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*  Sucrase-isomaltase - Wikipedia
Sucrase-isomaltase's mechanism results in a net retention of configuration at the anomeric center. Sucrase-isomaltase consists ... Not only has the structure of human sucrase-isomaltase been studied, but also sucrase-isomaltase's structure in sea lions and ... Congenital sucrase-isomaltase deficiency (CSID), also called genetic sucrase-isomaltase deficiency (GSID), and sucrose ... Structure and evolution of the mammalian maltase-glucoamylase and sucrase-isomaltase Sucrase-isomaltase complex at the US ...
https://en.wikipedia.org/wiki/Sucrase-isomaltase
*  Sucrase-Isomaltase Deficiency
n Sucrase-isomaltase. n -limit dextrins glucose. n Sucrase-isomaltase. n Sucrose glucose + fructose. n Sucrase-isomaltase. n ... Sucrase-Isomaltase: Digestive Function n Brush border disaccharidase. n Required for hydrolysis of dietary sucrose. n Catalyzes ... Mapping of the gene encoding human sucrase-isomaltase (SI) to chromosome 3q25-26. Cytogenet. Cell Genet. 46:604, 1987. n ... n Complete lack of sucrase in all forms. n Isomaltase activity varies depending on phenotype. n Genetic variability likely ...
http://www.nafwa.org/sucrase.php
*  Naturally occurring mutations in intestinal sucrase-isomaltase provide evidence for the existence of an intracellular sorting...
Mutations in the sucrase-isomaltase gene can lead to the synthesis of transport-incompetent or functionally altered enzyme in ... The sucrase subunit is not transported to the cell surface and is most likely degraded intracellularly. We conclude that ... The first phenotype revealed a sucrase-isomaltase protein that is synthesized as a single chain, mannose-rich polypeptide ... Naturally occurring mutations in intestinal sucrase-isomaltase provide evidence for the existence of an intracellular sorting ...
http://jcb.rupress.org/content/115/1/45
*  The human sucrase-isomaltase gene directs complex patterns of gene ex" by A J. Markowitz, G D. Wu et al.
Sucrase-isomaltase (SI) is an enterocyte-specific gene that is expressed in complex developmental and spatial patterns. In this ... Sucrase-isomaltase (SI) is an enterocyte-specific gene that is expressed in complex developmental and spatial patterns. In this ... Markowitz, A J.; Wu, G D.; Birkenmeier, E H.; and Traber, P G., " The human sucrase-isomaltase gene directs complex patterns of ... The human sucrase-isomaltase gene directs complex patterns of gene expression in transgenic mice. ...
https://mouseion.jax.org/stfb1990_1999/453/
*  The sucrase-isomaltase structural gene (Si-s) and a regulatory gene (" by E H. Birkenmeier, L B. Rowe et al.
Nine animals (16%) were homozygous for the CBA/CaJ allele (C) and had an average sucrase activity (jejunum+ileum) of 1.51 ... for Si-s with an average sucrase activity of 3.70 mumoles/h/mg protein (SE = 0.127). We conclude that Si-s and Si-r are closely ... Fifty-six mice from the F2 generation were assayed for sucrase activity, and the genotype of the murine SI structural gene ... Since CBA/CaJ mice have approximately threefold less sucrase activity than other strains, we intercrossed them with SJL/J mice ...
https://mouseion.jax.org/stfb1990_1999/440/
*  Sucrose intolerance - Wikipedia
Sucrose intolerance, also called sucrase-isomaltase deficiency, congenital sucrase-isomaltase deficiency (CSID), or genetic ... A deficiency of sucrase may result in malabsorption of sugar, which can lead to potentially serious symptoms. Since sucrose- ... All GSID patients lack fully functional sucrase, while the isomaltase activity can vary from minimal functionality to almost ... GSID involves deficiency in the enzyme sucrase-isomaltase, which breaks apart the glucose and fructose molecules. When ...
https://en.wikipedia.org/wiki/Sucrose_intolerance
*  Ontogeny of Small Intestinal Function
Considering these facts, it would make physiologic sense for neonatal intestine to have high lactase activity, but low sucrase ... The bottom figure to the right shows the inverse relationship between lactase and sucrase concentrations in the small intestine ... As another example, and in contrast to rats, cattle do not express small intestinal sucrase activity at any time during ... As might be expected from changes in sucrase expression, fructose transport is low during the suckling period and rises ...
http://www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/ontogeny.html
*  Four novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD) | BMC Gastroenterology | Full Text
... the activity for maltase and sucrase were normal (data not shown). Lactase activity was 8 U and the lactase/sucrase ratio was ... again with normal maltase and sucrase activities (data not shown) (disaccharidase activities were measured at the Academic ...
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-9-8
*  Disaccharidases synonyms, Disaccharidases antonyms - FreeThesaurus.com
6 words related to disaccharidase: enzyme, invertase, saccharase, sucrase, Lactaid, lactase. What are synonyms for ... Activities of mucosal disaccharidases including lactase, sucrase, and maltase have long been used as indicators of mucosa ... the activities of sucrase and maltase were mainly localized in the distal part of the small intestine, and lactase was ... sucrase','type':4},{'name':'Lactaid','type':4},{'name':'lactase','type':4}]},/script, ,svg width='720px' height='600px' id=' ...
http://www.freethesaurus.com/Disaccharidases
*  Peroxisome proliferator‐activated receptor gamma (PPARγ) regulates lactase expression and activity in the gut | EMBO Molecular...
Relative expression of genes encoding sucrase‐isomaltase (SIM) and maltase‐glucoamylase (MGAM) compared to LCT in Caco‐2 cells ... 2 cells such as sucrase‐isomaltase (SIM) and maltase‐glucoamylase (MGAM) (Fig EV2). ...
http://d3gz45kfcn01zz.cloudfront.net/content/early/2017/09/25/emmm.201707795
*  Sucrase - Wikipedia
... genetic sucrase-isomaltase deficiency (GSID), or sucrase-isomaltase deficiency) occurs when sucrase is not secreted in the ... Sucrase is a digestive enzyme secreted in the small intestine. Sucrase enzymes are located on the brush border of the small ... Sucrase is secreted by the tips of the villi of the epithelium in the small intestine. Its levels are reduced in response to ... The sucrase enzyme invertase, which occurs more commonly in plants, also hydrolyzes sucrose but by a different mechanism. EC ...
https://en.wikipedia.org/wiki/Sucrase
*  SUCRASE - Semantic Scholar
SUCRASE. Known as: Sucrose alpha-D-Glucohydrolase, Sucrase [Chemical/Ingredient], alpha-D-Glucohydrolase, Sucrose (More). ... Sacrosidase therapy for congenital sucrase-isomaltase deficiency.. *William R. Treem, L. Mcadams, L. Xiao Stanford, G Kastoff, ... HEREDITARY SUCROSE INTOLERANCE: LEVELS OF SUCRASE ACTIVITY IN JEJUNAL MUCOSA.. *Elizabeth A. Burgess, Bernard H. Levin, Dilip ... The goal of our study was to determine how sucrase-isomaltase (SI) gene expression in the rat small intestine is modulated by… ...
https://www.semanticscholar.org/topic/SUCRASE/84745
*  Sucrase - Biology-Online Dictionary | Biology-Online Dictionary
Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Sucrase&oldid=53121" ...
https://www.biology-online.org/dictionary/Sucrase
*  Biogenesis of intestinal plasma membrane: Posttranslational route and cleavage of sucrase-isomaltase | PNAS
The biosynthesis in vivo of rat intestinal sucrase-isomaltase [a complex of sucrose α-glucohydrolase, EC 3.2.1.48, and oligo-1, ... These data suggest that sucrase-isomaltase is synthesized as a one-chain polypeptide precursor that is split into the subunits ... Immunoprecipitation of sucrase-isomaltase from Triton-X-100-solubilized Golgi or basolateral membranes and subsequent ... Biogenesis of intestinal plasma membrane: Posttranslational route and cleavage of sucrase-isomaltase. Hans-Peter Hauri, Andrea ...
https://www.pnas.org/content/76/10/5183.short
*  Congenital Sucrase-Isomaltase Deficiency: Heterogeneity of... : Journal of Pediatric Gastroenterology and Nutrition
Other sucrase-based mutations such as Q1098P and G1073D support this view. An abolition of sucrase enzymatic activity reduces ... A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase- ... Biosynthesis of the human sucrase-isomaltase complex. Differential O-glycosylation of the sucrase subunit correlates with its ... Starch Digestion and Patients With Congenital Sucrase-Isomaltase Deficiency * Congenital Sucrase-Isomaltase Deficiency: Diet ...
https://journals.lww.com/jpgn/Fulltext/2012/11002/Congenital_Sucrase_Isomaltase_Deficiency__.5.aspx
*  Clinical Aspects and Treatment of Congenital Sucrase-Isomalt... : Journal of Pediatric Gastroenterology and Nutrition
Evaluation of liquid yeast-derived sucrase enzyme replacement in patients with sucrase-isomaltase deficiency. Gastroenterology ... including 4 of 44 with isolated low sucrase activity, and 11 of 44 with sucrase and pandisaccharidase deficiency, but no ... Congenital sucrase-isomaltase deficiency (CSID) in the era of Sucraid. J Pediatr Gastroenterol Nutr 2009; 53 (Suppl 1):E85.. * ... Intestinal sucrase-isomaltase deficiency and renal calculi. N Engl J Med 1970; 282:1023-1024.. * Cited Here... , ...
https://journals.lww.com/jpgn/Fulltext/2012/11002/Clinical_Aspects_and_Treatment_of_Congenital.4.aspx
*  Sucraid Supply Restored for Patients With Genetic Sucrase-Isomaltase Deficiency - MPR
In the absence of endogenous human sucrase, as in CSID, sucrose is not metabolized. Sucraid helps to improve the breakdown and ... Sucraid is indicated as oral replacement therapy of the genetically determined sucrase deficiency, which is part of congenital ... Sucraid is indicated as oral replacement therapy of the genetically determined sucrase deficiency, which is part of congenital ... sucrase-isomaltase deficiency (CSID). CSID is a chronic, autosomal recessive, inherited phenotypically heterogeneous disease ...
https://www.empr.com/news/sucraid-sacrosidase-congenital-sucrase-isomaltase-deficiency-csid-manufacturing-shortage-resolved/article/804470/
*  The effects of L-arabinose on intestinal sucrase activity: dose-response studies in vitro and in humans. - PubMed - NCBI
The effects of L-arabinose on intestinal sucrase activity: dose-response studies in vitro and in humans.. Krog-Mikkelsen I1, ... l-Arabinose inhibits sucrase activity from Caco-2 cells; 4% l-arabinose in sucrose beverages reduces postprandial glucose, ... On the basis of results in cell cultures, rodents, and pigs, l-arabinose may inhibit intestinal sucrase activity and thereby ... The objective was to investigate the dose-response effects of l-arabinose on intestinal sucrase activity in vitro and glucose ...
https://www.ncbi.nlm.nih.gov/pubmed/21677059
*  Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition | Gut
Sucrase-isomaltase (SI) 15Phe-driven IBS risk effects are stronger in low-starch consumers. The prevalence of IBS (%) across ... Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut 2018;67:263- ... Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition ... Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition ...
https://gut.bmj.com/content/68/1/177.long
*  Increased Prevalence of Rare Sucrase-isomaltase (SI) Pathogenic Variants in Irritable Bowel Syndrome Patients
... Garcia- ... Increased Prevalence of Rare Sucrase-isomaltase (SI) Pathogenic Variants in Irritable Bowel Syndrome Patients}, url = {http:// ...
https://lup.lub.lu.se/search/publication/037dbd9a-69cb-4daa-bfdb-b07be23ee185
*  JCI - Congenital sucrase-isomaltase deficiency. Identification of a glutamine to proline substitution that leads to a transport...
Here, we analyze at the molecular level a phenotype of congenital sucrase-isomaltase deficiency in which sucrase-isomaltase (SI ... Sequencing of the cDNA revealed a single mutation, A/C at nucleotide 3298 in the coding region of the sucrase subunit of the ... Congenital sucrase-isomaltase deficiency is an example of a disease in which mutant phenotypes generate transport-incompetent ... Congenital sucrase-isomaltase deficiency. Identification of a glutamine to proline substitution that leads to a transport block ...
https://www.jci.org/articles/view/118459
*  Most recent papers with the keyword Sucrase | Read by QxMD
Glucoamylase and sucrase were employed to hydrolyse the starch and sucrose present in the mixed F&B waste because of the high ... Amylase, maltase and sucrase activities were kept over a broad range of pH and temperature and exhibited Michaelis-Menten ... Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition. ... Glucose homeostasis in the euryhaline crab Cytograpsus angulatus: Effects of the salinity in the amylase, maltase and sucrase ...
https://www.readbyqxmd.com/keyword/18485
*  Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome
We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS. Design We sequenced SI exons in seven ... We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS. Design We sequenced SI exons in seven ... We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS. Design We sequenced SI exons in seven ... Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Henström, Maria; ...
https://lup.lub.lu.se/search/publication/6913f984-7554-41d3-873c-c71bcc3edea0
*  KAKEN - Research Projects | Biosynthesis of sucrase-isomaltase in the small intestine hereditarily deficient in sucrase...
Sucrase and isomaltase was of 116 and 96 kDa, respectively. The maltase activity of the complex was mainly ascribed to sucrase. ... Biosynthesis of sucrase-isomaltase in the small intestine hereditarily deficient in sucrase activity. Research Project ... The results of quantitative precipitation in test tube showed that normal sucrase-isomaltase and sucrase-free isomaltase were ... First, we have purified normal sucrase-isomaltase and abnormal sucrase-free isomaltase from normal and mutant indibiduals, ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05680545/
*  Isolation of a cDNA probe for a human jejunal brush-border hydrolase, sucrase-isomaltase, and assignment of the gene locus to...
... isomaltase region of human sucrase-isomaltase (SI). A plasmid containing this cDNA, pS12, identifies a 6-kb mRNA found in human ... Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence ... Congenital sucrase-isomaltase deficiency. Identification of a glutamine to proline substitution that leads to a transport block ... Isolation of a cDNA probe for a human jejunal brush-border hydrolase, sucrase-isomaltase, and assignment of the gene locus to ...
https://www.semanticscholar.org/paper/Isolation-of-a-cDNA-probe-for-a-human-jejunal-and-Green-Edwards/90d8dff7d1f537318c3a560faf390cafe3e2bd95