Loading...
*  Genes | Free Full-Text | Solving the Telomere Replication Problem
This is known as the telomere replication problem. In this article, different and new aspects of telomere replication, that can ... Telomere replication is a major challenge because many obstacles to the progression of the replication fork are concentrated at ... In particular, we will focus on the functions of shelterin and the replisome for the preservation of telomere integrity ... Telomeres are complex nucleoprotein structures that protect the extremities of linear chromosomes. ...
http://www.mdpi.com/2073-4425/8/2/55
*  Positive and negative regulation of telomerase access to the telomere | Journal of Cell Science
Positive and negative regulation of telomerase access to the telomere Message Subject (Your Name) has sent you a message from ... The protective caps on chromosome ends - known as telomeres - consist of DNA and associated proteins that are essential for ... A fundamental part of ensuring proper telomere function is maintaining adequate length of the telomeric DNA tract. Telomeric ... Evidence from both yeast and mammals suggests that telomere-associated proteins positively or negatively control access of ...
http://jcs.biologists.org/content/113/19/3357
*  G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells | Molecular Cancer...
SYUIQ-5 Induced Telomere DNA Damage in an ATM-Dependent Manner. To further investigate the signal pathway of telomere DNA ... Telomere DNA Damage Induced by SYUIQ-5. To investigate the consequence of TRF2 delocalization on telomeres, CNE2 and HeLa cells ... 5). Since TRF2 was reported to be a specific inhibitor of ATM on telomeres and prevented inappropriate DNA repair at telomeres ... Ligands that selectively bind to and stabilize G-quadruplexes structures may interfere with telomere conformation and telomere ...
http://mct.aacrjournals.org/content/8/12/3203.long
*  Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ε3/ε3 subjects
Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length ... A critically short telomere will trigger the cell to enter a state of cellular senescence or to apoptose. The rate of telomere ... 1. Telomeres and the brain: an investigation into the relationships of leukocyte telomere length with functional and structural ... In Paper I, telomere length was shown to be longer among non-demented carriers of the apolipoprotein E (APOE) ε4 allele, a well ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:516681
*  Leicester Research Archive: Investigation of epigenetic alterations related to telomere maintenance in human cells
Human telomeres can be maintained by the enzyme telomerase, which catalyses the addition of telomere repeats, or by the ... No relationship between telomere length and DNA methylation at XpYp was found in telomerase positive cells. Additionally, ... In marked contrast to mouse models, no relationship was found between the level of any of these modifications and telomere ... This may indicate that the role such marks play at telomeres differs between humans and mice. Additionally, the level of ...
https://lra.le.ac.uk/handle/2381/10324
*  Brunel University Research Archive: Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic...
... using known telomere length assays. We measured telomere lengths using: Telomere Restriction Fragment length (TRF), absolute ... Background: Telomere length dysregulation plays a major role in cancer development and aging. Telomeres are maintained by a ... The increase in telomere lengths was consistently observed when various telomere length methods were used. Conclusions: Further ... Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic modifying drug. ...
http://bura.brunel.ac.uk/handle/2438/14059
*  Molecular genetics of telomeres and telomerase | Department of Biology
Several other yeast telomere binding proteins are involved in the assembly of the functional telomere cap of the yeast ... Start › Research › Research groups › Genetics: Telomeres and Telomerase › Molecular genetics of telomeres and telomerase ... The length of telomeres are regulated, so that each species has a defined average mean length. The RAP1 protein has been shown ... When the telomeres shorten and the number of protein molecules decrease, the enzyme would regain its ability to bind and ...
https://www.biology.lu.se/research/research-groups/genetics-telomeres-and-telomerase/molecular-genetics-of-telomeres-and-telomerase
*  Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins |...
Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins. ... Telomere repeat binding factors (TRFs) 1 and 2 bind to telomere double-stranded DNA and function to regulate telomere length ... Do Telomeres Adapt to Physiological Stress? Exploring the Effect of Exercise on Telomere Length and Telomere-Related Proteins ... stranded telomere DNA and regulate telomere length by controlling the access of telomerase to telomeres [36]. In addition, ...
http://circleofdocs.com/do-telomeres-adapt-to-physiological-stress-exploring-the-effect-of-exercise-on-telomere-length-and-telomere-related-proteins/
*  The paradox of longer sperm telomeres in older men's testes: a birth-cohort effect caused by transgenerational telomere erosion...
Intergenerational telomere erosionBirth-cohort effectTelomere lengtheningTelomeraseAlternative lengthening of telomeres ... Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genetics. 2008;4(2):e37. doi: ... Spermatozoa telomeres determine telomere length in early embryos and offspring. Reproduction. 2016;151(1):1-7. doi:10.1530/REP- ... This is what I based my theory of telomere-driven macroevolution on, 12 years ago. On the basis of published data on telomere ...
https://molecularcytogenetics.biomedcentral.com/articles/10.1186/s13039-016-0224-1
*  Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita
age-adjusted mean telomere length < 1%ile in peripheral blood lymphocytes as reported. by a CLIA-approved laboratory; OR ... DC is part of a spectrum of telomere biology disorders, which include some forms of. inherited idiopathic aplastic anemia, ... Telomere Disease. Trial Phase:. Phase 2. Minimum Age:. N/A. Maximum Age:. 30 Years ...
http://www.knowcancer.com/cancer-trials/NCT01659606/
*  Rapid Quantification of Telomerase Activity Employing an Improved Real-time Telomeric Repeat Amplification Protocol in Clinical...
2003) Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis. J Hepatol 5: 786-792 ... Kojima H, Yokosuka O, Imazeki F, Saisho H, Omata M (1997) Telomerase activity and telomere length in hepatocellular carcinoma ... Telomerase, a ribonucleoprotein with reverse transcriptase activity, plays a pivotal role in maintaining telomere length and ... In cells without telomerase activity, replication-associated telomere attrition limits the replicative lifespan [1]. Therefore ...
https://www.omicsonline.org/rapid-quantification-of-telomerase-activity-employing-an-improved-real-time-telomeric-repeat-amplification-1948-5956.1000084.php?aid=2044
*  Brief Report: Differential Effects of Tenofovir, Abacavir, Emtricitabine, and Darunavir on Telomerase Activity In Vitro
Telomeres are made up of hexamer repeat TTAGGG sequences. Telomerase binds to the 3' end of the telomeres through its own RNA ... Although Leeansyah and colleagues reported that in vivo telomere length was significantly inversely associated with the total ... patientscould be telomere shortening caused by antiretroviral drugs.5There is a close association between shortened telomere ... patients could be telomere shortening caused by antiretroviral drugs.5 There is a close association between shortened telomere ...
http://www.natap.org/2016/HIV/120816_01.htm
*  Terf2ip MGI Mouse Gene Detail - MGI:1929871 - telomeric repeat binding factor 2, interacting protein
J:243602 Liu H, et al., NLRP3 inflammasome induced liver graft injury through activation of telomere-independent RAP1/KC axis. ...
http://www.informatics.jax.org/marker/MGI:1929871
*  Telomerase catalytic subunit Antibody 600-401-252
In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to limited lifespan and ... compensating for the telomere shortening that occurs with DNA replication. ... Telomerase is a reverse transcriptase that adds telomeric repeats (TTAGGG)n to chromosomal ends, compensating for the telomere ... In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to limited lifespan and ...
https://rockland-inc.com/store/Cancer-Research-Antibodies-600-401-252-O4L_22960.aspx
*  telomere
The telomere is a nucleoprotein structure comprising the terminal section of a eukaryotic chromosome. It has a specialized ...
http://www.uniprot.org/locations/SL-0276
*  Telomere News, Research
Telomere News and Research. RSS A telomere is a region of repetitive DNA at the end of a chromosome, which protects the end of ... Telomere shortening in adulthood is not caused by smoking, say researchers A new study suggests that telomere length in adults ... Study: Smoking does not shorten the length of telomeres A new study has surprised the medical world, finding that smoking does ... People born with short telomeres found to have short-lived immune system cells Scientists at Johns Hopkins say they have found ...
https://www.news-medical.net/?tag=/Telomere
*  Telomere length homeostasis | SpringerLink
... known as telomeres, protect chromosome ends from nucleolytic degradation and DNA repair activities. Conventional DNA ... Telomere Length Short Telomere Cajal Body Telomere Elongation Nonextendible State These keywords were added by machine and not ... Correct telomere length setting is crucial for long-term survival. The telomere length reserve must be sufficient to avoid ... In vivo analysis of telomere elongation kinetics shows that telomerase does not act on every telomere in each cell cycle but ...
https://link.springer.com/article/10.1007%2Fs00412-006-0067-3
*  Telomere Research Positions
... Lustig, Arthur J. alustig at MAILHOST.TCS.TULANE.EDU Wed Sep 25 10:36:35 EST 1996 *Previous ... the role of the telomere-binding protein RAP1 in telomere size control and telomeric silencing (see Lustig et al. MCB 16: 2483- ... that appears to combine elements of intrachromatid recombination and pairing of non-homologous telomeres to regulate telomere ... POSTDOCTORAL POSITIONS AVAILABLE TO STUDY TELOMERE SIZE REGULATION AND TELOMERIC SILENCING IN SACCHAROMYCES CEREVISIAE. I am ...
http://www.bio.net/bionet/mm/yeast/1996-September/005803.html
*  Telomeres - Scientific American
... although telomere shortening may play a role in limiting cellular life span, there is no evidence that telomere shortening ... long-lived species often have shorter telomeres than do short-lived species, indicating that telomere length probably does not ... 56Kakuo S, Asaoka K, Ide T. Human is a unique species among primates in terms of telomere length. Biochem Biophys Res Commun. ... Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460. 54Vaziri H, Dragowska W, Allsopp RC, Thomas TE, ...
https://www.scientificamerican.com/article/telomeres/
*  Vitamin D Council| telomere length
Tag Archives: telomere length. New research explores the relationship between telomere length and vitamin D status. A study ... investigated whether low vitamin D status is associated with short telomeres, since both are linked to risk of chronic health ...
https://www.vitamindcouncil.org/tag/telomere-length/
*  telomeres Archives - ExtremeTech
This newsletter may contain advertising, deals, or affiliate links. Subscribing to a newsletter indicates your consent to our Terms of Use and Privacy Policy. You may unsubscribe from the newsletter at any time ...
https://www.extremetech.com/tag/telomeres
*  Telomeres and Cancer
... compensating for the normal shortening of telomeres in all dividing cells. ... A ribonucleoprotein enzyme complex known as telomerase maintains telomere length in cancer cells by adding TTAGGG repeats onto ... Certain individuals may be born with shorter telomeres or may have genetic disorder leading to shorter telomeres. Telomeres are ... Hiyama K, Hiyama E, Tanimoto K, Nishiyama M. Role of Telomeres and Telomerase in Cancer. In: Hiyama K, editor. Telomeres and ...
https://www.news-medical.net/life-sciences/Telomeres-and-Cancer.aspx
*  Telomeres and Telomerase | SpringerLink
... rapid advances in technology have equipped us with a variety of tools and platforms to ask fundamental questions of telomere ... Cancer progression Cell growth Chromatin Genomics Model systems Protein interaction networks Proteomics Telomere DNA Telomere ... Telomeres and Telomerase: Methods and Protocols, Second Edition builds upon the telomerase assays featured in the popular first ... Authoritative and practical, Telomeres and Telomerase: Methods and Protocols, Second Edition serves as an ideal, up-to-date ...
https://link.springer.com/book/10.1007/978-1-61779-092-8
*  Telomere Images, Stock Photos & Vectors | Shutterstock
Find telomere Stock Images in HD and millions of other royalty-free stock photos, illustrations, and vectors in the ... Telomere stock photos. 568 Telomere stock photos, vectors, and illustrations are available royalty-free. See telomere stock ... Telomeres DNA and telomere length medical concept on the end caps of a chromosome as a symbol for aging and genetic protection ... Telomeres length loss with DNA and shortening telomere medical concept as a tree with falling leaves on the end caps of a ...
https://www.shutterstock.com/search/telomere
*  telomeres | NextBigFuture.com
telomeres Archive antiaging100 years ago the world absolute poverty rate was as bad as the poorest country today. No Comments ...
https://www.nextbigfuture.com/tag/telomeres