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*  Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis. - The Kennedy Institute of...
Toll-like receptors (TLRs), key players in innate immunity, are upregulated in atherosclerotic lesions, but their functional ... a signaling adaptor shared by most TLRs and interleukin-1 receptor (IL-1R), in an in vitro model of human atherosclerosis. ... In contrast, TLR-2 neutralizing antibodies inhibited nuclear factor-kappaB activation (P,0.05) and significantly reduced ... CONCLUSIONS: Our data indicate that TLR-2 signaling through MyD88 plays a predominant role in inflammation and matrix ...
https://www.kennedy.ox.ac.uk/publications/224454
*  Catching the adaptor-WDFY1, a new player in the TLR-TRIF pathway | EMBO Reports
Kawai T, Akira S (2011) Toll‐like receptors and their crosstalk with other innate receptors in infection and immunity Immunity ... The Toll‐like receptors (TLRs) are the best‐described set of PRRs. TLRs are membrane‐bound receptors localized on the plasma ... 1 receptor domain‐containing adapter that preferentially activates the IFN‐beta promoter in the Toll‐like receptor signaling J ... Yamamoto M, Sato S, Hemmi H et al (2003) TRAM is specifically involved in the Toll‐like receptor 4‐mediated MyD88‐independent ...
http://embor.embopress.org/content/early/2015/03/03/embr.201540145
*  JCI - Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes
Hyperactivation of immune cells by bacterial products through toll-like receptors (TLRs) is thought of as a causative mechanism ... Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. ... Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. ...
https://www.jci.org/articles/view/20762/pdf
*  Abstract 3601: Toll-Like Receptor-2/-6 Stimulation Promotes Angiogenesis and Reendothelialization | Circulation
Abstract 3601: Toll-Like Receptor-2/-6 Stimulation Promotes Angiogenesis and Reendothelialization. Karsten Grote, Gustavo ... Introduction: Toll-like receptors (TLRs) are crucial for the recognition of pathogens which subsequently lead to the activation ... Abstract 3601: Toll-Like Receptor-2/-6 Stimulation Promotes Angiogenesis and Reendothelialization ... Abstract 3601: Toll-Like Receptor-2/-6 Stimulation Promotes Angiogenesis and Reendothelialization ...
http://circ.ahajournals.org/content/118/Suppl_18/S_449.2
*  Abstract 13685: Toll-Like Receptor 2 Mediates Cardiac Adaptive Response to Pressure Overload | Circulation
Background: Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. TLR2 is a ... Abstract 13685: Toll-Like Receptor 2 Mediates Cardiac Adaptive Response to Pressure Overload. Yasutomi Higashikuni, Ryozo Nagai ... Abstract 13685: Toll-Like Receptor 2 Mediates Cardiac Adaptive Response to Pressure Overload ... Abstract 13685: Toll-Like Receptor 2 Mediates Cardiac Adaptive Response to Pressure Overload ...
http://circ.ahajournals.org/content/126/Suppl_21/A13685
*  Suppression of osteoblast toll-like receptor 2 signaling by endothelin-1
In the present study, we examined the alterations in Toll-like receptor 2 (TLR2) signaling induced by ET-1 in an in vitro ...
https://insights.ovid.com/joor/201407000/01445461-201407000-00008
*  Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2 | JEM
... these motifs are found in many receptors including B and T cell antigen receptors, Fc receptors, and NK activating receptors. ... The innate immune system uses a wide variety of microbial recognition receptors including Toll-like receptors (TLRs),*lectins, ... The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature. 401:811-815. ... a structure found on a variety of proinflammatory signaling receptors including Fc receptors, T cell receptors, and NK ...
http://jem.rupress.org/content/197/9/1107?ijkey=becf7cdea16f20e20ae0ac23a54c5dcca06c919d&keytype2=tf_ipsecsha
*  Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis | Springer for Research & Development
Background Previously we reported that mice deficient in toll-like receptor 4 (TLR-4) signalling were protected from diet- ... induced non-alcoholic steatohepatitis (NASH). Another member of the toll-like... ... Toll-like receptor-4 signalling is augmented in toll-like receptor-2 deficient mice. To investigate activation of TLR-4 ... Toll-like receptor-4 expression correlates with mRNA levels of TNF-α. Real-time PCR data for TLR-4 and CD-14 were compared with ...
https://rd.springer.com/article/10.1186/1471-230X-10-52
*  Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system. - PubMed - NCBI
Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system.. Brun P1, Giron ... Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system: why were TLR3's ... In the intestines, Toll-like receptor 2 (TLR2) mediates immune responses to pathogens and regulates epithelial barrier function ... Toll-like receptor 2; Ulcerative Colitis; WT; enteric glial cells; enteric nervous system; glial cell line-derived neurotrophic ...
https://www.ncbi.nlm.nih.gov/pubmed/23994200?dopt=Abstract
*  Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma. | Sigma-Aldrich
Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma.. [Lovisa Farnebo, Arash Shahangian, ... where ligands derived from their wall components have been shown to specifically bind to Toll-like receptor 2 (TLR2). Although ... In summary, our data show that TLR2 is a functional receptor expressed in human HNSCC that plays a direct pro-tumorigenic role ... indicating that this receptor is functional in HNSCC and that the signaling through these pathways is intact. TLR2 blockade ...
https://www.sigmaaldrich.com/catalog/papers/25846753
*  The toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury
Stimulation of the innate immune receptor Toll-like receptor-2 (TLR2) has shown to be beneficial following SCI, and it ... The toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury. ... This enhanced response was observed 2 to 4 h following SCI and was most prominent in areas closer to the ablation site. In ...
https://insights.ovid.com/exneur/201708000/00003702-201708000-00001
*  Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes. - PubMed - NCBI
Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes.. Devaraj S1, Dasu MR, Park SH, Jialal I. ... We have shown increased Toll-like receptor 2 (TLR2) and TLR4 expression and signalling in monocytes from type 1 diabetic ...
https://www.ncbi.nlm.nih.gov/pubmed/19455302?dopt=citation
*  Yersinia V-Antigen Exploits Toll-like Receptor 2 and CD14 for Interleukin 10-mediated Immunosuppression | JEM
... pattern recognition receptor; TLR, toll-like receptor; TTS, type III protein secretion and translocation system. ... Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J. Immunol. 168:348-355. ... Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274:33419-33425 ... The toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature. 401:811-815. ...
http://jem.rupress.org/content/196/8/1017
*  Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2
Toll-like receptors (TLRs) mediate the cellular response to conserved molecular patterns shared by microorganisms. We report ... LEISHMANIA LIPOPHOSPHOGLYCAN (LPG) ACTIVATES NK CELLS THROUGH TOLL-LIKE RECEPTOR-2. MOL BIOCHEM PARASIT 130(2):65-74 ... The effect of LPG on cytokine production and on membrane expression of TLR-2 could be blocked with F(ab')2 fragments of the mAb ... Binding of LPG to TLR-2 in NK cells was demonstrated by immunoprecipitations done with anti-TLR-2 and anti-LPG mAb followed by ...
http://www.ifc.unam.mx/publications/leishmania-lipophosphoglycan-lpg-activates-nk-cells-through-toll-like-receptor-2/
*  Activation and regulation of Toll-like receptors 2 and 1 in human leprosy - Infoscience
The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical ... Activation was enhanced by type-1 cytokines and inhibited by type-2 cytokines. In addition, interferon (IFN)-gamma and ... Home , Activation and regulation of Toll-like receptors 2 and 1 in human leprosy , HTML MARC ... aThe expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical ...
https://infoscience.epfl.ch/record/151245/export/hm
*  TRIF Mediates Toll-Like Receptor 2-Dependent Inflammatory Responses to Borrelia burgdorferi | Infection and Immunity
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637-650. ... Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor ... Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J. Immunol. 168:348-355. ... TRIF Mediates Toll-Like Receptor 2-Dependent Inflammatory Responses to Borrelia burgdorferi. Tanja Petnicki-Ocwieja, Erin Chung ...
https://iai.asm.org/content/81/2/402
*  Toll-like receptor-2 and interleukin-1 signaling in keratinocytes during Staphylococcus aureus infections (46.9) | The Journal...
Toll-like receptor-2 and interleukin-1 signaling in keratinocytes during Staphylococcus aureus infections (46.9). Liselotte ... Toll-like receptor-2 and interleukin-1 signaling in keratinocytes during Staphylococcus aureus infections (46.9) ... Toll-like receptor-2 and interleukin-1 signaling in keratinocytes during Staphylococcus aureus infections (46.9) ... Toll-like receptor-2 and interleukin-1 signaling in keratinocytes during Staphylococcus aureus infections (46.9) ...
http://www.jimmunol.org/content/184/1_Supplement/46.9
*  PRIME PubMed | Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic...
PubMed journal article Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic ... Toll-Like Receptor 1. Toll-Like Receptor 2. Transcutaneous Electric Nerve Stimulation. Wound Healing. Pub Type(s). Journal ... S. aureus is sensed by many pattern recognition receptors, including Toll-like receptor 2 (TLR2). We hypothesized that an ... S. aureus is sensed by many pattern recognition receptors, including Toll-like receptor 2 (TLR2). We hypothesized that an ...
https://www.unboundmedicine.com/medline/citation/23223142/Activation_of_epidermal_toll_like_receptor_2_enhances_tight_junction_function:_implications_for_atopic_dermatitis_and_skin_barrier_repair_
*  Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2 |...
Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor ... members of the Toll-like receptor (TLR)3 family have recently emerged as candidate receptors capable of transmitting LPS ... Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274: 33419. ... Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps ...
http://www.jimmunol.org/content/165/2/618
*  Frontiers | Toll-Like Receptor 2 Is a Regulator of Circadian Active and Inactive State Consolidation in C57BL/6 Mice |...
We describe a previously unappreciated role that toll-like receptor 2 (Tlr2, a membrane bound pattern recognition receptor that ... a membrane bound pattern recognition receptor that recognizes specific bacterial, viral, and fungal peptides), contributes ... We describe a previously unappreciated role that toll-like receptor 2 (Tlr2, ... Tlr2 forms heterodimers with similarly shaped partners such as toll-like receptor 1 (Tlr1), or toll-like receptor 6 (Tlr6). ...
https://www.frontiersin.org/articles/10.3389/fnagi.2017.00219/full
*  Human Cytomegalovirus-Platelet Interaction Triggers Toll-Like Receptor 2-Dependent Proinflammatory and Proangiogenic...
HCMV can interact with a plethora of receptors, including integrins and growth factor receptors.9 HCMV is also sensed by Toll- ... toll-like receptors. Introduction. Human cytomegalovirus (HCMV), a member of the β-herpesvirus family, is a widespread, well- ... Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol. 2005;83:196-198. ... B, Human platelets (3×108/mL) in the presence and absence of a blocking anti-Toll-like receptor (TLR) 2 antibody (25 μg/mL) or ...
http://atvb.ahajournals.org/content/34/4/801
*  VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in...
Senn JJ (2006) Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J ... Könner AC, Brüning JC (2011) Toll-like receptors: linking inflammation to metabolism. Trends Endocrinol Metab 22:16-23CrossRef ... Kuo LH, Tsai PJ, Jiang MJ et al (2011) Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin ... VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in ...
https://link.springer.com/article/10.1007/s00125-017-4401-5
*  Frontiers | HP1330 Contributes to Streptococcus suis Virulence by Inducing Toll-Like Receptor 2- and ERK1/2-Dependent Pro...
The results revealed that the pro-inflammatory activity of HP1330 depended on the recognition of Toll-like receptor 2 (TLR2). ... The results revealed that the pro-inflammatory activity of HP1330 depended on the recognition of Toll-like receptor 2 (TLR2). ... Streptococcus suis 2 (SS2) has evolved into a highly invasive pathogen responsible for two large-scale outbreaks of ... Streptococcus suis 2 (SS2) has evolved into a highly invasive pathogen responsible for two large-scale outbreaks of ...
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00869/full
*  Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous...
... through a variety of pattern-recognition receptors (PRR), including Toll-like receptors (TLRs). In this study, we evaluated the ... Zhu J, Mohan C (2010) Toll-like receptor signaling pathways-therapeutic opportunities. Mediat Inflamm. doi: 10.1155/2010/781235 ... Okun E, Griffioen KJ, Lathia JD, Tang SC, Mattson MP, Arumugam TV (2009) Toll-like receptors in neurodegeneration. Brain Res ... Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous ...
https://link.springer.com/article/10.1007%2Fs00430-012-0247-0