Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term responses and relied on ... Despite their importance, the molecular circuits that control the differentiation of naive T cells remain largely unknown. ... a proinflammatory T-cell subset that has been implicated in the pathogenesis of multiple autoimmune diseases. The TH17 ... T-cell subsets. Our study identifies and validates 39 regulatory factors, embeds them within a comprehensive temporal network ...
Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency. In: ... Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency. / ... Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency. Clinical ... title = "Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency", ...
... increased frequencies of Th17 cells were found with a positive correlation in SLEDAI. Higher frequencies of Th17 cells were ... Human TH17 cells are long-lived effector memory cells. Sci Transl Med 2011;3:104ra 100. ... Increased Th17 cells in flow cytometer-sorted CD45RO-positive memory CD4 T cells from patients with systemic lupus ... Increased Th17 cells in flow cytometer-sorted CD45RO-positive memory CD4 T cells from patients with systemic lupus ...
Th17-DC vaccines induce a unique T cell-mediated cytokine network. To determine if Th17-DC-induced T cell immunity was ... non-antigen pulsed Th17-inducing DCs (Th17-DCs), antigen-pulsed cDCs (Ag+cDCs) or antigen-pulsed Th17-DCs (Ag+Th17 DCs). (B) ... Th17 cell-derived IL-17 is dispensable for B cell antibody production. Cytokine 2012;59:108-14. doi:10.1016/j.cyto.2012.03.018 ... non-antigen Th17-DCs (Th17-DCs), antigen-pulsed cDCs (Ag+cDCs), antigen-pulsed Th17-DCs (Ag+Th17 DCs)) at day 42 following ...
Consistent with the requirement of Th17 cells for limiting fungal growth, IL-17-producing TRM cells in the mucosa were ... Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa Aug 27, 2020 9:11:21 AM ... Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa. ... Reference: Kirchner, F.R., LeibundGut-Landmann, S. Tissue-resident memory Th17 cells maintain stable fungal commensalism in the ...
CD4+ T helper 17 (Th17) cells protect vertebrate hosts from extracellular pathogens at mucosal surfaces. Th17 cells form from ... N2 - CD4+ T helper 17 (Th17) cells protect vertebrate hosts from extracellular pathogens at mucosal surfaces. Th17 cells form ... AB - CD4+ T helper 17 (Th17) cells protect vertebrate hosts from extracellular pathogens at mucosal surfaces. Th17 cells form ... abstract = "CD4+ T helper 17 (Th17) cells protect vertebrate hosts from extracellular pathogens at mucosal surfaces. Th17 cells ...
A Metabolic Switch for Th17 Pathogenicity.. Davis, Fred P; Kanno, Yuka; OShea, John J. Cell ; 163(6): 1308-10, 2015 Dec 03. ... T helper 17 (Th17) cells are critical for host defense but can also drive autoimmunity. This divergent behavior is explored by ... and Wang et al., who identify inflammation-associated genes by measuring gene expression in nearly 1,000 individual Th17 cells ... Encefalomielite Autoimune Experimental/patologia Análise de Sequência de RNA Análise de Célula Única Células Th17/metabolismo ...
We found that MSC-Exo greatly reduced the intensity of ongoing EAU as their parent cells by reducing the infiltration of T cell ... The in vitro effects of MSC-Exo on immune cell migration and responder T cell proliferation were examined by chemotactic assays ... However, no inhibitory effect of MSC-Exo on IRBP-specific T cell proliferation was observed. These results suggest that MSC-Exo ... Furthermore, the chemoattractive effects of CCL2 and CCL21 on inflammatory cells were inhibited by MSC-Exo. ...
Compared to TH17 cells, TH1/17 cells have gene signatures with marked similarity to mouse pathogenic TH17 cells. Assessing 15 ... which can be used to both identify pathogenic TH17 cells and to measure the effect of treatment on TH17 cells in human ... Here we show that human peripheral blood IFN-γ+IL-17+ (TH1/17) and IFN-γ−IL-17+ (TH17) CD4+ T cells display distinct ... Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis. * ...
Th17) cells and Tregs; however, the factors that promote Th17-driven autoimmunity are unclear. Here, we present evidence that ... is increased and required during Th17 cell differentiation. Isolation of naive T cells from a murine model of lupus revealed ... Importantly, silencing CaMK4 in T cells from patients with SLE and healthy individuals inhibited Th17 differentiation through ... Furthermore, naive T cells from mice lacking CaMK4 did not produce IL-17. Genetic or pharmacologic inhibition of CaMK4 ...
Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes. In: ... Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes. / Cho, ... Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes. ... title = "Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes", ...
Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells ... Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells ...
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Deletion of STIM1 in pathogenic Th17 cells reduces the expression of genes required for mitochondrial function and oxidative ... or inhibition of OXPHOS is associated with a non-pathogenic Th17 gene expression signature and impaired pathogenic Th17 cell ... attenuates pathogenic Th17 cell function and inflammation associated with STAT3C expression. ... findings establish Ca2+ influx as a critical regulator of mitochondrial function and oxidative stress in pathogenic Th17 cell- ...
Magnetically isolated naive and non-naive CD4+ T-cells were stimulated under Th17-polarizing proinflammatory cytokine ... arthritis under Th17-cytokine polarizing conditions in an explorative way using a transwell system prohibiting any cell-cell- ... as under Th17-polarizing conditions MSCs are still able to control T-cell differentiation and proinflammatory cytokine ... In patients, MSCs significantly decreased the proportion of IL-9 and IL-17 producing effector T-cells. MSCs also reduced IFN-γ ...
CONCLUSION: Our data indicate that the induction of IDO controls the accumulation of Th1 and Th17 pathogenic T cells at the ... cytokines interferon-gamma and interleukin-17 by lymph node T cells and later with increased infiltration of Th1 and Th17 cells ... RESULTS: IDO was induced in lymph node dendritic cells after collagen immunization. Systemic inhibition of tryptophan ... CONCLUSION: Our data indicate that the induction of IDO controls the accumulation of Th1 and Th17 pathogenic T cells at the ...
IL-21 regulates Th17 cell homeostasis enhances the differentiation of storage B cells and antibody-secreting plasma cells and ... Role of p38 MAPK in enhanced human cancer cells killing. IL-21 regulates Th17 cell homeostasis enhances the differentiation of ... IL-21+ T cells is normally mixed up in preferential lack of Th17 cells thats connected with SIV disease development. Further ... Furthermore treatment with IL-21 elevated the in vivo degrees of Th17 cells in SIV-infected RMs. On the other hand normal ...
STAT3 Inhibition Prevents Lung Inflammation, Remodeling, and Accumulation of Th2 and Th17 Cells in a Murine Asthma Model. ...
Th17 and Tc17 cells expressed high levels of CXCR3 and CCR6, Tc17 cells also expressed CXCR6. Binding to human sinusoidal ... The recruitment of murine Th17 cells to the liver was studied in vivo using intra-vital microscopy. Results: IL-17+ T cells ... and induced CCR6-dependent migration of Th17 cells suggesting that local cholangiocyte chemokine secretion localises Th17 cells ... in the case of Th17 cells, VAP-1. Th17 recruitment via sinusoids in mice with liver inflammation was reduced by treatment with ...
... we find that male Th17 cells induce disease of increased severity relative to female Th17 cells, irrespective of whether ... Throughout the disease course, a greater frequency of male Th17 cells produce IFNγ, a hallmark of pathogenic Th17 responses. ... is downregulated in pathogenic male murine Th17 cells, and functional experiments reveal that it represses the severity of Th17 ... Intriguingly, XY chromosomal complement increases the pathogenicity of male Th17 cells. An X-linked immune regulator, Jarid1c, ...
In recent years, several newly identified T helper (TH) cell subsets, such as TH9, TH17, and TH22 cells, and their respective ... TH9, TH17, and TH22 cell subsets and their main cytokine products in the pathogenesis of colorectal cancer. Cui, Guanglin ... Cui, G. (2019). TH9, TH17, and TH22 cell subsets and their main cytokine products in the pathogenesis of colorectal cancer. ... TH17/IL-17, and TH22/IL-22 in the pathogenesis of CRC have recently become an increasingly popular area of scientific ...
84% were Th17 IL-17A/F+ IL-22+ and/or TNFα+. iNKT cells were increased and TCRβhi. 75% were iNKT IL-10+ and 13% iNKTh17 IL-22+ ... Additionally, Treg IL-10+ and IL-22+ cells were increased. A novel dendritic cell subset was identified in anastomotic regions ... Healing is a concerted effort between intestinal epithelial cells (IECs), immune cells, and commensal bacteria. IEC TLR4 ... A distinct TCRβhi CD4+ T cells subset after anastomosis was 10-20-fold greater than in control mice. ...
The percentage of Th17 cells/CD4+ T cells was detected by flow cytometry. IL-17 level was measured by ELISA. The interaction of ... Over-expression of LncRNA H19 decreased IL-17 level and the percentage of Th17 cells/CD4+ T cells. Besides, we confirmed that ... 3p expression was up-regulated and the percentage of Th17 cells was increased in PFMCs of patients with EMS or under Th17 ... In vivo experiments showed LncRNA H19 over-expression suppressed the growth of Th17 cell differentiation-induced endometriosis- ...
... s disease and regulate Th1/Th17 cell responses",. abstract = "Increased T helper (Th)1/Th17 immune responses are a hallmark of ... CD-MFs demonstrated reduced capacity to suppress Th1 and Th17 responses from activated CD4+ T cells. By contrast, ... CD-MFs demonstrated reduced capacity to suppress Th1 and Th17 responses from activated CD4+ T cells. By contrast, ... CD-MFs demonstrated reduced capacity to suppress Th1 and Th17 responses from activated CD4+ T cells. By contrast, ...
... reduced numbers of Th17 cells; and an increased number of Treg cells in draining lymph nodes. ... with lower expression on CD4+ T cells. In human/mouse DR5-transgenic LysM.Cre mice, transgenic DR5 was restrictively expressed ... and T cell subset development were evaluated. ...
Th17 cells in human disease. Immunol Rev. 2008 Jun. 223:87-113. [QxMD MEDLINE Link]. [Full Text]. ... T cells are activated following antigen presentation by antigen-presenting cells such as macrophages and microglia, or B cells ... Ongoing inflammation leads to epitope spread and recruitment of other inflammatory cells (ie, bystander activation). The T cell ... These infiltrates are composed of activated T cells, B cells, and macrophages. ...
T cells in the colon. Furthermore, we show that IL-1β promotes Th17 responses from CD4(+) T cells and ILCs in the intestine, ... Using a T cell transfer colitis model, we demonstrate a key role for T cell-specific IL-1 receptor (IL-1R) signals in the ... inflammation by augmenting the recruitment of granulocytes and the accumulation and activation of innate lymphoid cells (ILCs ... T cells in the colon. Furthermore, we show that IL-1β promotes Th17 responses from CD4(+) T cells and ILCs in the intestine, ...
T cells in the colon. Furthermore, we show that IL-1β promotes Th17 responses from CD4(+) T cells and ILCs in the intestine, ... Using a T cell transfer colitis model, we demonstrate a key role for T cell-specific IL-1 receptor (IL-1R) signals in the ... inflammation by augmenting the recruitment of granulocytes and the accumulation and activation of innate lymphoid cells (ILCs ... T cells in the colon. Furthermore, we show that IL-1β promotes Th17 responses from CD4(+) T cells and ILCs in the intestine, ...
Supplementary Table S1 from Stromal Fibroblasts Induce CCL20 through IL6/C/EBPβ to Support the Recruitment of Th17 Cells during ... Th17) cells, a T-cell subset with protumorigenic properties. Neoplastic cells express only low endogenous levels of the Th17 ... Th17 cells may in turn maintain chronic inflammation within high-grade cervical lesions to further promote cancer progression. ... Supplementary Table S1 from Stromal Fibroblasts Induce CCL20 through IL6/C/EBPβ to Support the Recruitment of Th17 Cells during ...
Th17 cell based vaccines in mucosal immunity. Curr Opin Immunol. 2013;25:373-80. DOIPubMedGoogle Scholar ... Ewer K, Deeks J, Alvarez L, Bryant G, Waller S, Andersen P, et al. Comparison of T-cell-based assay with tuberculin skin test ... Understanding and overcoming the barriers to T cell-mediated immunity against tuberculosis. Semin Immunol. 2014;26:578-87. DOI ... Activation of T-cell immunity by influenza vaccination may contribute to our observed lower risk of incident TB among ...