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*  C/EBPα Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer | Diabetes
TZD, thiazolidinedione. Adiponectin is exclusively expressed in adipocytes (1-4) and has diverse roles that include regulation ... Gustafson B, Jack MM, Cushman SW, Smith U: Adiponectin gene activation by thiazolidinediones requires PPAR gamma 2, but not C/ ... neither did thiazolidinedione (TZD) treatment (Fig. 5A). The differences in results relative to the earlier studies may be ...
http://diabetes.diabetesjournals.org/content/54/6/1744.full
*  The peroxisome proliferator-activated receptor γ agonist pioglitazone reduces the development of cartilage lesions in an...
Use of thiazolidinediones and the risk of elective hip or knee replacement: a population based case-control study, British ...
http://onlinelibrary.wiley.com/doi/10.1002/art.22726/abstract
*  A Cohort Study of Metformin Exposure and Survival in Patients with Stage I-III Colorectal Cancer | Cancer Epidemiology,...
Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ ... thiazolidinediones) was more prevalent in the metformin group. The median metformin dosing intensity in the year before ... and other ADDs such as thiazolidinediones, DPP4 inhibitors, meglitinides, and α-glucosidase inhibitors) in the year before ...
http://cebp.aacrjournals.org/content/22/8/1364?rss=1
*  Frontiers | Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines? | Frontiers in...
A Note on Thiazolidinediones. There is very little information regarding the use PPARγ agonists for neuropathic pain treatment ... Thiazolidinediones (TZDs) decrease monocyte migration toward MCP-1 (Kintscher et al., 2000; Tanaka et al., 2005) likely by PPAR ... 2007). Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor ... The most commonly used synthetic agonists for PPAR receptors include the fibrates, which bind PPARα the thiazolidinediones ( ...
https://www.frontiersin.org/articles/10.3389/fncel.2014.00238/full
*  Thiazolidinedione
... , Glitazone, Rosiglitazone, Avandia, Pioglitazone, Actos, Troglitazone, Rezulin. ... Thiazolidinedione (product), Thiazolidinedione (substance), Thiazolidinedione, Thiazolidinediones. Japanese. チアゾリジンジオン類, ... thiazolidinediones, thiazolidinediones (medication), Thiazolidinediones [Chemical/Ingredient], glitazone, glitazones, ... It is a type of thiazolidinedione.. Definition (NCI). An orally-active thiazolidinedione with antidiabetic properties and ...
http://www.fpnotebook.com/legacy/Endo/Pharm/Thzldndn.htm
*  Thiazolidinediones and Lowered HDL Cholesterol | Diabetes Care
There are no published case reports of this reaction occurring with other thiazolidinediones, where the reaction resolved when ... Paradoxical lowering of high-density lipoprotein cholesterol level in 2 patients receiving fenofibrate and a thiazolidinedione ...
http://care.diabetesjournals.org/content/28/9/2329.2
*  TZD, thiazolidinedione | Diabetes
Dae Ryong Cha, Xiaoyan Zhang, Yahua Zhang, Jing Wu, Dongming Su, Jee Young Han, Xuefen Fang, Bo Yu, Matthew D. Breyer, Youfei Guan ...
http://diabetes.diabetesjournals.org/keyword/tzd-thiazolidinedione
*  Cardiovascular, Ocular and Bone Adverse Reactions Associated with Thiazolidinediones | SpringerLink
... macular oedema and bone fractures associated with thiazolidinediones (TZDs) has been extensively investigated. Objective: The ... Thiazolidinediones and fractures in men and women. Arch Intern Med 2009; 169: 1395-402PubMedCrossRefGoogle Scholar ... Thiazolidinedione use and the longitudinal risk of fractures in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab ... The risk of fractures associated with thiazolidinediones: a self-controlled caseseries study. PLoS Med 2009; 6: e1000154PubMed ...
https://link.springer.com/article/10.2165%2F11596510-000000000-00000
*  Effect of Thiazolidinediones on Human Bone - Full Text View - ClinicalTrials.gov
The effects of thiazolidinediones on human bone marrow stromal cell differentiation in vitro and in thiazolidinedione-treated ... Effect of Thiazolidinediones on Human Bone. The safety and scientific validity of this study is the responsibility of the study ... Effects of Thiazolidinediones on Human Bone Marrow Stromal Cell Differentiation Capacity:In Vitro and In Vivo- A Pilot Study. ...
https://clinicaltrials.gov/ct2/show/NCT00927355
*  A Retrospective Review of Thiazolidinediones with Development of a Troglitazone Conversion Protocol
... Cameron Lindsey, Maqual ... Cameron Lindsey, Maqual Graham, and Julie McMurphy, "A Retrospective Review of Thiazolidinediones with Development of a ...
https://www.hindawi.com/journals/tswj/2003/345346/cta/
*  Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial - Full Text View - ClinicalTrials.gov
Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents.Intervention Trial (TOSCA IT). The safety and scientific ... or a thiazolidinedione (TZD). Since the two classes of drugs clearly differ in terms of mechanisms of action, side effects, ... Thiazolidinediones Or Sulphonylureas and Cardiovascular Accidents. Intervention Trial). Addition of either pioglitazone or a ...
https://clinicaltrials.gov/ct2/show/NCT00700856
*  Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization | PNAS
Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. D. D. Sears, G. Hsiao, A. Hsiao, J ... Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. D. D. Sears, G. Hsiao, A. Hsiao, J ... Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. D. D. Sears, G. Hsiao, A. Hsiao, J ... Thiazolidinediones (TZDs) are insulin-sensitizing drugs used to treat type 2 diabetes. TZDs enhance insulin sensitivity by ...
https://www.pnas.org/content/106/44/18745
*  Thiazolidinediones Reduce Endothelial Expression of Receptors for Advanced Glycation End Products | Diabetes
Thiazolidinediones Reduce Endothelial Expression of Receptors for Advanced Glycation End Products. Nikolaus Marx, Daniel ... Thiazolidinediones Reduce Endothelial Expression of Receptors for Advanced Glycation End Products. Nikolaus Marx, Daniel ... Thiazolidinediones Reduce Endothelial Expression of Receptors for Advanced Glycation End Products Message Subject (Your Name) ... The present study investigated whether thiazolidinediones (TZDs), antidiabetic agents clinically used to treat patients with ...
http://diabetes.diabetesjournals.org/content/53/10/2662.short
*  Thiazolidinediones tied to lower cancer risk in diabetes patients
HealthDay) -- Thiazolidinediones are associated with a lower risk of liver and colorectal cancer in patients with type 2 ... Thiazolidinediones tied to lower cancer risk in diabetes patients. April 27, 2012 in Medicine & Health / Cancer ... HealthDay) -- Thiazolidinediones are associated with a lower risk of liver and colorectal cancer in patients with type 2 ... There was no association between thiazolidinedione use and lung and bladder cancer, although there was a potentially higher ...
https://medicalxpress.com/print254720415.html
*  Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy - Full Text View - ClinicalTrials.gov
Thiazolidinediones (TZDs) are insulin sensitizers that decrease plasma glucose in type 2 diabetic patients. Thiazolidinediones ... Thiazolidinediones (TZDs) are insulin sensitizers that decrease plasma glucose in type 2 diabetic patients. Thiazolidinediones ... Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy. The safety and scientific validity of this study is the ... 2,4-thiazolidinedione. Acarbose. Hypoglycemic Agents. Physiological Effects of Drugs. Glycoside Hydrolase Inhibitors. Enzyme ...
https://clinicaltrials.gov/ct2/show/study/NCT01175486?show_desc=Y
*  Possible New Type 2 Diabetes Mellitus Therapy - A PPAR³ Sparing Thiazolidinedione
Home / Letter From The Editor / Possible New Type 2 Diabetes Mellitus Therapy - A PPAR³ Sparing Thiazolidinedione ... Possible New Type 2 Diabetes Mellitus Therapy - A PPAR³ Sparing Thiazolidinedione. Share * Facebook ... Possible New Type 2 Diabetes Mellitus Therapy - A PPAR? Sparing Thiazolidinedione. Amy Talmage, University of Florida College ... A first in a new class of second-generation thiazolidinediones (TZDs), MSDC-0160 (Mitoglitazone®), is currently a participant ...
http://www.diabetesincontrol.com/possible-new-type-2-diabetes-mellitus-therapy-a-ppars-sparing-thiazolidinedione/
*  A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias
Thiazolidinediones (TZDs) are medications used to treat diabetes. Beside their glucose lowering effects, TZDs are shown to ... Home » Topics » Cardiology » Research » A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of ... A Retrospective Study of the Role of Thiazolidinediones to Reduce the Incidence of Atrial Arrhythmias. 2014-08-27 03:44:55 , ... Thiazolidinediones (TZDs) are antidiabetic agents that enhance insulin sensitivity through activating peroxisome proliferators- ...
https://www.bioportfolio.com/resources/trial/107827/A-Retrospective-Study-of-the-Role-of-Thiazolidinediones-to-Reduce-the-Incidence.html
*  Thiazolidinedione - Wikipedia
Thiazolidinediones reduce bone mineral density and increase the risk of fractures in women, possibly as a result of biasing the ... The thiazolidinediones /θaɪ.əˌzoʊlɪdiːnˈdaɪ.oʊn/, abbreviated as TZD, also known as glitazones after the prototypical drug ... Replacing one oxygen atom in a thiazolidinedione with an atom of sulfur gives a rhodanine. The only approved use of the ... Because of this, the FDA recommends two to three month checks of liver enzymes for the first year of thiazolidinedione therapy ...
https://en.wikipedia.org/wiki/Thiazolidinedione
*  Current Advances in the Biochemical and Physiological Aspects of the Treatment of Type 2 Diabetes Mellitus with...
Thiazolidinediones (TZDs). TZDs are compounds used clinically as insulin sensitizers in order to lower blood glucose levels as ... Figure 4: Mechanism of action of PPARγ when it is activated by its exogenous ligands thiazolidinediones (TZDs). ... S. Horita, M. Nakamura, N. Satoh, M. Suzuki, and G. Seki, "Thiazolidinediones and edema: recent advances in the pathogenesis of ... V. A. Verma, B. Halu, and V. R. Kulkarni, "Understanding the antihyperglycemic agents of thiazolidinediones analogues using ...
https://www.hindawi.com/journals/ppar/2016/7614270/
*  The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects | Diabetes
Thiazolidinediones (TZDs) improve insulin sensitivity and have emerged as an effective treatment for type 2 diabetes and other ... The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects. ... The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects ... The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects ...
http://diabetes.diabetesjournals.org/content/51/10/2968
*  Reversible inhibition of vasoconstriction by thiazolidinediones related to PI3K/Akt inhibition in vascular smooth muscle cells....
Compounds bearing the thiazolidinedione structure have also been shown to inhibit phosphoinositide 3-kinase (PI3K). Here we ... Thiazolidinediones decrease vasoconstriction of isolated vessels possibly by inhibiting PI3K/Akt pathway. Such an effect of ... Thiazolidinediones (also referred to as glitazones), agonists for Peroxisome Proliferator-Activated Receptor gamma (PPARγ), are ... Reversible inhibition of vasoconstriction by thiazolidinediones related to PI3K/Akt inhibition in vascular smooth muscle cells. ...
https://www.sigmaaldrich.com/catalog/papers/23194750
*  Thiazolidinediones Reduce Pathological Neovascularization in Ischemic Retina Via an Adiponectin-Dependent Mechanism |...
Thiazolidinediones Reduce Pathological Neovascularization in Ischemic Retina Via an Adiponectin-Dependent Mechanism. Akiko ... Thiazolidinediones Reduce Pathological Neovascularization in Ischemic Retina Via an Adiponectin-Dependent Mechanism ... Thiazolidinediones Reduce Pathological Neovascularization in Ischemic Retina Via an Adiponectin-Dependent Mechanism ... Thiazolidinediones Reduce Pathological Neovascularization in Ischemic Retina Via an Adiponectin-Dependent Mechanism ...
http://atvb.ahajournals.org/content/early/2009/11/12/ATVBAHA.109.198465
*  Plus it
The Thiazolidinedione Pioglitazone Alters Mitochondrial Function in Human Neuron-Like Cells. Sangeeta Ghosh, Nishant Patel, ... The Thiazolidinedione Pioglitazone Alters Mitochondrial Function in Human Neuron-Like Cells. Sangeeta Ghosh, Nishant Patel, ... The Thiazolidinedione Pioglitazone Alters Mitochondrial Function in Human Neuron-Like Cells. Sangeeta Ghosh, Nishant Patel, ... The Thiazolidinedione Pioglitazone Alters Mitochondrial Function in Human Neuron-Like Cells Message Subject (Your Name) has ...
http://molpharm.aspetjournals.org/content/71/6/1695
*  The effect of metformin and thiazolidinedione use on lung cancer in diabetics
... Peter J Mazzone,. 1 Hardeep Rai,2 Mary Beukemann ... Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. J Clin Oncol. 2007;25:1476-1481 ... Thiazolidinediones are ligands for PPAR-gamma, a transcription factor highly expressed in cancer cell lines [28]. Exposure to ... PPAR-γ-independent antitumor effects of thiazolidinediones. Cancer Lett. 2009;276:119-124. doi: 10.1016/j.canlet.2008.08.008. [ ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3517374/?lang=en-ca
*  Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease
Effect of 2,4-thiazolidinedione on the survival rate induced by with MTS assay in SH-SY5Y. The survival rate was found to be ... Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease. ...
https://www.hindawi.com/journals/ppar/2017/4089214/sup/