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*  Th17 Cell Plasticity and Functions in Cancer Immunity
M. A. Munegowda, Y. Deng, S. J. Mulligan, and J. Xiang, "Th17 and Th17-stimulated CD8+ T cells play a distinct role in Th17- ... H. Liu, A. T. Cao, T. Feng et al., "TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression," European ... R. Du, H. Zhao, F. Yan, and H. Li, "IL-17+Foxp3+ T cells: an intermediate differentiation stage between Th17 cells and ... P. Muranski, Z. A. Borman, S. P. Kerkar et al., "Th17 cells are long lived and retain a stem cell-like molecular signature," ...
https://www.hindawi.com/journals/bmri/2015/314620/ref/
*  Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor | Nature
It is shown here to induce regulatory T cells when bound to the ligand TCCD and promote TH17 differentiation when bound to FICZ ... Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. . Proc. ... Cell 126, 1121-1133 (2006). **CAS*PubMed*Article*Google Scholar*11.. Bettelli, E., Oukka, M. & Kuchroo, V. K. TH17 cells in the ... Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation *Keiko Yasuda ...
https://www.nature.com/articles/nature06880?error=cookies_not_supported&code=b305d1de-2f52-46e9-9349-f081d9238557
*  "Playing Nice": Transcription Factors in TH17 Cells | Science Translational...
"Playing Nice": Transcription Factors in TH17 Cells Message Subject. (Your Name) has forwarded a page to you from Science ... Ciofani et al. aimed to define how TH17-cell TFs work together to determine cell lineage and function. To do this, the authors ... M. Ciofani et al., A validated regulatory network for TH17 cell specification. Cell 151, 289-303 (2012). [Abstract] ... which is produced by TH17 cells, but little is known about how these TFs govern TH17 specification and cell function. ...
http://stm.sciencemag.org/content/4/158/158ec198
*  Study identifies protein regulator that induces Th17 cells to cause multiple sclerosis
Th17 cells aren't always so helpful. In fact, studies have shown that excessive inflammation induced by Th17 cells is actually ... was more highly expressed in Satb1-deficient Th17 cells compared with normal Th17 cells, indicating that Satb1 normally ... Interleukin 17-producing T-helper (Th17) cells are a recently-identified class of immune cells that play a major role in ... gene expression in Th17 cells could form the basis of novel treatments for various autoimmune diseases caused by Th17 cells. If ...
https://www.news-medical.net/news/20190214/Study-identifies-protein-regulator-that-induces-Th17-cells-to-cause-multiple-sclerosis.aspx
*  IFN-β Inhibits Human Th17 Cell Differentiation | The Journal of Immunology
IFN-β-1a directly inhibits Th17 cell differentiation. A direct effect of IFN-β-1a on Th17 cell differentiation was investigated ... cells cultured in Th17-polarizing conditions. Two × 106 negatively selected CD4+CD45RA+ cells were cultured as above in Th17- ... and the Th17 cell surface marker IL-23R. The IFN-β-1a-mediated suppression of Th17 cell differentiation is also supported by ... the differentiation of Th17 cells is orchestrated by cytokines secreted by APCs. Although TGF-β and IL-6 induce Th17 cell ...
http://www.jimmunol.org/content/183/8/5418?ijkey=7ddbecc251ce7249d4f5f8fcd06fdb702cf45964&keytype2=tf_ipsecsha
*  Abstract 2867: TH17 cells promote early pancreatic tumorigenesis. | Cancer Research
We have found that TH17 cells, a subtype of CD4+ T-helper cells known to play an active role in other models of inflammation- ... Abstract 2867: TH17 cells promote early pancreatic tumorigenesis.. Florencia McAllister, Jennifer M. Bailey, Janivette Alsina, ... Abstract 2867: TH17 cells promote early pancreatic tumorigenesis.. Florencia McAllister, Jennifer M. Bailey, Janivette Alsina, ... Abstract 2867: TH17 cells promote early pancreatic tumorigenesis.. Florencia McAllister, Jennifer M. Bailey, Janivette Alsina, ...
http://cancerres.aacrjournals.org/content/73/8_Supplement/2867
*  Bronchoalveolar Lavage Fluid IFN- Th17 Cells and Regulatory T Cells in Pulmonary Sarcoidosis
... biological response modifiers and the family of cell adhesion-promoting molecules. ... IFN-γ+ Th17 cells were highly correlated with Th1 cells (. , , and ), and the ratio of IFN-γ+ Th17/FoxP3+ CD4+ T cells was ... T cells and Th17 cells were both lower in sarcoidosis compared to controls (. and , resp.). The proportion of Th17 cells ... IFN-γ+ Th17 cells may represent a pathogenic subset of Th17 cells, yet their expression of IFN-γ could be a consequence of a ...
https://www.hindawi.com/journals/mi/2014/438070/abs/
*  The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells | Nature Immunology
show that Hippo signaling is required for TH17 cell differentiation but inhibits Treg cell differentiation. ... Hippo signaling controls cell and tissue growth. Geng et al. ... T cells or are self-induced to become Th17 cells in the absence ... Th17 and regulatory T cells in mediating and restraining inflammation. . Cell 140, 845-858 (2010). ... Cell Biol. 10, 837-848 (2008).. **CAS*PubMed*Article*Google Scholar*14.. Varelas, X. et al. The Crumbs complex couples cell ...
https://www.nature.com/articles/ni.3748?error=cookies_not_supported&code=93e533d7-4798-45c9-8104-d71a2e60b7ff
*  JCI - miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity
Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger autoimmune diseases. Therefore, ... miR-146a-deficient 2D2 T cells induced more severe EAE and were more prone to differentiate into Th17 cells. Microarray ... miR-146a has emerged as a critical modulator of immune reactions, but its role in regulating autoreactive Th17 cells and organ- ... miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. ...
https://jci.org/articles/view/94012/figure/1
*  TGF-β in Th17 cell development: the truth is out there.
2011) demonstrate in this issue of Immunity that autocrine TGF-β cytokine promotes Th17 cell development and maintenance. ... As Th17 cell developmental requirements continue to be studied, Gutcher et al. ( ... As Th17 cell developmental requirements continue to be studied, Gutcher et al. (2011) demonstrate in this issue of Immunity ...
http://www.biomedsearch.com/nih/TGF-in-Th17-Cell-Development/21435582.html
*  Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. | Broad Institute
Th17 Cells. Abstract. TH17 cells (interleukin-17 (IL-17)-producing helper T cells) are highly proinflammatory cells that are ... These data demonstrate that SGK1 has a critical role in the induction of pathogenic TH17 cells and provide a molecular insight ... SGK1 is critical for regulating IL-23R expression and stabilizing the TH17 cell phenotype by deactivation of mouse Foxo1, a ... Here we used transcriptional profiling of developing TH17 cells to construct a model of their signalling network and nominate ...
https://www.broadinstitute.org/publications/broad4831
*  Transcription Factor IRF8 Directs a Silencing Programme for TH17 Cell Differentiation
T\(_H\)17 cells are recognized as a unique subset of T helper cells that have critical roles in the pathogenesis of ... Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. Nature Communications 2: 314. ... 17-cell differentiation. Mice with a conventional knockout, as well as a T cell-specific deletion, of the Irf8 gene exhibited ... IRF8 was induced steadily and inhibited T\(_H\)17-cell differentiation during T\(_H\)17 lineage commitment at least in part ...
https://dash.harvard.edu/handle/1/5978716
*  Vaccines | Free Full-Text | Dendritic Cell-Induced Th1 and Th17 Cell Differentiation for Cancer Therapy
While Th1/Tc1 cells are traditionally used for their potent anti-tumor responses, mounting evidence suggests Th17/Tc17 cells ... IL-17 producing T-cells (Th17/Tc17) play an important role in autoimmune diseases, but their function in cancer is more ... The induction of polarized T-cell responses can be regulated by dendritic cells (DCs). DCs are key regulators of the immune ... The type of T-cell response generated (e.g., Th1 or Th2) will determine the efficacy of the therapy, and it is generally ...
http://www.mdpi.com/2076-393X/1/4/527
*  Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist | JEM
Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell. 163:367-380. doi:10.1016/j.cell.2015.08.058. ... Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 139:485-498. doi:10.1016/j.cell.2009.09.033. ... 6 B). In contrast to the small intestinal Th17 cells, no significant changes were found in the frequency of Th17 cells in the ... In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were ...
http://jem.rupress.org/content/213/4/555
*  MINK1: The missing link between ROS and its inhibition of Th17 cells | JEM
... leads to increased ROS that negatively affect Th17 cell generation. Moreover, the DCA inhibitory effect on Th17 cell generation ... Mink1 deficiency results not only in a T cell-intrinsic enhanced Th17 cell commitment, but also in an increase in activated/ ... which in turn leads to enhanced Th17 cell generation in WT cells. This study demonstrated that Mink1 is the molecular mechanism ... MINK1: The missing link between ROS and its inhibition of Th17 cells. View ORCID ProfileGustavo J. Martinez ...
http://jem.rupress.org/content/214/5/1205.long
*  Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. -...
Treg cell signatures generated from (D) CXCR3+ versus CXCR3− Treg cells, (E) WT versus IRF4 KO Treg cells and (F) Treg cells ... TIGIT+ Treg cells suppress Th1 and Th17 cell but not Th2 cell responses ... or no Treg cells as controls (Teff:Treg cell ratio was 4.4:1 for TIGIT+ Treg cells and 3.6:1 for TIGIT− Treg cells). (A) Mice ... and Th17 cell, but not Th2 cell responses. Transcriptional profiling characterized TIGIT(+) Treg cells as an activated Treg ...
https://www.ncbi.nlm.nih.gov/pubmed/24745333
*  Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis. | Sigma-Aldrich
... activity of Th17 cells from children with LN and suggest that therapeutic modulation of the Akt activity may inhibit Th17 cell ... Th17 cells infiltrate the kidneys of patients with lupus nephritis (LN) and are critical for the pathogenesis of this disease. ... Th17 cells from children with LN exhibit high Akt activity and enhanced migratory capacity. Inhibition of the Akt signaling ... effector T cells from children with LN correlates with increased frequencies of IL-17-producing cells within these T cell ...
https://www.sigmaaldrich.com/catalog/papers/25339666
*  Human Th17 cells | Arthritis Research & Therapy | Full Text
Th17 cells produce IL-26 [34], whose exact role in the Th17 response is not yet established (Figure 2). Murine Th17 cells are ... cell into a Foxp3+ T regulatory (Treg) cell. IL-23 produced by DCs allows the expansion and/or survival of Th17 cells. Th17 ... Discovery of murine Th17 cells and their origin. *Properties of murine Th17 cells and their role in protection and ... Th17 CellExperimental Autoimmune EncephalomyelitisTreg CellTh17 DifferentiationDevelopmental Relationship. Introduction. The ...
https://arthritis-research.biomedcentral.com/articles/10.1186/ar2392
*  Protocol for the Differentiation and Characterization of Human Th17 Cells: R&D Systems
Flow Cytometric Analysis, single and Multi-analyte Assay of Cell Supernatants. ... Protocol for the Differentiation and Characterization of Human Th17 Cells. ... In vitro differentiation of Th17 cells from the larger CD4+ T cell population provides increased numbers of Th17 cells to ... Verify successful Th17 cell differentiation by analysis of the cells with flow cytometry and analysis of the cell culture media ...
https://www.rndsystems.com/resources/protocols/protocol-differentiation-and-characterization-human-th17-cells
*  Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation | Protocol
Next generation electroporation is an efficient method for transfecting human Th17 cells with small RNAs to alter gene ... Figure 2: RNA Interference in Primary Human Th17 Cells. Human CD4+ T cells from umbilical cord blood cultured under Th17 ... This protocol provides an improved method for the delivery of small RNAs into human Th17 cells. Although human Th17 cells were ... and IL-6 have been used for the development of human Th17 cells. Human Th17 cells express CCR6, a chemokine receptor that is ...
https://www.jove.com/video/55546/small-rna-transfection-primary-human-th17-cells-next-generation
*  Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi. | Sigma-Aldrich
Th17 cells are a subset of CD4+ T cells known to play a central role in the pathogenesis of many autoimmune diseases, as well ... Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi.. [Catherine W Cai, Jennifer ... Mechanistically, Th17 cells can directly protect infected cells through the IL-17A-dependent induction of NADPH oxidase, ... Th17 cells confer significantly stronger protection against T. cruzi-related mortality than even Th1 cells, traditionally ...
https://www.sigmaaldrich.com/catalog/papers/27695083
*  Th17 cell cytokine secretion profile in host defense and autoimmunity | Springer for Research & Development
Objective and design The goal of this review is to examine the effector functions of Th17 cells in host defense and ... Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases ... IL-9 induces differentiation of TH17 cells and enhances function of FoxP3 + natural regulatory T cells. Proc Natl Acad Sci USA ... Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. Clin Immunol ...
https://rd.springer.com/article/10.1007/s00011-011-0419-1
*  Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation | Protocol (Translated to Korean)
우리는 우리의 인간 Th17 체외 분화 분석의 견고성을 평가하기 위해 세 가지 Th17 관련 마커 (CCR6, RORγt, IL-17A)의 발현을 조사 하였다. 또한, 우리는이 Th17 마커의 발현이 매우 낮은 또는 부재이어야 ... 성공적으로 인간의 Th17 세포를 electroporating의 신뢰할 수있는 시스템을 개발하는 첫 번째 단계는 체외 차별화 된 인간의 Th17 세포 배양에서 강력한 생성하는 것이었다. Th17 - 편광 조건 하에서 배양 된 T ... 인간 Th17 세포는 적절한 환경 편광판 (4)을 제공함으로써 체외 나이브 CD4 + T 세포로부터 생성 될 수있다. 바리오. 사이토 카인의 우리 조합은 IL-1β, IL-23, TGFβ, 및 IL-6는 인간의 Th17 세포의 ... Th17 - 편광 조건 하에서 배양 된 T 세포는 재 자극시 IL-17A를 생성하지만 THN 조건 (도 1B, 우측) (좌측도 1b). Th17 분화 여전히 작은 RNA를 가진 형질 전환 후에 발생하지만, 일부 실험에서, ...
https://www.jove.com/video/55546/-th17-rna-?language=Korean
*  Probiotic and IL-21 Treatment Promotes Th17 Cell Recovery in ARV-Treatment of Pigtail Macaques
... ... Probiotic Supplementation of ARV Treatment during SIV Infection of Pigtail Macaques Results in Enhanced GI Tract CD4+ T Cell ...
http://natap.org/2014/IAC/IAC_103.htm
*  Th1 or Th17 cells: What are the pathogenic T cells in CNS autoimmunity? | The New York Academy of Sciences
... but the recent discovery of Th17 cells has questioned whether Th1 cells are indeed pathogenic or whether Th17 cells are the ... Th1 or Th17 cells: What are the pathogenic T cells in CNS autoimmunity?. Thursday, March 22, 2007. The New York Academy of ... T-helper (TH) cells are traditionally thought to differentiate into TH1 and TH2 cell subsets. TH1 cells are necessary to clear ... Induction of CNS Autoimmunity by Th1 and Th17 cells.. Vijay K. Kuchroo, DVM, PhD. Center for Neurologic Diseases, Brigham and ...
https://www.nyas.org/events/2007/th1-or-th17-cells-what-are-the-pathogenic-t-cells-in-cns-autoimmunity/