A Syntaxin 1, Gαo, and N-Type Calcium Channel Complex at a Presynaptic Nerve Terminal: Analysis by Quantitative...
GαO association with syntaxin. We next tested for a biochemical association of syntaxin 1 with GαO. However, neither ... Syntaxin association with MUNC18. A, Immunoprecipitation of MUNC18 from chick brain lysate coprecipitates syntaxin 1 (right ... Glutathione S-transferase-syntaxin 1A synthesis and purification. Syntaxin constructs in pGEX-4T-3 vectors (from G. Zamponi, ... D, E, As in Figure 5B,C but comparing the intensities of Ca channel (green, left panel; B/W center panel) and syntaxin 1 (red, ...
Syntaxin 3 - Wikipedia
Mutations in Syntaxin 3 cause Microvillus inclusion disease. Syntaxin 3 has been shown to interact with SNAP-25, SNAP23 and ... Syntaxin 3, also known as STX3, is a protein which in humans is encoded by the STX3 gene. The protein encoded by this gene is a ... Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (Dec 1998). "Three novel proteins of the syntaxin/SNAP- ... "Entrez Gene: STX3 syntaxin 3". Darios F, Davletov B (April 2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane ...
The specifics of membrane fusion | Nature
VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex *Vincenzo Benagiano ... VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex *Vincenzo Benagiano ... as well as ensuring that vesicles deliver their cargo to the right compartment1,2. Writing on pages 153, 194 and 198 of this ...
The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during...
use single-molecule imaging to reveal the diffusional signature for the SNARE proteins Munc18-1 and syntaxin-1A during ... Syntaxin-1A-GFP was generated from pECFP-N1 syntaxin-1A provided by Y. Liu (University of Oklahoma, Norman, OK). In brief, ... We first expressed syntaxin-1A-GFP in these cells. TIRF imaging of syntaxin-1A-GFP revealed a relatively homogeneous staining ... 6, D-F). This strongly suggests that the reduction in syntaxin-1A mobility results from syntaxin-1A engagement in the SNARE ...
STXBP1 encephalopathy: MedlinePlus Genetics
Syntaxin-binding protein 1 is also thought to play a role in the positioning and growth of neurons during brain development. ... This gene provides instructions for making syntaxin-binding protein 1. In nerve cells (neurons. ), this protein helps regulate ... Research suggests that a shortage of syntaxin-binding protein 1 also impairs neuron development in the brain, which could ... Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic ...
Munc18-1: Sequential Interactions with the Fusion Machinery Stimulate Vesicle Docking and Priming | Journal of Neuroscience
... protect their syntaxin partners from degradation (Bryant and James, 2001; Rowe et al., 2001). However, syntaxin levels are ... 2001) Syntaxin 1A is delivered to the apical and basolateral domains of epithelial cells: the role of munc-18 proteins. J Cell ... 1998) Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. J Cell Sci 111: ... It should be mentioned, however, that our suggestion of a Munc18:syntaxin docking platform is based on the in vitro effect of ...
regulatory pathway pertinent to the brain - Ontology Report - Rat Genome Database
syntaxin binding protein 1. TAS. RGD. PMID:8247129. RGD:1299066. NCBI chr 3:16,076,725...16,138,431 Ensembl chr 3:16,076,391... ... Ensembl chr 1:77,417,477...77,428,905 G. Clta. clathrin, light chain A. ISO. RGD. PMID:22763746. RGD:10450547. NCBI chr 5: ... Ensembl chr 1:242,736,189...242,802,604 G. Epn1. Epsin 1. ISO. RGD. PMID:22763746. RGD:10450547. NCBI chr 1:68,742,491... ... Ensembl chr 1:95,384,309...95,414,147 G. Ap2a2. adaptor related protein complex 2 subunit alpha 2. ISO. RGD. PMID:22763746. RGD ...
Product Listing - SNARE Complex Antibodies - Cedarlane
Mouse anti-human Syntaxin (CL2706AP) 1:500; Alexa Fluor 488 Goat anti-mouse 1:500 (Molecular Probes) and Normal Goat Serum ( ... Purified Anti-Human Syntaxin (CL2706AP) staining of paraformaldehyde-fixed paraffin-embedded human cerebellum sections at 200x ... During this process syntaxin-1, SNAP-25 and munc18-1 associate and form a complex at the pre-synaptic membrane. This complex ... Mouse anti-human Synaptophysin (CL2702AP) 1:500; Alexa Fluor 488 Goat anti-mouse 1:500 (Molecular Probes) and Normal Goat Serum ...
Carla SCHMIDT | Group Leader | Professor | Johannes Gutenberg-Universität Mainz, Mainz | JGU | Research profile
Together with Syntaxin-1A and SNAP25, it forms the core membrane fusion machinery that is responsible for neurotransmitter ... The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic ... It forms, together with SNAP25 and Syntaxin-1A, the neuronal soluble N-ethylmaleimide-sensitive factor attachment protein ...
Frontiers | VAPYRIN Marks an Endosomal Trafficking Compartment Involved in Arbuscular Mycorrhizal Symbiosis
Huisman, R., Hontelez, J., Mysore, K. S., Wen, J. Q., Bisseling, T., and Limpens, E. (2016). A symbiosis-dedicated SYNTAXIN OF ... Catalano, C. M., Czymmek, K. J., Gann, J. G., and Sherrier, D. J. (2007). Medicago truncatula syntaxin SYP132 defines the ... Kalde, M., Nuhse, T. S., Findlay, K., and Peck, S. C. (2007). The syntaxin SYP132 contributes to plant resistance against ... FIGURE 1. Figure 1. Localization of VAPYRIN-GFP in N. benthamiana, P. hybrida, and A. thaliana. (a) N. benthamiana leaves ...
Stxbp3-ps MGI Mouse Pseudogene Detail - MGI:3586869 - syntaxin-binding protein 3, pseudogene
The role of extracellular vesicle fusion with target cells in triggering systemic inflammation | Lund University Publications
Syntaxin-binding protein 1 is essential for the merge and activation of intracellular signaling. Subsequent analysis show that ... Syntaxin-binding protein 1 is essential for the merge and activation of intracellular signaling. Subsequent analysis show that ... Syntaxin-binding protein 1 is essential for the merge and activation of intracellular signaling. Subsequent analysis show that ... 10.1038/s41467-024-45125-1. language. English. LU publication?. yes. id. aa4db098-f72d-47f1-a871-bd7aded86851. date added to ...
Gene List for L00000020 - Genes2Cognition Neuroscience Research Programme
syntaxin binding protein 1. G00000673. Stx1a. Mus musculus. syntaxin 1A (brain). G00000935. Gapdh. Mus musculus. glyceraldehyde ... guanine nucleotide binding protein (G protein), beta 1. G00000217. Gnb2. Mus musculus. guanine nucleotide binding protein (G ... homer homolog 1 (Drosophila). G00000210. Gnb1. Mus musculus. ... phospholipase C, beta 1. G00000625. Cdh2. Mus musculus. ...
Botulinum Neurotoxin Detection and Differentiation by Mass Spectrometry - Volume 11, Number 10-October 2005 - Emerging...
Synaptobrevin on the synaptic vesicle must interact with syntaxin and SNAP (synaptosomal-associated protein)-25 on the neuronal ... Synaptobrevin on the synaptic vesicle must interact with syntaxin and SNAP (synaptosomal-associated protein)-25 on the neuronal ... In addition to cleaving SNAP-25, BoNT-C also cleaves syntaxin (1). ... An aliquot of a 1-mL sample that contained 100 MLD50 to 0.31 mouse LD50 in water was tested by both the MALDI-TOF-MS and HPLC- ...
Epimorphin/Syntaxin 2 293T Cell Transient Overexpression Lysate (H00002054-T02): Novus Biologicals
Epimorphin/Syntaxin 2 293T Cell Transient Overexpression Lysate. Tested Reactivity: Hu. Validated: WB. Backed by our 100% ... Blogs on Epimorphin/Syntaxin 2. There are no specific blogs for Epimorphin/Syntaxin 2, but you can read our latest blog posts. ... PTMs for Epimorphin/Syntaxin 2 Lysate (H00002054-T02). Learn more about PTMs related to Epimorphin/Syntaxin 2 Lysate (H00002054 ... Publications for Epimorphin/Syntaxin 2 Lysate (H00002054-T02) (0). There are no publications for Epimorphin/Syntaxin 2 Lysate ( ...
SMED30002549
syntaxin 2 [Source:MGI Symbol;Acc:MGI:108059]. [more]. Stx3. 2.230e-93. 55.30. syntaxin 3 [Source:MGI Symbol;Acc:MGI:103077]. [ ... syntaxin 2 [Source:HGNC Symbol;Acc:HGNC:3403]. [more]. STX2. 9.433e-101. 52.60. syntaxin 2 [Source:HGNC Symbol;Acc:HGNC:3403]. ... syntaxin 1B [Source:ZFIN;Acc:ZDB-GENE-000330-4]. [more]. stx1a. 1.203e-93. 54.30. syntaxin 1A (brain) [Source:ZFIN;Acc:ZDB-GENE ... syntaxin-1B [Source:NCBI gene;Acc:103042529]. [more]. stx1a. 2.458e-114. 61.45. syntaxin 1A [Source:NCBI gene;Acc:103022407]. [ ...
Intestinal Organoid Mini-Review
When sequenced, these samples identified the syntaxin 3 gene as a contributor to the loss of microvilli. ... 2014) Loss of syntaxin 3 causes variant microvillus inclusion disease. Gastroenterology 147(1): 65-8. ... Figure 1. Diagram of the small intestinal epithelium highlighting the identity and spatial arrangement of key epithelial cell ... The seminal work on the intestinal organoid culture system that came out of the laboratory of Hans Clevers in 20091 describes a ...
YRC Public Data Repository - Protein Overview - SY121 ARATH
RePub, Erasmus University Repository:
Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11α protein up...
We investigated protein levels of the signaling pathway: p35, cyclin-dependent kinase 5, Munc18a, syntaxin 1A and 1B, Munc18- ... Cyclin-dependent kinase 5 and its activator p35 disrupt Munc18a-syntaxin 1 binding, thereby promoting synaptic vesicle fusion ... Jacobs, E.H, Williams, R.J, & Francis, P.T. (2006). Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11α ... Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11α protein up-regulation in Alzheimers disease. ...
CDD Conserved Protein Domain Family: SNARE NTD Tlg1p-like
... also called syntaxin TLG1, is a soluble NSF attachment protein receptor (SNARE) protein (of Qc type) involved in membrane ... t-SNARE affecting a late Golgi compartment protein 1 (Tlg1p), ... Feature 1 # ## ## ### ## ## ## 2C5J_A 67 nEDVSGREAQVKNIKQQLDALK ... Feature 1 # ## # ## ## ## ## ## # # # # # ## # ## 2C5J_A 6 DPFQQVVKDTKEQLNRINNYITRHNta-------------gdDDQEEEIQDILKDVEETIVDLDRSII ... also called syntaxin TLG1, is a soluble NSF attachment protein receptor (SNARE) protein (of Qc type) involved in membrane ...
Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain
... syntaxin 1, and synaptobrevin 2. SNAP-25 contributes two helices to the complex and … ... syntaxin 1, and synaptobrevin 2. SNAP-25 contributes two helices to the complex and is targeted to the plasma membrane by ... Gábor Nagy 1 , Ira Milosevic, Dirk Fasshauer, E Matthias Müller, Bert L de Groot, Thorsten Lang, Michael C Wilson, Jakob B ... 1 Department of Membrane Biophysics, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany. ...
TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications | European Respiratory Society
et al. Cooperative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1. Mol Biol Cell 2014; ... TASK-1 (KCNK3) channels in the lung: from cell biology to clinical implications. Andrea Olschewski, Emma L. Veale, Bence M. ... TASK-1 is expressed in rabbit [52], mouse [100], rat [54, 101] and human [56] PASMCs and the non-inactivating K+ current (IKN ... TASK-1 two-pore domain potassium channel. The TASK family. The TASK (TWIK-related Acid Sensitive K+) family of K2P is comprised ...
GAL Receptors
Syntaxin 1 (mouse monoclonal, 11000, Hybridoma Lender, Iowa, USA), Synaptophysin (mouse monoclonal, 11000, Dako Diagnostics S. ... Carlos Vicario, CSIC, Spain), neuronal specific -III Tubulin (TUJ-1, mouse monoclonal, 14000, Babco, Richmond, VA), A2B5 (mouse ... Carlos Vicario, CSIC, Spain), neuronal specific -III Tubulin (TUJ-1, mouse monoclonal, 14000, Babco, Richmond, VA), A2B5 (mouse ... the progression of ongoing fibrosis when given at 1?mg/kg. Toxicogenetics analysis revealed that only 42 ...
Fact file for Familial haemophagocytic lymphohistiocytosis type 4
NIOSHTIC-2 Search Results - Full View
Volume 77, Number 1, 2020 | Journal of Alzheimer's Disease
... and syntaxin-1. However, Aβ interactions with SNARE proteins to ultimately disrupt synaptic vesicular fusion are not well ... Volume 77, Number 1, 2020. Pages 1-14. Review. Jieun Kim*, Yujeong Lee*, Seulah Lee, Kipom Kim, Minjung Song, Jaewon Lee *These ... Volumes 1-78. Volume 79. Volume 80. Volume 81. Volume 82. Volume 83. Volume 84. Volume 85. Volume 86. Volume 87. Volume 88. ... Finally, HSV-1 DNA has been confirmed as present in human brains and is associated with APOE ε4 in AD. HSV-1 and APOE ε4 ...
WikiGenes - Gardenal - 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
Eduardo Soriano - Publications
Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip. The European ... Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip European ... Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth. Oncotarget. 9: ... A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. Plos Genetics. ...
Neuronal trafficking - Queensland Brain Institute - University of Queensland
Rickman, Colin, Meunier, Frederic A., Binz, Thomas and Davletov, Bazbek (2004).High affinity interaction of syntaxin and SNAP- ... Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to ... 2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Molecular ... Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites. Neuropharmacology, 169 107554, 107554. doi: ...
Page 1 | Search Results | Journal of Cell Science | The Company of Biologists
Helmut Kubista; Hannah Edelbauer; Stefan Boehm The core complex, formed by the SNARE proteins synaptobrevin 2, syntaxin 1 and ... and in which SNAP-25 and syntaxin predominate over synaptobrevin. Their formation increased upon Ca 2+ -stimulated exocytosis; ... synaptobrevin and syntaxin (known as SNAREs). Synaptotagmin I has been implicated as the Ca 2+ -sensor because it binds Ca 2+ ... with syntaxin and have been implicated in the docking of synaptic vesicles at the plasma membrane. The onset of toxin-induced ...