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*  The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis | Science Translational Medicine
We developed a phenotypic screen to repurpose existing drugs using ALS motor neuron survival as readout. Motor neurons were ... motor neurons from patients with sporadic ALS or other forms of familial ALS caused by mutations in TAR DNA binding protein ( ... Src/c-Abl inhibitors increased survival of ALS iPSC-derived motor neurons in vitro. Knockdown of Src or c-Abl with small ... One of the drugs was effective for promoting survival of motor neurons derived from ALS patients with different genetic ...
http://stm.sciencemag.org/content/9/391/eaaf3962
*  Amyotrophic Lateral Sclerosis | Encyclopedia.com
1] (a neurodegenerative disease) of unknown cause that affects the nerves responsible for movement. ... It is believed to reduce the level of ALS-induced injury to motor neurons and to have a modest effect on prolonging survival. ... Other possible causes of ALS include defects in the gene that makes the neurofilament proteins that support nerve cell axons, ... Motor neurons are nerve cells that control movement. ALS is also known as motor neuron disease and Lou Gehrig's disease. Lou ...
https://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/amyotrophic-lateral-sclerosis
*  oligodendrocyte precursor cells - Dwight Bergles Laboratory
Specifically, we show that C9orf72 promoter activity is enriched in corticospinal and spinal motor neurons as well as in ... Selective removal of mutant SOD1 from oligodendroglia substantially delayed disease onset and prolonged survival in ALS mice, ... some traverse the lesion core and express reduced amounts of synaptic proteins. Our studies suggest that proteoglycan-mediated ... suggesting that ALS-linked genes enhance the vulnerability of motor neurons and accelerate disease by directly impairing the ...
http://bergleslab.com/index.php/tag/oligodendrocyte-precursor-cells/
*  Survival Motor Neuron Protein (Component Of Gems 1 or Gemin 1 or SMN1 or SMN2)-Pipeline Review, H1 2018, Trends, Share, Size...
Survival Motor Neuron Protein (Component Of Gems 1 or Gemin 1 or SMN1 or SMN2)-Pipeline Review, H1 2018 Size and trends ... Survival of motor neuron or survival motor neuron (SMN) is a protein encoded by the SMN1 and SMN2 genes. The SMN complex plays ... The latest report Survival Motor Neuron Protein - Pipeline Review, H1 2018, outlays comprehensive information on the Survival ... Survival Motor Neuron Protein (Component Of Gems 1 or Gemin 1 or SMN1 or SMN2)-Pipeline Review, H1 2018. Jan 2018 Global ...
https://www.marketresearchhub.com/report/survival-motor-neuron-protein-component-of-gems-1-or-gemin-1-or-smn1-or-smn2-pipeline-review-h1-2018-report.html
*  Survival of motor neuron protein interacting protein 1 | definition of survival of motor neuron protein interacting protein 1...
What is survival of motor neuron protein interacting protein 1? Meaning of survival of motor neuron protein interacting protein ... What does survival of motor neuron protein interacting protein 1 mean? ... survival of motor neuron protein interacting protein 1 explanation free. ... Looking for online definition of survival of motor neuron protein interacting protein 1 in the Medical Dictionary? ...
http://medical-dictionary.thefreedictionary.com/survival+of+motor+neuron+protein+interacting+protein+1
*  Spinal Muscular Atrophy (SMA) - Pipeline Review, H1 2018
Survival Motor Neuron Protein (Component Of Gems 1 or Gemin 1 or SMN1 or SMN2) - Pipeline Review, H2 2018 * Drug Pipelines ... Spinal muscular atrophy (SMA) is a genetic disease that attacks nerve cells, called motor neurons, in the spinal cord. These ... Without the proper input from the motor neurons, muscle cells cannot function properly. The muscle cells will, therefore, ... Oct 03, 2017: RG7916 Increased SMN Protein Production in SUNFISH Clinical Trial in Patients with Type 2/3 Spinal Muscular ...
https://www.researchandmarkets.com/reports/4464937/spinal-muscular-atrophy-sma-pipeline-review
*  Investigation of the role of SMN1 and SMN2 haploinsufficiency as a risk factor for Hirayama's disease: clinical,...
... the most extensively studied susceptibility and modifying genetic factors in adult onset motor neuron diseases - as a genetic ... 0/RNA-Binding Proteins; 0/SMN Complex Proteins; 0/SMN1 protein, human; 0/SMN2 protein, human; 0/Survival of Motor Neuron 1 ... RNA-Binding Proteins / genetics*. SMN Complex Proteins. Spain. Spinal Cord / pathology. Survival of Motor Neuron 1 Protein. ... Motor Neuron Disease / diagnosis, genetics*, physiopathology. Motor Neurons / physiology. Muscle Weakness / diagnosis, genetics ...
http://www.biomedsearch.com/nih/Investigation-role-SMN1-SMN2-haploinsufficiency/17850955.html
*  JCI - The basics of epithelial-mesenchymal transition
... survival of motor neuron protein interacting protein 1 (SIP1) and E12 (also known as E47-E2A). These transcription factors are ... survival of motor neuron protein interacting protein 1; FOXC2, forkhead box C2. ... The first of these involves Smad proteins, which mediate TGF-β action to induce EMTs via the ALK-5 receptor (51, 91-95). Smad- ... Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 344:1196-1206. View this ...
https://www.jci.org/articles/view/39104
*  Progressive spinal muscular atrophy | definition of progressive spinal muscular atrophy by Medical dictionary
Defects of SMN1, which encodes a survival motor neuron protein, cause spinal muscular atrophy types 1-4.. progressive spinal ... one of the subgroups of motor neuron disease; a progressive degenerative disorder of the motor neurons of the spinal cord, ... predominantly produces exon 7-skipped transcripts and only low amounts of full-length transcripts that encode for a protein ... spinal muscular atrophy type 1. An autosomal recessive condition (OMIM:253300) characterised by degeneration of the anterior ...
https://medical-dictionary.thefreedictionary.com/Progressive+spinal+muscular+atrophy
*  Merging microarray data from separate breast cancer studies provides a robust prognostic test | BMC Bioinformatics | Full Text
survival of motor neuron protein interacting protein 1. 57. 200918_s_at ... 1. M. z. m. log. p. m. (. 1. −. q. m. ). q. m. (. 1. −. p. m. ). +. ∑. m. =. 1. M. log. 1. −. p. m. 1. −. q. m. MathType@MTEF@5 ... 1. M. p. m. z. m. (. 1. −. p. m. ). 1. −. z. m. q. m. z. m. (. 1. −. q. m. ). 1. −. z. m. MathType@MTEF@5@5@+= ... 1. ≤. n. ≤. N. ,. x. i. n. ,. x. j. n. ,. y. n. =. k. }. ,. ,. k. =. 1. ,. 2. .. MathType@MTEF@5@5@+= ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-9-125
*  JCI early table of contents for Jan. 27, 2014 | EurekAlert! Science News
The disease results from deletion of survival of motor neuron 1 (SMN1) and SMN protein deficiency. In humans, a duplication ... TITLE: Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation AUTHOR CONTACT: ... Spinal muscle atrophy (SMA) is a devastating disease that is characterized by loss of motor neuron function and subsequent ... Timing of protein depletion influences spinal muscular atrophy development in mice ...
https://www.eurekalert.org/pub_releases/2014-01/joci-jet012114.php
*  Survival motor neuron domain containing 1 - Wikipedia
Survival of motor neuron-related-splicing factor 30 is a protein that in humans is encoded by the SMNDC1 gene. GRCh38: Ensembl ... "Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex". Hum ... "Entrez Gene: SMNDC1 survival motor neuron domain containing 1". Rappsilber J, Ajuh P, Lamond AI, Mann M (2001). "SPF30 is an ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
https://en.wikipedia.org/wiki/Survival_motor_neuron_domain_containing_1
*  Mechanisms Underlying Childhood Neuromuscular Disease Found - Healthcanal.com : Healthcanal.com
The disease is caused by defects in a gene called SMN1 (survival motor neuron 1), which encodes the SMN protein. There are ... The flies' cells contained low levels of SMN protein, resulting in reduced muscle size and motor function, much as in humans ... "Scientists call SMA a motor neuron disease, and there is post-mortem evidence that it does cause motor neurons to die," said ... In motor circuits, which coordinate muscle movement, specialized sensory neurons called proprioceptive neurons pick up and ...
https://www.healthcanal.com/brain-nerves/32897-mechanisms-underlying-childhood-neuromuscular-disease-found.html
*  JCI - Volume 124, Issue 2
Spinal muscular atrophy is a common motor neuron disease caused by low survival motoneuron (SMN), a key protein in the proper ... Homozygous deletion of survival of motor neuron 1 (. SMN1. ) and resulting SMN protein deficiency manifests predominantly with ... Spinal muscular atrophy is a pediatric neuromuscular disorder caused by mutation in the survival of motor neuron 1 (. SMN1. ) ... explored the temporal requirement for survival motoneuron (SMN) proteins using an inducible deletion strategy in mice. Their ...
https://www.jci.org/124/2
*  Recombinant Human SIP1 293 Cell Lysate SIP1-1836HCL - Creative BioMart
Antigen standard for survival of motor neuron protein interacting protein 1 (SIP1), transcript variant alpha is a lysate ... survival of motor neuron protein interacting protein 1. ... Bring this labeled protein directly to your bench! * ... SIP1; SIP1-delta; gem-associated protein 2; gemin-2; component of gems 2; SMN interacting protein 1-delta; ... Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for ...
https://www.creativebiomart.net/description_403502_318.htm
*  Gem-associated protein 2 - Wikipedia
Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that ... "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1". Mourelatos, Zissimos; Dostie Josée; Paushkin Sergey ... 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset ... 2001). "Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal ...
https://en.wikipedia.org/wiki/Gem-associated_protein_2
*  Genentech Announces New Data for Risdiplam in Spinal Muscular Atrophy (SMA) at the World Muscle Society Congress - Drugs.com...
SMA is caused by a mutation in the survival motor neuron 1 (SMN1) gene that results in a deficiency of SMN protein. SMN protein ... It is designed to help the SMN2 gene produce more functional SMN protein, to better support motor neurons and muscle function. ... Of the patients treated with risdiplam for at least one year (n=30), the median change from baseline in Motor Function Measure ... "SMA therapies that produce a sustained increase in SMN protein in both the CNS and periphery may provide comprehensive benefits ...
https://www.drugs.com/clinical_trials/genentech-announces-new-data-risdiplam-spinal-muscular-atrophy-sma-world-muscle-society-congress-17943.html?utm_source=ddc&utm_medium=rss&utm_campaign=Genentech+Announces+New+Data+for+Risdiplam+in+Spinal+Muscular+Atrophy+%28SMA%29+at+the+World+Muscle+Society+Congress
*  Cancer associated fibroblasts: An essential role in the tumor microenvironment (Review)
... survival of motor neuron protein interacting protein 1; IL-8, interleukin-8; CXCL1, C-X-C motif chemokine ligand 1; CK8, ... and the expression of survival proteins (74,75). Disruption of the CXCR4/CXCL12 signaling pathway has been demonstrated to ... Fibroblast activation protein α (FAPα) is a cytomembrane protein that is selectively expressed by activated CAFs in various ... YAP regulates the expression of specific cytoskeletal proteins, including anillin actin binding protein, diaphanous related ...
https://www.spandidos-publications.com/ol/14/3/2611
*  Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis
... ... "Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis." Journal ... Here, we investigated the levels of the survival of motor neuron (SMN) expression in OA cartilage considering the fundamental ... role of the SMN protein in cell survival and its involvement in other stress-associated pathologies. We report that SMN ...
https://dash.harvard.edu/handle/1/13581238
*  Researchers discover target that could ease spinal muscular atroph... ( COLUMBIA Mo. There is no cure for s...)
With the therapy MU researchers inhibited myostatin a protein that ...SMA is caused by the loss of survival motor neuron-1(SMN1 ... With the therapy MU researchers inhibited myostatin a protein that ...SMA is caused by the loss of survival motor neuron-1(SMN1 ... SMA is caused by the loss of survival motor neuron-1(SMN1). Humans have a nearly identical copy gene called SMN2. Because of a ... After treatment, the mice had increased muscle mass, gross motor function improvement and an increase in average life span of ...
http://www.bio-medicine.org/medicine-news-1/Researchers-discover-target-that-could-ease-spinal-muscular-atrophy-symptoms-33294-1/
*  A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of RO7034067 in Type 2 and 3...
Survival of Motor Neuron (SMN) Protein Levels in Blood [ Time Frame: Part 2: Days -1, 7, 28, 120, 246, 365, 729 ] ... Survival of Motor Neuron (SMN) Protein Levels in Blood [ Time Frame: Part 2: Days -1, 7, 28, 120, 246, 365, 729 ] ... Survival of Motor Neuron 2 (SMN2) Messenger Ribonucleic Acid (mRNA) Levels in Blood [ Time Frame: Part 2: Days -1, 1, 7, 28, ... Survival of Motor Neuron 2 (SMN2) Messenger Ribonucleic Acid (mRNA) Levels in Blood [ Time Frame: Part 2: Days -1, 1, 7, 28, ...
https://clinicaltrials.gov/ct2/show/record/NCT02908685?term=Roche+and+SMA&show_locs=Y
*  RBMY1A1 - RNA-binding motif protein, Y chromosome, family 1 member A1 - Homo sapiens (Human) - RBMY1A1 gene & protein
Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. ... RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. ... Protein. Similar proteins. Species. Score. Length. Source. P0DJD3. RNA-binding motif protein, Y chromosome, family 1 member B. ... Protein. Similar proteins. Species. Score. Length. Source. P0DJD3. RNA-binding motif protein, Y chromosome, family 1 member E. ...
https://www.uniprot.org/uniprot/P0DJD3
*  Gene Transfer Clinical Trial for Spinal Muscular Atrophy Type 1 - Full Text View - ClinicalTrials.gov
SMA is caused by low levels of the survival motor neuron (SMN) protein, and affects all muscles in the body. There is no ... Motor Neuron Disease. Neurodegenerative Diseases. Neuromuscular Diseases. Heredodegenerative Disorders, Nervous System. Genetic ... Change in CHOP-INTEND from baseline score and demonstration of improvement of motor function and muscle strength as determined ... Hypotonia by clinical evaluation with delay in motor skills, poor head control, round shoulder posture and hypermobility of ...
https://clinicaltrials.gov/ct2/show/NCT02122952?term=NCT02122952&rank=1%3Chttps%3A%2F%2Furldefense.proofpoint.com%2Fv1%2Furl%3Fu%3Dhttp%3A%2F%2Fwww.clinicaltrials.gov%2Fct2%2Fshow%2FNCT02122952%3Fterm%3DNCT02122952%26rank%3D1&k=aVCDkbis9JveikZ8%2Br3%2Fkw%3D%3D%0A&r=xUiGbG1kUDqQeUC4%2BANyPbgsWfYnp5t2njb%2Fxy2hwEwxs0yD1iERMzDzy%2FiVku%2BJ%0A&m=peLioUqRFciL7CdX4mBRVsTd8qIH%2FeqZUagOkXLI%2BzQ%3D%0A&s=b233272f4ef0eb8318e7a226d8221ff5c019039d29aaeda9485efb1f437febd0%3E
*  SMN Antibody (2B1) [HRP] (NB100-1936H): Novus Biologicals
survival motor neuron protein. *survival of motor neuron 1, telomeric. Limitations. This product is for research use only and ... FAQs for SMN Antibody (NB100-1936H). (Showing 1 - 1 of 1 FAQ).. * Could you recommond the Human specific SMN antibody? It will ...
https://www.novusbio.com/products/smn-antibody-2b1_nb100-1936h
*  Isis Pharmaceuticals, Inc. Advances ISIS-SMN Rx In Infants And Children With Spinal Muscular Atrophy | BioSpace
... gene leading to a decrease in the survival motor neuron (SMN) protein. SMN is critical to the health and survival of nerve ... SMA is caused by a loss of, or defect in, the survival motor neuron 1 (SMN1) ... The severity of SMA correlates with the amount of SMN protein. Infants with Type I SMA, the most severe form of the disease, ... Children with Type II have greater amounts of SMN protein but still have a shortened lifespan and are never able to stand ...
https://www.biospace.com/article/releases/isis-pharmaceuticals-inc-advances-isis-smn-rx-in-infants-and-children-with-spinal-muscular-atrophy-/