Loading...
*  Gliclazide - DrugBank
... route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral ... Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may ... Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in ... glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. ...
https://www.drugbank.ca/drugs/DB01120
*  Glimepiride Side Effects aka Glyburide | Glipizide or Sulfonylurea
Sulfonylurea)? Prolonged usage can lead to multiple side effects. Read on to find out. ... It does so by specifically binding to sulfonylurea receptors of the pancreatic beta cells. This binding initiates a complex ... Sulfonylureas must be taken with great precaution and only if the benefits outweigh the potential risks in pregnant and nursing ... Glimepiride is a sulfonylurea antidiabetic medication drug, also known as a "secretagogue," that stimulates the beta cells in ...
https://www.sepalika.com/type-2-diabetes/glimepiride-side-effects/
*  Patent US6492130 - Modulation of the sulfonylurea receptor and calcium in adipocytes for ... - Google Patents
The present invention recognizes the presence of the sulfonylurea receptor in adipocytes and its utility in identifying ... provides methods for determining the ability of compounds to regulate lipogenesis and lipolysis by acting as a sulfonylurea-1 ( ... 1, the sulfonylurea receptor mRNA was the only observed in adipocytes.. Example 2. The Adipocyte Sulfonylurea Receptor ... Sulfonylurea Receptor is Expressed in Human Adipocytes. To determine if the sulfonylurea receptor is present in human ...
http://www.google.com/patents/US6492130?dq=6,123,819
*  Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury. - PubMed -...
... and sulphonylurea-binding, modulatory subunits [sulfonylurea receptor (SUR) 1, 2A, or 2B]. Cardiovascular K(ATP) channels are ... Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury.. Lefer DJ1, ... Sulfonylurea receptor type 1 (SUR1) subunits are involved in cardioprotection. Multiple targets and cellular processes may be ... Sulfonylurea Receptor 1 Subunits of ATP-Sensitive Potassium Channels and Myocardial Ischemia/Reperfusion Injury ...
https://www.ncbi.nlm.nih.gov/pubmed/19577714
*  Sulfonylurea receptor - Wikipedia
... the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of ... sulfonylurea receptor at the US National Library of Medicine Medical Subject Headings (MeSH) Aguilar-Bryan L, Clement JP 4th, ... Three forms of the sulfonylurea receptor are known, SUR1 encoded by the ABCC8 gene, and SUR2A and SUR2B, which are splice ... The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in ...
https://en.wikipedia.org/wiki/Sulfonylurea_receptor
*  Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury |...
Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury. ... Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury ... Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury ... Role of Sulfonylurea Receptor Type 1 Subunits of ATP-Sensitive Potassium Channels in Myocardial Ischemia/Reperfusion Injury ...
http://circ.ahajournals.org/content/early/2008/03/03/CIRCULATIONAHA.107.745539
*  Potentiation of Quantal Catecholamine Secretion by Glibenclamide: Evidence for a Novel Role of Sulphonylurea Receptors in...
These results demonstrate that sulfonylurea receptors can modulate Ca2+-dependent exocytosis via a mechanism downstream of Ca2+ ... Potentiation of Quantal Catecholamine Secretion by Glibenclamide: Evidence for a Novel Role of Sulphonylurea Receptors in ... Potentiation of Quantal Catecholamine Secretion by Glibenclamide: Evidence for a Novel Role of Sulphonylurea Receptors in ... Potentiation of Quantal Catecholamine Secretion by Glibenclamide: Evidence for a Novel Role of Sulphonylurea Receptors in ...
http://www.jneurosci.org/content/19/14/5741
*  Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium...
The sulfonylurea receptor (SUR1; encoded by ABCC8) and its associated potassium channel (Kir6.2; encoded by KCNJ11) have been ... The genes for the sulfonylurea receptor (SUR1; encoded by ABCC8) and its associated islet ATP-sensitive potassium channel ( ... Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium ... Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium ...
http://diabetes.diabetesjournals.org/content/53/5/1360.full
*  Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293...
Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 ... 1. The pharmacological properties of K(ATP) channels generated by stable co-expression of the sulphonylurea receptor SUR1 and ... Specific binding was displaced by a series of sulphonylurea analogues with rank order potencies consistent with those observed ... Diazoxide-evoked responses were inhibited by various sulphonylurea analogues with rank order potencies that correlated well ...
https://www.sigmaaldrich.com/catalog/papers/10742287
*  A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of...
A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of ... A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of ... A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of ... A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of ...
http://diabetes.diabetesjournals.org/content/48/2/408
*  Rundown and DAMN | Philosophical Transactions of the Royal Society B: Biological Sciences
3. Is sulfonylurea receptor involved in rundown?. Neither SUR1 nor Kir6.2 is correctly trafficked to the membrane in the ... 1997 Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor. Nature 387, 179-183 ... 2006 ATP-sensitive K+ channels: regulation of bursting by the sulphonylurea receptor, PIP2 and regions of Kir6.2. J. Physiol. ... 1999 Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoforms. J. Biol ...
http://rstb.royalsocietypublishing.org/content/371/1700/20150426
*  Dopamine and Aging: Intersecting Facets | SpringerLink
Sulfonylurea receptors. TN. Tyrosine hydroxylase. VMAT2. Vesicular monoamine transporter 2. Special issue article in honor of ... Yu SP, Yeh CH, Strasser U et al (1999) NMDA Receptor-mediated K+ efflux and neuronal apoptosis. Science 284:336-339PubMed ... Hussain T, Lokhandwala MF (1998) Renal dopamine receptor function in hypertension. Hypertension 32:187-197PubMedGoogle Scholar ... Zeng C, Yang Z, Wang Z et al (2005) Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule ...
https://link.springer.com/article/10.1007%2Fs11064-008-9858-7
*  Altered cadherin expression is important for metastasis in many carcinomas including - Aurora Kinases as Druggable Targets in...
The sulfonylurea receptor SUR1 associates with Kir6. electrophysiological and FRET research. The sulfonylurea receptor SUR1 ... adipogenic activity of cultured human being periosteal-derived cells and studied perioxisome proliferator-activated receptor ( ...
http://www.exposed-skin-care.net/2016/12/01/altered-cadherin-expression-is-important-for-metastasis-in-many-carcinomas-including/
*  The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal...
Transient receptor potential melastatin member 4 (TRPM4), a Ca2+-activated nonselective cation channel, has been found to ... The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm4) channel. J Biol Chem. 2013;288(5):3655-67. ... an increased sulfonylurea receptor 1 (SUR1)-TRPM4 interaction has been reported in spinal cords from EAE mice, suggesting a ... Transient receptor potential melastatin member 4 (TRPM4), a Ca2+-activated nonselective cation channel, has been found to ...
https://link.springer.com/article/10.1186%2Fs13041-018-0385-4
*  Laparoscopic Diagnosis and Cure of Hyperinsulinism in Two Cases of Focal Adenomatous Hyperplasia in Infancy | ELECTRONIC...
... sulfonylurea receptor (SUR)1 (ABCC8) and potassium inward rectifier (Kir)6.2 (KCNJ11).1 In rarer cases of PHHI, mutations in ... sulfonylurea receptor • Kir, potassium inward rectifier. REFERENCES. *↵. Dunne MJ, Cosgrove KE, Shepherd RM, Lindley KJ, ...
http://pediatrics.aappublications.org/content/114/4/e520
*  Genetic variants tied to type 1 diabetes heterogeneity
T2DM risk cut by variant in sulfonylurea receptor encoder. April 25, 2017 (HealthDay)-A common missense variant in the gene ... encoding a component of the sulfonylurea receptor (ABCC8 p.A1369S), which promotes closure of the target channel of ...
https://medicalxpress.com/news/2017-11-genetic-variants-tied-diabetes-heterogeneity.html
*  JCI - Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP...
... the sulfonylurea receptor, from the endoplasmic reticulum to the plasma membrane (45). The strong dependence of the interaction ... sulfonylurea receptor; ABC1, ATP-binding cassette transporter 1; TAP1, transporter for antigen processing 1; CDR2, multidrug ... G protein-coupled receptor kinase 6A phosphorylates the Na+/H+ exchanger regulatory factor via a PDZ domain-mediated ... Sensitivity of a renal K+ channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression ...
https://www.jci.org/articles/view/9622
*  Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin...
ABCC8 and KCNJ11 (encoding, respectively, the sulphonylurea receptor and inwardly rectifying potassium channel KIR 6.2).. The ... 1999a) Variants in the sulphonylurea receptor gene: Association of the exon 16-3t variant with Type II diabetes mellitus in ... 1996) Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians. Diabetes 45: 825-831. ... sulphonylurea receptor), KCNJ11 (KIR6.2), SLC2A2 (GLUT2), HNF4A (HNF4α), and INS (insulin)-significantly altered disease risk, ...
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0000020
*  Sur - ATP-binding cassette sub-family C member Sur - Drosophila melanogaster (Fruit fly) - Sur gene & protein
"A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system.". Nasonkin ... "A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system.". Nasonkin ...
http://www.uniprot.org/uniprot/Q9VL32
*  Articles by David O. Okonkwo, MD, PhD : Critical Care Medicine
Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury. Jha, Ruchira M.; Puccio, Ava M ...
https://journals.lww.com/ccmjournal/pages/author.aspx?firstName=David&middleName=O.&lastName=Okonkwo
*  The Arg972 Variant in Insulin Receptor Substrate-1 Is Associated With an Increased Risk of Secondary Failure to Sulfonylurea in...
The Arg972 Variant in Insulin Receptor Substrate-1 Is Associated With an Increased Risk of Secondary Failure to Sulfonylurea in ... The Arg972 Variant in Insulin Receptor Substrate-1 Is Associated With an Increased Risk of Secondary Failure to Sulfonylurea in ... The Arg972 Variant in Insulin Receptor Substrate-1 Is Associated With an Increased Risk of Secondary Failure to Sulfonylurea in ... The Arg972 Variant in Insulin Receptor Substrate-1 Is Associated With an Increased Risk of Secondary Failure to Sulfonylurea in ...
http://care.diabetesjournals.org/content/27/6/1394
*  Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach | Diabetes Care
Insulin secretagogues, sulfonylurea receptors and K(ATP) channels. Curr Pharm Des 2005;11:2699-2716. ... GLP-1 receptor agonist; HF, heart failure; SU, sulfonylurea. aConsider beginning at this stage in patients with very high HbA1c ... a sulfonylurea, TZD, DPP-4 inhibitor, GLP-1 receptor agonist, or basal insulin. (The order in the chart is determined by ... GLP-1 receptor agonists are associated with weight reduction (38), which in some patients may be substantial. ...
http://care.diabetesjournals.org/content/35/6/1364?ijkey=e06c18eb47a76d8efd41ab1e532fd59ed06febbf&keytype2=tf_ipsecsha
*  ABCC9 gene - Genetics Home Reference - NIH
The ABCC9 gene provides instructions for making the sulfonylurea receptor 2 (SUR2) protein. This protein forms one part ( ...
https://ghr.nlm.nih.gov/gene/ABCC9
*  Plus it
1997) Truncation of Kir6.2 produces ATP-sensitive K channels in the absence of the sulphonylurea receptor. Nature 387: 179-183. ... Inagaki N, Gonoi T, Clement JP, Wang CZ, Aguilar-Bryan L, Bryan J, and Seino S (1996) A family of sulphonylurea receptors ... ABBREVIATIONS: KATP channel, ATP-sensitive potassium channel; SUR, sulfonylurea receptor; HEK, human embryonic kidney; NPo, ... Liss B, Bruns R, and Roeper J (1999a) Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP ...
http://jpet.aspetjournals.org/content/322/2/871
*  Plus it
The ATP-sensitive potassium channel consists of a pore-forming subunit coupled to a sulfonylurea receptor (Inagaki et al., 1995 ... ABBREVIATIONS: KATP, ATP-sensitive potassium; SUR, sulfonylurea receptor; APD90, action potential duration at 90% ... Three different sulfonylurea receptor subtypes have been isolated: SUR1 (on pancreatic islet cells), SUR2A (on cardiac tissue ... an inward rectifier subunit plus the sulfonylurea receptor. Science (Wash DC) 270: 1166-1170. ...
http://jpet.aspetjournals.org/content/309/1/182