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*  Reactive site mutations in tissue inhibitor of metalloproteinase-3 disrupt inhibition of matrix metalloproteinases but not...
... is a dual inhibitor of the matrix metalloproteinases (MMPs) and some adamalysins, two families of extracellular and cell ... The mutant proteins are also effective inhibitors of tumor necrosis factor alpha (TNF-alpha) release from phorbol ester- ... stimulated cells, indicating that they provide a lead for engineering TACE-specific inhibitors that may reduce side effects ... surface metalloproteinases that function in extracellular matrix turnover and the shedding of cell surface proteins. The ...
https://www.ndorms.ox.ac.uk/publications/226931
*  TIMP-3 Antibody | Abbiotec
Tissue inhibitor of metalloproteinases 3) is a secreted extracellular matrix protein, metalloprotease inhibitor. It forms ... Tissue inhibitor of metalloproteinases 3; TIMP-3; Protein MIG-5; TIMP3 ... It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, ... the proliferation of quiescent tissues in response to angiogenic factors and by inhibiting protease activity in tissues ...
http://abbiotec.com/antibodies/timp-3-antibody-1
*  Matrix metalloproteinase inhibition impairs adipose tissue development in mice - Lijnen Roger
... in adipose tissues of the inhibitor-treated group. Adipose tissue of the inhibitor-treated mice contained more collagen than ... Matrix Metalloproteinase Inhibition Impairs Adipose Tissue Development in Mice.pdf. Publisher postprint. 430.68 kB. View/Open. ... en] The effect of galardin, a broad-spectrum matrix metalloproteinase (MMP) inhibitor, was studied in mice kept on a high fat ... of adipose tissue appears to be limited by the formation of a collagen-rich matrix cap around the inhibitor-treated tissue. ...
http://orbi.ulg.ac.be/handle/2268/27181
*  UniProtKB/SwissProt variant VAR 010901
Metalloproteinase inhibitor 3. Disulfide bond. 145 - 192. Literature citations. Night blindness in Sorsby's fundus dystrophy ... It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, ... 3. The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures ...
http://web.expasy.org/variant_pages/VAR_010901.html
*  TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody - Without BSA - Rabbit Polyclonal Antibody IHC-P, IF, FC - Buy Now! ...
Tissue Inhibitor of Metalloproteinase-3) Antibody - Without BSA, Rabbit Polyclonal Antibody validated in IHC-P, IF, FC (AH10767 ... TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the ... Tissue inhibitor of metalloproteinases 3, TIMP-3, TIMP3. Format 200ug/ml of Ab purified from rabbit anti-serum by Protein A. ... Tissue Inhibitor of Metalloproteinase-3) Antibody - Without BSA TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Antibody - ...
http://www.abgent.com/products/AH10767-TIMP-3-Tissue-Inhibitor-of-Metalloproteinase-3-Antibody-Without-BSA
*  Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby's fundus dystrophy or retinitis pigmentosa |...
Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby's fundus dystrophy or retinitis pigmentosa ... Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby's fundus dystrophy or retinitis pigmentosa ...
https://bjo.bmj.com/content/82/11/1329.responses
*  Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling | Cell...
Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry ... and their endogenous inhibitors, the tissue inhibitors of metalloproteinases (TIMPs) (37). TIMPs are a family of four ... Woessner JF Jr. That impish TIMP: the tissue inhibitor of metalloproteinases-3. J Clin Invest 108: 799-800, 2001. ... Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling. Lamis ...
http://ajpcell.physiology.org/content/296/4/C735
*  Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus...
Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus ... Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus ... A transient COS-7 cell expression system was used to investigate the functional domain arrangement of tissue inhibitor of ... ECM bound MMP inhibitor, whereas a chimeric TIMP molecule, consisting of the NH2-terminal domain of TIMP-2 fused to the COOH- ...
http://eprints.whiterose.ac.uk/440/
*  Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Induces Endothelial Apoptosis via MMP- and Caspase-Independent Mechanisms |...
Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Induces Endothelial Apoptosis via MMP- and Caspase-Independent Mechanisms ... Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Induces Endothelial Apoptosis via MMP- and Caspase-Independent Mechanisms ... Jian Qi, Bela Anand-Apte; Tissue Inhibitor of Metalloproteinase-3 (TIMP3) Induces Endothelial Apoptosis via MMP- and Caspase- ... Furthermore, either a polycaspase inhibitor or a specific inhibitor of caspase 3 or 8 were ineffective against TIMP3-mediated ...
https://iovs.arvojournals.org/article.aspx?articleid=2149467
*  TIMP3 - tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases ... SFD; K222TA2; HSMRK222; K222 expressed in degenerative retinas; Tissue inhibitor of metalloproteinase-3. ... The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases ... Graff JR Methylation-associated silencing of the tissue inhibitor ofmetalloproteinase-3 gene suggest a suppressor role in ...
http://www.urogene.org/kgdb/gene/28.html
*  TIMP3 elisa kit | Mouse Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) ELISA Kit-AAL31488.1
Mouse Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) ELISA Kit-AAL31488.1 (MBS2019432) product datasheet at MyBioSource, ... The concentration of Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) in the samples is then determined by comparing the O.D. ... This assay has high sensitivity and excellent specificity for detection of Tissue Inhibitors Of Metalloproteinase 3 (TIMP3).. ... After TMB substrate solution is added, only those wells that contain Tissue Inhibitors Of Metalloproteinase 3 (TIMP3), biotin- ...
https://www.mybiosource.com/timp3-mouse-elisa-kits/tissue-inhibitors-of-metalloproteinase-3-timp3/2019432
*  Tissue inhibitor of metalloproteinases-3 mediates the death of immature oligodendrocytes via TNF-α/TACE in focal cerebral...
TIMP-3 expression was increased in WT reactive astrocytes. GST-π was reduced in ischemic white matter of WT mice compared with ... TIMP-3 promotes apoptosis in ischemic neurons by inhibiting proteolysis of TNF-α superfamily of death receptors. Since OLs ... There were significantly higher levels of cleaved caspase-3 at 72 h in WT white matter than in KO. Greater expression of MMP-3 ... Future studies will be needed to delineate the role of MMP-3 and MMP-9 that were increased in the Timp-3 wild type. ...
https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-8-108
*  Specific Methylation Events Contribute to the Transcriptional Repression of the Mouse Tissue Inhibitor of Metalloproteinases-3...
The tissue inhibitor of metalloproteinases-3 (TIMP-3) gene is specifically down-regulated in neoplastic cells of the mouse JB6 ... Specific Methylation Events Contribute to the Transcriptional Repression of the Mouse Tissue Inhibitor of Metalloproteinases-3 ... Targeting Cell Surface Nucleoproteins Inhibit Cancer Cell Invasion through Tissue Inhibitor of Metalloproteinases 3 (TIMP-3) ... Ultraviolet Radiation and the Role of Matrix Metalloproteinases in the Pathogenesis of Ocular Surface Squamous Neoplasia. , ...
http://cgd.aacrjournals.org/cgi/content/abstract/10/4/279
*  Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus - Metalloproteinase inhibition is...
The tissue inhibitors of metalloproteinases (TIMPs) are a family of four secreted inhibitors of matrix metalloproteinases (MMPs ... Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus - Metalloproteinase inhibition is ... Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus - Metalloproteinase inhibition is ... Furthermore, a point mutation at residue 1 of TIMP-3 totally abolished MMP-inhibitory activity of TIMP-3 and also failed to ...
http://eprints.gla.ac.uk/17091/
*  Timp3 - tissue inhibitor of metalloproteinase 3 | International Mouse Phenotyping Consortium
Expression No Expression No Tissue Available Ambiguous Show Wildtype Expression. Anatomy. #HET Specimens HOM Images? WT Expr ... Expression No Expression No Tissue Available Ambiguous Anatomy. #HET Specimens WT Expr Mutant Expr. Images ...
https://www.mousephenotype.org/data/genes/MGI:98754
*  546 TIMP-3 (Tissue Inhibitor of Metalloproteinase-3); Rabbit Polyclonal (Concentrate) - RA0309-C.1 ( Antibodies, Research...
Tissue Inhibitor of Metalloproteinase-3); Rabbit Polyclonal (Concentrate) - RA0309-C.1 ( Antibodies, Research Antibodies) ... Tissue Inhibitor of Metalloproteinase-3); Rabbit Polyclonal (Concentrate). Species: Rabbit. Immunogen: Recombinant fragment ...
https://www.scytek.com/products/78.18-RA0309-C.1-TIMP-3-
*  Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: Relation to tumor...
Tissue inhibitors of metalloproteinases (TIMPs) are natural MMP inhibitors and impede the proteolytic activity of MMPs by ... Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. ... Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and ... The micrographs show tissue inhibitor of metalloproteinases (TIMP)-3 in the cytoplasm of a lobular carcinoma (a), both the ...
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr1607
*  Oncostatin M-Induced Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase-3 Genes Expression in Chondrocytes...
Oncostatin M-Induced Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase-3 Genes Expression in Chondrocytes ... We have previously shown that OSM induces MMP and tissue inhibitor of metalloproteinase-3 (TIMP-3) gene expression in ... A JAK3-specific inhibitor blocked OSM-stimulated STAT1 tyrosine phosphorylation, DNA-binding activity of STAT1 as well as ... In contrast, a JAK2-specific inhibitor, AG490, had no impact on these events. OSM-induced ERK1/2 activation was also not ...
https://core.ac.uk/display/22814021
*  Tissue Inhibitor of Metalloproteinase 1 Enhances Cell Survival in a Matrix Metalloproteinase Dependent Mechanism in the...
Tissue Inhibitor of Metalloproteinase 1 Enhances Cell Survival in a Matrix Metalloproteinase Dependent Mechanism in the ... Tissue Inhibitor of Metalloproteinase 1 Enhances Cell Survival in a Matrix Metalloproteinase Dependent Mechanism in the ... Tissue Inhibitor of Metalloproteinase 1 Enhances Cell Survival in a Matrix Metalloproteinase Dependent Mechanism in the ... of cone mosaic is restored and cone outer segments are protected at later stages with Tissue Inhibitor of Metalloproteinase 1 ( ...
https://iovs.arvojournals.org/article.aspx?articleid=2559862
*  Expression of tissue inhibitor of matrix metalloproteinases TIMP-3 protein in invasive breast carcinoma: Relation to tumor...
Expression of tissue inhibitor of matrix metalloproteinases TIMP-3 protein in invasive breast carcinoma: Relation to tumor ... Expression of tissue inhibitor of matrix metalloproteinases TIMP-3 protein in invasive breast carcinoma: Relation to tumor ... Expression of tissue inhibitor of matrix metalloproteinases TIMP-3 protein in invasive breast carcinoma: Relation to tumor ... IntroductionOur aim was to study the expression pattern of tissue inhibitor of metalloproteinases TIMP-3 protein in invasive ...
http://libros.duhnnae.com/2017/jul7/150134619652-Expression-of-tissue-inhibitor-of-matrix-metalloproteinases-TIMP-3-protein-in-invasive-breast-carcinoma-Relation-to-tumor-phenotype-and-clinical-outc.php
*  Timp3 - Metalloproteinase inhibitor 3 precursor - Mus musculus (Mouse) - Timp3 gene & protein
May form part of a tissue-specific acute response to remodeling stimuli. ... Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc ... Brain cDNA, clone MNCb-5810, similar to Mus musculus tissue inhibitor of metalloproteinase 3 (Timp3), mRNA. MOUSE ... Metalloproteinase inhibitor 3Add BLAST. 188. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ...
https://www.uniprot.org/uniprot/P39876
*  CADM1 | Cancer Genetics Web
Tissue Inhibitor of Metalloproteinase-3. *Non-Small Cell Lung Cancer. *Apoptosis. *Cell Proliferation ... The data showed that TSLC1-AS1 expression was down-regulated in tumor tissues compared with that in adjacent normal tissues, ... Furthermore, in tumor tissues obtained from gastric cancer patients, the expression of miR-126 was negatively correlated with ... Furthermore, in tumor tissues obtained from liver cancer patients, the expression of miR-1246 was negatively correlated with ...
http://www.cancerindex.org/geneweb/CADM1.htm
*  TIMP3 Gene - GeneCards | TIMP3 Protein | TIMP3 Antibody
TIMP Metallopeptidase Inhibitor 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - ... Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like ... matrix metalloproteinase,tissue inhibitor 3,expressed in retinal pigment epithelium,placenta,localized in extracellular matrix ... Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to ...
https://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=7078
*  Differentiation of the Mammary Epithelial Cell during Involution: Implications for Breast Cancer | Springer for Research &...
tissue-inhibitor of metalloproteinase 3. TMEM4/CNPY2. MIR-interacting saposin-like protein or canopy 2 homolog or transmembrane ... matrix metalloproteinase. MMTV-Neu. expression of the Neu oncogene (HER2/ErbB2) using the mouse mammary tumor virus LTR ... ECM degrading proteases and tissue remodelling in the mammary gland. Bioessays. 2005;27(9):894-903. doi: 10.1002/bies.20281. ... An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal. ...
https://rd.springer.com/article/10.1007/s10911-009-9121-0
*  Plus it
37, 38), Tissue inhibitor of metalloproteinases-3 (TIMP-3; refs. 38, 39), and Ras association (RalGDS/AF-6) domain family 1 ( ... HPV gene expression and virion production are linked to epithelial differentiation in the squamous tissue but how the virus ... Figure 3. Joint effects for the longitudinal age trends and net drifts by histopathologic type, race, and stage (SEER 9; 1976- ... 3 ). Both longitudinal age trends and net drifts were less for squamous cell carcinomas than adenocarcinomas in Fig. 3A, ...
http://cebp.aacrjournals.org/content/18/3/792