A 100 mM (25 mg in 1007 µl) sterile-filtered solution of Tetrahydrouridine (Cat. No.1671) in H₂O. ...
Tetrahydrouridine and decitabine were rapidly absorbed into the systemic circulation after a single combination oral dose, with ... Tetrahydrouridine (THU) inhibits CDA, safeguarding decitabine. METHODS:. The pharmacokinetics and pharmacodynamics of three ... Pharmacokinetics and pharmacodynamics of an oral formulation of decitabine and tetrahydrouridine. Lau, Henry; Woost, Philip G; ...
Wentworth DF, Wolfenden R (November 1975). "On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase ...
Tetrahydrouridine (cytidine deaminase inhibitor) Phase I Solid tumors No response Jeffrey Petty Decitabine ATRA Preclinical ... Tetrahydrouridine (cytidine deaminase inhibitor) Phase I Solid tumors No response Jeffrey Petty Decitabine ATRA Preclinical ... 3).5 Inhibition of deamination by the cytidine deaminase inhibitor tetrahydrouridine may enhance specific antineoplastic ... the activity of which is blocked by zebularine and tetrahydrouridine. Deoxyribose-containing compounds are sequentially ...
N. Funamizu, C. R. Lacy, K. Fujita et al., "Tetrahydrouridine inhibits cell proliferation through cell cycle regulation ...
... tetrahydrouridine (5 µg), butylated hydroxytoluene (10 µM) and pentostatin (1 µg). The mixture was incubated with the RNA for 2 ...
... and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer Chemother Pharmacol ...
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A Multi-Histology Phase II Study of 5-Fluoro-2-Deoxycytidine With Tetrahydrouridine (FdCyd + THU). Completed. USA. 0. ...
Deamination can be inhibited by tetrahydrouridine. III. PLANT ALKALOIDS VINBLASTINE (Velban) 1. CHEMICAL NATURE: Vinblastine ...
CheckOrphan is a non-profit organization located in Basel, Switzerland and Santa Cruz, California that is dedicated to rare, orphan and neglected diseases. CheckOrphan offers users an interactive and dynamic platform for all these diseases. This strategy allows visitors to be updated daily on all the latest news and interact with people internationally. This is essential, because due to the nature of these diseases, there is not a large concentration of individuals within any given proximity ...
1. NDec is a novel, oral, fixed-dose formulation of decitabine and tetrahydrouridine that is currently being developed for the ...
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... which include tetrahydrouridine and dihydro 5 azacytidine, FCdR showed enhanced stability and enhanced exercise. ...
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine. Lavelle D, Vaitkus K, Ling Y, Ruiz MA ... Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 ... Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 ... Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Terse P, Engelke K, Chan K, ...
Tetrahydrouridine. Phase 1 completed. NCT02847000. Vorinostat. Capecitabine. Phase 1 completed. NCT00983268. Azacitidine. nab- ...
The drug tetrahydrouridine (THU) blocks an enzyme that breaks down Dec. This increases the time cells are exposed to Dec. The ... alone or in combination with Oral Decitabine/Tetrahydrouridine as Second Line Therapy for Non-Small Cell Lung Cancer. This ...
7. Combinations of tetrahydrouridine and cytosine arabinoside in mouse tumors.. Kreis W; Hession C; Soricelli A; Scully K. ... Influence of tetrahydrouridine on the phosphorylation of 1-beta-D-arabinofuranosyl-cytosine (ara-C) by enzymes from solid ... Effect of tetrahydrouridine on the action of 1-beta-D-arabinofuranosylcytosine in synchronized cultures of normal rat kidney ... Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2-deoxycytidine and 1-beta-D- ...
Orphan designation for treatment sickle cell disease in combination with tetrahydrouridine. Orphan indication sponsor. * ...
Phase I Trial of Oral 5-Fluoro-2-Deoxycytidine with Oral Tetrahydrouridine in Patients with Advanced Solid Tumors; 12-C-0066; ...
Phase I Trial of Oral 5-Fluoro-2-Deoxycytidine with Oral Tetrahydrouridine in Patients with Advanced Solid Tumors; 12-C-0066; ...
... and tetrahydrouridine, which turns off an enzyme in the body that destroys decitabine. In 2012, with support from the National ...
Tetrahydrouridine,modify,31-OCT-05,(null),(null) C2698,Monoclonal_Antibody_CC49-delta_CH2,modify,31-OCT-05,(null),(null) C28681 ...
... and tetrahydrouridine (50 µg/mL) (Calbiochem, San Diego, CA), and the antioxidant desferrioxamine (0.1 mM) (Sigma-Aldrich Corp ...
... tetrahydrouridine, and carboplatin. Marsh JH, Kreis W, Barile B, Akerman S, Schulman P, Allen SL, DeMarco LC, Schuster MW, ...
p53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Refractory/Relapsed Lymphoid Malignancies. ...
Tetrahydrouridine Preferred Term Term UI T040450. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... Tetrahydrouridine. Tree Number(s). D03.383.742.680.852.800. D13.570.685.852.800. D13.570.800.892.800. Unique ID. D013767. RDF ... Tetrahydrouridine Preferred Concept UI. M0021239. Registry Number. 18771-50-1. Scope Note. An inhibitor of nucleotide ...
Tetrahydrouridine Preferred Term Term UI T040450. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1975). ... Tetrahydrouridine. Tree Number(s). D03.383.742.680.852.800. D13.570.685.852.800. D13.570.800.892.800. Unique ID. D013767. RDF ... Tetrahydrouridine Preferred Concept UI. M0021239. Registry Number. 18771-50-1. Scope Note. An inhibitor of nucleotide ...
Effects of Tetrahydrouridine on Pharmacokinetics and Pharmacodynamics of Oral Decitabine • Blood • Feb. 2, 2012 ... Subchronic Oral Toxicity Study of Decitabine in Combination with Tetrahydrouridine in CD-1 Mice • International Journal of ...
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Tetrahydrouridine - Preferred Concept UI. M0021239. Scope note. An inhibitor of nucleotide metabolism. ...
Decitabine + Tetrahydrouridine Celecoxib + Decitabine + Tetrahydrouridine Adjuvant Oral Decitabine and Tetrahydrouridine With ... Tetrahydrouridine THU. Tetrahydrouridine is a synthetic pyrimidine analogue that inhibits deoxycytidine monophosphate (dCMP) ... Decitabine + Tetrahydrouridine p53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Refractory/ ... Decitabine + Tetrahydrouridine p53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Pancreatic ...
Cmax for tetrahydrouridine from pharmacokinetic assessment [Time Frame: At week 24] Change in foetal haemoglobin as a ... A Multicentre Trial Evaluating the Efficacy and Safety of Oral Decitabine Tetrahydrouridine (NDec) in Patients With Sickle Cell ...
Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 ...
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Funamizu N, Lacy CR, Fujita K, Furukawa K, Misawa T, Yanaga K, Manome Y. Tetrahydrouridine inhibits cell proliferation through ...
CheckOrphan is a non-profit organization located in Basel, Switzerland and Santa Cruz, California that is dedicated to rare, orphan and neglected diseases. CheckOrphan offers users an interactive and dynamic platform for all these diseases. This strategy allows visitors to be updated daily on all the latest news and interact with people internationally. This is essential, because due to the nature of these diseases, there is not a large concentration of individuals within any given proximity ...
Dehydrogenase Tetrahydrofolates Tetrahydroisoquinolines Tetrahydronaphthalenes Tetrahydropapaveroline Tetrahydrouridine ...
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