Hypoxia-inducible factor 1α is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cell. Roser ... Hypoxia-inducible factor 1α is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cell ...
Transcription Factors/genetics/*metabolism, Transcription; Genetic, Ubiquitin/metabolism National Category Medical and Health ... Cell Line, DNA Damage, DNA-Binding Proteins/genetics/*metabolism, Humans, Nuclear Proteins/genetics/metabolism, Promoter ... Here, we demonstrate that the transcription factor Yin Yang 1 (YY1) interacts with p53 and inhibits its transcriptional ... The tumor suppressor p53 regulates cell-cycle progression and apoptosis in response to genotoxic stress, and inactivation of ...
Myc Proto Oncogene Protein (Transcription Factor p64 or Class E... ... Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Pipeline Review, H2 2017 report by Global ... a regulator gene that code for a transcription factor. The protein plays a role in cell cycle progression, apoptosis and ... Myc Proto Oncogene Protein (Transcription Factor p64 or Class E Basic Helix Loop Helix Protein 39 or MYC) - Myc (c-Myc) protein ...
... regulates distinct target genes in several cell types. We hypothesized that interaction with the Ets family factor PU.1, whose ... The microphthalmia transcription factor (MITF), a basic-helix-loop-helix zipper factor, ... Genetic and Physical Interactions between Microphthalmia Transcription Factor and PU.1 Are Necessary for Osteoclast Gene ... This activation was dependent on intact binding sites for both factors in the TRAP promoter. MITF and PU.1 physically ...
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.. Iwakoshi NN1, Lee ... The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded ... Signals involved in plasma cell differentiation, specifically interleukin-4, control the transcription of XBP-1, whereas its ... mouse B cells, providing an integral link between XBP-1, the UPR and plasma cell differentiation. ...
glial cells missing transcription factor 1provided by HGNC. Primary source. HGNC:HGNC:4197 See related. Ensembl:ENSG00000137270 ... GCM1 glial cells missing transcription factor 1 [ Homo sapiens (human) ] Gene ID: 8521, updated on 23-Dec-2018 ... GCM1 glial cells missing transcription factor 1 [Homo sapiens] GCM1 glial cells missing transcription factor 1 [Homo sapiens]. ... New insights into the regulation of placental growth factor gene expression by the transcription factors GCM1 and DLX3 in human ...
Neurath and colleagues show that TH9 cells are also important for the pathogenesis of mouse and human colitis by disrupting gut ... Neurath and colleagues show that TH9 cells are also important for the pathogenesis of mouse and human colitis by disrupting gut ... The TH9 subset of helper T cells has specialized roles in parasite immunity. ... The TH9 subset of helper T cells has specialized roles in parasite immunity. ...
CD4 T cells can adopt one of two opposing fates: a helper T cell (Th) specialized in supporting pathogen clearance, or a ... IL-17A-producing inflammatory Th17 cells stand out among Th cells, possessing a high level of inherent plasticity in response ... Increased generation of regulatory T cells in the presence of reduced T cell receptor signaling capacity correlates with a ... Here, we (i) use fate-mapping reporter mice to dissect the requirement for JunB in maintaining Th17 cell stability, (ii) define ...
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat. Immunol. 4:321- ... Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 384:474-478. ... XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell ... Towards an understanding of the transcription factor network of dendritic cell development. Trends Immunol. 27:140-145. ...
T-cell factor; LEF, lymphoid enhancer-binding factor; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ... When TE8 cells were cocultured with 293 cells expressing Wnt-7A or Wnt-5A, TCF-dependent transcription was not activated (Fig. ... Consistent with this idea, TCF-dependent transcription in TE8 cells was activated as a function of the cell number of the ... Cell Lines.. Human ESCC cell lines (TE1, TE3, TE5, TE8, TE10, TE11, TE12, and TE15) and human hepatoblastoma HepG2 cells, ...
Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line.. ... Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. ... Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. ... Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. ...
... an epithelial mesenchymal transition via upregulation of the transcription factor Twist in human breast epithelial cells. ... a transcription factor known to suppress E-cadherin gene transcription and upregulate mesenchymal markers. SiRNA-mediated Twist ... an epithelial mesenchymal transition via upregulation of the transcription factor Twist in human breast epithelial cells ... an epithelial mesenchymal transition via upregulation of the transcription factor Twist in human breast epithelial cells ...
Abstract 190: Purinergic Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: New AP-1 Site and ... Abstract 190: Purinergic Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: New AP-1 Site and ... Abstract 190: Purinergic Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: New AP-1 Site and ... Abstract 190: Purinergic Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: New AP-1 Site and ...
... mediated transcription of beta-galactosidase in J.NFATZ.1 cells. ... Inhibition of nuclear factor of activated T-cells (NFAT) ...
... cerevisiae wild-type and Δyap1 cells, but not Δgpx3 cells, in response to treatment of the cells with H2O2 (21) (see Fig. S5 in ... The Atf1 transcription factor is a target for the StyI stress-activated MAP kinase pathway in fission yeast. Genes Dev. 10:2289 ... The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans. J. ... The bZIP transcription factor MoAP1 mediates the oxidative stress response and is critical for pathogenicity of the rice blast ...
Activation of several transcription factors, including the nuclear factor of activated T cells-3 (NFAT3), contributes in part ... Activation of the nuclear factor of activated T cells-3 (NFAT3) transcription factor has been shown to result from endocrine ... Antioxidants inhibit ANG II from activating nuclear factor of activated T cells-3 (NFAT3) transcription factor in ... EMSA was used to verify the activation of NFAT3 transcription factor. The binding of NFAT3 transcription factor to its cis- ...
Although CD4- CD8- thymocytes are able to produce a wide spectrum of cytokines in response to a T-cell receptor (TcR)- ... NFAT-luciferase transgenic mice to analyze the transcriptional and DNA-binding activities of these two transcription factors ... NFAT transcriptional activities are not inducible in the majority of DP cells but that during the differentiation of DP cells ... high thymocytes to DP TcRhigh CD69high HSAhigh cells, which is considered to be the consequence of the first signal that ...
RESULTS: HRPE cells constitutively expressed two members of the IFN regulatory factor (IRF) family of transcription factors, ... suggesting that it may regulate gene transcription in RPE cells and possibly in other nonimmunologic cell types. ... METHODS: RNA, whole-cell extracts, and nuclear extracts were prepared from HRPE cells cultured in the presence or absence of ... ICSBP is thought to be exclusively used in immunologic responses and has previously been detected only in lymphoid cells. ...
... a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and ... a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and ... a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and ... a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and ...
The transcription factor nuclear factor (NF)-κB plays a key role in endothelial cell activation and the inflammatory response. ... ONeill LAJ, Kaltschmidt C. NF-kB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 1997; ... The transcription factor nuclear factor (NF)-κB binds to the promoter of a large number of genes involved in the inflammatory ... Hypertonic Mannitol Loading of NF-κB Transcription Factor Decoys in Human Brain Microvascular Endothelial Cells Blocks ...
The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells. Tatjana ... The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells. Tatjana ... The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells. Tatjana ... The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells ...
ßT-cell development and to rapid development of T-cell lymphoma. Mol. Cell. Biol., 17: 4782-4791, 1997.. [Abstract/Free Full ... of MHC-positive cells in cells transfected with pCMV-p300 relative to the number of fluorescent cells observed among cells ... Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix-loop-helix factor Id3. J. ... Regulators of transcription in eukaryotic organisms. Mol. Cell. Biol., 20: 429-440, 2000.. [Free Full Text]. * Weintraub H., ...
HSG cells, which endogenously express P2Y2 receptors and are derived from a human submandibular gland tumor, were utilized as a ... and the downstream transcription factors p90RSK, and ELK, suggesting that P2Y2 receptors may play a role in gene transcription ... Our results show that UTP, the P2Y2 receptor selective agonist, causes phosphorylation of the epidermal growth factor receptor ... cell model to analyze downstream signaling pathways in response to UTP. ...
Cell Growth & Differentiation, Vol 3, Issue 8 523-529, Copyright © 1992 by American Association of Cancer Research ... Cell Growth & Differentiation. Copyright © 1992 by the American Association of Cancer Research. ... Ternary complexes composed of the DNA binding site, the adaptor protein, and a leucine zipper factor can stimulate reporter ... This system is used to assay the transcriptional function and the interactions between various AP-1 factors. This article has ...
... a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha ... cells with antibodies to various surface markers and transcription factors reveal that the synthesis of TCF-1 and GATA-3 ... Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the ... N Hattori, H Kawamoto, S Fujimoto, K Kuno, Y Katsura; Involvement of transcription factors TCF-1 and GATA-3 in the initiation ...