We showed recently that these abnormalities are strongly attenuated in mice knockout for Toll-like receptors-2, -4, MyD88, ASC ... Renal physiology, 305(2), F155-F163 (2013-05-10). Adenine overload promotes intratubular crystal precipitation and interstitial ... Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic ...
for intraperitoneal administration in mice to investigate the effect of toll-like receptors (TLR-3) activation on neonatal ...
... which triggers a potent host immune response through the complex of toll-like-receptor 4 (TLR4) and myeloid differentiation ... 2.. Sharan SK, Thomason LC, Kuznetsov SG, Court DL. 2009. Recombineering: a homologous recombination-based method of genetic ... Figure 2. Kdo-Lipid A Degradation Pathways. Many enzymes are involved in the degradation of Kdo2-lipid A. Genes encoding these ... Strain 2 generated a 14X yield increase over strain 1, making it the best candidate for large-scale production of Kdo2-lipid A ...