FOXC1 | Cancer Genetics Web
Sterile alpha motif and histidine/aspartic acid domain containing protein 1 (SAMHD1) limits the efficacy of cytarabine (ara-C) ... Forkhead box C1 (FOXC1) is a conserved transcription factor that is involved in tumorigenesis; however, the function of FOXC1 ... protein binding - regulation of blood vessel size - regulation of organ growth - regulation of sequence-specific DNA binding ... The Forkhead box C1 (FOXC1) transcription factor has been shown to be specifically overexpressed in TNBC and associated with ...
STK11 | Cancer Genetics Web
F-box and WD repeat domain containing 7 (FBXW7), fibroblast growth factor receptor 1 (FGFR1), FGFR3 (fibroblast growth factor ... protein complex - protein heterooligomerization - protein kinase activator activity - protein phosphorylation - protein serine/ ... The protein expression of AMPK, liver kinase B1 (LKB1) and NF-ĸB in tumors was examined by western blotting.. RESULTS: ... What pathways are this gene/protein implicaed in?. Show (2). STK11 is involved in:. - Adipocytokine signaling pathway KEGG. - ...
ESR2 | Cancer Genetics Web
F-box and WD repeat domain containing 7 (FBXW7), fibroblast growth factor receptor 1 (FGFR1), FGFR3 (fibroblast growth factor ... By applying native protein complex purification followed by nano LC-MS/MS before and after in vitro RNA removal, we generated a ... The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus ... binding to strong canonical E-boxes at promoters and invading abundant weaker non-canonical E-boxes clustered at enhancers. ...
PRB2 | Cancer Genetics Web
Furthermore, we suggested that pRb2/p130 could cooperate with ICBP90 (inverted CCAAT box binding protein of 90 kDa) and DNA ... Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy.. J ... RESULTS: We found that the HCV core protein expression down-regulated pRb2/p130 protein and mRNA levels in HuH-7-CORE cells by ... Here, we compared the protein expression profiles of p53, p73, pRb family proteins, and PCNA, as main regulators of cell ...
RHOC | Cancer Genetics Web
protein binding - protein domain specific binding - regulation of dendrite development - regulation of small GTPase mediated ... HOTAIR promoter activity was demonstrated to be regulated by the RhoC-MRTF-A-SRF signaling in a CArG-box-dependent manner. ... Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein ... protein, which are regulated by miR-93, while its upregulation induced RhoC, P70S6 K, Bcl-xL, and MMP2 protein expression. In ...
AXL | Cancer Genetics Web
The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, ... X‑box‑binding protein 1 (XBP1) contributes to various types of cancer including breast, bladder cancer and esophageal squamous ... positive regulation of protein kinase B signaling cascade - protein binding - protein heterodimerization activity - protein ... transmembrane receptor protein tyrosine kinase activity - vagina development Data from Gene Ontology via CGAP [Hide] ...
LATS1 | Cancer Genetics Web
In the nucleus, in order to induce target gene expression, YAP/TAZ bind to the TEA domain (TEAD) proteins, and this binding ... Intracellular Signaling Peptides and Proteins. *Nuclear Proteins. *Zinc Finger E-box-Binding Homeobox 1 ... protein binding - protein kinase binding - protein phosphorylation - protein serine/threonine kinase activity - regulation of ... LATS1/2 (large tumour suppressor homolog 1 and 2), YAP1 (Yes-associated protein 1), and TEAD4 (TEA domain-containing sequence- ...
EPB41 | Cancer Genetics Web
positive regulation of protein binding - protein binding - protein complex - spectrin - spectrin binding - spectrin-associated ... Mutations of SET domain-containing 2 (SETD2), a methyltransferase that catalyses the trimethylation of histone 3 on lysine 36 ( ... SRY-related high-mobility-group box 9 (SOX9) is a member of the SOX family of transcription factors. Accumulating evidence has ... What pathways are this gene/protein implicaed in?. Show (2). EPB41 is involved in:. - Synaptic Proteins at the Synaptic ...
CDK6 | Cancer Genetics Web
... dependent protein kinase type II subunit beta (CAMK2B), retinoblastoma‑associated protein (RB1) and protein kinase C beta type ... Acetylated FOXO3a recognizes the BD2 domain of BRD4, recruits the BRD4/RNAPII complex to the CDK6 gene promoter, and induces ... BACKGROUND: Following up on previous work demonstrating the involvement of the transcription factor forkhead box M1 (FOXM1) in ... The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic ...
MMP7 | Cancer Genetics Web
Expression of Wnt/β-catenin related proteins and unfolded protein response (UPR)-related proteins was detected by western blot. ... The PAX3 (paired box 3) gene plays an important role in embryonic development, diseases, and cancer formation. Our preliminary ... Coiled-coil domain containing 85 B (CCDC85B) is involved in diverse biological processes; however, its expression patterns and ... BACKGROUND: Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a microtubule-associated proteinrequired for mitosis ...
FYN | Cancer Genetics Web
... through silencing DEAD/H-box RNA helicase 6 (DDX6), RNA helicase, which enhanced HER2 protein expression at the translational ... Many other genes might also be involved in the pathogenesis of UM such as the Ras and EF-hand domain containing (RASEF) gene, ... protein autophosphorylation - protein binding - protein phosphorylation - protein tyrosine kinase activity - regulation of cell ... In NASH, the proteins that showed upregulated levels of expression were BAK1 and GNAI1 and the protein that showed ...