Plus it
taurocholic acid. EHBR. Eisai hyperbilirubinemic rat. cMOAT. canalicular multispecific organic anion transporter. SDR. Sprague- ... were compared between control rats and rats given an intravenous infusion of a bile acid, taurocholate (TCA), and an organic ...
Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug...
taurocholic acid. TOL. tolcapone. TRO. troglitazone. XIM. ximelagatran. Y-27632. 4-(1-aminoethyl)-N-(4-pyridyl) ... Taurocholic acid (TCA) was supplied by PerkinElmer (Boston, MA). Specific antibodies against phospho-MLC2 (Ser19) and HSC70 ( ... bile acid. BOS. bosentan. BSEP. bile salt export pump. BUS. buspirone. CaM. calmodulin. CIM. cimetidine. CPZ. chlorpromazine. ... 2015) Cellular accumulation and toxic effects of bile acids in cyclosporine A-treated HepaRG hepatocytes. Toxicol Sci 147:573- ...
Substrate-Dependent Drug-Drug Interactions between Gemfibrozil, Fluvastatin and Other Organic Anion-Transporting Peptide (OATP)...
Taurocholic acid, troglitazone sulfate, fluvastatin, pravastatin, and simvastatin, as known OATP1B1 substrates, were used in ... 4). Taurocholic acid showed the same sensitivity toward inhibition by gemfibrozil as statins. ... Inhibitory effect of gemfibrozil on the active uptake of taurocholic acid, estrone-3-sulfate, troglitazone-sulfate, fluvastatin ... Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y, and Kim RB (2006) Drug and bile acid transporters in ...
Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model | Drug...
To reduce nonspecific binding to cell culture plates, binding of deltorphin II, CCK8, taurocholic acid, and pravastatin to ... taurocholic acid, [3H]propranolol, and [3H]estrone-3-sulfate were from PerkinElmer Life and Analytical Sciences (Waltham, MA ... and taurocholic acid were from Sigma-Aldrich (Buchs, Switzerland). [14C]Napsagatran and napsagatran were produced in house ( ... 2-hydroxypropanesulfonic acid with 0.5% (w/v) glycocholic acid at pH 6.5], so that the final sample concentration is 150 μM and ...
Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling | Drug...
... including taurocholic acid, taurodeoxycholic acid, CA, and DCA in bile and its metabolites in the liver, tauro-α-muricholic ... glycolithocholic acid, and taurolithocholic acid (TLCA) and a negative association with glycodeoxycholic acid. However, the ... lithocholic acid. MCA. muricholic acid. NAFLD. nonalcoholic fatty liver disease. NASH. nonalcoholic steatohepatitis. NTCP. ... cholic acid. CAR. constitutive androstane receptor. CDCA. chenodeoxycholic acid. CYP27A1. sterol 27-hyroxylase. CYP7A1. ...