Thiosemicarbazones are also widely used as ligands in coordination chemistry. The affinity of thiosemicarbazones for metal ions ... A thiosemicarbazone is an organosulfur compound with the formula H2NC(S)NHN=CR2. Many variations exist, including those where ... Thiosemicarbazones are usually produced by condensation of a thiosemicarbazide with an aldehyde or ketone: H2NC(S)NHNH2 + O=CR2 ... Some thiosemicarbazones have medicinal properties, e.g. the antiviral metisazone and the antibiotic thioacetazone. ...

22 thiosemicarbazone derivatives (3a-y) were synthesized. Then, ADME parameters, pharmacokinetic properties, drug-like ... Synthesis Thiosemicarbazone Derivatives (3a-y). A series of thiosemicarbazones (3a-y) was prepared from the reaction of ... General synthetic procedure for thiosemicarbazones (3a-y) To a solution of benzaldehyde derivatives (1a-y) (0.01 mol) in warm ... When the results were evaluated in detail, the IC50 values of thiosemicarbazone derivatives (3a-y) in the MCF 7 cell line were ...

An efficient synthesis of novel carbohydrate and thiosemicarbazone hybrid benzimidazole derivatives and their antimicrobial ...

4-dimethyl-3-thiosemicarbazone (Dp44mT) or di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC). Simultaneous ... which is known to be activated and upregulated by thiosemicarbazones in adult cancers, was also detected in thiosemicarbazone- ... Thiosemicarbazones_and_selected_tyrosine_kinase_inhibitors_synergize_in_pediatric_solid_tumors_NDRG1_upregulation_and_impaired_ ... Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired ...

Pyridoxal (vitamin B-6 aldehyde) thiosemicarbazone (B6TSC) is deprotonated to its anion (B6TSC - H+) in basic solution at pH = ... Pyridoxal (vitamin B-6 aldehyde) thiosemicarbazone (B6TSC) is deprotonated to its anion (B6TSC - H+) in basic solution at pH = ... Intraligand fluorescence of Zn(II) and Pt(II) complexes of pyridoxal thiosemicarbazone ... METAL-COMPLEXES; SPECTROSCOPIC PROPERTIES; LUMINESCENCE; Fluorescence; Pyridoxal thiosemicarbazone; Zinc(II); Platinum(II). ...

Copper thiosemicarbazone derivative,canSAR2783865 , Compound overview, Drug targets, Compound forms, Similar compounds , ...

Copper thiosemicarbazone derivative,canSAR2732426 , Compound overview, Drug targets, Compound forms, Similar compounds , ...

The compounds contain the diimine 1,10-phenanthroline (phen) or 2,2′-bipyridine (bpy) and the thiosemicarbazone is derived from ... Based on elemental analyses and spectroscopic data, the compounds are best formulated as [(phen)2Ru(thiosemicarbazone)](PF6)2 ... and [(phen)2Ru(thiosemicarbazone)](PF6)2 where thiosemicarbazone = 9-anthraldehydethiosemicarbazone, 9-anthraldehyde-N(4)- ... compounds containing diimine as well as bidentate thiosemicarbazone ligands. ...

... , Tetrahedron ... Cyclometallated Pd(II) thiosemicarbazone complexes: new catalyst precursors for Suzuki-coupling reactions. ...

Copy For Citation ALTINTOP M. D., SEVER B., ÖZDEMİR A. 55th International Conference on Medicinal Chemistry, Nantes-France, 3 - 05 July 2019 ...

Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands

Four thiosemicarbazones ligands,H3T(1),H3M(2),H3E(3) andH3P(4) have been prepared with good yield by refluxing 2,4- ... The doubly deprotonated thiosemicarbazone acts as a tridentate ONS-donor ligand while 2,2-bipyridne as the NN-donor ligand. ... doubly deprotonated thiosemicarbazones = HT(5); HM(6); HE(7) and HP(8)). These compounds were characterized and their ... interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with topoisomerase I. Polyhedron, 38 (2012). pp. ...

Bp44mT: An orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy. British Journal of ... Bp44mT: An orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy. / Yu, Y.; Rahmanto, Y. ... Yu, Y. ; Rahmanto, Y. Suryo ; Richardson, D. R. / Bp44mT : An orally active iron chelator of the thiosemicarbazone class with ... Yu, Y., Rahmanto, Y. S., & Richardson, D. R. (2012). Bp44mT: An orally active iron chelator of the thiosemicarbazone class with ...

Strong Effect of Copper(II) Coordination on Antiproliferative Activity of Thiosemicarbazone-Piperazine and Thiosemicarbazone- ... Comparative solution and structural studies on anticancer copper complexes of thiosemicarbazones and 2-substituted sterane- ... Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes solution structure, stability and ... Effects stepwise terminal NH2-methylation of estronesalicylaldehyde-thiosemicarbazone and copper coordination, solution ...

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F] ... Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F] ... Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([18F] ... T1 - Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([ ...

thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2󸀠-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-. 1-(1󸀠-nitro-2󸀠- ... thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2󸀠-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3󸀠- ... thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2耠-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1耠-nitro-2耠- ... thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2耠-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1耠-nitro-2耠- ...

Thiosemicarbazone (TB-1) in the treatment of leprosy preliminary communication Martin Vegas; Jacinto Convit; Jose Antonio ... Thiosemicarbazone (TB-1) in the treatment of leprosy preliminary communication. Int. J. Lepr. 1950;18(4):451-5 ...

深入研究「G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone ... T1 - G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone ... G2/M cell cycle arrest and tumor selective apoptosis of acute leukemia cells by a promising benzophenone thiosemicarbazone ... Our findings further describe a novel activity for a benzophenone thiosemicarbazone and propose T44Bf as a promising anti- ...

... thiosemicarbazone) complexes in human cancer cells has been studied by fluorescence microscopy and the cellular distribution ... Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells ... The uptake of zinc bis(thiosemicarbazone) complexes in human cancer cells has been studied by fluorescence microscopy and the ... Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells ...

Synthesis, crystal structure and bio-macromolecular interaction studies of pyridine-based thiosemicarbazone and its Ni(ii) and ... Synthesis, crystal structure and bio-macromolecular interaction studies of pyridine-based thiosemicarbazone and its Ni(ii) and ...

Thiosemicarbazones. Hilton JB, Mercer SW, Lim NKH, Faux NG, Buncic G, Beckman JS, Roberts BR, Donnelly PS, White AR, Crouch PJ ...

Glycogen phosphorylase complexed with 4-chlorobenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone ... Glycogen phosphorylase complexed with 4-chlorobenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone Coordinates. PDB Format ... Alexacou, K.M. et al., The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new ...

02/01/1978 - "New derivatives (esters, amides, nitriles, amidines, thiosemicarbazones and guanylhydrazones) of 1H-benz[e]indene ...

It was also used in the synthesis of a series of thiosemicarbazones. . ... boronic acids affords a series of thiosemicarbazones containing boronic acids. Addition of 2-formylphenylboronic acid to the ...

Glycogen phosphorylase complexed with 2-chlorobenzaldehyde-4-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl) thiosemicarbazone ... Alexacou, K.M. et al., The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new ... Glycogen phosphorylase complexed with 2-chlorobenzaldehyde-4-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl) thiosemicarbazone ...

Spectroscopic characterization of formylferrocene thiosemicarbazone (TFF) by SERS.... Physical Chemistry. Masters Dissertation ...

An estrone-salicylaldehyde thiosemicarbazone hybrid (estrone-TSC) containing integrated domains was designed and synthesized ... Salicylaldehyde thiosemicarbazone copper complexes: impact of hybridization with estrone on cytotoxicity, solution stability ...

and vanillin-N-phenyl-thio-semicarbazone [1.2726 (17), 1.3801 (15) and 1.2404 (15) Å; Layana et al., 2016. ] ...

2-hydroxy-5-methylacetophenone thiosemicarbazone, (E)-4-bromoacetophenone thiosemicarbazone have been investigated in solution ... 2-hydroxy-5-methylacetophenone thiosemicarbazone in solution studied by NMR spectroscopy. ...

... synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with ...