losing their normal morphology. C: Four days after ...

Antitumor agent comprising the histone deacetylase inhibitor FK228 and a topoisomerase II inhibitor ... Topoisomerase ii poison and bis-dioxypiperazine derivative combination therapy KR20230043062A (en) 2023-03-30. Pharmaceutical ... Use of vegf inhibitors for the treatment of human cancer CA2570887C (en) * 2004-06-18. 2014-09-16. Genentech, Inc.. Tumor ... 상기 겜시타빈은 유방암, 난소암 또는 췌장암 등 여러 암에 대하여 사용되는 항암제로서, 세포 사멸과 관련된 DNA 생성을 억제하는 효과를 가진다.The streptonigrin is a Tgase2 inhibitor ...

Alkylating agents and topoisomerase II inhibitors induce therapy related leukemia.. Chromosome changes of the same type in ... Chromosomal changes in AML related to topoisomerase II inhibitors are rearrangement abnormalities without gain or loss of ... Alkylating agents or radiation related and topoisomerase II inhibitor related acute myelogenous leukemia are often related to ... Certain alkylating agents like melphalan, platinum compounds, and topoisomerase II inhibitors like etoposide reported to confer ...

2,3] Population-based data suggests that guidelines for therapy are not uniformly followed in community practice.[4] In ... for women with stage II disease, 25% for women with stage III disease, and 15% for women with stage IV disease. Among women ... Agents currently under evaluation include the topoisomerase I inhibitor topotecan (Hycamtin), gemcitabine (Gemzar), and two ... Adjuvant Treatment of Early-Stage (FIGO I/II) Title: A Randomized Phase III Trial of IV Carboplatin (auc 6) and Paclitaxel 175 ...

Teniposide [Vumon]: Type II topoisomerase inhibitors * What to worry about with Cytarabine [Cytosar-U]? ... The only TWO taxoid mitotic inhibitors each have unique and serious AEs. What are the agents and what AEs to watch for? ... Mitotic inhibitors: b/c act during mitosis*Antimetabolites: during active phases*Bleomycin: Nonanthracycline antitum antibios* ... Two antimetabolites cause myeolosuppression that can be staved off with the administration of other agents. Which ...

Topoisomerase I Inhibitors / administration & dosage* * Topoisomerase I Inhibitors / adverse effects * Topotecan / ... Results: Twenty-two patients enrolled in the study, of whom 20 were eligible and assessable for toxicity and 16 were assessable ... Phase 2 clinical trial of intrathecal topotecan in children with refractory leptomeningeal leukemia: a Childrens Oncology ... Purpose: We performed a phase 2 study in children with recurrent or refractory leptomeningeal leukemia to determine the ...

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion. MBio. ... Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair. J Med Chem. 2017 May 11;60(9):3979-4001. PMCID: ... Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human ... Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. J ...

OBJECTIVES: Etoposide (Vepesid, VP-16), an inhibitor of topoisomerase II, is a chemotherapeutic drug commonly used for ... By inhibiting the topoisomerase II enzyme activity in cancer cells, this drug leads to DNA damage and subsequently to cell ... inhibition of topoisomerase II and formation of cytochrome P450 (CYP)- and peroxidase-mediated covalent DNA adducts. This is ... Impact of histone deacetylase inhibitor valproic acid on the anticancer effect of etoposide on neuroblastoma cells.. Groh T, ...

... patients received epirubicin at clinically relevant doses after dose-escalation.Results of the topoisomerase activity will be ... regimen in patients with upper gastrointestinalmalignancies and breast cancer will be investigated as partof phase II studies, ... administered IV at a fixeddose of 250 mg/m2 on day 1 in combination with capecitabine at a fixeddose of 1,500 mg/m2 for days 2 ... topoisomerase II inhibitor) on days 7 to 9.[6] In addition, levels of topoisomerase I and II were measured in tumors before and ...

In the phase II HERTHENA-Lung01 trial, the topoisomerase-1 HER3-targeting antibody-drug conjugate patritumab deruxtecan... ... The combination of the ATR inhibitor ceralasertib and the immune checkpoint inhibitor durvalumab has demonstrated notable ... the benefit of two KRAS G12C inhibitors in advanced non-small cell lung cancer (NSCLC) was upheld by the 2-year follow-up ... the role of immune checkpoint inhibitors following disease progression with tyrosine kinase inhibitors has been unclear. ...

We found that women who had higher body mass index had higher risk of developing poor prognosis breast cancers within two years ... In this study, a SIK inhibitor enhanced bone formation and blocked bone resorption. This promising profile was due to ... Employing this framework to two independent cohorts (n=555, n=503), we found that lesions in motor and language areas help ... When a human cell divides, it physically cleaves through its middle to form two identical daughter cells. Errors in this ...