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*  Effects of sarcoplasmic reticulum calcium pump inhibitors on vascular smooth muscle. | Hypertension
We found the following common vascular effects of thapsigargin and cyclopiazonic acid, which are known to be selective ... thapsigargin and cyclopiazonic acid inhibited the attachment of cultured aortic muscle cells to the substrate in a similar ...
http://hyper.ahajournals.org/content/23/1_Suppl/I156
*  Thapsigargin - Wikipedia
Thapsigargin is non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Structurally, thapsigargin is ... Thapsigargin raises cytosolic (intracellular) calcium concentration by blocking the ability of the cell to pump calcium into ... Thapsigargin specifically inhibits the fusion of autophagosomes with lysosomes; the last step in the autophagic process. The ... A prodrug of thapsigargin, mipsagargin, is currently undergoing clinical trials for the treatment of glioblastoma. The ...
https://en.wikipedia.org/wiki/Thapsigargin
*  thapsigargin (CHEBI:9516)
... has role calcium channel blocker (CHEBI:38215) thapsigargin (CHEBI:9516) has role EC 3.6.3.8 (Ca2+- ... thapsigargin (CHEBI:9516) is a butyrate ester (CHEBI:50477) thapsigargin (CHEBI:9516) is a organic heterotricyclic compound ( ... CHEBI:9516 - thapsigargin. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ... Thapsigargin inhibits Ca2+-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=9516
*  Thapsigargin (CAS 67526-95-8) 98% purity (ab120286) |Abcam
Thapsigargin, Ca2+-ATPase inhibitor (CAS 67526-95-8), with ,98% purity. Cited in 12 publications. Join researchers using our ... Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage.. Agents Actions 27:17-23 (1989). ... Thapsigargin, a high affinity and global inhibitor of intracellular Ca2+ transport ATPases.. Arch Biochem Biophys 298:313-7 ( ... A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases.. Trends Pharmacol Sci 19:131- ...
https://www.abcam.com/thapsigargin-ca2-atpase-inhibitor-ab120286.html?productWallTab=Questions
*  Thapsigargin inhibits Ca2+ entry into human neutrophil granulocytes | Biochemical Journal
Thapsigargin inhibits Ca2+ entry into human neutrophil granulocytes. M Geiszt, K Káldi, J B Szeberényi, E Ligeti ... Thapsigargin inhibits Ca2+ entry into human neutrophil granulocytes Message Subject (Your Name) has forwarded a page to you ... Thapsigargin, an inhibitor of microsomal Ca(2+)-ATPase, is an important tool in inducing store-regulated Ca2+ influx. In the ... As thapsigargin has been frequently applied at concentrations up to 2 microM, its inhibitory action on plasma-membrane Ca2+ ...
http://www.biochemj.org/content/305/2/525
*  RX871024 Induces Ca2+ Mobilization From Thapsigargin-Sensitive Stores in Mouse Pancreatic β-Cells | Diabetes
RX871024 Induces Ca2+ Mobilization From Thapsigargin-Sensitive Stores in Mouse Pancreatic β-Cells. ... RX871024 Induces Ca2+ Mobilization From Thapsigargin-Sensitive Stores in Mouse Pancreatic β-Cells ... RX871024 Induces Ca2+ Mobilization From Thapsigargin-Sensitive Stores in Mouse Pancreatic β-Cells ... RX871024 Induces Ca2+ Mobilization From Thapsigargin-Sensitive Stores in Mouse Pancreatic β-Cells ...
http://diabetes.diabetesjournals.org/content/47/2/211
*  Thapsigargin-induced nuclear calcium signals in rat basophilic leukaemia cells | Biochemical Journal
Thapsigargin-induced nuclear calcium signals in rat basophilic leukaemia cells. Y Horikoshi, T Furuno, R Teshima, J Sawada, M ... Thapsigargin-induced nuclear calcium signals in rat basophilic leukaemia cells. Y Horikoshi, T Furuno, R Teshima, J Sawada, M ... Thapsigargin-induced nuclear calcium signals in rat basophilic leukaemia cells Message Subject (Your Name) has forwarded a page ... By a confocal fluorescence microscope with an argon-ion laser (488 nm) and a He-Cd laser (325 nm) we have studied thapsigargin- ...
http://www.biochemj.org/content/304/1/57
*  Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)...
The thapsigargin-releasable pool of microsomal Ca2+ includes the pools sensitive to inositol 1,4,5-trisphosphate and GTP. ... Thapsigargin Induces Expression of Activating Transcription Factor 3 in Human Keratinocytes Involving Ca2+ Ions and c-Jun N- ... Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many ... Thapsigargin pretreatment of microsomes blocks subsequent loading with 45Ca2+, suggesting that its target is the ATP-dependent ...
http://www.pnas.org/content/87/7/2466?ijkey=97f32d20f29f3df8a06d5572e7dbffc51ffc47ee&keytype2=tf_ipsecsha
*  A23187- and thapsigargin-dependent increase in calretic | Open-i
... and thapsigargin-dependent increase in calreticulin mRNA levels (A) and protein levels (B). (A) Nontransfected NIH/3T3 cells ... thapsigargin. Mentions: Treatment of nontransfected cells with A23187 and thapsigargin also led to altered expression of the ... Thapsigargin also induced a fourfold increase in calreticulun protein levels. Importantly, we show by nuclear run-on ... B) NIH/3T3 cells were incubated for 16 h with 100 nM thapsigargin and cellular extracts were prepared as described by Mery et ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2141645_JCB.12347f4a&req=4
*  Mechanism of inhibition of the calcium pump of sarcoplasmic reticulum by thapsigargin | Biochemical Journal
In the presence of thapsigargin, only a single Ca2+ ion binds to the ATPase. Similarly, addition of thapsigargin to the ATPase ... Mechanism of inhibition of the calcium pump of sarcoplasmic reticulum by thapsigargin. M Wictome, I Henderson, A G Lee, J M ... Addition of thapsigargin prevents phosphorylation of the ATPase by P(i) and results in a very low steady-state level of ... The steady-state ATPase activity of sarcoplasmic-reticulum (Ca(2+)-Mg2+)-ATPase is inhibited by thapsigargin at a molar ratio ...
http://www.biochemj.org/content/283/2/525
*  THAPSIGARGIN INDUCES APOPTOSIS AND INDUCIBLE NO SYNTHASE EXPRESSION IN CULTURED RAT MESANGIAL CELLS | Biochemical Society...
THAPSIGARGIN INDUCES APOPTOSIS AND INDUCIBLE NO SYNTHASE EXPRESSION IN CULTURED RAT MESANGIAL CELLS. A.M. Rodríguez-López, J.M. ... THAPSIGARGIN INDUCES APOPTOSIS AND INDUCIBLE NO SYNTHASE EXPRESSION IN CULTURED RAT MESANGIAL CELLS ... THAPSIGARGIN INDUCES APOPTOSIS AND INDUCIBLE NO SYNTHASE EXPRESSION IN CULTURED RAT MESANGIAL CELLS ... THAPSIGARGIN INDUCES APOPTOSIS AND INDUCIBLE NO SYNTHASE EXPRESSION IN CULTURED RAT MESANGIAL CELLS ...
http://www.biochemsoctrans.org/content/24/4/566S.2
*  Phospholipase A(2) is involved in thapsigargin-induced sodium influx in human lymphocytes. - Semantic Scholar
Both, thapsigargin-induced Na(+) influx and AA liberation were completely inhibited in the presence of tyrosine kinase ... In addition, thapsigargin stimulated formation of arachidonic acid (AA), the physiological PLA(2) product. AA induced Na(+) ... 269, 26239-26242). In the present study we examined the mechanism underlying the thapsigargin-induced Na(+) entry. We found ... ATP-ase inhibitor thapsigargin leads to the Na(+) influx in human lymphocytes (M. Tepel et al., 1994, J. Biol. Chem. ...
https://www.semanticscholar.org/paper/Phospholipase-A%282%29-is-involved-in-sodium-influx-in-Nofer-Junker/8148e6eadaf2392604a348c5efd7d3e0c4d14cf7
*  Thapsigargin and di-tert-butylhydroquinone induce synergistic...
Thapsigargin and di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in ... Thapsigargin and DBHQ caused a marked reduction in the ability of bombesin to induce a rapid and transient increase in ... Thapsigargin and di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in ... Thapsigargin and DBHQ did not potentiate protein kinase C-mediated signals such as direct phosphorylation of myristoylated ...
https://www.mysciencework.com/publication/show/thapsigargin-di-tert-butylhydroquinone-induce-synergistic-stimulation-dna-synthesis-phorbol-ester-bombesin-swiss-3t3-ce-3bad7ffb
*  AID 1387 - Determination of dose dependent inhibition of thapsigargin-initiated p38 MAPK activation in ER stress signaling...
Determination of dose dependent inhibition of thapsigargin-initiated p38 MAPK activation in ER stress signaling using ...
https://pubchem.ncbi.nlm.nih.gov/bioassay/1387
*  Sarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes. -...
Addition of 5 nmol thapsigargin (TG) per milligram cell protein abolished Ca2+ uptake completely in both species. The [TG] ... Sarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes.. @article ... HoveMadsen1993SarcoplasmicRC, title={Sarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit ...
https://www.semanticscholar.org/paper/Sarcoplasmic-reticulum-Ca2%2B-uptake-and-thapsigargin-Hove-Madsen-Bers/b1b6f65ef26e906e9cd37ee6f2b338dbbd903176
*  Thapsigargin | SERCA inhibitor | Hello Bio
Buy Thapsigargin - an affordable, high quality SERCA inhibitor from Hello Bio, a trusted supplier for life science researchers ... References for Thapsigargin. *. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ... Targeting thapsigargin towards tumors.. Doan NT et al (2014) Steroids : PubMedID: 25065587 ... Targeting thapsigargin towards tumors.. Doan NT et al (2014) Steroids : PubMedID: 25065587 ...
https://www.hellobio.com/thapsigargin.html
*  Phyton Biotech Achieves Manufacturing Milestone with Thapsigargin, the Active Agent in Mipsagargin
... thus providing a more sustainable source of high-quality thapsigargin. Phyton is converting the Thapsia plant into thapsigargin ... Phyton Biotech Achieves Manufacturing Milestone with Thapsigargin, the Active Agent in Mipsagargin ... Phyton Biotech Achieves Manufacturing Milestone with Thapsigargin, the Active Agent in Mipsagargin. This milestone signifies ... a clinical-stage biotechnology company that has a patented technology platform utilizing thapsigargin for its prodrug delivery ...
http://tramatob.blogspot.com/2016/08/phyton-biotech-achieves-manufacturing.html
*  Polyenoic very-long-chain fatty acids mobilize intracellular calcium from a thapsigargin-insensitive pool in human neutrophils....
... mobilized Ca2+ from a thapsigargin-insensitive intracellular pool distinct from the thapsigargin-sensitive pools affected by ... Further studies suggested that the thapsigargin-insensitive Ca2+ mobilization elicited by 30:4 (n - 6) was not related to ... which was inhibited by thapsigargin pretreatment. In contrast, fatty acid-induced superoxide production progressively declined ... oxyradical formation, while the thapsigargin-sensitive Ca2+ mobilization induced by 20:4 (n - 6) may be involved in the ...
https://www.semanticscholar.org/paper/Polyenoic-very-long-chain-fatty-acids-mobilize-from-Hardy-Robinson/f5cfe4f14a51bb4abcdaeb408bda9b82a882ae57
*  Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest - Research Database, The...
We report that thapsigargin, an ER stressor widely used to induce autophagy, in fact blocks autophagy. Thapsigargin does not ... Strikingly, thapsigargin has no effect on endocytosis-mediated degradation of epidermal growth factor receptor. Molecularly, ... Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest. Research output: ... Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest. *Overview ...
http://discovery.dundee.ac.uk/portal/en/research/distinct-autophagosomallysosomal-fusion-mechanism-revealed-by-thapsigargininduced-autophagy-arrest
*  MacOdrum Library - Carleton's Institutional Repository: The regulation of thapsigargin-sensitive sarcoendoplasmic reticulum...
The regulation of thapsigargin-sensitive sarcoendoplasmic reticulum Ca 2+-ATPase activity in estivation. Publication. ... Ramnanan, C.J. (Christopher J.), & Storey, K. (2008). The regulation of thapsigargin-sensitive sarcoendoplasmic reticulum Ca 2+ ...
https://ir.library.carleton.ca/pub/3524
*  Influence of external calcium and thapsigargin on the uptake of polystyrene beads by the macrophage-like cell lines U937 and MH...
Furthermore, the presence of thapsigargin, known to lead to an increase of cytosolic calcium levels, did not have a significant ... In this study, the influence of external calcium concentrations and thapsigargin on the phagocytosis of polystyrene latex beads ... Influence of thapsigargin concentration and medium composition on phagocytosis. The influence of the thapsigargin concentration ... 10 nM thapsigargin, and 1 μM thapsigargin), the Pierce™ LDH Cytotoxicity Assay Kit from Thermo Scientific (Schwerte, Germany) ...
https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/2050-6511-15-16
*  Plus it
Thapsigargin administration for 8 h (300 nmol/l) was used as a positive control for JNK activation. B: BiP protein, ... Thapsigargin administration of islets.. After isolation and a 6-h recovery period after isolation in RPMI/10% FBS media, ... We previously demonstrated that the ER stress agent thapsigargin reduced Akt phosphorylation (9). As shown in Fig. 4C, the ... Ex vivo administration of wild-type (WT) and RIP-DNFoxo islets with thapsigargin and palmitate. A: Western blot for cleaved ...
http://diabetes.diabetesjournals.org/content/57/4/846
*  Functional Coupling Between Glycolysis and Sarcoplasmic Reticulum Ca2+ Transport | Circulation Research
Thapsigargin. Thapsigargin (6 to 20 μmol/L), a specific inhibitor of SR Ca2+-ATPase, was used in each experiment. ATPase ... C, Skeletal muscle SR+ADP+PEP without thapsigargin (1-minute incubation). Without thapsigargin, the ATP produced by PK is ... Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J Biol Chem. 1991;266:17067- ... Without thapsigargin (Fig 5C⇓), only small amounts of ATP could be detected in the supernatant because of its immediate ...
http://circres.ahajournals.org/content/77/1/88
*  Activation of the Endothelial Store-Operated ISOC Ca2+ Channel Requires Interaction of Protein 4.1 With TRPC4 | Circulation...
Thapsigargin Treatment Cells were exposed to 1 μmol/L thapsigargin (Calbiochem) for 2.5 to 3 minutes at room temperature before ... b, Thapsigargin-induced SOC entry was decreased in PAECs expressing TRPC4Δ. PAECs were infected with Ad-TRPC4wt or Ad-TRPC4Δ at ... Left panel, Infusion of thapsigargin (1 μmol/L) activated a small, inward Ca2+ current in Ad-TRPC4wt- but not in Ad-TRPC4Δ- ... In cells transfected with prr/4.1 peptide, the global [Ca2+]i response to thapsigargin was decreased 37% at the plateau phase ...
http://circres.ahajournals.org/content/97/11/1164