Wnt signaling pathway - Wikipedia
Staal FJ, Clevers H (February 2000). "Tcf/Lef transcription factors during T-cell development: unique and overlapping functions ... T-cell factor/lymphoid enhancing factor) transcription factors. β-catenin recruits other transcriptional coactivators, such as ... eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF ... β-catenin binds to transcription factors such as the protein TCF4 and in combination the molecules activate the necessary genes ...https://en.wikipedia.org/wiki/Wnt_signaling_pathway
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector...
The transcription factor TCF1, a member of the TCF/lymphoid enhancer factor (LEF) family of high-mobility group (HMG) box ... A recent study revealed that activating transcription factor 2 family transcription factors (ATF2) can promote transcription ... and the transcription factor c-myc. LEF1 also directly augments expression of the effector fate-specifying transcription factor ... The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity. ...http://jem.rupress.org/content/early/2015/04/14/jem.20141849
anti-LEF1 antibody [1C3.1D10] | GeneTex
... lymphoid enhancer-binding factor 1) for WB. Anti-LEF1 mAb (GTX12033) is tested in Human samples. 100% Ab-Assurance. ... It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF1, TCF1, TCF3 and TCF4). These ... lymphoid enhancer-binding factor 1. Background. Lymphoid enhancer factor, LEF1, is a transcription factor of the High Mobility ... factors play crucial roles in WNT/Wingless signaling, a signal transduction cascade that directs cell differentiation. Aberrant ...http://www.genetex.com/LEF1-antibody-1C31D10-GTX12033.html
WNT5A transforms intestinal CD8αα+ IELs into an unconventional phenotype with pro-inflammatory features | BMC Gastroenterology ...
... where it associates with TCF/LEF family transcription factors to activate target gene expression. While WNT/β-catenin has been ... Its induced transcription factor nuclear factor κB (NF-κB) is crucial for inflammation, immunity and tissue homeostasis , ... The Th2 cytokine IL-4 and transcription factor GATA-2 expression level were unaffected by the treatment (Fig. 5a).. ... 1). The transcription factor NFATc1 was reported to play an essential role in the pathogenesis of inflammatory bowel disease ...https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-015-0402-3
The Wnt Homepage
... which enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes. ... In comparison to other growth factors, Wnt signals have several unique properties, including a short range of action. Thereby, ...http://stanford.edu/group/nusselab/cgi-bin/wnt/main
Wnt (Inhibitors Agonists Modulators Antagonists)-MedChemExpress.com
ICG-001 is an antagonist of Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) ... iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive ... iCRT3 is an inhibitor of both Wnt and β-catenin-responsive transcription. ... The canonical Wnt pathway leads to regulation of gene transcription, the noncanonical planar cell polarity pathway regulates ...http://update.medchemexpress.com/Targets/Wnt.html
Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis
... transcription factor 2) , Osterix (Osx) , Msx1/2, and T-cell factor/lymphoid enhancer factor (TCF/LEF) . These ... abnormal expression of one of the TCF/LEF transcription factors may be partially compensated by other factors. TCF/LEF ... TCF/LEF, as an intracellular transcription factor in the canonical Wnt signaling pathway, initiates the transcription of ... Yu Q, Erman B, Park JH, Feigenbaum L, Singer A. IL-7 receptor signals inhibit expression of transcription factors TCF-1, LEF-1 ...http://www.medsci.org/v15p1415.htm
Expression of TCF/LEF transcription factors appears red | Open-i
Expression of TCF/LEF transcription factors appears reduced in LX-2 cells.(A) Western Blot for TCF1, TCF3, TCF4 and LEF1in ... pone.0142794.g005: Expression of TCF/LEF transcription factors appears reduced in LX-2 cells.(A) Western Blot for TCF1, TCF3, ... pone.0142794.g005: Expression of TCF/LEF transcription factors appears reduced in LX-2 cells.(A) Western Blot for TCF1, TCF3, ... that tether β-catenin to its transcription factor partners the TCF/LEF proteins, were all expressed at the mRNA level in LX-2 ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4643911_pone.0142794.g005&req=4
A combinatorial code of maternal GATA, Ets and β-catenin-TCF transcription factors specifies and patterns the early ascidian...
A combinatorial code of maternal GATA, Ets and β-catenin-TCF transcription factors specifies and patterns the early ascidian ... A combinatorial code of maternal GATA, Ets and β-catenin-TCF transcription factors specifies and patterns the early ascidian ... A combinatorial code of maternal GATA, Ets and β-catenin-TCF transcription factors specifies and patterns the early ascidian ... A combinatorial code of maternal GATA, Ets and β-catenin-TCF transcription factors specifies and patterns the early ascidian ...http://dev.biologists.org/content/134/22/4023
Gentaur Molecular :EIAab \ Homo sapiens,Human,Mitochondrial transcription factor 1,MtTF1,mtTFA,TCF6,TCF-6,TCF6L2,TFAM...
TCF-6,TCF6L2,TFAM,Transcription factor 6,Transcription factor 6-like 2,Transcription factor A, mitochondrial \ EIAAB42084 for ... Mitochondrial transcription factor 1,MtTF1,mtTFA,TCF6,TCF-6,TCF6L2,TFAM,Transcription factor 6,Transcription factor 6-like 2, ... Mitochondrial transcription factor 1,MtTF1,mtTFA,TCF6,TCF-6,TCF6L2,TFAM,Transcription factor 6,Transcription factor 6-like 2, ... TCF-6,TCF6L2,TFAM,Transcription factor 6,Transcription factor 6-like 2,Transcription factor A, mitochondrial Ask technical file ...http://www.antibody-antibodies.com/product2893419-search-Homo_sapiens,Human,Mitochondrial_transcription_factor_1,MtTF1,mtTFA,TCF6,TCF_6,TCF6L2,TFAM,Transcription_factor_6,Transcription_factor_6_like_2,Transcription_factor_A,_mitochondrial.html
Gentaur Molecular :Signosis 2011 \ TCF LEF EMSA Kit Runt-related transcription factor 2 \ GS-0048
TCF_LEF EMSA Kit Runt-related transcription factor 2 \ GS-0048 for more molecular products just contact us ... Tcf7 Tcf-1 Tcf1] Transcription factor 7 (TCF-7) (T-cell-specific transcription factor 1) (T-cell factor 1) (TCF-1). [tcf7l1a ... TCF-3) (Transcription factor A1). [tcf7l1-a tcf3 tcf3a] Transcription factor 7-like 1-A (HMG box transcription factor 3-A) (TCF ... Transcription factor 1) (TCF-1). [TCF7L1 TCF3] Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3). [HNF1B ...http://www.antibody-antibodies.com/product_det.php?id=1779155&supplier=search&name=TCF_LEF%20EMSA%20Kit%20Runt_related%20transcription%20factor%202
The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta...
The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta- ... catenin-TCF protein complex is an eagle-i resource of type Journal article at The University of Pennsylvania. ... The intestine-specific transcription factor Cdx2 inhibits beta-catenin/TCF transcriptional activity by disrupting the beta- ... catenin-TCF protein complex. eagle-i ID. http://eagle-i.itmat.upenn.edu/i/0000013b-042c-a65a-e44e-976d80000000 ...http://eagle-i.itmat.upenn.edu/i/0000013b-042c-a65a-e44e-976d80000000
beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium.
TCF Transcription Factors / genetics. Time Factors. Transcription Factor 7-Like 2 Protein. Uteroglobin / genetics. beta Catenin ... 0/TCF Transcription Factors; 0/Tcf7l2 protein, mouse; 0/Transcription Factor 7-Like 2 Protein; 0/beta Catenin; 2166IN72UN/ ...http://www.biomedsearch.com/nih/beta-Catenin-Not-Necessary-Maintenance/19213872.html
TEL - Thèses en ligne - The Transcription Factor Barhl2 Inhibits Wnt Canonical Signaling during Xenopus Embryogenesis
... this territory Barhl2 inhibits Wnt activity via its interaction with the co-repressor Groucho and the transcription factor Tcf ... The results presented in this manuscript provide evidence that the evolutionarily conserved transcription factor Barhl2 limits ... Using a Xenopus tropicalis Tcf reporter line we demonstrate that Barhl2 inhibitory effect on Groucho-Tcf activities is ... The Transcription Factor Barhl2 Inhibits Wnt Canonical Signaling during Xenopus Embryogenesis Le facteur de transcription ...https://tel.archives-ouvertes.fr/tel-02275802v2
Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription. | Lee...
Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription. ... Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription. ... we surveyed transcription factors that might recruit Mtgr1 in intestinal stem cells or progenitor cells and found that MTG ... Canonical Wnt signaling is mediated by a molecular "switch" that regulates the transcriptional properties of the T-cell factor ...https://medschool.vanderbilt.edu/lee-lab/publication/myeloid-translocation-gene-family-members-associate-t-cell-factors-tcfs-and-influence
Modulación de la expresión de genes de incretinas mediada por nutrientes: revisión sistemática
... transcription factor TCF7L2 or TCF-4 (T-cell transcription factor, not to be confused with transcription factor 4), was found ... The TCF/LEF family of DNA-bound transcription factors is the main companion of β-catenin in gene regulation. TCF represses the ... TCF proteins are high-mobility group (HMG) DNA-binding transcription factors that not only bind to a DNA consensus sequence ... and the target genes of the Wnt pathway are therefore repressed by the DNAbound T-cell factor/lymphoid enhancer factor (TCF/ ...http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112012000100006
A Genetic Analysis of Synaptic Development Pre- and Postsynaptic dCBP Control Transmitter Release at the Drosophila NMJ -...
Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling. *Lucas Waltzer, Mariann Bienz ...https://www.semanticscholar.org/paper/A-Genetic-Analysis-of-Synaptic-Development-Pre-and-Marek-Ng/d49daa3553eed58a39b56fa32bfc67f856f5f1e0
Altered maturation of thymocytes in class I-restricte | Open-i
TCF Transcription Factors. *Transcription Factor 7-Like 1 Protein. *Transfection. *Tumor Cells, Cultured ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195738_JEM991075.f4d&req=4
Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and...
Roose, J. and Clevers, H. (1999). TCF transcription factors: molecular switches in carcinogenesis. Biochim. Biophys. Acta 1424 ... β-catenin translocates to the nucleus and binds transcription factors of the TCF/LEF family (comprising four members: Lef1, ... Upstream of LEF/TCF transcription factors, overexpression of dishevelled 2, Wnt3 (Millar et al., 1999) or the β-catenin related ... 1G). We conclude that the suppression of LEF/TCF-mediated transcription shown in Fig. 1E is not an indirect consequence of ...http://dev.biologists.org/content/129/1/95
JCI - Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs
Previous studies showed that Gata3 is regulated by transcription factors HEB (37, 38), T cell factor 1 (TCF-1) (39), and RBP-J/ ... TCF-1 belongs to the TCF/LEF transcription factor family that binds to DNA through an HMG box and is strongly expressed in T ... TCF-1, HEB, and RBP-J regulate Gata3 transcription by binding within Tce1. Several transcription factors have been proposed as ... Prediction of putative transcription factor-binding sites. A search for putative transcription factor-binding sites in Tce1 was ...https://www.jci.org/articles/view/83894
Gene Regulatory Networks Mediating Canonical Wnt Signal-Directed Control of Pluripotency and Differentiation in Embryo Stem...
All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res 2001;29:1410-1419.. * ... 2A). Given that β-catenin regulates gene expression through Tcf transcription factors, of which Tcf3 is most abundantly ... Lef/Tcf factors bind DNA directly at a consensus Lef/Tcf site and recruit transducin-like enhancer of split proteins to silence ... S2F). As expected, the DNA target site for Lef/Tcf factors, the DNA-binding partner for β-catenin, was highly enriched in the ...http://onlinelibrary.wiley.com/doi/10.1002/stem.1371/full?globalMessage=0
Echoes of the embryo: using the developmental biology toolkit to study cancer | Disease Models & Mechanisms
TCF, T-cell-specific transcription factor; LEF, lymphoid enhancer binding factor; HH, hedgehog; PTC, patched; SMO, smoothened; ... TCF) and lymphoid enhancer-binding factor (LEF) family (TCF/LEF) (Anastas and Moon, 2013). Some of these TCF/LEF targets, in ... 2005). The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation ... Since the initial discovery that four transcription factors can reprogram terminally differentiated cells to a pluripotent ...http://dmm.biologists.org/content/9/2/105
lef1 Summary [species: Xenopus laevis and Xenopus tropicalis] - Xenbase Gene Catalog
K] Transcription factor TCF-4 Reagents. tropicalis. laevis.L. laevis.S. CRISPR / TALEN. CRISPR tools CRISPR tools CRISPR tools ... XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. [Cell 1996]. ... Gene Name: lymphoid enhancer binding factor 1 Synonyms: xlef-1 , lef-1 , xlef1 Add Xenopus synonyms , Nomenclature history Gene ... NM_001088655,Xenopus laevis lymphoid enhancer binding factor 1 L homeolog (lef1.L), mRNA ...http://www.xenbase.org/gene/showgene.do?method=display&geneId=485516
E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity | JCB
TCF transcription factors: molecular switches in carcinogenesis. Biochim. Biophys. Acta. 1424:M23-M37. ... lymphoid enhancer binding factor; TCF, T cell factor. ... XTcf-3 transcription factor mediates beta-catenin-induced axis ... 6 B). Coexpression of β-catenin or LEF-1 or TCF-3 together with E-cadherin rescued E2F-dependent transcription to values close ... Nuclear localization of beta-catenin by interaction with transcription factor LEF-1. Mech. Dev. 59:3-10. ...http://jcb.rupress.org/content/154/6/1185.long
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice | SpringerLink
Aims/hypothesis Individuals carrying type 2 diabetes risk alleles in TCF7L2display decreased beta cell levels of T cell factor ... T cell factor 7 like-2 (TCF7L2) is a member of the T cell factor (TCF) family of transcription factors, which is involved in ... Roose J, Clevers H (1999) TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta 1424:M23-M37 ... An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF ...https://link.springer.com/article/10.1007%2Fs00125-012-2600-7